chlorzoxazone has been researched along with phenacetin in 27 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (11.11) | 18.2507 |
2000's | 8 (29.63) | 29.6817 |
2010's | 14 (51.85) | 24.3611 |
2020's | 2 (7.41) | 2.80 |
Authors | Studies |
---|---|
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Dai, R; Liu, Y; She, M; Wu, Z | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D | 1 |
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T | 1 |
Back, DJ; Eagling, VA; Tjia, JF | 1 |
Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T | 1 |
Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO | 1 |
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
Court, MH; Greenblatt, DJ; von Moltke, LL; Warrington, JS | 1 |
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y | 1 |
Li, D; Lin, ZB; Lou, YQ; Wang, X; Zhang, GL; Zhao, X | 1 |
Alcorn, J; Allouh, MZ; Elbarbry, FA; McNamara, PJ | 1 |
Ahn, T; Jung, HC; Kim, D; Kim, DH; Pan, JG; Park, SH; Yun, CH | 1 |
Taylor, LS; Van Eerdenbrugh, B | 1 |
Lu, Y; Zhai, X | 1 |
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL | 1 |
Liang, DL; Zheng, SL | 1 |
Jilek, JL; Tian, Y; Yu, AM | 1 |
Chen, W; Ge, T; Peng, D; Sun, J; Tang, X; Xu, Q | 1 |
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N | 1 |
Chen, LJ; Chen, XP; Chen, Y; Guo, J; Liou, YL; Tan, ZR; Xu, Y; Zhang, SX; Zhang, W; Zhou, HH | 1 |
27 other study(ies) available for chlorzoxazone and phenacetin
Article | Year |
---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide | 1997 |
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide | 1998 |
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide | 1998 |
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide | 2000 |
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines | 2001 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2002 |
Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.
Topics: Aging; Animals; Biotransformation; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Inbred F344 | 2004 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone | 2004 |
Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Topics: Adjuvants, Immunologic; Animals; BCG Vaccine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dealkylation; Ganoderma; Hepatitis; Hydroxylation; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Nifedipine; Nitric Oxide; Oxidation-Reduction; Phenacetin; Polysaccharides; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2007 |
Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity.
Topics: Age Factors; Aging; Animals; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochromes; Dealkylation; Hydroxylation; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Models, Biological; Nitrophenols; Organ Size; Oxazines; Phenacetin; Proteins; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Risk Assessment; Substrate Specificity | 2007 |
Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
Topics: Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Carbon; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Stability; Escherichia coli; Heme; Humans; Indigo Carmine; Indoles; Kinetics; Molecular Dynamics Simulation; NADPH-Ferrihemoprotein Reductase; Nitrophenols; Oxazines; Oxidation-Reduction; Phenacetin; Protein Engineering; Recombinant Proteins; Transformation, Genetic; Umbelliferones | 2010 |
Small scale screening to determine the ability of different polymers to inhibit drug crystallization upon rapid solvent evaporation.
Topics: Acrylates; Benzamides; Chlorpropamide; Chlorzoxazone; Chromatography, High Pressure Liquid; Crystallization; Flurbiprofen; Hypromellose Derivatives; Imidazoles; Lidocaine; Methylcellulose; Phenacetin; Polymers; Polyvinyls; Povidone; Pyrrolidines; Solvents | 2010 |
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium.
Topics: Analgesics, Non-Narcotic; Animals; Anticoagulants; Calibration; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Hypoglycemic Agents; In Vitro Techniques; Liquid-Liquid Extraction; Microsomes, Liver; Muscle Relaxants, Central; Phenacetin; Quality Control; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Testosterone; Tolbutamide | 2013 |
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs].
Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide | 2013 |
Effects of icaritin on cytochrome P450 enzymes in rats.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Flavonoids; Half-Life; Indicators and Reagents; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide; Xenobiotics | 2014 |
Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Male; Mice; MicroRNAs; Midazolam; Pharmacokinetics; Phenacetin | 2017 |
Effect of Gambogenic Acid on Cytochrome P450 1A2, 2B1 and 2E1, and Constitutive Androstane Receptor in Rats.
Topics: Animals; Bupropion; Chlorzoxazone; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inducers; Dose-Response Relationship, Drug; Drug Interactions; Liver; Male; Phenacetin; Rats; Receptors, Cytoplasmic and Nuclear; Xanthenes | 2018 |
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography.
Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water | 2020 |
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug.
Topics: Animals; Chlorzoxazone; Gastrointestinal Microbiome; Metoprolol; Mice; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Pharmaceutical Preparations; Phenacetin; Tolbutamide | 2022 |