chlorzoxazone and acetaminophen

chlorzoxazone has been researched along with acetaminophen in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (37.78)	18.7374
1990's	5 (11.11)	18.2507
2000's	5 (11.11)	29.6817
2010's	16 (35.56)	24.3611
2020's	2 (4.44)	2.80

Authors

Authors	Studies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bharate, SS; Vishwakarma, RA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Coldren, JW; Honigberg, IL; Stewart, JT	1
Miller, AR	1
Gready, DM	1
Gaitonde, CD; Pathak, PV	1
Chatterjee, PK; Jain, CL; Sethi, PD	1
Chao, SY; Chem, ZS	1
Cattau, EL; Powers, BJ; Zimmerman, HJ	1
Walker, JM	1
Bürgisser, J	1
Scheiner, JJ	1
Vernon, WG	1
Darienzo, C	1
Kare, V	1
Frank, O; Klemmayer, K	1
Boldus, RA; Liederman, PC	1
Desiraju, RK; Nayak, RK; Ng, KT; Renzi, NL	1
Adams, SP; Kalhorn, TF; Nelson, SD; Slattery, JT; Thummel, KE; Wright, JM; Zand, R	1
Alexander, A; Berthou, F; Mapoles, J; Ménez, JF; Simon, F	1
Krähenbühl, S; Kronenberg, A; Streuli, R; Zimmermann, A	1
Bebawy, LI; El-Kousy, NM	1
Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO	1
Ding, L; Wu, H; Yang, C; Zhan, W; Zheng, K	1
OGDEN, HD; SCHOCKET, L	1
Cai, YM; Cao, D; Huang, XR; Tai, Y	1
Devkhile, AB; Shaikh, KA	1
Chou, KC; Li, J; Wang, JF; Wei, DQ; Yu, ZT	1
Desai, PP; Mehta, PJ; Patel, NR; Sherikar, OD	1
Abdelaleem, EA; Abdelwahab, NS	1
Langhammer, AJ; Nilsen, OG	1
Elshahed, MS; Hegazy, MA; Helmy, MI; Toubar, SS	1
Elshahed, MS; Hegazy, MA; Helmy, MI; Mohamed, D; Toubar, SS	1
Abdulaziz, MA; Abdulkhair, BY; Alothman, ZA; Aqel, A; Badjah-Hadj-Ahmed, AY; Salih, ME	1
AlAlamein, AMA; Galal, MM; Saad, AS; Zaazaa, HE	1
Azhar, I; Chi, Z; Feng, Y; Khan, H; Yang, L	1
Bedair, MM; Belal, TS; El-Yazbi, AF; Guirguis, KM	1
Jiang, X; Liang, Z; Wang, L; Wen, C; Yang, W	1

Reviews

2 review(s) available for chlorzoxazone and acetaminophen

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases. Archives of internal medicine, 1986, Volume: 146, Issue:6 Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Biopsy; Chlorzoxazone; Drug Combinations; Drug Evaluation; Female; Humans; Liver; Male; Middle Aged; Necrosis; Time Factors	1986

