cholest-5-ene-3,4-diol has been researched along with rifampin in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 14 (70.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertilsson, L; Bodin, K; Diczfalusy, U; Eichelbaum, M; Fromm, MF; Kivistö, KT; Niemi, M | 1 |
| Andersson, TB; Bäckström, T; Bertilsson, L; Böttiger, Y; Bredberg, E; Diczfalusy, U; Kanebratt, KP; Sparve, E | 1 |
| Andersson, TB; Bertilsson, L; Böttiger, Y; Bredberg, E; Diczfalusy, U; Kanebratt, KP | 1 |
| Rodrigues, AD; Yang, Z | 1 |
| Block, W; Freyer, J; Grube, M; Kroemer, HK; Lämmer, M; Lütjohann, D; Oswald, S; Peters, J; Siegmund, W; Venner, M | 1 |
| Diczfalusy, U; Kanebratt, KP; Lövgren-Sandblom, A; Mårde Arrhén, Y; Nylén, H; Wide, K | 1 |
| Andersson, TB; Bäckström, T; Bertilsson, L; Björkhem-Bergman, L; Bredberg, E; Diczfalusy, U; Nylén, H; Rönquist-Nii, Y | 1 |
| Cho, JY; Choi, MH; Jang, IJ; Lim, KS; Shin, KH; Yu, KS | 1 |
| Feng, H; Gu, Z; Han Hsu, H; Li, K; Shu, P; Wang, Y; Wu, X; Zhang, L; Zhao, S | 1 |
| Boulton, DW; Goodenough, A; Jemal, M; Kasichayanula, S; LaCreta, F; Lee, M; Luo, WL; Rodrigues, AD; Yang, Z | 1 |
| Dutreix, C; Lorenzo, S; Wang, Y | 1 |
| Aklillu, E; Bakari, M; Bertilsson, L; Burhenne, J; Diczfalusy, U; Janabi, M; Minzi, O; Mugusi, F; Mugusi, S; Ngaimisi, E; Riedel, KD; Sasi, P; Suda, A; Ueda, N | 1 |
| Dutreix, C; Jarugula, V; Jiang, X; Rebello, S; Sun, H; Won, CS | 1 |
| Hasan, M; Oswald, S; Siegmund, W | 1 |
| Chen, Y; Dean, B; Fan, P; Hop, CECA; Ismaili, MHA; Mao, J; Wang, J; Wong, S; Wright, M | 1 |
| Chun, DY; Dutreix, C; Einolf, HJ; Gu, H; He, H; Ouatas, T; Rebello, S; Wang, L | 1 |
| Hasegawa, M; Tahara, H; Watanabe, M | 1 |
| Hakkola, J; Hassani-Nezhad-Gashti, F; Hautajärvi, H; Hukkanen, J; Rysä, J; Salonurmi, T | 1 |
| Chen, C; Chen, SJ; Chen, XQ; Fancher, RM; Puszczalo, PD; Shen, H; Shuster, DJ; Sinz, M; Yang, Z; Zhang, Y | 1 |
| Rodrigues, AD; Rowland, A; Vourvahis, M; Wood, LS | 1 |
7 trial(s) available for cholest-5-ene-3,4-diol and rifampin
| Article | Year |
|---|---|
Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol.
Topics: Adult; Anti-Ulcer Agents; Antibiotics, Antitubercular; Antihypertensive Agents; Antimalarials; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Drug Combinations; Enzyme Induction; Female; Humans; Hydroxycholesterols; Losartan; Male; Middle Aged; Omeprazole; Quinine; Rifampin | 2008 |
Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.
Topics: Adult; Biomarkers; Cholesterol; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Humans; Hydrocortisone; Hydroxycholesterols; Male; Metabolic Clearance Rate; Midazolam; Rifampin | 2013 |
Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.
Topics: Adult; Biomarkers; Cortisone; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hydroxycholesterols; Ketoconazole; Liver; Male; Metabolomics; Midazolam; Pharmacogenetics; Rifampin; Young Adult | 2013 |
Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.
Topics: Adolescent; Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Hydroxycholesterols; Injections, Intravenous; Ketoconazole; Limit of Detection; Midazolam; Middle Aged; Rifampin; Saliva; Substrate Specificity; Time Factors; Tissue Distribution; Young Adult | 2014 |
Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between midostaurin and rifampicin.
