chlorzoxazone and 6-hydroxychlorzoxazone

chlorzoxazone has been researched along with 6-hydroxychlorzoxazone in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.28)	18.7374
1990's	22 (36.07)	18.2507
2000's	30 (49.18)	29.6817
2010's	7 (11.48)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carter, HK; Stewart, JT	1
Desiraju, RK; Nayak, RK; Ng, KT; Renzi, NL	1
Dreisbach, AW; Ferencz, N; Fuentes, MG; George, WJ; Hopkins, NE; Lertora, JJ; Rege, AB	1
Bodénez, P; Girre, C; Hispard, E; Lucas, D; Ménez, C; Ménez, JF	1
A-Rahim, YI; Seaton, TD; Vesell, ES	1
Becker, CE; de Vries, JD; Hoener, BA; Horie, S; Salphati, L	1
Dally, S; Girre, C; Hispard, E; Lucas, D; Menez, C; Menez, JF	1
Berthou, F; Girre, C; Lucas, D; Ménez, JF; Poitrenaud, F	1
Branch, RA; Frye, RF; Stiff, DD	1
Chen, L; Yang, CS	1
Berthou, F; Lucas, D; Menez, JF	1
Baird, S; Beaune, P; Belloc, C; Berthou, F; Carrière, V; de Waziers, I	1
Frye, RF; Stiff, DD	1
Nakanishi, S; Yamazaki, H	1
Chittur, SV; Tracy, TS	1
Eap, CB; Savary, L; Schnyder, C	1
Tanaka, E	2
Branch, RA; Burckart, GJ; Frye, RF; Fung, JJ; Jain, A; Kelly, P; Starzl, TE; Venkataramanan, R	1
Korsunsky, Z; Vesell, ES	1
Crivello, J; Wall, KL	1
Emery, MG; Jubert, C; Kharasch, ED; Thummel, KE	1
Blouin, RA; Gardner, BM; Poloyac, SM; Shedlofsky, SI; Tosheva, RT	1
Bridges, RJ; Devor, DC; Gerlach, AC; Gondor, M; Pilewski, JM; Singh, AK	1
Misawa, S; Mizuno, D; Tanaka, E; Tanno, K	1
Donohue, TM; Fang, C; French, BA; French, SW; Fu, P; Gouillon, Z; Hagbjork, AL; Ingelman-Sundberg, M; Li, J; Lucas, D	1
Inoue, K; Shimada, T; Yamazaki, H	1
Blouin, RA; Perez, A; Poloyac, SM; Scheff, S	1
Li, L; Zhang, Y	2
Chen, XP; Han, XM; Huang, SL; Jiang, CH; Liu, ZQ; Zhou, G; Zhou, HH; Zhu, B	1
Bartges, J; Cox, SK; Hamner, T	1
Anari, MR; Baillie, TA; Bakhtiar, R; Franklin, RB; Pearson, PG	1
Cho, MK; Kim, EJ; Kim, SG; Kim, YC; Kim, YG; Lee, MG	1
Chung, HC; Kim, EJ; Kim, SG; Kim, SH; Lee, AK; Lee, DC; Lee, I; Lee, MG; Moon, YJ	1
Chung, W; Kim, EJ; Kim, SG; Kim, SH; Lee, I; Lee, MG	1
Albores, A; Berthou, F; González-Jasso, E; López, T; Lucas, D; Manno, M; Ortega, A	1
Bies, RR; Frye, RF; Gastonguay, MR; Matzke, GR; Nolin, TD	1
Hack, A; Roos, PH; Tschirbs, S; Welge, P; Wilhelm, M	1
Fisher, JM; Gardner, MJ; Kolluri, S; Moller, RA; Obach, RS; Taylor, AE; Walsky, RL	1
Ha, JM; Kim, KA; Park, JY; Park, PW	1
Mehvar, R; Vuppugalla, R	2
Bae, SK; Baek, HW; Lee, MG; Sohn, YT	1
Joshi, M; Lee, AM; Tyndale, RF; Yue, J	1
Chen, ZC; He, ZM; Hou, DF; Wang, SL; Yang, F	1
Ernstgård, L; Johanson, G; Karlsson, AS; Warholm, M	1
Chtioui, H; Dufour, JF; Ledermann, M; Semela, D; Zimmermann, A	1
Komolmit, P; Prompila, N; Wittayalertpanya, S	2
Ishizaki, J; Khemawoot, P; Miyamoto, K; Nishino, K; Yokogawa, K	1
Ahn, CY; Bae, SK; Jung, YS; Kim, YC; Lee, I; Lee, MG; Shin, WG	1
Bietto, FM; Castro, GD; Castro, JA; Delgado de Layño, AM; Díaz Gómez, MI; Fanelli, SL	1
Choi, YH; Jung, HY; Kang, HE; Kim, SH; Lee, MG	1
Bartolucci, GB; Carrieri, M; Di Mare, M; Fracasso, ME; Lepera, JS; Manno, M; Padovano, L; Piccoli, P	1
Feng, YQ; Wu, JY; Yue, J	1
Langhammer, AJ; Nilsen, OG	1
Koyama, N; Umehara, K; Yamamura, Y	1
Burhenne, J; Haefeli, WE; Hohmann, N; Mikus, G; Suzuki, Y; Witt, L	1
Bucher, S; Gade, C; Gicquel, T; Holst, H; Loyer, P; Quesnot, N; Robin, MA; Valença, S; Vene, E; Vlach, M	1
Aboagye, EO; Clarke, S; Edwards, RJ; Lee, P; Liddle, C; Lozan-Kuehne, JP; Maslen, L; Ramaswami, R; Sharma, R; Trousil, S	1

Reviews

1 review(s) available for chlorzoxazone and 6-hydroxychlorzoxazone

Article	Year
[Induction of cytochrome P-450 IIE1 after chronic ethanol administration in man and in animals]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl Topics: Alcoholism; Animals; Biomarkers; Chlorzoxazone; Cytochrome P-450 CYP2E1; Enzyme Induction; Ethanol; Humans; Microsomes, Liver; Substrate Specificity	1997

Trials

8 trial(s) available for chlorzoxazone and 6-hydroxychlorzoxazone

Article	Year