Trials

7 trial(s) available for chlorzoxazone and acetaminophen

Article	Year
Parafon Forte tablets: a review of the literature. Current therapeutic research, clinical and experimental, 1975, Volume: 17, Issue:1 Topics: Acetaminophen; Benzoxazoles; Chlorzoxazone; Clinical Trials as Topic; Drug Combinations; History, 20th Century; Muscle Relaxants, Central; Placebos; Tablets	1975
A comparative study of Parafon Forte tablets and soma compound in the treatment of painful skeletal muscle conditions. Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:4 Topics: Acetaminophen; Adolescent; Adult; Benzoxazoles; Carisoprodol; Chlorzoxazone; Drug Combinations; Female; Humans; Male; Middle Aged; Muscular Diseases; Pain; Spasm	1976
Parafon Forte versus Robaxisal in skeletal muscle disorders: a double-blind study. Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:5 Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Benzoxazoles; Chlorzoxazone; Clinical Trials as Topic; Drug Combinations; Female; Humans; Male; Methocarbamol; Middle Aged; Muscular Diseases	1976
Value of an acetaminophen-chlorzoxazone combination (parafon forte) in the treatment of acute musculoskeletal disorders. Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:5 Topics: Acetaminophen; Benzoxazoles; Chlorzoxazone; Clinical Trials as Topic; Drug Combinations; Humans; Lumbosacral Region; Muscle Relaxants, Central; Muscular Diseases; Placebos; Sprains and Strains; Time Factors	1973
Evaluation of a combined muscle relaxant-analgesic as an effective therapy for painful skeletal muscle spasm. Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:4 Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics; Benzoxazoles; Chlorzoxazone; Clinical Trials as Topic; Drug Combinations; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Muscle Cramp; Muscle Relaxants, Central; Time Factors	1972
A double-blind evaluation of Parafon Forte in the treatment of musculo-skeletal back conditions. Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:12 Topics: Acetaminophen; Adolescent; Adult; Back; Benzoxazoles; Bone Diseases; Chlorzoxazone; Clinical Trials as Topic; Drug Combinations; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscular Diseases; Pain; Placebos; Spasm	1972
Muscle relaxant-analgesic therapy (report on institutionalized spastic children). Diseases of the nervous system, 1966, Volume: 27, Issue:3 Topics: Acetaminophen; Cerebral Palsy; Child, Preschool; Chlorzoxazone; Clinical Trials as Topic; Female; Humans; Infant; Male; Muscles	1966

