chondroitin-sulfates and pheophorbide-a

chondroitin-sulfates has been researched along with pheophorbide-a* in 1 studies

Other Studies

1 other study(ies) available for chondroitin-sulfates and pheophorbide-a

Article	Year
A highly tumor-specific light-triggerable drug carrier responds to hypoxic tumor conditions for effective tumor treatment. Biomaterials, 2016, Volume: 77 Light-triggered drug delivery is among the most investigated stimulus-response strategies and has been widely explored in cancer treatment. However, the limited specificity of light-triggered drug delivery reduces the therapeutic efficacy and causes considerable undesirable side effects. In this work, we demonstrate a highly tumor-specific light-triggerable drug carrier (H-LTDC) induced by a combination of internal (i.e., tumor hypoxia) and external stimuli (i.e., light). The doxorubicin (DOX)-loaded H-LTDC was self-assembled from type-1-reactive oxygen species (ROStype1)-mediated degradable chondroitin sulfate (CS) conjugated with a photosensitizer (PS), Pheophorbide-a, which has a spherical shape and a uniform size distribution. Under hypoxic conditions, ROSType1 was mainly generated due to the electron-rich sulfate groups in the polysaccharide backbone. The ROStype1 generated by H-LTDC allowed laser-triggered drug release at low oxygen concentrations. From the in vitro cytotoxicity tests with colon cancer cells (HCT-116), under laser irradiation, DOX-loaded H-LTDCs showed higher toxicity under hypoxic conditions than that under normoxic conditions. In vivo and ex vivo biodistribution studies demonstrated that H-LTDCs selectively accumulated in the tumor tissues. As a result, drug-loaded H-LTDCs exhibited high anti-tumor activity in vivo. Overall, we believe that this approach could represent a promising platform for the treatment of tumor and hypoxia-associated diseases without undesirable side effects. Topics: Animals; Antibiotics, Antineoplastic; Carbohydrate Conformation; Cell Hypoxia; Chlorophyll; Chondroitin Sulfates; Doxorubicin; Drug Carriers; Drug Delivery Systems; Energy Transfer; HCT116 Cells; Humans; Hyaluronic Acid; Lasers, Semiconductor; Light; Mice; Mice, Nude; Nanoparticles; Optical Fibers; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Polysaccharides; Random Allocation; Reactive Oxygen Species; Singlet Oxygen; Xenograft Model Antitumor Assays	2016

Article

Year

A highly tumor-specific light-triggerable drug carrier responds to hypoxic tumor conditions for effective tumor treatment.

Biomaterials, 2016, Volume: 77

Light-triggered drug delivery is among the most investigated stimulus-response strategies and has been widely explored in cancer treatment. However, the limited specificity of light-triggered drug delivery reduces the therapeutic efficacy and causes considerable undesirable side effects. In this work, we demonstrate a highly tumor-specific light-triggerable drug carrier (H-LTDC) induced by a combination of internal (i.e., tumor hypoxia) and external stimuli (i.e., light). The doxorubicin (DOX)-loaded H-LTDC was self-assembled from type-1-reactive oxygen species (ROStype1)-mediated degradable chondroitin sulfate (CS) conjugated with a photosensitizer (PS), Pheophorbide-a, which has a spherical shape and a uniform size distribution. Under hypoxic conditions, ROSType1 was mainly generated due to the electron-rich sulfate groups in the polysaccharide backbone. The ROStype1 generated by H-LTDC allowed laser-triggered drug release at low oxygen concentrations. From the in vitro cytotoxicity tests with colon cancer cells (HCT-116), under laser irradiation, DOX-loaded H-LTDCs showed higher toxicity under hypoxic conditions than that under normoxic conditions. In vivo and ex vivo biodistribution studies demonstrated that H-LTDCs selectively accumulated in the tumor tissues. As a result, drug-loaded H-LTDCs exhibited high anti-tumor activity in vivo. Overall, we believe that this approach could represent a promising platform for the treatment of tumor and hypoxia-associated diseases without undesirable side effects.

Topics: Animals; Antibiotics, Antineoplastic; Carbohydrate Conformation; Cell Hypoxia; Chlorophyll; Chondroitin Sulfates; Doxorubicin; Drug Carriers; Drug Delivery Systems; Energy Transfer; HCT116 Cells; Humans; Hyaluronic Acid; Lasers, Semiconductor; Light; Mice; Mice, Nude; Nanoparticles; Optical Fibers; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Polysaccharides; Random Allocation; Reactive Oxygen Species; Singlet Oxygen; Xenograft Model Antitumor Assays

2016