cholecalciferol and mizolastine

The present study aimed to observe the therapeutic effect of combined mizolastine and proteoglycan in chronic urticaria. The patients were randomly divided into the treatment group (n = 56) and the control group (n = 44). The treatment group was medicated with calcium gluconate (10 mg/ time, 1 time/day), vitamin D3 (intramuscular 10 mg/time, 1 time/week), mizolastine (10 mg/time, 1 time/day), and proteoglycan (1.2 g/time, 3 times/day), while the control group was administered with the same drugs except proteoglycan for 4 weeks. After treatment with combined mizolastine and proteoglycan, therapeutic effect with symptoms decline index (SDI) more than 60% was significant different (44 vs. 24, p = 0.000973) and the relapse rate after 2 months was significantly lower (17.9% vs. 38.6%, p = 0.0202). Using ELISA, we found that the IFN-γ (37.88 ± 4.27 pg/mL vs. 21.91 ± 4.95 pg/mL, p = 0.028) levels were specifically increased in the experiment group. The combination of mizolastine plus proteoglycan is effective in treating chronic urticaria with better therapeutic effect and lower relapse rate through promoting IFN-γ production.

Topics: Administration, Oral; Adolescent; Adult; Aged; Benzimidazoles; Calcium Gluconate; Cholecalciferol; Chronic Urticaria; Double-Blind Method; Drug Therapy, Combination; Female; Gene Expression Regulation; Histamine H1 Antagonists, Non-Sedating; Humans; Immunologic Factors; Injections, Intramuscular; Interferon-gamma; Male; Middle Aged; Proteoglycans; Secondary Prevention; Severity of Illness Index; Skin; Tablets; Young Adult