Other Studies

36 other study(ies) available for chlorzoxazone and acetaminophen

Article	Year
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7 Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics	2015
Liquid chromatography in pharmaceutical analysis XI: determination of muscle relaxant--analgesic mixture using reversed-phase and ion-pair techniques. Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:1 Topics: Acetaminophen; Analgesics; Aspirin; Chlorzoxazone; Chromatography, High Pressure Liquid; Drug Combinations; Methocarbamol; Methods; Muscle Relaxants, Central	1979
Estimation of the analgesic muscle relaxants chlorzoxazone and diazepam in human plasma by reversed-phase liquid chromatography. Journal of chromatography, 1990, Jun-29, Volume: 528, Issue:2 Topics: Acetaminophen; Analgesics; Benzoxazoles; Chlorzoxazone; Chromatography; Diazepam; Humans; Muscle Relaxants, Central; Oxyphenbutazone; Theophylline	1990
Simultaneous determination of chlorzoxazone and acetaminophen in combined dosage forms by an absorbance ratio technique and difference spectrophotometry. Journal of pharmaceutical and biomedical analysis, 1989, Volume: 7, Issue:6 Topics: Acetaminophen; Chlorzoxazone; Drug Combinations; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets	1989
[Nonsurgical treatment of TMJ disorders--chemical and physical therapy]. Zhonghua ya yi xue hui za zhi, 1987, Volume: 6, Issue:3 Topics: Acetaminophen; Chlorzoxazone; Diazepam; Electric Stimulation Therapy; Facial Pain; Humans; Lidocaine; Mandibular Condyle; Taiwan; Temporomandibular Joint Disorders; Ultrasonic Therapy	1987
[On Predniflex-plus therapy in general practice]. Praxis, 1966, May-19, Volume: 55, Issue:20 Topics: Acetaminophen; Analgesics; Arthritis, Rheumatoid; Back Pain; Chlorzoxazone; Family Practice; Humans; Muscles; Prednisolone	1966
[Experiences with the antirheumatic Predniflex-Plus (C 7243-25)]. Wiener medizinische Wochenschrift (1946), 1967, Feb-18, Volume: 117, Issue:7 Topics: Acetaminophen; Benzoxazoles; Chlorzoxazone; Humans; Joint Diseases; Muscles; Prednisolone	1967
[On the two-phase therapy of degenerative rheumatism with a myotonolytic-antiphlogistic and an analgesic combination preparation]. Praxis, 1968, Aug-27, Volume: 57, Issue:34 Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Chlorzoxazone; Female; Humans; Male; Middle Aged; Muscles; Osteoarthritis; Prednisolone	1968
Psychic side effects of a chlorzoxazone and acetaminophen mixture; a case report. JAMA, 1967, Oct-02, Volume: 202, Issue:1 Topics: Acetaminophen; Adult; Chlorzoxazone; Humans; Male; Muscles; Psychoses, Substance-Induced	1967
Pharmacokinetics of chlorzoxazone in humans. Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:9 Topics: Acetaminophen; Adult; Benzoxazoles; Biotransformation; Chlorzoxazone; Drug Combinations; Half-Life; Humans; Kinetics; Male; Models, Biological	1983
Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:2 Topics: Acetaminophen; Acetylation; Adult; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Isoniazid; Male; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Sulfamethazine	1993
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression. European journal of biochemistry, 1993, Jun-15, Volume: 214, Issue:3 Topics: 1-Butanol; Acetaminophen; Animals; Butanols; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ditiocarb; Genetic Engineering; Humans; Hydroxylation; Microsomes; Oxidoreductases, N-Demethylating; Oxygenases; PC12 Cells; Transfection	1993
[Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage]. Praxis, 1998, Oct-07, Volume: 87, Issue:41 Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Drug Therapy, Combination; Humans; Liver; Low Back Pain; Middle Aged; Muscle Relaxants, Central	1998
Simultaneous determination of some multicomponent dosage forms by quantitative thin layer chromatography densitometric method. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 20, Issue:4 Topics: Acetaminophen; Caffeine; Chlorzoxazone; Chromatography, Thin Layer; Densitometry; Diflunisal; Dosage Forms; Naproxen; Pharmaceutical Preparations; Solvents; Theophylline	1999
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:3 Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines	2001
[Determination of chlorzoxazone and paracetamol in co-chlorzoxazone tablet by multi-wavelength linear regression method]. Guang pu xue yu guang pu fen xi = Guang pu, 2000, Volume: 20, Issue:3 Topics: Acetaminophen; Analgesics; Chlorzoxazone; Drug Combinations; Linear Models; Spectrophotometry, Ultraviolet; Tablets	2000
Controlled studies of chlorzoxazone and chlorzoxazone plus acetaminophen in the treatment of myalgia associated with headache. Southern medical journal, 1960, Volume: 63 Topics: Acetaminophen; Acetanilides; Chlorzoxazone; Disease; Headache; Humans; Muscles; Muscular Diseases; Myalgia; Zoxazolamine	1960