Variability in the disposition of chlorzoxazone. Biopharmaceutics & drug disposition, 1994, Volume: 15, Issue:7 Topics: Administration, Oral; Adult; Alcohol Drinking; Asian People; Black People; Blood Proteins; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; Male; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Protein Binding; Spectrophotometry, Ultraviolet; White People	1994
Pedigree analysis of a subject with abnormally slow renal elimination of 6-hydroxychlorzoxazone. Pharmacology, 1998, Volume: 56, Issue:5 Topics: Adult; Biotransformation; Child; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Half-Life; Humans; Male; Pedigree	1998
Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1 Topics: Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Disulfiram; Enzyme Inhibitors; Female; Half-Life; Humans; Male; Substrate Specificity; Time Factors	1999
Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:6 Topics: Adult; Aged; Area Under Curve; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Female; Humans; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Muscle Relaxants, Central; Pharmacogenetics	2003
Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism. The Annals of pharmacotherapy, 2006, Volume: 40, Issue:1 Topics: Administration, Oral; Chlorzoxazone; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dextromethorphan; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Dyspepsia; Female; Humans; Inpatients; Metabolic Clearance Rate; Middle Aged; Postmenopause; Pyrrolidines; Retrospective Studies; Tetrahydronaphthalenes; Time Factors	2006
Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe. Journal of clinical pharmacology, 2006, Volume: 46, Issue:1 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chlorzoxazone; Cytochrome P-450 CYP2E1; Drug Administration Schedule; Humans; Korea; Liver; Male	2006
Phenotyping of cytochrome P450 2E1 in vitro and in vivo. Current drug metabolism, 2007, Volume: 8, Issue:5 Topics: Adult; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Humans; Male; Middle Aged	2007
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation. British journal of pharmacology, 2019, Volume: 176, Issue:18 Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Cytokines; Dextromethorphan; Female; Humans; Inflammation; Middle Aged; Omeprazole; Ovarian Neoplasms	2019

Other Studies

52 other study(ies) available for chlorzoxazone and 6-hydroxychlorzoxazone

Article	Year
High-performance liquid chromatography with electrochemical detection of chlorzoxazone and its hydroxy metabolite in serum using solid-phase extraction. Journal of chromatography, 1986, Jul-11, Volume: 380, Issue:1 Topics: Benzoxazoles; Chemical Phenomena; Chemistry; Chlorzoxazone; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Spectrophotometry, Ultraviolet	1986
Pharmacokinetics of chlorzoxazone in humans. Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:9 Topics: Acetaminophen; Adult; Benzoxazoles; Biotransformation; Chlorzoxazone; Drug Combinations; Half-Life; Humans; Kinetics; Male; Models, Biological	1983
Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:5 Topics: Adolescent; Adult; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Humans; Male; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating	1995
Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase. Alcoholism, clinical and experimental research, 1995, Volume: 19, Issue:2 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Hydroxylation; Liver; Male; Middle Aged; Oxidoreductases, N-Demethylating; Reference Values	1995
Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe. Pharmacogenetics, 1995, Volume: 5, Issue:1 Topics: Adult; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Kidney; Kinetics; Male; Middle Aged; Molecular Probes; Oxidoreductases, N-Demethylating	1995
Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. Biochemical pharmacology, 1994, Apr-29, Volume: 47, Issue:9 Topics: Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chlorzoxazone; Cytochrome P-450 Enzyme System; Enzyme Induction; gamma-Glutamyltransferase; Humans; Male; Metabolic Clearance Rate; Middle Aged	1994
