Compounds > chlorzoxazone

chlorzoxazone and 7-ethoxycoumarin

chlorzoxazone has been researched along with 7-ethoxycoumarin in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's3 (42.86)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL1
Bell, LC; Gillam, EM; Guengerich, FP; Nakano, M; Shimada, T; Yamazaki, H1
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T1
Shimada, T; Tsumura, F; Yamazaki, H1
Inoue, K; Shimada, T; Yamazaki, H1
Axelsson, H; Floby, E; Granhall, C; Jaksch, Y; Sohlenius-Sternbeck, AK; Svedling, M1
Ahn, T; Jung, HC; Kim, D; Kim, DH; Pan, JG; Park, SH; Yun, CH1

Other Studies

7 other study(ies) available for chlorzoxazone and 7-ethoxycoumarin

ArticleYear
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
    Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18

    Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride

2005
Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes.
    Biochemical pharmacology, 1996, Jul-26, Volume: 52, Issue:2

    Topics: Aniline Compounds; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Dimethylnitrosamine; Humans; Kinetics; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Recombinant Proteins

1996
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide

1998
Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:11

    Topics: Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Oxidation-Reduction; Recombinant Proteins

1999
Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene.
    Archives of toxicology, 2000, Volume: 74, Issue:7

    Topics: Asian People; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2E1; DNA; Genotype; Humans; Hydroxylation; Japan; Microsomes, Liver; Polymerase Chain Reaction; Polymorphism, Genetic; White People

2000
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2003, Volume: 17, Issue:4

    Topics: Animals; Antidepressive Agents; Antimalarials; Antitussive Agents; Calcium Channel Blockers; Cell Survival; Chlorzoxazone; Coloring Agents; Coumarins; Cryopreservation; Cytochrome P-450 Enzyme System; Dextromethorphan; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Pharmaceutical Preparations; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Testosterone; Verapamil; Xanthenes

2003
Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:5

    Topics: Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Carbon; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Stability; Escherichia coli; Heme; Humans; Indigo Carmine; Indoles; Kinetics; Molecular Dynamics Simulation; NADPH-Ferrihemoprotein Reductase; Nitrophenols; Oxazines; Oxidation-Reduction; Phenacetin; Protein Engineering; Recombinant Proteins; Transformation, Genetic; Umbelliferones

2010