chondroitin-sulfates and sodium-pyrophosphate

The inhibitory capacity of pyrophosphate, citrate, magnesium and chondroitin sulphate was investigated, using the urine of 21 calcium oxalate stone-forming patients without metabolic alterations. The inhibitory effect of these substances was assessed by a combination of nephelometry (light scattering) and optical microscopy. The results showed that citrate and magnesium had an inhibitory effect in a significant number of cases. Pyrophosphate and chondroitin sulphate had a less marked effect. The main urinary lithogenic biochemical parameters of the patients were also studied to see if there was a relationship between them and the inhibitory capacity of the compounds.

Topics: Calcium Oxalate; Chondroitin; Chondroitin Sulfates; Citrates; Citric Acid; Crystallization; Diphosphates; Humans; Magnesium; Urinary Calculi