chlorzoxazone and debrisoquin

chlorzoxazone has been researched along with debrisoquin in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's5 (50.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ1
Adedoyin, A; Branch, RA; Frye, RF; Matzke, GR; Porter, JA1
Adedoyin, A; Branch, RA; Frye, RF; Mauro, K1
Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ1
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ1
Branch, RA; Frye, RF1
Aherne, Z; Blakey, GE; Lockton, JA; Norwood, P; Perrett, J; Plume, J; Russell, M1
Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK1
Branch, RA; Frye, RF; Romkes, M; Tracy, TS; Zgheib, NK1
Berka, K; Otyepka, M; Paloncýová, M1

Trials

5 trial(s) available for chlorzoxazone and debrisoquin

ArticleYear
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4

    Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values

1997
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:5

    Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating

2001
Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.
    British journal of clinical pharmacology, 2004, Volume: 57, Issue:2

    Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Combinations; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Plasma; Tolbutamide

2004
Liver disease selectively modulates cytochrome P450--mediated metabolism.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline

2006
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged

2006

Other Studies

5 other study(ies) available for chlorzoxazone and debrisoquin

ArticleYear
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.
    Pharmaceutical research, 1999, Volume: 16, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity

1999
Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail.
    British journal of clinical pharmacology, 1998, Volume: 46, Issue:3

    Topics: Adult; Analysis of Variance; Antimalarials; Caffeine; Chloroquine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Drug Interactions; Humans; Isoenzymes; Male; Phenotype

1998
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 1999, Volume: 13, Issue:23

    Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline

1999
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
    British journal of clinical pharmacology, 2002, Volume: 53, Issue:2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Disulfiram; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mephenytoin; Mixed Function Oxygenases; Time Factors

2002
Molecular insight into affinities of drugs and their metabolites to lipid bilayers.
    The journal of physical chemistry. B, 2013, Feb-28, Volume: 117, Issue:8

    Topics: Caffeine; Cell Membrane; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Ibuprofen; Lipid Bilayers; Molecular Dynamics Simulation; Pharmaceutical Preparations; Phosphatidylcholines; Phosphatidylglycerols; Thermodynamics; Xenobiotics

2013