cholecalciferol and dysidiolide

cholecalciferol has been researched along with dysidiolide* in 2 studies

Other Studies

2 other study(ies) available for cholecalciferol and dysidiolide

Article	Year
Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors. Bioorganic & medicinal chemistry letters, 2004, Jun-21, Volume: 14, Issue:12 Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D(3). These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC(50)=0.44-0.89 microM). Topics: 4-Butyrolactone; cdc25 Phosphatases; Cholecalciferol; Drug Design; Enzyme Inhibitors; Humans	2004
Synthesis of a novel class of cdc25A inhibitors from vitamin D3. Bioorganic & medicinal chemistry letters, 2000, Apr-03, Volume: 10, Issue:7 We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 microM) and caused GI arrest of HL60 cells. Topics: 4-Butyrolactone; Antineoplastic Agents; cdc25 Phosphatases; Cholecalciferol; Enzyme Inhibitors; G1 Phase; HL-60 Cells; Humans	2000

Article

Year

Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors.

Bioorganic & medicinal chemistry letters, 2004, Jun-21, Volume: 14, Issue:12

Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D(3). These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC(50)=0.44-0.89 microM).

Topics: 4-Butyrolactone; cdc25 Phosphatases; Cholecalciferol; Drug Design; Enzyme Inhibitors; Humans

2004

Synthesis of a novel class of cdc25A inhibitors from vitamin D3.

Bioorganic & medicinal chemistry letters, 2000, Apr-03, Volume: 10, Issue:7

We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 microM) and caused GI arrest of HL60 cells.

Topics: 4-Butyrolactone; Antineoplastic Agents; cdc25 Phosphatases; Cholecalciferol; Enzyme Inhibitors; G1 Phase; HL-60 Cells; Humans

2000