chlorzoxazone has been researched along with mephenytoin in 20 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (10.00) | 18.2507 |
2000's | 11 (55.00) | 29.6817 |
2010's | 6 (30.00) | 24.3611 |
2020's | 1 (5.00) | 2.80 |
Authors | Studies |
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Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D | 1 |
Adedoyin, A; Branch, RA; Frye, RF; Matzke, GR; Porter, JA | 1 |
Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T | 1 |
Chen, XP; He, N; Huang, SL; Ou-Yang, DS; Tan, ZR; Zhou, HH; Zhu, B | 1 |
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ | 1 |
Branch, RA; Frye, RF | 1 |
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A | 1 |
Chen, XP; Huang, SL; Huang, Z; Ou-Yang, DS; Tan, ZR; Zhou, HH | 1 |
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y | 1 |
Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK | 1 |
Branch, RA; Frye, RF; Romkes, M; Tracy, TS; Zgheib, NK | 1 |
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US | 1 |
Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M | 1 |
Auchus, RJ; Peng, HM | 1 |
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N | 1 |
1 review(s) available for chlorzoxazone and mephenytoin
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
5 trial(s) available for chlorzoxazone and mephenytoin
Article | Year |
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Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes.
Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values | 1997 |
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating | 2001 |
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline | 2006 |
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged | 2006 |
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged | 2007 |
14 other study(ies) available for chlorzoxazone and mephenytoin
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide | 1997 |
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide | 2000 |
Assessment of cytochrome P450 activity by a five-drug cocktail approach.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating | 2001 |
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Disulfiram; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mephenytoin; Mixed Function Oxygenases; Time Factors | 2002 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2002 |
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline | 2002 |
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline | 2003 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone | 2004 |
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2011 |
The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.
Topics: Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochromes b5; Humans; Hydroxylation; Mephenytoin; Models, Molecular; Muscle Relaxants, Central; NADP; Oxidoreductases Acting on CH-CH Group Donors; Phospholipids; Point Mutation; Progesterone | 2013 |
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography.
Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water | 2020 |