chlorzoxazone and warfarin

chlorzoxazone has been researched along with warfarin in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (15.38)	18.2507
2000's	11 (42.31)	29.6817
2010's	10 (38.46)	24.3611
2020's	1 (3.85)	2.80

Authors

Authors	Studies
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bell, LC; Gillam, EM; Guengerich, FP; Nakano, M; Shimada, T; Yamazaki, H	1
Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H	1
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T	1
Shimada, T; Tsumura, F; Yamazaki, H	1
Inoue, K; Shimada, T; Yamazaki, H	1
Juvonen, R; Pelkonen, O; Taavitsainen, P	1
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P	1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K	1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A	1
Axelsson, H; Floby, E; Granhall, C; Jaksch, Y; Sohlenius-Sternbeck, AK; Svedling, M	1
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y	1
Brittebo, EB; Carlsson, C; Franzén, A; Hermansson, V; Lang, M	1
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US	1
Ahn, T; Jung, HC; Kim, D; Kim, DH; Pan, JG; Park, SH; Yun, CH	1
Berka, K; Otyepka, M; Paloncýová, M	1
Lu, Y; Zhai, X	1
Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L	1
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N	1

Reviews

1 review(s) available for chlorzoxazone and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for chlorzoxazone and warfarin

Article	Year
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:3 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged	2007

Other Studies

24 other study(ies) available for chlorzoxazone and warfarin

Article	Year
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochemical pharmacology, 1996, Jul-26, Volume: 52, Issue:2 Topics: Aniline Compounds; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Dimethylnitrosamine; Humans; Kinetics; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Recombinant Proteins	1996
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Archives of biochemistry and biophysics, 1997, Jun-15, Volume: 342, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin	1997
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide	1998
Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:11 Topics: Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Oxidation-Reduction; Recombinant Proteins	1999
Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene. Archives of toxicology, 2000, Volume: 74, Issue:7 Topics: Asian People; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2E1; DNA; Genotype; Humans; Hydroxylation; Japan; Microsomes, Liver; Polymerase Chain Reaction; Polymorphism, Genetic; White People	2000
In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Binding Sites; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Methoxsalen; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Monoterpenes; Spectrophotometry; Terpenes; Tranylcypromine	2001
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide	2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2002
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacology & toxicology, 2002, Volume: 90, Issue:3 Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline	2002
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. Toxicology in vitro : an international journal published in association with BIBRA, 2003, Volume: 17, Issue:4 Topics: Animals; Antidepressive Agents; Antimalarials; Antitussive Agents; Calcium Channel Blockers; Cell Survival; Chlorzoxazone; Coloring Agents; Coumarins; Cryopreservation; Cytochrome P-450 Enzyme System; Dextromethorphan; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Pharmaceutical Preparations; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Testosterone; Verapamil; Xanthenes	2003
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9 Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone	2004
CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Injections, Intraperitoneal; Liver; Metyrapone; Mice; Microscopy, Electron, Transmission; Microsomes, Liver; Mixed Function Oxygenases; Nitriles; Olfactory Mucosa; Pyrazoles; Sulfhydryl Compounds; Sulfones	2006
Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:5 Topics: Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Carbon; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Stability; Escherichia coli; Heme; Humans; Indigo Carmine; Indoles; Kinetics; Molecular Dynamics Simulation; NADPH-Ferrihemoprotein Reductase; Nitrophenols; Oxazines; Oxidation-Reduction; Phenacetin; Protein Engineering; Recombinant Proteins; Transformation, Genetic; Umbelliferones	2010
Molecular insight into affinities of drugs and their metabolites to lipid bilayers. The journal of physical chemistry. B, 2013, Feb-28, Volume: 117, Issue:8 Topics: Caffeine; Cell Membrane; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Ibuprofen; Lipid Bilayers; Molecular Dynamics Simulation; Pharmaceutical Preparations; Phosphatidylcholines; Phosphatidylglycerols; Thermodynamics; Xenobiotics	2013
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Die Pharmazie, 2013, Volume: 68, Issue:1 Topics: Analgesics, Non-Narcotic; Animals; Anticoagulants; Calibration; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Hypoglycemic Agents; In Vitro Techniques; Liquid-Liquid Extraction; Microsomes, Liver; Muscle Relaxants, Central; Phenacetin; Quality Control; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Testosterone; Tolbutamide	2013
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches. Molecules (Basel, Switzerland), 2017, Nov-20, Volume: 22, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin	2017
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography. Scientific reports, 2020, 06-01, Volume: 10, Issue:1 Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water	2020