[Ratio spectrophotometry and its application to assay of compound pharmacy preparations]. Guang pu xue yu guang pu fen xi = Guang pu, 2005, Volume: 25, Issue:4 Topics: Acetaminophen; Algorithms; Caffeine; Chemistry, Pharmaceutical; Chlorzoxazone; Pharmaceutical Preparations; Reference Standards; Reproducibility of Results; Sodium Benzoate; Spectrophotometry, Ultraviolet	2005
Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form. Journal of chromatographic science, 2008, Volume: 46, Issue:7 Topics: Acetaminophen; Chlorzoxazone; Chromatography, High Pressure Liquid; Diclofenac; Reproducibility of Results; Sensitivity and Specificity	2008
Molecular dynamics simulations of CYP2E1. Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:2 Topics: Acetaminophen; Aniline Compounds; Benzene; Biocatalysis; Catalytic Domain; Chlorzoxazone; Crystallography, X-Ray; Cytochrome P-450 CYP2E1; Models, Molecular; Molecular Dynamics Simulation; Structure-Activity Relationship; Theophylline	2012
Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms. Journal of chromatographic science, 2012, Volume: 50, Issue:9 Topics: Acetaminophen; Carbon Dioxide; Chlorzoxazone; Chromatography, Supercritical Fluid; Diclofenac; Drug Combinations; Linear Models; Methanol; Pressure; Reproducibility of Results; Sensitivity and Specificity; Temperature	2012
Stability-indicating TLC-densitometric method for simultaneous determination of paracetamol and chlorzoxazone and their toxic impurities. Journal of chromatographic science, 2013, Volume: 51, Issue:2 Topics: Acetaminophen; Aminophenols; Capsules; Chlorophenols; Chlorzoxazone; Chromatography, Thin Layer; Densitometry; Drug Contamination; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity	2013
Fennel and raspberry leaf as possible inhibitors of acetaminophen oxidation. Phytotherapy research : PTR, 2014, Volume: 28, Issue:10 Topics: Acetaminophen; Benzoquinones; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Foeniculum; Humans; Imines; Inactivation, Metabolic; Inhibitory Concentration 50; Oxidation-Reduction; Plant Leaves; Rubus	2014
Novel pure component contribution, mean centering of ratio spectra and factor based algorithms for simultaneous resolution and quantification of overlapped spectral signals: An application to recently co-formulated tablets of chlorzoxazone, aceclofenac an Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2016, Jun-15, Volume: 163 Topics: Acetaminophen; Algorithms; Calibration; Chemistry, Pharmaceutical; Chlorzoxazone; Diclofenac; Least-Squares Analysis; Reference Standards; Regression Analysis; Reproducibility of Results; Solutions; Spectrum Analysis; Tablets	2016
Liquid chromatography-tandem MS/MS method for simultaneous quantification of paracetamol, chlorzoxazone and aceclofenac in human plasma: An application to a clinical pharmacokinetic study. Biomedical chromatography : BMC, 2018, Volume: 32, Issue:7 Topics: Acetaminophen; Chlorzoxazone; Chromatography, Liquid; Diclofenac; Humans; Limit of Detection; Linear Models; Male; Reproducibility of Results; Tandem Mass Spectrometry	2018
Simultaneous Determination of Paracetamol and Chlorzoxazone in Their Combined Pharmaceutical Formulations by Reversed-phase Capillary Liquid Chromatography Using a Polymethacrylate Monolithic Column. Journal of chromatographic science, 2018, Oct-01, Volume: 56, Issue:9 Topics: Acetaminophen; Chlorzoxazone; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Limit of Detection; Linear Models; Polymethacrylic Acids; Reproducibility of Results; Tablets	2018
Traditional versus advanced chemometric models for the impurity profiling of paracetamol and chlorzoxazone: Application to pure and pharmaceutical dosage forms. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2018, Dec-05, Volume: 205 Topics: Acetaminophen; Algorithms; Analysis of Variance; Chlorzoxazone; Chromatography, High Pressure Liquid; Dosage Forms; Drug Contamination; Least-Squares Analysis; Neural Networks, Computer; Spectrophotometry, Ultraviolet	2018
Automatic Dissolution Testing with High-Temporal Resolution for Both Immediate-Release and Fixed-Combination Drug Tablets. Scientific reports, 2019, 11-19, Volume: 9, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Automation; Chemistry, Pharmaceutical; Chlorzoxazone; Drug Combinations; Drug Liberation; Humans; Muscle Relaxants, Central; Quality Control; Solubility; Tablets	2019
Validated specific HPLC-DAD method for simultaneous estimation of paracetamol and chlorzoxazone in the presence of five of their degradation products and toxic impurities. Drug development and industrial pharmacy, 2020, Volume: 46, Issue:11 Topics: Acetaminophen; Capsules; Chlorzoxazone; Chromatography, High Pressure Liquid; Reproducibility of Results	2020
Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme. Molecules (Basel, Switzerland), 2022, Dec-13, Volume: 27, Issue:24 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 CYP2E1; Humans; Liver; Rats; Silymarin	2022