Compounds > chlorzoxazone

chlorzoxazone and metyrapone

chlorzoxazone has been researched along with metyrapone in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Babol, J; Lundström, K; Squires, EJ1
Brittebo, EB; Carlsson, C; Franzén, A; Hermansson, V; Lang, M1
Huang, P; Hueni, SE; Lash, LH; Parker, JC; Putt, DA1

Reviews

1 review(s) available for chlorzoxazone and metyrapone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

5 other study(ies) available for chlorzoxazone and metyrapone

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Hepatic metabolism of skatole in pigs by cytochrome P4502E1.
    Journal of animal science, 1998, Volume: 76, Issue:3

    Topics: Allyl Compounds; Animals; Antioxidants; Chlorzoxazone; Crosses, Genetic; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Female; Kinetics; Male; Metyrapone; Microsomes, Liver; Proadifen; Skatole; Sulfides; Swine

1998
CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Injections, Intraperitoneal; Liver; Metyrapone; Mice; Microscopy, Electron, Transmission; Microsomes, Liver; Mixed Function Oxygenases; Nitriles; Olfactory Mucosa; Pyrazoles; Sulfhydryl Compounds; Sulfones

2006
Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
    Toxicology, 2007, Jun-03, Volume: 235, Issue:1-2

    Topics: Animals; Biotransformation; Carcinogens, Environmental; Cell Survival; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hepatocytes; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Metyrapone; Microsomes; Proadifen; Pyridines; Rats; Rats, Inbred F344; Tetrachloroethylene; Trichloroethylene

2007