chlorzoxazone has been researched along with dapsone in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Adedoyin, A; Branch, RA; Frye, RF; Matzke, GR; Porter, JA | 1 |
| Adedoyin, A; Branch, RA; Frye, RF; Mauro, K | 1 |
| Branch, RA; Frye, RF | 1 |
| Hu, JP; Xu, YX; Yan, SL; Zhang, JN | 1 |
| Arsenault, M; Bélanger, PM; Hamelin, BA; Pilote, S; Sharma, A | 1 |
| Branch, RA; Frye, RF; Romkes, M; Tracy, TS; Zgheib, NK | 1 |
| Ge, B; Jiang, S; Li, Y; Liu, X; Min, G; Tang, H | 1 |
| Gao, J; Gao, X; Jia, H; Xu, A; Yuan, J | 1 |
| Gao, J; Li, GQ; Shi, Z; Yan, R; Yao, M; Zhu, S | 1 |
| Lin, Y; Lu, T; Mao, C; Song, Y; Su, T; Yin, F; Yu, Z | 1 |
| Cui, J; Li, J; Li, R; Lin, W; Ling, X; Yang, H; Yu, N; Zhang, J | 1 |
| Chang, ZQ; Li, J; Zhai, QQ | 1 |
| Bhateria, M; Bhatta, RS; Ramakrishna, R; Singh, R | 1 |
1 review(s) available for chlorzoxazone and dapsone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
2 trial(s) available for chlorzoxazone and dapsone
| Article | Year |
|---|---|
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes.
Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values | 1997 |
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged | 2006 |
17 other study(ies) available for chlorzoxazone and dapsone
| Article | Year |
|---|---|
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride | 2005 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail.
Topics: Adult; Analysis of Variance; Antimalarials; Caffeine; Chloroquine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Drug Interactions; Humans; Isoenzymes; Male; Phenotype | 1998 |
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Disulfiram; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mephenytoin; Mixed Function Oxygenases; Time Factors | 2002 |
[Simultaneous determination of three probe drugs by reversed-phase high performance liquid chromatography].
Topics: Animals; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Dapsone; Male; Rats | 2002 |
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.
Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Drug Combinations; Humans; Male; Metoprolol; Phenformin; Pilot Projects; Tolbutamide | 2004 |
Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs.
Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Bilirubin; Caffeine; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Chromatography, High Pressure Liquid; Dapsone; Drugs, Chinese Herbal; Liver; Liver Function Tests; Male; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar | 2008 |
[Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus].
Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Drugs, Chinese Herbal; Fermentation; Male; Random Allocation; Rats; Rats, Wistar | 2009 |
Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches.
Topics: Adamantane; Animals; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Activators; Enzyme Inhibitors; Herb-Drug Interactions; Isoenzymes; Male; Plant Extracts; Rats; Rats, Wistar; Rheum; Theophylline; Tolbutamide; Wine | 2013 |
Effects of unprocessed versus vinegar-processed Schisandra chinensis on the activity and mRNA expression of CYP1A2, CYP2E1 and CYP3A4 enzymes in rats.
Topics: Acetic Acid; Animals; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Dapsone; Dose-Response Relationship, Drug; Drug Compounding; Drugs, Chinese Herbal; Enzyme Induction; Herb-Drug Interactions; Male; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Schisandra; Substrate Specificity; Theophylline | 2013 |
Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: a cocktail approach.
Topics: Administration, Oral; Animals; Antipyrine; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dapsone; Limit of Detection; Linear Models; Male; Metoprolol; Omeprazole; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Solid Phase Extraction | 2013 |
Evaluation on activity of cytochrome p450 enzymes in turbot via a probe drug cocktail.
Topics: Animals; Antitubercular Agents; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Enzyme Induction; Flatfishes; Folic Acid Antagonists; Muscle Relaxants, Central; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Rifampin | 2014 |
Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dapsone; Dextromethorphan; Gene Expression Regulation; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Tolbutamide | 2016 |