ci 953 has been researched along with phenytoin in 1 studies
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
| Studies (ci 953) | Trials (ci 953) | Recent Studies (post-2010) (ci 953) | Studies (phenytoin) | Trials (phenytoin) | Recent Studies (post-2010) (phenytoin) |
|---|---|---|---|---|---|
| 5 | 0 | 3 | 14,105 | 758 | 1,497 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Catterall, WA; Macdonald, RL; McLean, MJ; Rock, DM; Taylor, CP | 1 |
1 other study(ies) available for ci 953 and phenytoin
| Article | Year |
|---|---|
Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Batrachotoxins; Carbamazepine; Cells, Cultured; Electrophysiology; Epilepsy; Kinetics; Mice; Neurons; Phenylurea Compounds; Phenytoin; Radioligand Assay; Sodium Channels; Spinal Cord; Synaptosomes; Thiazoles | 1991 |