Topics: Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Female; Humans; Hydrocortisone; Hydroxycholesterols; Male; Middle Aged; Protein Kinase Inhibitors; Rifampin; Staurosporine; Young Adult | 2014 |
An Exposure-Response Modeling Approach to Examine the Relationship Between Potency of CYP3A Inducer and Plasma 4β-Hydroxycholesterol in Healthy Subjects.
Topics: Adult; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Female; Healthy Volunteers; Humans; Hydroxycholesterols; Male; Middle Aged; Models, Theoretical; Rifampin; Young Adult | 2017 |
Pregnane X Receptor Activator Rifampin Increases Blood Pressure and Stimulates Plasma Renin Activity.
Topics: Adult; Biomarkers; Blood Pressure; Cell Line, Tumor; Cross-Over Studies; Female; Finland; Healthy Volunteers; Heart Rate; Humans; Hydroxycholesterols; Liver X Receptors; Male; Pregnane X Receptor; Renin; Renin-Angiotensin System; Rifampin; Single-Blind Method; Time Factors; Young Adult | 2020 |
13 other study(ies) available for cholest-5-ene-3,4-diol and rifampin
| Article | Year |
|---|---|
Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Genotype; Humans; Hydroxycholesterols; Liver; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Polymorphism, Genetic; Rifampin | 2006 |
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.
Topics: Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydroxycholesterols; Rifampin | 2009 |
Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric?
Topics: Biomarkers; Carbamazepine; Computer Simulation; Cytochrome P-450 CYP3A; Enzyme Induction; Enzyme Inhibitors; Half-Life; Humans; Hydroxycholesterols; Models, Biological; Rifampin; Time Factors | 2010 |
Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.
Topics: Absorption; Animals; ATP-Binding Cassette Transporters; Bronchi; Cholesterol; Clarithromycin; Drug Interactions; Epithelial Cells; Horses; Hydroxycholesterols; Lung; Mouth Mucosa; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Pregnane X Receptor; Receptors, Steroid; Rifampin; RNA, Messenger | 2011 |
A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction.
Topics: Antibiotics, Antitubercular; Biomarkers; Cholesterol; Chromatography, Liquid; Cytochrome P-450 CYP3A; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hydroxycholesterols; Male; Rifampin | 2013 |
4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys.
Topics: Administration, Oral; Animals; Biomarkers; Biotransformation; Cholesterol; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Drug Evaluation, Preclinical; Enzyme Induction; Female; Hydroxycholesterols; Macaca fascicularis; Male; Midazolam; Rifampin; Substrate Specificity; Tandem Mass Spectrometry | 2014 |
Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment.
Topics: Adult; Alkynes; Anti-HIV Agents; Antitubercular Agents; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Female; Genotype; HIV Infections; Humans; Hydroxycholesterols; Male; Middle Aged; Rifampin; Tuberculosis | 2014 |
Rapid LC-MS/MS method for the determination of 4-hydroxycholesterol/cholesterol ratio in serum as endogenous biomarker for CYP3A activity in human and foals.
Topics: Adult; Animals; Biomarkers; Cholesterol; Chromatography, Liquid; Cytochrome P-450 CYP3A; Horses; Humans; Hydroxycholesterols; Male; Reference Standards; Reproducibility of Results; Rifampin; Tandem Mass Spectrometry; Young Adult | 2016 |
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Topics: Administration, Oral; Animals; Computer Simulation; Cytochrome P-450 CYP3A; Drug Discovery; Drug Interactions; Enzyme Induction; Humans; Hydrocortisone; Hydroxycholesterols; Liver; Macaca fascicularis; Midazolam; Models, Biological; Pharmacokinetics; Rifampin; RNA, Messenger | 2017 |
Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.
Topics: Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Hydroxycholesterols; Ketoconazole; Male; Midazolam; Middle Aged; Models, Biological; Rifampin; Staurosporine; Young Adult | 2018 |
A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys.
Topics: Alprazolam; Animals; Area Under Curve; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Drug Interactions; Hydrocortisone; Hydroxycholesterols; Macaca fascicularis; Male; Midazolam; Rifampin; Triazolam | 2019 |
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
Topics: Animals; Biomarkers; Coproporphyrins; Female; Gene Expression; Hydroxycholesterols; Intestine, Small; Kidney; Liver; Macaca fascicularis; Male; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2020 |
Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil.
Topics: Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Extracellular Vesicles; Healthy Volunteers; Humans; Hydroxycholesterols; Liquid Biopsy; Liver; Modafinil; Models, Biological; Plasma; Proteomics; Rifampin; Time Factors | 2022 |