Page last updated: 2024-09-03

cholylsarcosine and sarcosine

cholylsarcosine has been researched along with sarcosine in 21 studies

*Sarcosine: An amino acid intermediate in the metabolism of choline. [MeSH]

*Sarcosine: An amino acid intermediate in the metabolism of choline. [MeSH]

Compound Research Comparison

Studies
(cholylsarcosine)
Trials
(cholylsarcosine)
Recent Studies (post-2010)
(cholylsarcosine)
Studies
(sarcosine)
Trials
(sarcosine)
Recent Studies (post-2010) (sarcosine)
21341,55069520

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (47.62)18.2507
2000's6 (28.57)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hofmann, AF; Lillienau, J; Schteingart, CD1
Danzinger, RG; Esch, O; Hofmann, AF; Kim, YS; Lillienau, J; Longmire-Cook, SJ; Schteingart, CD1
Heuman, DM; Hofmann, AF; Hylemon, PB; Kim, YS; Lillienau, J; Pandak, WM; Vlahcevic, ZR1
Angellotti, MA; Hofmann, AF; Marcus, SN; Rossi, SS; Schmassmann, A; Schteingart, CD; Ton-Nu, HT1
Fehr, HF; Hofmann, AF; Lillienau, J; Locher, J; Rossi, SS; Schmassmann, A; Schteingart, CD1
Hagey, LR; Hofmann, AF; Jorgensen, RA; Lindor, KD; Ricci, P; Rolland Dickson, E1
Fordtran, JS; Gruy-Kapral, C; Hagey, LR; Hofmann, AF; Little, KH; Meziere, TL1
Stein, J; Weinand, I1
Heydorn, S; Jeppesen, PB; Mortensen, PB1
Jojić, N; Necić, D; Popović, OS1
Dillmann, R; Drewe, J; Fahr, A; Fricker, G; Michael, S; Thöle, M1
Emmett, M; Fordtran, JS; Guirl, MJ; Hofmann, AF; Neimark, S; Porter, JL; Santa Ana, CA1
Alvarez, MA; Ausina, V; Bartolí, R; Gassull, MA; Hagey, LR; Hernández, JM; Hofmann, AF; Lorenzo-Zúñiga, V; Mañé, J; Planas, R; Viñado, B1
Hofmann, AF; Kapral, C; Lenz, K; Praxmarer, V; Wewalka, F1
Bott, C; Dressman, JB; Fürst, T; Stein, J1
Chen, F; Chen, X; Dawson, PA; Glaeser, H; Hofmann, AF; Kim, RB; Liu, S; Pang, KS; Shneider, BL1
Fricker, G; Hartmann, FJ; Parmentier, J1
Alstrup, AK; Frisch, K; Hofmann, AF; Jakobsen, S; Keiding, S; Munk, OL; Ott, P; Sørensen, M1
Alstrup, AK; Andersen, KJ; Frisch, K; Hofmann, AF; Keiding, S; Mortensen, FV; Munk, OL; Ott, P; Sørensen, M; Ørntoft, NW1
Frisch, K; Keiding, S; Munk, OL; Ott, P; Sørensen, M; Ørntoft, NW1
Frisch, K; Keiding, S; Ott, P; Sørensen, M; Ørntoft, N1

Reviews

1 review(s) available for cholylsarcosine and sarcosine

ArticleYear
Functional assessment of hepatobiliary secretion by
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:4 Pt B

    Topics: Anti-Bacterial Agents; Bile Acids and Salts; Bile Ducts; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cholestasis; Cholic Acids; Feasibility Studies; Female; Humans; Liver; Middle Aged; Molecular Imaging; Pneumonia; Positron-Emission Tomography; Radioactive Tracers; Sarcosine

2018

Trials

3 trial(s) available for cholylsarcosine and sarcosine

ArticleYear
Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome.
    Scandinavian journal of gastroenterology, 1999, Volume: 34, Issue:8

