chlorzoxazone and midazolam

chlorzoxazone has been researched along with midazolam in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (4.76)	18.2507
2000's	14 (33.33)	29.6817
2010's	22 (52.38)	24.3611
2020's	4 (9.52)	2.80

Authors

Authors	Studies
Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ	1
Inomata, S; Tanaka, E; Yasuhara, H	1
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P	1
Chen, XP; He, N; Huang, SL; Ou-Yang, DS; Tan, ZR; Zhou, HH; Zhu, B	1
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ	1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K	1
Lin, KM; Nuccio, C; Poland, RA; Wilkinson, GR	1
Chen, XP; Huang, SL; Huang, Z; Ou-Yang, DS; Tan, ZR; Zhou, HH	1
Buc Calderon, P; Verbeeck, RK; Wauthier, V	1
Aherne, Z; Blakey, GE; Lockton, JA; Norwood, P; Perrett, J; Plume, J; Russell, M	1
Chalasani, N; Gorski, JC; Hall, SD; Kolwankar, D; Liangpunsakul, S; Pinto, A	1
Ang, CY; Cui, Y; Gardner, SF; Gentry, WB; Gurley, BJ; Hubbard, MA; Williams, DK	1
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US	1
Kochanek, PM; Poloyac, SM; Tortorici, MA	1
Cho, JY; Hong, JH; Jang, IJ; Kim, BH; Kim, J; Kim, KP; Lim, KS; Shin, SG; Yi, S; Yu, KS	1
Hao, HP; Peng, Y; Roberts, MS; Shang, LL; Sun, JG; Wang, GJ; Wang, XJ; Xia, CH; Xie, L; Zhang, R; Zhang, XX	1
Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M	1
Guo, C; Han, YL; Jing, GP; Li, D; Li, Y; Meng, XL; Ren, B; Wan, LL; Yu, Q; Zhou, ZY	1
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I	1
Jiao, J; Li, Q; Liu, Y; Lou, J; Zhang, C	1
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL	1
Huang, Y; Xu, RA; Xu, ZS; Zheng, SL; Zhu, HY	1
Liang, DL; Zheng, SL	1
Cao, X; Huang, Y; Lan, YY; Li, YJ; Liao, SG; Liu, Y; Lu, Y; Tang, L; Wang, AM; Wang, YL; Zheng, L	1
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ	1
Christensen, HR; Dalhoff, KP; Gade, C; Holm, JC; Holst, H; Mikus, G	1
Jilek, JL; Tian, Y; Yu, AM	1
Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L	1
Gaudette, F; Huguet, J; Michaud, V; Turgeon, J	1
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ	1
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J	1
Blank, A; Burhenne, J; Haefeli, WE; Hohmann, N; Mikus, G; Suzuki, Y	1
Ohtsuki, S; Otagiri, M; Sakai, H; Taguchi, K; Tokuno, M; Yamasaki, K	2
Chen, LJ; Chen, XP; Chen, Y; Guo, J; Liou, YL; Tan, ZR; Xu, Y; Zhang, SX; Zhang, W; Zhou, HH	1
Chen, SY; Chen, Y; Gong, ZP; Huang, J; Huang, Y; Li, Y; Li, YT; Wang, YL; Yang, HL; Zheng, L	1

Reviews

3 review(s) available for chlorzoxazone and midazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The clinical importance of conventional and quantitative liver function tests in liver transplantation. Journal of clinical pharmacy and therapeutics, 2000, Volume: 25, Issue:6 Topics: Chlorzoxazone; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Midazolam	2000
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Critical care medicine, 2007, Volume: 35, Issue:9 Topics: Anesthetics; Anticonvulsants; Cardiovascular Agents; Chlorzoxazone; Cytochrome P-450 Enzyme System; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Midazolam; Neuromuscular Blocking Agents; Pharmaceutical Preparations	2007

