Page last updated: 2024-09-03

cholesta-5,8-dien-3 beta-ol and 7-dehydrocholesterol

cholesta-5,8-dien-3 beta-ol has been researched along with 7-dehydrocholesterol in 24 studies

Compound Research Comparison

Studies (cholesta-5,8-dien-3 beta-ol)	Trials (cholesta-5,8-dien-3 beta-ol)	Recent Studies (post-2010) (cholesta-5,8-dien-3 beta-ol)	Studies (7-dehydrocholesterol)	Trials (7-dehydrocholesterol)	Recent Studies (post-2010) (7-dehydrocholesterol)
36	1	8	426	5	142

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (33.33)	18.2507
2000's	11 (45.83)	29.6817
2010's	5 (20.83)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Batta, AK; Salen, G; Shefer, S; Tint, GS	1
Chevy, F; Citadelle, D; Kolf-Clauw, M; Mulliez, N; Pham, J; Roux, C; Wolf, C	1
Gerst, N; Ruan, B; Schroepfer, GJ; Shey, J; Wilson, WK	1
de Jong, JG; Janssen-Zijlstra, FS; Jira, PE; Wendel, U; Wevers, RA	1
Batta, AK; Elias, ER; Honda, A; Irons, M; Salen, G; Shefer, S; Tint, GS; Xu, G	1
Nijenhuis, AA; Schutgens, RB; van Rooij, A; Wijburg, FA	1
Abuelo, D; Batta, AK; Cordier, MP; Elias, ER; Honda, A; Honda, M; Irons, M; Salen, G; Shefer, S; Till, M; Tint, GS; Xu, G	1
Batta, AK; Honda, A; Honda, M; Matsuzaki, Y; Salen, G; Shefer, S; Shoda, J; Tanaka, N; Tint, GS; Xu, G	1
de Jong, J; Janssen-Zijlstra, FS; Jira, PE; Rubio-Gozalbo, E; Sengers, RC; Smeitink, JA; van Heyst, AF; Wevers, RA	1
Andersson, U; Babiker, A; Björkhem, I; Diczfalusy, U; Lütjohann, D; Pikuleva, I; Starck, L; von Bahr, S	1
Aldaghlas, TA; Haidl, G; Henkel, SM; Kelleher, JK; Lindenthal, B; Tolba, R; von Bergmann, K	1
Corso, G; De, BD; Dello, RA; Parenti, G; Rossi, I; Rossi, M	1
Björkhem, I; Lövgren-Sandblom, A; Starck, L	1
Cui, J; Javitt, NB; Porter, FD; Wassif, CA; Yu, J	1
Beemer, FA; de Barse, MM; Dorland, L; Duran, M; Langius, FA; Oostheim, W; Poll-The, BT; Romeijn, GJ; Wanders, RJ; Waterham, HR	1
Connor, WE; Flavell, DP; Lin, DS; Linck, LM; Merkens, LS; Steiner, RD	1
Chevy, F; Humbert, L; Wolf, C	1
Armbrust, S; Fusch, C; Haas, D; Haas, JP; Mühlmann, K; Neumann, LM; Zschocke, J	1
Berger, R; de Barse, M; de Sain-van der Velden, MG; Prinsen, BH; Verrips, A; Visser, G	1
Corso, G; D'Apolito, O; Dello Russo, A; Gelzo, M; Paglia, G	1
Beblo, S; Becker, S; Ceglarek, U; Empting, S; Haas, D; Husain, RA; Mohnike, K; Mütze, U; Röhnike, S; Thiery, J	1
Abdel-Khalik, J; Bigger, BW; Björkhem, I; Clayton, PT; Crick, PJ; Griffiths, WJ; Honda, A; Kwok, MK; Morris, AA; Ogundare, M; Porter, NA; Shackleton, CH; Tuschl, K; Wang, Y; Xu, L	1
Armstrong, K; Konradi, C; Korade, Ž; Liu, W; Porter, NA; Warren, EB	1
Dias, P; Rocha, P; Sousa, AB; Travessa, A	1

Reviews

1 review(s) available for cholesta-5,8-dien-3 beta-ol and 7-dehydrocholesterol

Article	Year
The Smith-Lemli-Opitz syndrome: a potentially fatal birth defect caused by a block in the last enzymatic step in cholesterol biosynthesis. Sub-cellular biochemistry, 1997, Volume: 28 Topics: Animals; Cholestadienols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Humans; Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Smith-Lemli-Opitz Syndrome	1997

Article

Year

The Smith-Lemli-Opitz syndrome: a potentially fatal birth defect caused by a block in the last enzymatic step in cholesterol biosynthesis.