    Topics: Aged; Analysis of Variance; Calorimetry; Cholic Acids; Cross-Over Studies; Dietary Fats; Energy Intake; Energy Metabolism; Fats; Feces; Female; Food, Formulated; Humans; Intestinal Absorption; Male; Middle Aged; Sarcosine; Short Bowel Syndrome

1999
Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome.
    The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:1

    Topics: Adult; beta Carotene; Chemistry, Pharmaceutical; Cholic Acids; Excipients; Feces; Female; Humans; Hydrogen-Ion Concentration; Lipids; Microscopy, Electron, Scanning; Middle Aged; Particle Size; Pilot Projects; Polymethacrylic Acids; Powders; Sarcosine; Short Bowel Syndrome; Solubility; Tablets, Enteric-Coated

2005
Hepatobiliary transport kinetics of the conjugated bile acid tracer
    Journal of hepatology, 2017, Volume: 67, Issue:2

    Topics: Aged; Bile; Bile Acids and Salts; Biological Transport, Active; Carbon Radioisotopes; Case-Control Studies; Cholestasis; Cholic Acids; Female; Humans; Kinetics; Liver; Liver Circulation; Male; Middle Aged; Positron-Emission Tomography; Sarcosine; Young Adult

2017

Other Studies

17 other study(ies) available for cholylsarcosine and sarcosine

ArticleYear
Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine.
    The Journal of clinical investigation, 1992, Volume: 89, Issue:2

    Topics: Animals; Bile Acids and Salts; Calcium; Cholic Acids; Colon; Humans; Intestine, Small; Lipolysis; Magnetic Resonance Spectroscopy; Malabsorption Syndromes; Micelles; Rabbits; Sarcosine; Solubility

1992
Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:8

    Topics: Absorption; Animals; Bile Acids and Salts; Body Weight; Cholic Acids; Diarrhea; Dietary Fats; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gastrointestinal Contents; Ileum; Malabsorption Syndromes; Male; Sarcosine; Time Factors

1992
Effect of cholylsarcosine on hepatic cholesterol and bile acid synthesis and bile secretion in rats.
    Gastroenterology, 1992, Volume: 103, Issue:5

    Topics: Animals; Bile Acids and Salts; Biliary Fistula; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholic Acids; Glycocholic Acid; Liver; Male; Phospholipids; Rats; Rats, Sprague-Dawley; Sarcosine; Taurocholic Acid

1992
Transport, metabolism, and effect of chronic feeding of cholylsarcosine, a conjugated bile acid resistant to deconjugation and dehydroxylation.
    Gastroenterology, 1990, Volume: 98, Issue:1

    Topics: Animals; Bile; Biological Transport; Biotransformation; Cholic Acids; Cricetinae; Enterohepatic Circulation; Ileum; Intestinal Absorption; Male; Rabbits; Rats; Sarcosine; Taurocholic Acid

1990
Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary secretion in humans.
    Gastroenterology, 1993, Volume: 104, Issue:4

    Topics: Adult; Aged; Bile; Bile Acids and Salts; Biotransformation; Cholecystectomy; Cholelithiasis; Cholic Acids; Duodenum; Female; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Reference Values; Sarcosine; Time Factors

1993
Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:6

    Topics: Adult; Cholagogues and Choleretics; Cholesterol; Cholic Acids; Drug Therapy, Combination; Female; Humans; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Middle Aged; Sarcosine; Ursodeoxycholic Acid

1998
Conjugated bile acid replacement therapy for short-bowel syndrome.
    Gastroenterology, 1999, Volume: 116, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Body Weight; Cattle; Cholic Acids; Diarrhea; Dietary Fats; Energy Intake; Feces; Female; Follow-Up Studies; Humans; Ileostomy; Intestinal Absorption; Middle Aged; Sarcosine; Short Bowel Syndrome

