chondroitin-sulfates and triphosphoric-acid

chondroitin-sulfates has been researched along with triphosphoric-acid* in 1 studies

Other Studies

1 other study(ies) available for chondroitin-sulfates and triphosphoric-acid

Article	Year
Chitosan based hydrogel microspheres as drug carriers. Macromolecular bioscience, 2007, May-10, Volume: 7, Issue:5 Chitosan/tripolyphosphate (CHIT/TPP) and chitosan/tripolyphosphate/chondroitin sulfate (CHIT/TPP/CHS) core-shell type microspheres were prepared by polyelectrolyte complexation in order to develop a biocompatible matrix for drug delivery. The continual method using a multi-loop reactor under sterile conditions was applied for microsphere preparation. All the types of microspheres produced were spherical in shape and had a porous structure. The mechanical resistance of the microspheres increased in the presence of CHS as the second polyanion, which toughened the microsphere shell structure. For a drug release application, the process of microsphere preparation was modified by dissolving ofloxacin (OFL), the fluoroquinolone antibiotic, in CHIT solution before complex formation. This study shows the difference in OFL release comparing the microspheres CHIT/TPP and CHIT/TPP/CHS and implies the potential to control this process. Topics: Chitosan; Chondroitin Sulfates; Drug Carriers; Hydrogels; Microscopy, Confocal; Microspheres; Ofloxacin; Polyphosphates	2007

Article

Year

Chitosan based hydrogel microspheres as drug carriers.

Macromolecular bioscience, 2007, May-10, Volume: 7, Issue:5

Chitosan/tripolyphosphate (CHIT/TPP) and chitosan/tripolyphosphate/chondroitin sulfate (CHIT/TPP/CHS) core-shell type microspheres were prepared by polyelectrolyte complexation in order to develop a biocompatible matrix for drug delivery. The continual method using a multi-loop reactor under sterile conditions was applied for microsphere preparation. All the types of microspheres produced were spherical in shape and had a porous structure. The mechanical resistance of the microspheres increased in the presence of CHS as the second polyanion, which toughened the microsphere shell structure. For a drug release application, the process of microsphere preparation was modified by dissolving ofloxacin (OFL), the fluoroquinolone antibiotic, in CHIT solution before complex formation. This study shows the difference in OFL release comparing the microspheres CHIT/TPP and CHIT/TPP/CHS and implies the potential to control this process.

Topics: Chitosan; Chondroitin Sulfates; Drug Carriers; Hydrogels; Microscopy, Confocal; Microspheres; Ofloxacin; Polyphosphates

2007