chondroitin-sulfates and ferrous-chloride

Individual antithrombotic activities of superoxide dismutase (SOD) and sodium chondroitin sulfate (CHS) as well as the activities of covalent and noncovalent complexes of SOD with CHS were compared in a rat model of arterial thrombosis induced by ferrous chloride. Covalent conjugate of SOD with CHS exerted the most potent antithrombotic effect, which was associated with adsorption of the conjugate on the glycocalyx of the vascular wall cells and stability of the covalent bond between CHS and SOD subunits. Theoretical and practical directions in the investigation of SOD and CHS preparations are outlined.

Topics: Animals; Carotid Arteries; Chondroitin Sulfates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Stability; Ferrous Compounds; Fibrinolytic Agents; Glycocalyx; In Vitro Techniques; Male; Rats; Superoxide Dismutase; Thrombosis