1999
[Cholysarkosin in treatment of bile acid deficiency syndrome].
    Zeitschrift fur Gastroenterologie, 1999, Volume: 37, Issue:7

    Topics: Administration, Oral; Bile Acids and Salts; Celiac Disease; Cholic Acids; Diarrhea; Humans; Ileum; Intestinal Absorption; Malabsorption Syndromes; Sarcosine; Short Bowel Syndrome; Treatment Outcome

1999
Cholylsarcosine for bile acid deficiency caused by ileal resection.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:9

    Topics: Adult; Animals; Bile Acids and Salts; Cholic Acids; Dogs; Female; Humans; Ileum; Male; Postoperative Complications; Sarcosine

1999
Improvement of intestinal peptide absorption by a synthetic bile acid derivative, cholylsarcosine.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 10, Issue:2

    Topics: Animals; Area Under Curve; Bile Acids and Salts; Caco-2 Cells; Cell Membrane Permeability; Cell Survival; Cholic Acids; Dextrans; Electric Impedance; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Intestinal Absorption; Male; Membranes, Artificial; Peptides; Rats; Rats, Wistar; Sarcosine; Stimulation, Chemical

2000
Conjugated bile acid replacement therapy reduces urinary oxalate excretion in short bowel syndrome.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 41, Issue:1

    Topics: Administration, Oral; Aged; Animals; Calcium Oxalate; Cattle; Celiac Disease; Cholic Acids; Feces; Humans; Hyperoxaluria; Male; Outpatients; Sarcosine; Short Bowel Syndrome; Urine

2003
Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:3

    Topics: Animals; Bacteria; Bacterial Translocation; Bile; Bile Acids and Salts; Cholic Acids; Endotoxemia; Glycocholic Acid; Ileum; Intestines; Liver Cirrhosis, Experimental; Male; Placebos; Rats; Rats, Sprague-Dawley; Sarcosine

2003
Conjugated bile acid replacement therapy in short bowel syndrome patients with a residual colon.
    Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:7

    Topics: Aged; Animals; Bile Acids and Salts; Body Mass Index; Body Weight; Cattle; Cholic Acids; Diarrhea; Dietary Fats; Female; Humans; Intestinal Absorption; Intestine, Small; Male; Middle Aged; Postoperative Complications; Sarcosine; Short Bowel Syndrome; Steatorrhea; Treatment Outcome

2004
Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor.
    Molecular pharmacology, 2006, Volume: 69, Issue:6

    Topics: Animals; Bile Acids and Salts; Biological Transport; Caco-2 Cells; Calcitriol; Cholic Acids; Erythrocytes; Gene Expression; Humans; Intestine, Small; Mutation; Organic Anion Transporters, Sodium-Dependent; Perfusion; Promoter Regions, Genetic; Rats; Receptors, Calcitriol; Retinoid X Receptors; RNA, Messenger; Sarcosine; Sequence Deletion; Symporters; Transcriptional Activation; Vitamin D Response Element

2006
In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2010, Volume: 76, Issue:3

    Topics: Administration, Oral; Amines; Caco-2 Cells; Cholesterol; Cholic Acids; Dextrans; Drug Carriers; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Humans; Liposomes; Macromolecular Substances; Phosphatidylcholines; Polyethylene Glycols; Sarcosine; Vitamin E

2010
[N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:5

    Topics: Animals; Bile Acids and Salts; Carbon Radioisotopes; Cholic Acids; Female; Liver; Liver Function Tests; Multimodal Imaging; Positron-Emission Tomography; Radioactive Tracers; Radiochemistry; Sarcosine; Swine; Tomography, X-Ray Computed

2012
Hepatobiliary Secretion Kinetics of Conjugated Bile Acids Measured in Pigs by 11C-Cholylsarcosine PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:6

    Topics: Animals; Biliary Tract; Carbon Radioisotopes; Cholic Acids; Female; Kinetics; Liver; Positron-Emission Tomography; Sarcosine; Swine

2016