choline has been researched along with pnu 120596 in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 13 (86.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hone, A; Innocent, N; Kimura, A; Livingstone, PD; McIntosh, JM; Whiteaker, P; Wonnacott, S; Young, T | 1 |
| Beach, JW; Buccafusco, JJ; Terry, AV | 1 |
| Gusev, AG; Uteshev, VV | 1 |
| Gusev, AG; Kalappa, BI; Uteshev, VV | 1 |
| Uteshev, VV | 2 |
| Carroll, FI; Damaj, MI; Freitas, K; Negus, SS | 1 |
| Jin, K; Johnson, SR; Kalappa, BI; Sun, F; Uteshev, VV | 1 |
| Crooks, PA; Fifer, EK; Kimbrell, MR; Pack, TF; Papke, RL; Peng, C; Tian, C | 1 |
| Kalappa, BI; Uteshev, VV | 1 |
| Mike, A; Pesti, K; Szabo, AK; Vizi, ES | 2 |
| Floyd, KL; Stevens, KE; Stitzel, JA; Zheng, L | 1 |
| Cheng, Q; Yakel, JL | 1 |
| Bortz, DM; Bruno, JP; Mikkelsen, JD; Upton, BA | 1 |
2 review(s) available for choline and pnu 120596
| Article | Year |
|---|---|
Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.
Topics: Allosteric Regulation; Animals; Binding Sites; Choline; Drug Design; Humans; Isoxazoles; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Piperazines; Pyridines; Rats; Receptors, Nicotinic | 2009 |
α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2012 |
13 other study(ies) available for choline and pnu 120596
| Article | Year |
|---|---|
Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Calcium; Choline; Conotoxins; Dopamine; Humans; Isoxazoles; Male; Nicotinic Antagonists; PC12 Cells; Phenylurea Compounds; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spiro Compounds | 2008 |
Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Drug Synergism; Female; Hypothalamic Area, Lateral; Isoxazoles; Male; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2010 |
Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Choline; Dose-Response Relationship, Drug; Drug Synergism; Female; Isoxazoles; Male; Nootropic Agents; Patch-Clamp Techniques; Phenylurea Compounds; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2010 |
Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Calcium; Choline; Hippocampus; Interneurons; Ion Channels; Isoxazoles; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2012 |
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines | 2013 |
A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain Ischemia; Choline; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Neurons; Neuroprotective Agents; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley | 2013 |
Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Choline; Cytotoxins; Female; Humans; Isoxazoles; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Xenopus laevis | 2013 |
The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Drug Synergism; Female; In Vitro Techniques; Ion Channel Gating; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley | 2013 |
Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biophysics; Cell Line, Tumor; Choline; Computer Simulation; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Isoxazoles; Membrane Potentials; Models, Biological; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pituitary Neoplasms; Rats; Transfection | 2014 |
Kinetic properties and open probability of α7 nicotinic acetylcholine receptors.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biophysical Phenomena; Cell Line, Tumor; Choline; Computer Simulation; Dose-Response Relationship, Drug; Electric Stimulation; Isoxazoles; Membrane Potentials; Models, Biological; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pituitary Neoplasms; Rats; Transfection | 2014 |
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline; Disease Models, Animal; Female; Heterozygote; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Transgenic; Phenylurea Compounds; Schizophrenia; Sensory Gating | 2015 |
Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.
Topics: Adenylyl Cyclases; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cells, Cultured; Choline; Cholinergic Agents; Cyclic AMP; Hippocampus; Intracellular Space; Isoxazoles; Mice, Inbred C57BL; Neurons; Phenylurea Compounds; Phosphorylation; Synapsins | 2015 |
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Anilides; Animals; Choline; Excitatory Amino Acid Agonists; Glutamic Acid; Isoxazoles; Male; N-Methylaspartate; Nucleus Accumbens; Phenylurea Compounds; Prefrontal Cortex; Rats; Rats, Wistar | 2016 |