Trials

7 trial(s) available for chlorzoxazone and midazolam

Article	Year
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A). British journal of clinical pharmacology, 2001, Volume: 52, Issue:5 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating	2001
Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1. British journal of clinical pharmacology, 2004, Volume: 57, Issue:2 Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Combinations; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Plasma; Tolbutamide	2004
Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:5 Topics: Adult; Alcohol Drinking; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Female; Humans; Liver; Lymphocytes; Male; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating; Predictive Value of Tests; RNA, Messenger	2005
Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs & aging, 2005, Volume: 22, Issue:6 Topics: Administration, Oral; Aged; Allyl Compounds; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dietary Supplements; Drug Administration Schedule; Female; Ginkgo biloba; Herb-Drug Interactions; Humans; Hypericum; Isoenzymes; Male; Midazolam; Panax; Phenotype; Plant Preparations; Sulfides	2005
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:3 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged	2007
The CYTONOX trial. Danish medical journal, 2016, Volume: 63, Issue:5 Topics: Adolescent; Caffeine; Child; Chlorzoxazone; Clinical Protocols; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Denmark; Female; Humans; Male; Midazolam; Pediatric Obesity	2016
Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses. British journal of clinical pharmacology, 2019, Volume: 85, Issue:10 Topics: Administration, Oral; Adult; Area Under Curve; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Phenotype; Young Adult	2019

Other Studies

32 other study(ies) available for chlorzoxazone and midazolam

Article	Year
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharmaceutical research, 1999, Volume: 16, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity	1999
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 1999, Volume: 13, Issue:23 Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline	1999
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide	2001
Assessment of cytochrome P450 activity by a five-drug cocktail approach. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:5 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating	2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2002
Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Europe; Female; Food-Drug Interactions; Humans; Los Angeles; Male; Mexican Americans; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Statistics, Nonparametric; White People	2002
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline	2003
Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress? Archives of toxicology, 2004, Volume: 78, Issue:3 Topics: Age Factors; Aging; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytosol; Gene Expression Regulation, Enzymologic; Isoenzymes; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Midazolam; Oxidative Stress; Oxidoreductases, N-Demethylating; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2004
Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers. Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:4 Topics: Adult; Angelica; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Dextromethorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Phytotherapy; Republic of Korea; Scutellaria baicalensis; Tandem Mass Spectrometry; Young Adult	2009
Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats. Planta medica, 2010, Volume: 76, Issue:3 Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Diclofenac; Drug Combinations; Drugs, Chinese Herbal; Herb-Drug Interactions; Inactivation, Metabolic; Inhibitory Concentration 50; Injections; Liver; Male; Midazolam; Ophiopogon; Panax; Plant Roots; Rats; Rats, Sprague-Dawley; Theophylline	2010
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	2011
Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs. Journal of ethnopharmacology, 2012, Jan-06, Volume: 139, Issue:1 Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Inhibitors; Erigeron; Herb-Drug Interactions; Metoprolol; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide	2012
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats. Biomedical research (Tokyo, Japan), 2012, Volume: 33, Issue:4 Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide	2012
Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach. Drug development and industrial pharmacy, 2014, Volume: 40, Issue:2 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Enzyme Activation; Female; Ischemic Preconditioning; Isoenzymes; Liver; Male; Metoprolol; Midazolam; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Tolbutamide	2014
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:12 Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide	2013
Effects of aescin on cytochrome P450 enzymes in rats. Journal of ethnopharmacology, 2014, Volume: 151, Issue:1 Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Escin; Gene Expression Regulation, Enzymologic; Half-Life; Herb-Drug Interactions; Hypnotics and Sedatives; Hypoglycemic Agents; Liver; Male; Midazolam; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2014
Effects of icaritin on cytochrome P450 enzymes in rats. Die Pharmazie, 2014, Volume: 69, Issue:4 Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Flavonoids; Half-Life; Indicators and Reagents; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide; Xenobiotics	2014
Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs. Journal of ethnopharmacology, 2014, Dec-02, Volume: 158 Pt A Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Midazolam; Omeprazole; Plant Extracts; Polygonum; Rats; Rats, Sprague-Dawley; Tolbutamide	2014
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress]. Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:3 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide	2015
Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:5 Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Male; Mice; MicroRNAs; Midazolam; Pharmacokinetics; Phenacetin	2017
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches. Molecules (Basel, Switzerland), 2017, Nov-20, Volume: 22, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin	2017
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide	2019
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency]. Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency	2017
Modulation of CYP450 Activities in Patients With Type 2 Diabetes. Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6 Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha	2019
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:5 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide	2020
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:5 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tolbutamide	2020
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug. Journal of advanced research, 2022, Volume: 39 Topics: Animals; Chlorzoxazone; Gastrointestinal Microbiome; Metoprolol; Mice; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Pharmaceutical Preparations; Phenacetin; Tolbutamide	2022
[Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:23 Topics: Animals; Caffeine; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Metoprolol; Midazolam; Omeprazole; Plant Extracts; Rats; Tandem Mass Spectrometry; Tolbutamide	2022