High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans. Journal of chromatography, 1993, Dec-08, Volume: 622, Issue:1 Topics: Administration, Oral; Adult; Alcoholism; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Humans; Male; Middle Aged; Oxidoreductases, N-Demethylating; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet	1993
Sensitive high-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma. Journal of chromatography, 1993, Mar-05, Volume: 613, Issue:1 Topics: Calibration; Chlorzoxazone; Chromatography, High Pressure Liquid; Drug Stability; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet	1993
Effects of cytochrome P450 2E1 modulators on the pharmacokinetics of chlorzoxazone and 6-hydroxychlorzoxazone in rats. Life sciences, 1996, Volume: 58, Issue:18 Topics: Allyl Compounds; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Male; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Sprague-Dawley; Sulfides	1996
Chlorzoxazone: an in vitro and in vivo substrate probe for liver CYP2E1. Methods in enzymology, 1996, Volume: 272 Topics: Chlorzoxazone; Cytochrome P-450 CYP2E1; Humans; Hydroxylation; In Vitro Techniques; Liver; Microsomes, Liver; Molecular Probes; Muscle Relaxants, Central; Phenotype; Recombinant Proteins; Substrate Specificity	1996
Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype. Pharmacogenetics, 1996, Volume: 6, Issue:3 Topics: Alleles; Chlorzoxazone; Cytochrome P-450 CYP2E1; Genotype; Humans; Hydroxylation; Phenotype	1996
Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications, 1996, Nov-15, Volume: 686, Issue:2 Topics: Chlorzoxazone; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet	1996
Rapid and sensitive high-performance liquid chromatographic assay for 6-hydroxychlorzoxazone and chlorzoxazone in liver microsomes. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jun-06, Volume: 693, Issue:2 Topics: Animals; Chlorzoxazone; Chromatography, High Pressure Liquid; Male; Microsomes, Liver; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet	1997
Determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma by gas chromatography--mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications, 1998, Jan-23, Volume: 705, Issue:1 Topics: Acetamides; Chlorzoxazone; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Humans; Muscle Relaxants, Central; Organosilicon Compounds; Sensitivity and Specificity	1998
Simultaneous determination of chlorzoxazone, indicator of CYP2E1, and its metabolite in human serum using a new reversed-phase chromatographic column of 2-microm porous microspherical silica-gel. Journal of pharmaceutical and biomedical analysis, 1998, Volume: 16, Issue:5 Topics: Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Humans; Male; Middle Aged; Particle Size; Reproducibility of Results; Sensitivity and Specificity; Silica Gel; Silicon Dioxide	1998
Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation. Clinical pharmacology and therapeutics, 1998, Volume: 63, Issue:3 Topics: Adult; Aged; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP2E1; Enzyme Induction; Female; Humans; Hydroxylation; Liver Transplantation; Male; Middle Aged; Time Factors	1998
Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts. Toxicology and applied pharmacology, 1998, Volume: 151, Issue:1 Topics: Aniline Compounds; Animals; Benzoflavones; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Ditiocarb; Enzyme Inhibitors; Female; Flounder; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Substrate Specificity; Troleandomycin; Water Pollutants, Chemical	1998
The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans. Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:6 Topics: Adult; C-Reactive Protein; Chlorzoxazone; Cytochrome P-450 CYP2E1; Humans; Interleukin-6; Kidney Tubules; Lipopolysaccharides; Liver; Male; Muscle Relaxants, Central; Reference Values; Serum Albumin; Tumor Necrosis Factor-alpha	1999
