chlorzoxazone has been researched along with tolbutamide in 43 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (11.63) | 18.2507 |
2000's | 6 (13.95) | 29.6817 |
2010's | 27 (62.79) | 24.3611 |
2020's | 5 (11.63) | 2.80 |
Authors | Studies |
---|---|
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Dai, R; Liu, Y; She, M; Wu, Z | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H | 1 |
Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D | 1 |
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T | 1 |
Back, DJ; Eagling, VA; Tjia, JF | 1 |
Abel, SM; Hyland, R; Jones, BC; Smith, DA | 1 |
Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T | 1 |
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P | 1 |
Mano, Y; Miyamoto, K; Nomura, M; Takeshita, H; Watanabe, M; Yokogawa, K | 1 |
Aherne, Z; Blakey, GE; Lockton, JA; Norwood, P; Perrett, J; Plume, J; Russell, M | 1 |
Arsenault, M; BĂ©langer, PM; Hamelin, BA; Pilote, S; Sharma, A | 1 |
Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M | 1 |
Guo, C; Han, YL; Jing, GP; Li, D; Li, Y; Meng, XL; Ren, B; Wan, LL; Yu, Q; Zhou, ZY | 1 |
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I | 1 |
Gao, J; Li, GQ; Shi, Z; Yan, R; Yao, M; Zhu, S | 1 |
Jiao, J; Li, Q; Liu, Y; Lou, J; Zhang, C | 1 |
Lu, Y; Zhai, X | 1 |
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL | 1 |
Huang, Y; Xu, RA; Xu, ZS; Zheng, SL; Zhu, HY | 1 |
Guo, S; Lin, Z; Liu, G; Liu, Y; Tai, S; Yin, S | 1 |
Liang, DL; Zheng, SL | 1 |
Cao, X; Huang, Y; Lan, YY; Li, YJ; Liao, SG; Liu, Y; Lu, Y; Tang, L; Wang, AM; Wang, YL; Zheng, L | 1 |
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ | 1 |
Bhateria, M; Bhatta, RS; Ramakrishna, R; Singh, R | 1 |
Li, Y; Lv, C; Rong, Q; Shi, F; Tang, H; Xu, M; Ye, G; Zhang, Y; Zhao, L | 1 |
Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L | 1 |
Gaudette, F; Huguet, J; Michaud, V; Turgeon, J | 1 |
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ | 1 |
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J | 1 |
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N | 1 |
Ohtsuki, S; Otagiri, M; Sakai, H; Taguchi, K; Tokuno, M; Yamasaki, K | 2 |
Chen, LJ; Chen, XP; Chen, Y; Guo, J; Liou, YL; Tan, ZR; Xu, Y; Zhang, SX; Zhang, W; Zhou, HH | 1 |
Chen, SY; Chen, Y; Gong, ZP; Huang, J; Huang, Y; Li, Y; Li, YT; Wang, YL; Yang, HL; Zheng, L | 1 |
2 review(s) available for chlorzoxazone and tolbutamide
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Human cytochrome P450s: selectivity and measurement in vivo.
Topics: Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Mixed Function Oxygenases; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship; Tolbutamide | 1998 |
1 trial(s) available for chlorzoxazone and tolbutamide
Article | Year |
---|---|
Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.
Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Combinations; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Plasma; Tolbutamide | 2004 |
40 other study(ies) available for chlorzoxazone and tolbutamide
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin | 1997 |
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide | 1997 |
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide | 1998 |
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide | 1998 |
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide | 2000 |
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide | 2001 |
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 Enzyme System; Half-Life; Isoenzymes; Lidocaine; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Wistar; Tolbutamide; Transaminases | 2004 |
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.
Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Drug Combinations; Humans; Male; Metoprolol; Phenformin; Pilot Projects; Tolbutamide | 2004 |
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2011 |
Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.
Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Inhibitors; Erigeron; Herb-Drug Interactions; Metoprolol; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide | 2012 |
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide | 2012 |
Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches.
Topics: Adamantane; Animals; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Activators; Enzyme Inhibitors; Herb-Drug Interactions; Isoenzymes; Male; Plant Extracts; Rats; Rats, Wistar; Rheum; Theophylline; Tolbutamide; Wine | 2013 |
Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach.
Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Enzyme Activation; Female; Ischemic Preconditioning; Isoenzymes; Liver; Male; Metoprolol; Midazolam; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Tolbutamide | 2014 |
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium.
Topics: Analgesics, Non-Narcotic; Animals; Anticoagulants; Calibration; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Hypoglycemic Agents; In Vitro Techniques; Liquid-Liquid Extraction; Microsomes, Liver; Muscle Relaxants, Central; Phenacetin; Quality Control; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Testosterone; Tolbutamide | 2013 |
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs].
Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide | 2013 |
Effects of aescin on cytochrome P450 enzymes in rats.
Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Escin; Gene Expression Regulation, Enzymologic; Half-Life; Herb-Drug Interactions; Hypnotics and Sedatives; Hypoglycemic Agents; Liver; Male; Midazolam; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide | 2014 |
Effects of eleutheroside B and eleutheroside E on activity of cytochrome P450 in rat liver microsomes.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dextromethorphan; Glucosides; Inhibitory Concentration 50; Kinetics; Lignans; Male; Microsomes, Liver; Phenylpropionates; Phytotherapy; Rats; Rats, Wistar; Testosterone; Tolbutamide | 2014 |
Effects of icaritin on cytochrome P450 enzymes in rats.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Flavonoids; Half-Life; Indicators and Reagents; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide; Xenobiotics | 2014 |
Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs.
Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Midazolam; Omeprazole; Plant Extracts; Polygonum; Rats; Rats, Sprague-Dawley; Tolbutamide | 2014 |
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide | 2015 |
Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dapsone; Dextromethorphan; Gene Expression Regulation; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Tolbutamide | 2016 |
The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.
Topics: Air Pollutants; Animals; Chlorzoxazone; Cytochrome P-450 Enzyme System; Formaldehyde; Isoenzymes; Male; Rats; Rats, Sprague-Dawley; Testosterone; Tolbutamide | 2017 |
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin | 2017 |
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.
Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide | 2019 |
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].
Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency | 2017 |
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha | 2019 |
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography.
Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water | 2020 |
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats.
Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide | 2020 |
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles.
Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tolbutamide | 2020 |
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug.
Topics: Animals; Chlorzoxazone; Gastrointestinal Microbiome; Metoprolol; Mice; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Pharmaceutical Preparations; Phenacetin; Tolbutamide | 2022 |
[Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method].
Topics: Animals; Caffeine; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Metoprolol; Midazolam; Omeprazole; Plant Extracts; Rats; Tandem Mass Spectrometry; Tolbutamide | 2022 |