Sub-cellular biochemistry, 1997, Volume: 28

Topics: Animals; Cholestadienols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Humans; Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Smith-Lemli-Opitz Syndrome

1997

Trials

1 trial(s) available for cholesta-5,8-dien-3 beta-ol and 7-dehydrocholesterol

Article	Year
Highly increased CSF concentrations of cholesterol precursors in Smith-Lemli-Opitz syndrome. Journal of inherited metabolic disease, 1997, Volume: 20, Issue:4 Topics: Cholestadienols; Cholesterol; Chromatography, Gas; Dehydrocholesterols; Female; Humans; Infant; Infant, Newborn; Male; Smith-Lemli-Opitz Syndrome	1997

Other Studies

22 other study(ies) available for cholesta-5,8-dien-3 beta-ol and 7-dehydrocholesterol

Article	Year
Identification of 19-nor-5,7,9(10)-cholestatrien-3 beta-ol in patients with Smith-Lemli-Opitz syndrome. Journal of lipid research, 1995, Volume: 36, Issue:11 Topics: Cholestadienols; Cholestenes; Cholesterol; Dehydrocholesterols; Humans; Mass Spectrometry; Molecular Structure; Smith-Lemli-Opitz Syndrome	1995
Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome. Journal of lipid research, 1996, Volume: 37, Issue:6 Topics: Animals; Child; Cholestadienols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Female; Heterozygote; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	1996
Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol. Proceedings of the National Academy of Sciences of the United States of America, 1996, Oct-15, Volume: 93, Issue:21 Topics: Animals; Carbon Radioisotopes; Cholestadienols; Chromatography, Gas; Chromatography, High Pressure Liquid; Dehydrocholesterols; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Rats; Silver; Sterols	1996
Pitfalls in measuring plasma cholesterol in the Smith-Lemli-Opitz syndrome. Clinical chemistry, 1997, Volume: 43, Issue:1 Topics: Adult; Child; Cholestadienols; Cholesterol; Cholesterol Oxidase; Chromatography, Gas; Dehydrocholesterols; False Positive Reactions; Humans; Infant; Infant, Newborn; Reference Values; Smith-Lemli-Opitz Syndrome	1997
Fetal Smith-Lemli-Opitz syndrome can be detected accurately and reliably by measuring amniotic fluid dehydrocholesterols. Prenatal diagnosis, 1998, Volume: 18, Issue:7 Topics: Adult; Amniocentesis; Amniotic Fluid; Cholestadienols; Cholesterol; Dehydrocholesterols; Female; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Pregnancy; Pregnancy Outcome; Reference Values; Smith-Lemli-Opitz Syndrome	1998
Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver. Journal of lipid research, 1999, Volume: 40, Issue:8 Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholestadienols; Cholestanetriol 26-Monooxygenase; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 Enzyme System; Dehydrocholesterols; Female; Humans; Infant; Infant, Newborn; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Models, Biological; Models, Chemical; Piperazines; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; Steroid Hydroxylases	1999
Simvastatin. A new therapeutic approach for Smith-Lemli-Opitz syndrome. Journal of lipid research, 2000, Volume: 41, Issue:8 Topics: Cholestadienols; Cholesterol; Dehydrocholesterols; Erythrocyte Membrane; Exchange Transfusion, Whole Blood; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant; Simvastatin; Smith-Lemli-Opitz Syndrome	2000
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. Journal of lipid research, 2001, Volume: 42, Issue:3 Topics: Adolescent; Animals; Cell Line; Child; Child, Preschool; Cholestadienols; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; COS Cells; Cytochrome P-450 Enzyme System; Dehydrocholesterols; Gene Expression; Humans; Hydroxycholesterols; Infant; Recombinant Proteins; Smith-Lemli-Opitz Syndrome; Steroid Hydroxylases; Substrate Specificity; Transfection	2001
Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. Journal of lipid research, 2001, Volume: 42, Issue:7 Topics: Animals; Cholestadienols; Cholesterol; Dehydrocholesterols; Desmosterol; Epididymis; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spermatozoa; Sterols; Testis	2001
Effects of sample storage on 7- and 8-dehydrocholesterol levels analysed on whole blood spots by gas chromatography-mass spectrometry-selected ion monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Jan-25, Volume: 766, Issue:2 Topics: Cholestadienols; Dehydrocholesterols; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity	2002
