Compounds > chlorzoxazone

chlorzoxazone and dimethylnitrosamine

chlorzoxazone has been researched along with dimethylnitrosamine in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Alexander, A; Berthou, F; Mapoles, J; Ménez, JF; Simon, F1
Bell, LC; Gillam, EM; Guengerich, FP; Nakano, M; Shimada, T; Yamazaki, H1
Harris, D; Park, JY1

Other Studies

5 other study(ies) available for chlorzoxazone and dimethylnitrosamine

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression.
    European journal of biochemistry, 1993, Jun-15, Volume: 214, Issue:3

    Topics: 1-Butanol; Acetaminophen; Animals; Butanols; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ditiocarb; Genetic Engineering; Humans; Hydroxylation; Microsomes; Oxidoreductases, N-Demethylating; Oxygenases; PC12 Cells; Transfection

1993
Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes.
    Biochemical pharmacology, 1996, Jul-26, Volume: 52, Issue:2

    Topics: Aniline Compounds; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Dimethylnitrosamine; Humans; Kinetics; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Recombinant Proteins

1996
Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations.
    Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9

    Topics: Amino Acid Sequence; Animals; Bacteria; Binding Sites; Chlorzoxazone; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Nitrophenols; Quantum Theory; Rabbits; Structure-Activity Relationship; Substrate Specificity; Thermodynamics

2003