Stimulation of Cl(-) secretion by chlorzoxazone. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2 Topics: Amiloride; Anions; Bronchi; Bumetanide; Cell Membrane; Cells, Cultured; Charybdotoxin; Chlorine; Chlorzoxazone; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Interactions; Epithelium; Glyburide; Humans; Isoproterenol; Nasal Mucosa; Nystatin; Potassium Channel Blockers; Rubidium; Zoxazolamine	2000
Chlorzoxazone: a probe drug whose metabolism can be used to monitor toluene exposure in rats. Archives of toxicology, 2000, Volume: 74, Issue:3 Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Environmental Monitoring; Half-Life; Injections, Intraperitoneal; Male; Microsomes, Liver; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley; Toluene	2000
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:4 Topics: Animals; Apoenzymes; Body Weight; Chlormethiazole; Chlorzoxazone; Chymotrypsin; Cysteine Endopeptidases; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Disease Models, Animal; Ethanol; Hydroxylation; Immunohistochemistry; Liver; Liver Diseases, Alcoholic; Male; Multienzyme Complexes; Organ Size; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Trypsin	2000
Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene. Archives of toxicology, 2000, Volume: 74, Issue:7 Topics: Asian People; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2E1; DNA; Genotype; Humans; Hydroxylation; Japan; Microsomes, Liver; Polymerase Chain Reaction; Polymorphism, Genetic; White People	2000
Tissue-specific alterations in the 6-hydroxylation of chlorzoxazone following traumatic brain injury in the rat. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3 Topics: Animals; Brain; Brain Injuries; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fomepizole; Hydroxylation; Kidney; Liver; Male; Microsomes; Organ Specificity; Pyrazoles; Rats; Rats, Sprague-Dawley	2001
Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat. Human & experimental toxicology, 2001, Volume: 20, Issue:8 Topics: Aniline Hydroxylase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 CYP2E1; Inhibitory Concentration 50; Injections, Intraperitoneal; Male; Metabolic Clearance Rate; Microsomes, Liver; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley	2001
[Changes of CYP2E1 activity in diabetic rat model]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:12 Topics: Aniline Hydroxylase; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Diabetes Mellitus, Experimental; Male; Random Allocation; Rats; Rats, Sprague-Dawley	1998
[Determination of chlorzoxazone and its metabolite 6-hydroxychlorzoxazone in plasma by HPLC and their pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:10 Topics: Adult; Animals; Asian People; Chlorzoxazone; Chromatography, High Pressure Liquid; Humans; Male; Muscle Relaxants, Central; Rats; Species Specificity; White People	1998
Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population. Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:11 Topics: Adolescent; Adult; Body Mass Index; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Humans; Male; Phenotype; Polymorphism, Genetic; Sex Factors; Time Factors	2002
Determination of 6-hydroxychlorzoxazone and chlorzoxazone in porcine microsome samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Jan-25, Volume: 784, Issue:1 Topics: Animals; Chlorzoxazone; Chromatography, High Pressure Liquid; Microsomes; Reference Standards; Spectrophotometry, Ultraviolet; Swine	2003
Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s. Analytical chemistry, 2003, Feb-01, Volume: 75, Issue:3 Topics: Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Humans; Mass Spectrometry; Peptide Fragments; Reproducibility of Results	2003
Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes. Biopharmaceutics & drug disposition, 2003, Volume: 24, Issue:2 Topics: Animals; Area Under Curve; Chlorzoxazone; Chromatography, High Pressure Liquid; Dehydration; Eating; Injections, Intravenous; Male; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley; Tissue Distribution; Water Deprivation	2003
Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6 Topics: Acute Kidney Injury; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Chlorzoxazone; Chromatography, High Pressure Liquid; Enzyme Induction; Gene Expression; Immunoblotting; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Uranyl Nitrate	2003
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. Life sciences, 2003, Jun-06, Volume: 73, Issue:3 Topics: Acute Kidney Injury; Animals; Area Under Curve; Blood Proteins; Catalysis; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Disease Models, Animal; Enzyme Induction; Human Growth Hormone; Humans; Hydroxylation; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Uranyl Nitrate	2003
CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes. Toxicology letters, 2003, Sep-15, Volume: 144, Issue:1 Topics: Acetone; Animals; Benzene; Blotting, Western; Cell Separation; Chlorzoxazone; Cytochrome P-450 CYP2E1; Enzyme Induction; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Indicators and Reagents; Liver; Lymphocytes; Male; Microsomes, Liver; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toluene; Weight Gain	2003
Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9 Topics: Administration, Oral; Animals; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Duodenum; Enzyme Induction; Estradiol; Female; Kidney; Liver; Male; Microsomes; Microsomes, Liver; Polycyclic Aromatic Hydrocarbons; Rats; Rats, Sprague-Dawley; Soil; Species Specificity; Swine; Swine, Miniature; Testosterone; Tissue Distribution; Xenobiotics	2004
Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Alcohol Oxidoreductases; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P450 Family 2; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Glucuronosyltransferase; In Vitro Techniques; Isosorbide Dinitrate; Kinetics; Liver; Male; Nitric Oxide Donors; Nitroprusside; Perfusion; Rats; Rats, Sprague-Dawley; Umbelliferones	2006
Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:7 Topics: Animals; Bile; Biomarkers; Chlorzoxazone; Cytochrome P-450 CYP2E1; In Vitro Techniques; Liver; Male; Muscle Relaxants, Central; Perfusion; Rats; Rats, Sprague-Dawley	2006
Pharmacokinetics of chlorzoxazone in rats with diabetes: Induction of CYP2E1 on 6-hydroxychlorzoxazone formation. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:11 Topics: Animals; Biotransformation; Blood Proteins; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Diabetes Mellitus, Experimental; Enzyme Induction; Injections, Intravenous; Male; Microsomes, Liver; Muscle Relaxants, Central; Protein Binding; Rats; Rats, Sprague-Dawley; RNA, Messenger	2006
Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism. European journal of pharmacology, 2006, Dec-15, Volume: 552, Issue:1-3 Topics: Administration, Oral; Animals; Area Under Curve; Blotting, Western; Brain; Chlorocebus aethiops; Chlorzoxazone; Cytochrome P-450 CYP2E1; Hypnotics and Sedatives; Immunohistochemistry; Liver; Phenobarbital	2006
Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro. Molecular and cellular biochemistry, 2007, Volume: 298, Issue:1-2 Topics: Animals; Biopsy; Cell Death; Cells, Cultured; Chlorzoxazone; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Doxycycline; Enzyme Induction; Humans; Mice; Nasopharyngeal Neoplasms; Nasopharynx; NIH 3T3 Cells; Nitrosamines; Recombinant Proteins; RNA, Messenger; Time Factors	2007
Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis. Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:6 Topics: Adult; Biopsy; Biotransformation; Chlorzoxazone; Cytochrome P-450 CYP2E1; Diagnosis, Differential; Fatty Liver; Female; Hepatitis; Humans; Hydroxylation; Liver; Male; Middle Aged; Muscle Relaxants, Central; Prognosis	2007
A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:1 Topics: Adult; Area Under Curve; Chlorzoxazone; Chromatography; Chromatography, High Pressure Liquid; Female; Humans; Male; Muscle Relaxants, Central; Thailand	2007
Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats. European journal of pharmacology, 2007, Nov-21, Volume: 574, Issue:1 Topics: Animals; Area Under Curve; Chlorzoxazone; Chromatography, High Pressure Liquid; Circadian Rhythm; Cytochrome P-450 CYP2E1; Half-Life; Hydroxylation; Kidney; Liver; Male; Microsomes; Muscle Relaxants, Central; Rats; Rats, Wistar; RNA, Messenger; Tissue Distribution	2007
Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Chlorzoxazone; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Infusions, Intravenous; Kidney; Liver; Liver Cirrhosis, Experimental; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Spleen	2008
Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2008, Volume: 91, Issue:5 Topics: Adult; Case-Control Studies; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Fatty Liver; Female; Humans; Lipid Peroxidation; Liver; Male; Muscle Relaxants, Central; Oxidative Stress; Pilot Projects	2008
Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet. Toxicology and industrial health, 2008, Volume: 24, Issue:10 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Nucleus; Chlorzoxazone; Comet Assay; Cytochrome P-450 CYP2E1; Data Interpretation, Statistical; Deoxyguanosine; Ethanol; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; tert-Butylhydroperoxide; Tumor Suppressor Protein p53	2008
Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. Biopharmaceutics & drug disposition, 2009, Volume: 30, Issue:8 Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug Interactions; Endotoxins; Injections, Intravenous; Klebsiella pneumoniae; Lipopolysaccharides; Male; Microsomes, Liver; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley	2009
In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene. Toxicology letters, 2010, Jan-15, Volume: 192, Issue:1 Topics: Acetylcysteine; Animals; Area Under Curve; Benzene; Biomarkers; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Humans; Male; Occupational Exposure; Phenotype; Random Allocation; Rats; Rats, Sprague-Dawley; Sorbic Acid; Statistics, Nonparametric	2010
Determination of brain cytochrome P450 2E1 activity in rat with the probe of chlorzoxazone by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Feb-01, Volume: 879, Issue:3-4 Topics: Animals; Brain; Brain Chemistry; Calibration; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 CYP2E1; Linear Models; Mass Spectrometry; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution	2011
Fennel and raspberry leaf as possible inhibitors of acetaminophen oxidation. Phytotherapy research : PTR, 2014, Volume: 28, Issue:10 Topics: Acetaminophen; Benzoquinones; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Foeniculum; Humans; Imines; Inactivation, Metabolic; Inhibitory Concentration 50; Oxidation-Reduction; Plant Leaves; Rubus	2014
Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies. Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:4 Topics: Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Humans; Hydroxylation; Microsomes, Liver; Recombinant Proteins; Tandem Mass Spectrometry	2015
Ultrasensitive quantification of the CYP2E1 probe chlorzoxazone and its main metabolite 6-hydroxychlorzoxazone in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry after chlorzoxazone microdosing. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Aug-01, Volume: 1027 Topics: Administration, Oral; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Humans; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry	2016
Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes. Archives of toxicology, 2018, Volume: 92, Issue:10 Topics: Animals; Chlorzoxazone; Chromatography, High Pressure Liquid; Culture Media; Cytochrome P-450 Enzyme System; Glucuronides; Glucuronosyltransferase; Hep G2 Cells; Hepatocytes; Humans; Hydroxylation; Male; Mice, Inbred C57BL; Recombinant Proteins	2018