choline has been researched along with methotrexate in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Poirier, LA | 1 |
| Barak, AJ; Sorrell, MF; Tuma, DJ | 1 |
| Freeman-Narrod, M | 1 |
| Custer, RP; Freeman-Narrod, M; Narrod, SA | 1 |
| Bradley, JD; Brater, DC; Hall, SD; Jones, DR; Krohn, K; Tracy, TS | 1 |
| Aarsaether, N; Aarsland, A; Berge, RK; Svardal, A; Ueland, PM | 1 |
| Thomas, DW | 1 |
| Barak, AJ; Tuma, DJ | 1 |
| Barak, AJ; Kemmy, RJ | 1 |
| Pérez de Miguelsanz, J; Ragel, C; Varela-Moreiras, G | 1 |
| Alonso-Aperte, E; Varela-Moreiras, G | 1 |
| Chan, YL; Chik, KW; Lau, KY; Li, CK; Roebuck, DJ; Yeung, KW; Yuen, MP | 1 |
| DERBES, VJ | 1 |
| Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL | 1 |
| Blamek, S; Ficek, K; Miszczyk, L; Sońta-Jakimczyk, D; Syguła, D; Tarnawski, R | 1 |
| Duarte, IF; Gil, AM; Lamego, I; Marques, MP | 1 |
1 review(s) available for choline and methotrexate
| Article | Year |
|---|---|
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
16 other study(ies) available for choline and methotrexate
| Article | Year |
|---|---|
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.
Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12 | 1975 |
Interaction of methotrexate with lipotropic factors in rat liver.
Topics: Animals; Cholesterol; Choline; Choline Deficiency; Diet; Drug Synergism; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Phospholipids; Rats; Triglycerides; Vitamin B 12 | 1975 |
Choline antagonism of methotrexate liver toxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Hydroxyurea; Liver; Liver Diseases; Male; Methotrexate; Methylation; Rats; Triglycerides | 1977 |
Chronic toxicity of methotrexate in rats: partial to complete projection of the liver by choline: Brief communication.
Topics: Animals; Bone Marrow; Choline; Choline Deficiency; Fatty Liver; Liver; Male; Methotrexate; Rats | 1977 |
The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Proteins; Choline; Female; Humans; Ibuprofen; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Protein Binding; Salicylates | 1992 |
Effect of methotrexate on long-chain fatty acid metabolism in liver of rats fed a standard or a defined, choline-deficient diet.
Topics: Animals; Carnitine O-Palmitoyltransferase; Choline; Choline Deficiency; Coenzyme A Ligases; Fatty Acids; Glycerol-3-Phosphate O-Acyltransferase; Kinetics; Liver; Male; Methotrexate; Models, Biological; Rats; Rats, Inbred Strains; Reference Values; Repressor Proteins; Saccharomyces cerevisiae Proteins; Subcellular Fractions | 1988 |
Discontinous antibody secretion during the secondary response to sheep erythrocytes in vitro.
Topics: Adenosine; Animals; Antibody Formation; Antibody-Producing Cells; Antigens; Cells, Cultured; Choline; Erythrocytes; Female; Hemolytic Plaque Technique; Immunologic Memory; Lymphocytes; Methotrexate; Mice; Mice, Inbred BALB C; Spleen; Thymidine; Tritium | 1974 |
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; Rats, Inbred Strains | 1982 |
Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats.
Topics: Animals; Choline; Choline Deficiency; DNA Modification Methylases; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Wistar | 1995 |
Brain folates and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate.
Topics: Animals; Brain; Choline; Choline Deficiency; Diet; DNA Methylation; Folic Acid; Male; Methotrexate; Rats; Rats, Wistar | 1996 |
Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Aspartic Acid; Brain; Brain Infarction; Cerebrovascular Disorders; Child; Choline; Cranial Irradiation; Creatine; Female; Humans; Injections, Spinal; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Time Factors | 2001 |
THERAPEUTIC PROGRESS IN DERMATOLOGY.
Topics: Choline; Dermatology; Drug Therapy; Humans; Leukopenia; Methotrexate; Pharmacology; Psoriasis; Urticaria | 1965 |
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous System Neoplasms; Choline; Creatine; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Immunocompetence; Lactic Acid; Lipid Metabolism; Lymphoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Protons; Survival Analysis | 2005 |
Evaluation of the late effects of CNS prophylactic treatment in childhood acute lymphoblastic leukemia (ALL) using magnetic resonance spectroscopy.
Topics: Adolescent; Aspartic Acid; Brain Injuries; Case-Control Studies; Child; Child, Preschool; Choline; Cranial Irradiation; Creatine; Drug Administration Routes; Drug Therapy; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution | 2010 |
Metabolic markers of MG-63 osteosarcoma cell line response to doxorubicin and methotrexate treatment: comparison to cisplatin.
Topics: Amino Acids; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Membrane; Choline; Cisplatin; Doxorubicin; Energy Metabolism; Humans; Lipid Metabolism; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methotrexate; Molecular Structure; Multivariate Analysis; Nucleotides; Osteosarcoma | 2014 |