chlorzoxazone has been researched along with diclofenac in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 17 (70.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Dai, R; Liu, Y; She, M; Wu, Z | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ | 1 |
| Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ | 1 |
| Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
| Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y | 1 |
| Devkhile, AB; Shaikh, KA | 1 |
| Hao, HP; Peng, Y; Roberts, MS; Shang, LL; Sun, JG; Wang, GJ; Wang, XJ; Xia, CH; Xie, L; Zhang, R; Zhang, XX | 1 |
| Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M | 1 |
| Desai, PP; Mehta, PJ; Patel, NR; Sherikar, OD | 1 |
| Ren, X; Taylor, E; Wong, LL; Yorke, JA; Zhang, T; Zhou, W | 1 |
| Elshahed, MS; Hegazy, MA; Helmy, MI; Toubar, SS | 1 |
| Jilek, JL; Tian, Y; Yu, AM | 1 |
| Elshahed, MS; Hegazy, MA; Helmy, MI; Mohamed, D; Toubar, SS | 1 |
| Misaka, S; Shimomura, K | 1 |
| Chiang, W; Li, ML; Lin, JH; Liu, YT; Yao, HT | 1 |
1 review(s) available for chlorzoxazone and diclofenac
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for chlorzoxazone and diclofenac
| Article | Year |
|---|---|
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating | 2001 |
22 other study(ies) available for chlorzoxazone and diclofenac
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline | 1999 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2002 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone | 2004 |
Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form.
Topics: Acetaminophen; Chlorzoxazone; Chromatography, High Pressure Liquid; Diclofenac; Reproducibility of Results; Sensitivity and Specificity | 2008 |
Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats.
Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Diclofenac; Drug Combinations; Drugs, Chinese Herbal; Herb-Drug Interactions; Inactivation, Metabolic; Inhibitory Concentration 50; Injections; Liver; Male; Midazolam; Ophiopogon; Panax; Plant Roots; Rats; Rats, Sprague-Dawley; Theophylline | 2010 |
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2011 |
Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms.
Topics: Acetaminophen; Carbon Dioxide; Chlorzoxazone; Chromatography, Supercritical Fluid; Diclofenac; Drug Combinations; Linear Models; Methanol; Pressure; Reproducibility of Results; Sensitivity and Specificity; Temperature | 2012 |
Drug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.
Topics: Catalysis; Chlorzoxazone; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Hydrogen Bonding; Kinetics; Naproxen; Oxidation-Reduction; Protein Engineering; Testosterone | 2015 |
Novel pure component contribution, mean centering of ratio spectra and factor based algorithms for simultaneous resolution and quantification of overlapped spectral signals: An application to recently co-formulated tablets of chlorzoxazone, aceclofenac an
Topics: Acetaminophen; Algorithms; Calibration; Chemistry, Pharmaceutical; Chlorzoxazone; Diclofenac; Least-Squares Analysis; Reference Standards; Regression Analysis; Reproducibility of Results; Solutions; Spectrum Analysis; Tablets | 2016 |
Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Male; Mice; MicroRNAs; Midazolam; Pharmacokinetics; Phenacetin | 2017 |
Liquid chromatography-tandem MS/MS method for simultaneous quantification of paracetamol, chlorzoxazone and aceclofenac in human plasma: An application to a clinical pharmacokinetic study.
Topics: Acetaminophen; Chlorzoxazone; Chromatography, Liquid; Diclofenac; Humans; Limit of Detection; Linear Models; Male; Reproducibility of Results; Tandem Mass Spectrometry | 2018 |
Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?
Topics: Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Diclofenac; Drug Interactions; Humans; Quercetin | 2018 |
Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats.
Topics: Administration, Intravenous; Administration, Oral; Animals; Capsaicin; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Diltiazem; Food-Drug Interactions; Intestinal Absorption; Intestines; Liver; Male; Plant Oils; Rats, Sprague-Dawley; Risk Assessment; Theophylline | 2019 |