cholesterol-alpha-oxide and cholesterol-hydroperoxide

cholesterol-alpha-oxide has been researched along with cholesterol-hydroperoxide* in 2 studies

Reviews

1 review(s) available for cholesterol-alpha-oxide and cholesterol-hydroperoxide

ArticleYear
[Relationship between oxysterols and atherosclerosis].
    Sheng li ke xue jin zhan [Progress in physiology], 1999, Volume: 30, Issue:1

    Oxysterols, being oxygenated derivatives of cholesterol, are as many kinds as one hundred. They are found in the foodstuffs, the blood and arterial tissues of animals with hypercholesterolemia, the human atheroma, the foam cell from atherosclerotic tissues, as well as in the oxidized low density lipoprotein. The results of experiments have demonstrated that oxysterols are cytotoxic and they are injurious to a variety of cells including vascular endothelial cells, smooth muscle cells and monocyte/macrophages, suggesting that oxysterols could play a key role in the initiation and pathogenesis of atherosclerosis.

    Topics: Animals; Arteriosclerosis; Carrier Proteins; Cholesterol; Humans; Lipoproteins, LDL; Receptors, Steroid

1999

Other Studies

1 other study(ies) available for cholesterol-alpha-oxide and cholesterol-hydroperoxide

ArticleYear
Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry.
    Free radical biology & medicine, 1994, Volume: 17, Issue:5

    The application of gas chromatography and high-pressure liquid chromatography/mass spectrometry techniques for analysis of plasma cholesterol oxidation products is described. Cholesterol oxides that are widely identified in biological samples were subjected to gas (GC) and high-pressure liquid chromatographic (HPLC) separations, and their detection and characterization by mass spectrometry (MS) were compared. Analysis of cholesterol oxides from plasma samples revealed distinct advantages for each method according to the specific cholesterol oxide in question. Whereas HPLC/MS analysis of cholesterol oxides provided less resolution and lower sensitivity as compared to GC/MS, a distinct advantage was evident for direct measurements of cholesterol-7-hydroperoxides and 7-ketocholesterol. These two cholesterol oxides are particularly sensitive to storage in solvents, derivatization procedures, and analytical conditions used for GC analysis, which are minimized or avoided using the HPLC/MS conditions described. Analysis of human and rabbit plasma samples identified cholest-5-ene-3 beta, 7 beta-diol (7 beta-hydroxycholesterol); 5,6 alpha-epoxy-5 alpha-cholestan-3 beta-ol (cholesterol-5 alpha, 6 alpha-epoxide); 5 alpha-cholestane-3 beta, 5,6 beta-triol (cholestanetriol); 3 beta-hydroxycholest-5-ene-7-one (7-ketocholesterol); and 5,6 beta-epoxy-5 beta-cholestan-3 beta-ol (cholesterol-5 beta,6 beta-epoxide) as commonly occurring components (trivial names indicated in parentheses). The latter two compounds were dramatically increased in hypercholesterolemic samples and were found in approximately equal amounts in the free cholesterol and cholesteryl ester fractions. Although most of the plasma cholesterol oxides are found in the dietary cholesterol, others are not, particularly cholesterol-5 beta,6 beta-epoxide, suggesting that at least some of these compounds are formed by in vivo oxidation of cholesterol. Despite the readily measurable levels of the above cholesterol oxides, as well as other less prominent oxides, there was no evidence of cholesterol-7-hydroperoxides associated with plasma free cholesterol. Although several of the plasma cholesterol oxides may derive from cholesterol-7-hydroperoxides, it appears that the latter are either unstable and decompose in plasma, are metabolized to other cholesterol oxidation products, or break down during their isolation.

    Topics: Animals; Cholesterol; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Ketocholesterols; Lipid Peroxides; Male; Mass Spectrometry; Oxidation-Reduction; Rabbits

1994