chlorzoxazone has been researched along with isoniazid in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Adams, SP; Kalhorn, TF; Nelson, SD; Slattery, JT; Thummel, KE; Wright, JM; Zand, R | 1 |
| Horbach, GJ; Maas, RF; van Miert, AS; Witkamp, RF; Zweers-Zeilmaker, WM | 1 |
| Kim, RB; O'Shea, D; Wilkinson, GR | 1 |
| Desager, JP; Horsmans, Y; Leclercq, I | 1 |
| Frye, RF; Poloyac, SM; Przychodzin, DI; Reynolds, RB; Tortorici, MA; Xie, W; Zemaitis, MA | 1 |
| Catania, JR; McGarrigle, BP; Olson, JR; Rittenhouse-Olson, K | 1 |
| Arti, D; Coetsee, C; Du Plessis, JB; Walubo, A | 1 |
| Chen, J; Dong, G; He, C; Liu, Y; Peng, R; Yue, J | 1 |
1 review(s) available for chlorzoxazone and isoniazid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
17 other study(ies) available for chlorzoxazone and isoniazid
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans.
Topics: Acetaminophen; Acetylation; Adult; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Isoniazid; Male; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Sulfamethazine | 1993 |
Cytochrome P4502E in vivo and in vitro in the dwarf goat: effects of enzyme induction and the applicability of chlorzoxazone as marker substrate.
Topics: Aniline Compounds; Animals; Antitubercular Agents; beta-Naphthoflavone; Biotransformation; Blotting, Western; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Inhibitors; Female; Goats; Hydroxylation; In Vitro Techniques; Isoniazid; Microsomes, Liver; Nitrophenols; Oxidoreductases, N-Demethylating | 1996 |
Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators.
Topics: Acetylation; Administration, Oral; Adolescent; Adult; Analysis of Variance; Antitubercular Agents; Chlorzoxazone; Cytochrome P-450 CYP2E1; Enzyme Induction; Female; Humans; Hydroxylation; Isoniazid; Male; Muscle Relaxants, Central; Phenotype | 1997 |
Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress.
Topics: Adult; Antitubercular Agents; Chlorzoxazone; Cytochrome P-450 CYP2E1 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Humans; Isoniazid; Isothiocyanates; Male; Middle Aged; Muscle Relaxants, Central; Reference Values | 1998 |
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Topics: Animals; Arachidonic Acid; Blotting, Western; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP4A; Dichloroethylenes; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hydroxylation; Isoniazid; Kidney; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley | 2004 |
Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium.
Topics: Animals; Blotting, Western; Cell Survival; Chlorzoxazone; Culture Media; Culture Media, Serum-Free; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; Isoenzymes; Isoniazid; Liver; Male; Microsomes, Liver; Organ Culture Techniques; Phenobarbital; Potassium; Rats; Rats, Sprague-Dawley | 2007 |
The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy.
Topics: Adult; Antitubercular Agents; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Electrophoresis, Polyacrylamide Gel; Female; Humans; Isoniazid; Lymphocytes; Male; Microsomes; Middle Aged; Muscle Relaxants, Central; Risk Factors; Tuberculosis, Pulmonary | 2005 |
Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Aniline Compounds; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytoprotection; Deoxyguanosine; Disease Models, Animal; DNA Adducts; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glutathione Transferase; Hydroxylation; Isoniazid; Kinetics; Liver; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Wistar; Tiopronin | 2009 |