chrysin has been researched along with pyrazole* in 1 studies
1 other study(ies) available for chrysin and pyrazole
| Article | Year |
|---|---|
Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition.
The overexpress of COX-2 was clearly associated with carcinogenesis and COX-2 as a possible target has long been exploited for cancer therapy. In this work, we described the design and synthesis of a series of diarylpyrazole derivatives integrating with chrysin. Among them, compound e9 exhibited the most potent inhibitory activity against COX-2 and antiproliferative activity against Hela cells with IC Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Flavonoids; HEK293 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Structure-Activity Relationship | 2018 |