Compounds > chlorzoxazone

chlorzoxazone and chlormethiazole

chlorzoxazone has been researched along with chlormethiazole in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's1 (12.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dai, R; Liu, Y; She, M; Wu, Z1
Baldwin, HA; Cross, AJ; Ingelman-Sundberg, M; Tindberg, N1
Gebhardt, AC; Lucas, D; Ménez, JF; Seitz, HK1
Besson, J; Buclin, T; Eap, CB; Savary, L; Schnyder, C1
Ingelman-Sundberg, M; Simi, A1
Donohue, TM; Fang, C; French, BA; French, SW; Fu, P; Gouillon, Z; Hagbjork, AL; Ingelman-Sundberg, M; Li, J; Lucas, D1
Blanchard, AP; Creegan, TP; Dehal, SS; Gangl, ET; Mason, AK; Perloff, ES; Singh, R; Stresser, DM1

Other Studies

8 other study(ies) available for chlorzoxazone and chlormethiazole

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3

    Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity

2011
Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury.
    Molecular pharmacology, 1996, Volume: 50, Issue:5

    Topics: Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Chlormethiazole; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Gerbillinae; Hydroxylation; Inflammation; Interleukin-1; Kinetics; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger

1996
Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans.
    Hepatology (Baltimore, Md.), 1997, Volume: 26, Issue:4

    Topics: Adult; Aged; Alcoholism; Chlormethiazole; Chlorzoxazone; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Female; Humans; Hydroxylation; Male; Middle Aged; Substance Withdrawal Syndrome

1997
Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers.
    Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:1

    Topics: Administration, Oral; Adult; Alcoholism; Anticonvulsants; Area Under Curve; Chlormethiazole; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central

1998
Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Animals; Anticonvulsants; Blotting, Northern; Chlormethiazole; Chlorzoxazone; Cricetinae; Cycloheximide; Cytochrome P-450 CYP2E1; Humans; Hydroxylation; Liver Neoplasms, Experimental; Microsomes, Liver; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Cells, Cultured

1999
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:4

    Topics: Animals; Apoenzymes; Body Weight; Chlormethiazole; Chlorzoxazone; Chymotrypsin; Cysteine Endopeptidases; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Disease Models, Animal; Ethanol; Hydroxylation; Immunohistochemistry; Liver; Liver Diseases, Alcoholic; Male; Multienzyme Complexes; Organ Size; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Trypsin

2000
Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

    Topics: Biotransformation; Chlormethiazole; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hydroxylation; Hypnotics and Sedatives; Kinetics; Liver; Male; Microsomes, Liver; Models, Biological; NADP; Risk Assessment; Substrate Specificity

2016