Simvastatin treatment in the SLO syndrome: a safe approach? American journal of medical genetics, 2002, Nov-22, Volume: 113, Issue:2 Topics: Adolescent; Alanine Transaminase; Cholestadienols; Dehydrocholesterols; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Photosensitivity Disorders; Simvastatin; Smith-Lemli-Opitz Syndrome; Time Factors; Treatment Outcome	2002
27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: a novel metabolic pathway. Steroids, 2003, Volume: 68, Issue:6 Topics: Adult; Case-Control Studies; Child; Child, Preschool; Cholestadienols; Cholesterol; Dehydrocholesterols; DNA-Binding Proteins; Humans; Hydroxycholesterols; Hydroxylation; Infant; Liver X Receptors; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Smith-Lemli-Opitz Syndrome	2003
Identification of three patients with a very mild form of Smith-Lemli-Opitz syndrome. American journal of medical genetics. Part A, 2003, Sep-15, Volume: 122A, Issue:1 Topics: Adolescent; Child; Cholestadienols; Cholesterol; Dehydrocholesterols; DNA Mutational Analysis; Female; Humans; Infant; Male; Oxidoreductases Acting on CH-CH Group Donors; Smith-Lemli-Opitz Syndrome	2003
Effects of dietary cholesterol on plasma lipoproteins in Smith-Lemli-Opitz syndrome. Pediatric research, 2004, Volume: 56, Issue:5 Topics: Apolipoproteins E; Child; Child, Preschool; Cholestadienols; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Dehydrocholesterols; Egg Yolk; Female; Genotype; Humans; Infant; Infant, Newborn; Male; Smith-Lemli-Opitz Syndrome	2004
Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit. Prenatal diagnosis, 2005, Volume: 25, Issue:11 Topics: Amniotic Fluid; Animals; Biomarkers; Cholestadienols; Cholesterol; Dehydrocholesterols; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Prenatal Diagnosis; Rats; Retrospective Studies; Smith-Lemli-Opitz Syndrome; Sterols	2005
Smith-Lemli-Opitz syndrome with a classical phenotype, oesophageal achalasia and borderline plasma sterol concentrations. Journal of inherited metabolic disease, 2005, Volume: 28, Issue:6 Topics: Cell Culture Techniques; Cholestadienols; Cholesterol; Culture Media; Dehydrocholesterols; DNA Mutational Analysis; Esophageal Achalasia; Female; Fibroblasts; Gas Chromatography-Mass Spectrometry; Heterozygote; Humans; Infant; Lipids; Mutation; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; Smith-Lemli-Opitz Syndrome; Sterols	2005
Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. Journal of inherited metabolic disease, 2008, Volume: 31 Suppl 2 Topics: Biomarkers; Chenodeoxycholic Acid; Child; Child, Preschool; Cholestadienols; Cholestanol; Cholesterol; Dehydrocholesterols; Humans; Lanosterol; Male; Predictive Value of Tests; Sitosterols; Time Factors; Treatment Outcome; Up-Regulation; Xanthomatosis, Cerebrotendinous	2008
Direct analysis of sterols from dried plasma/blood spots by an atmospheric pressure thermal desorption chemical ionization mass spectrometry (APTDCI-MS) method for a rapid screening of Smith-Lemli-Opitz syndrome. The Analyst, 2010, Volume: 135, Issue:4 Topics: Cholestadienols; Dehydrocholesterols; Humans; Smith-Lemli-Opitz Syndrome; Spectrometry, Mass, Electrospray Ionization; Sterols	2010
LC-MS/MS-based quantification of cholesterol and related metabolites in dried blood for the screening of inborn errors of sterol metabolism. Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:17 Topics: Cholestadienols; Cholesterol; Chromatography, Liquid; Dehydrocholesterols; Dried Blood Spot Testing; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Limit of Detection; Smith-Lemli-Opitz Syndrome; Tandem Mass Spectrometry	2015
Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. The Journal of steroid biochemistry and molecular biology, 2017, Volume: 169 Topics: Cholestadienols; Dehydrocholesterols; Free Radicals; Humans; Mutation; Oxidoreductases Acting on CH-CH Group Donors; Oxysterols; Plasma; Smith-Lemli-Opitz Syndrome; Sterols	2017
Effect of psychotropic drug treatment on sterol metabolism. Schizophrenia research, 2017, Volume: 187 Topics: Adult; Animals; Antidepressive Agents; Antipsychotic Agents; Body Mass Index; Cholestadienols; Clozapine; Dehydrocholesterols; Female; Haloperidol; Humans; Lipid Metabolism; Male; Mental Disorders; Psychiatric Status Rating Scales; Random Allocation; Rats, Sprague-Dawley; Weight Gain	2017
Prenatal diagnosis of holoprosencephaly associated with Smith-Lemli-Opitz syndrome (SLOS) in a 46,XX fetus. Taiwanese journal of obstetrics & gynecology, 2017, Volume: 56, Issue:4 Topics: Adult; Amniotic Fluid; Cholestadienols; Chorionic Villi Sampling; Dehydrocholesterols; Diagnosis, Differential; Female; Holoprosencephaly; Homozygote; Humans; Karyotype; Mutation; Pregnancy; Prenatal Diagnosis; Smith-Lemli-Opitz Syndrome	2017