Compounds > chlorzolamide
Page last updated: 2024-09-05

chlorzolamide and celecoxib

chlorzolamide has been researched along with celecoxib in 15 studies

Compound Research Comparison

Studies
(chlorzolamide)		Trials
(chlorzolamide)		Recent Studies (post-2010)
(chlorzolamide)		Studies
(celecoxib)		Trials
(celecoxib)		Recent Studies (post-2010) (celecoxib)
33075,2738432,428

Protein Interaction Comparison

ProteinTaxonomychlorzolamide (IC50)celecoxib (IC50)
Chain A, Carbonic anhydrase IIHomo sapiens (human)0.021
Prostaglandin E synthaseHomo sapiens (human)0.4825
Histone deacetylase 3Homo sapiens (human)1.637
Prostaglandin G/H synthase 1 Bos taurus (cattle)7.9667
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.057
Cytochrome c oxidase subunit 1Ovis aries (sheep)6.5
Cytochrome c oxidase subunit 2Ovis aries (sheep)0.0881
Catechol O-methyltransferaseMus musculus (house mouse)0.036
Cytochrome c oxidase subunit 2Homo sapiens (human)0.371
Carbonic anhydrase 1Homo sapiens (human)0.1555
Carbonic anhydrase 2Homo sapiens (human)0.0925
Prostaglandin G/H synthase 1Ovis aries (sheep)5.271
Procathepsin LHomo sapiens (human)0.56
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)7.308
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)0.07
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)4.295
Cytochrome P450 2D6Homo sapiens (human)1
Cytochrome P450 2C9 Homo sapiens (human)10
Calpain-2 catalytic subunitHomo sapiens (human)0.002
Alpha-2B adrenergic receptorHomo sapiens (human)1.516
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.12
Prostaglandin G/H synthase 1Mus musculus (house mouse)3.6401
Prostaglandin G/H synthase 1Homo sapiens (human)3.5499
Sodium-dependent noradrenaline transporter Homo sapiens (human)7.308
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.006
Sodium-dependent serotonin transporterHomo sapiens (human)6.276
Prostaglandin G/H synthase 2Homo sapiens (human)0.3818
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.4028
Urotensin-2 receptorRattus norvegicus (Norway rat)7.6
Histone deacetylase 4Homo sapiens (human)1.637
D(2) dopamine receptorRattus norvegicus (Norway rat)0.03
Prostaglandin G/H synthase 2Ovis aries (sheep)0.6343
Mu-type opioid receptorCavia porcellus (domestic guinea pig)7.7
Sodium-dependent dopamine transporter Homo sapiens (human)2.431
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.045
Histone deacetylase 1Homo sapiens (human)1.411
Mitogen-activated protein kinase 14Homo sapiens (human)0.81
Carbonic anhydrase 9Homo sapiens (human)0.016
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.05
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.3
Prostaglandin G/H synthase 1Canis lupus familiaris (dog)5.57
Cyclooxygenase-2 Canis lupus familiaris (dog)0.9
Histone deacetylase 7Homo sapiens (human)1.637
Histone deacetylase 2Homo sapiens (human)1.637
Carbonic anhydrase 4Bos taurus (cattle)0.2227
Polyamine deacetylase HDAC10Homo sapiens (human)1.637
Histone deacetylase 11 Homo sapiens (human)1.637
Histone deacetylase 8Homo sapiens (human)1.637
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.04
Histone deacetylase 6Homo sapiens (human)1.14
Histone deacetylase 9Homo sapiens (human)1.637
Histone deacetylase 5Homo sapiens (human)1.637

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's8 (53.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cecchi, A; Minakuchi, T; Nishimori, I; Onishi, S; Scozzafava, A; Supuran, CT; Vullo, D1
Arslan, O; Aydin, M; Guler, OO; Innocenti, A; Isik, S; Kockar, F; Scozzafava, A; Supuran, CT1
Hilvo, M; Innocenti, A; Kulomaa, MS; Parkkila, S; Salzano, AM; Scaloni, A; Scozzafava, A; Supuran, CT1
Minakuchi, T; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D2
Innocenti, A; Minakuchi, T; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D1
Hall, RA; Innocenti, A; Mühlschlegel, FA; Schlicker, C; Scozzafava, A; Steegborn, C; Supuran, CT1
Carta, F; Covarrubias, AS; Jones, TA; Maresca, A; Mowbray, SL; Supuran, CT1
Joseph, P; Köhler, S; Minakuchi, T; Montero, JL; Nishimori, I; Ouahrani-Bettache, S; Scozzafava, A; Supuran, CT; Turtaut, F; Vullo, D; Winum, JY1
Joseph, P; Köhler, S; Minakuchi, T; Montero, JL; Nishimori, I; Ouahrani-Bettache, S; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY1
Jackson, DJ; Ohradanova, A; Pastorek, J; Pastorekova, S; Supuran, CT; Vullo, D; Wörheide, G1
Hewitson, KS; Mastrolorenzo, A; Scozzafava, A; Supuran, CT; Vullo, D1
Capasso, C; Carginale, V; De Luca, V; Del Prete, S; Isik, S; Scozzafava, A; Supuran, CT; Vullo, D1
Capasso, C; Leewattanapasuk, W; Mastrolorenzo, A; Mühlschlegel, FA; Supuran, CT; Vullo, D1
Bhatt, A; Mahon, BP; McKenna, R; Supuran, CT; Vullo, D1

Other Studies

15 other study(ies) available for chlorzolamide and celecoxib

ArticleYear
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
    Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23

    Topics: Amino Acid Sequence; Carbonic Anhydrase III; Carbonic Anhydrase Inhibitors; Cloning, Molecular; Cytosol; Enzyme Activation; Humans; Isoenzymes; Kinetics; Molecular Sequence Data; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids

2007
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
    Bioorganic & medicinal chemistry, 2009, Feb-01, Volume: 17, Issue:3

    Topics: Amino Acid Sequence; Antifungal Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Kinetics; Molecular Sequence Data; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sulfonamides; Sulfonic Acids

2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
    Journal of medicinal chemistry, 2009, Feb-12, Volume: 52, Issue:3

    Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Isoenzymes; Kidney; Mice; Protein Processing, Post-Translational

2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
    Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalysis; Cloning, Molecular; Drug Resistance, Multiple, Bacterial; Humans; Molecular Sequence Data; Mycobacterium tuberculosis; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids

2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Amino Acid Sequence; Biocatalysis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Molecular Sequence Data; Mycobacterium tuberculosis; Sulfonamides; Sulfonic Acids

2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
    Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13

    Topics: Amino Acid Sequence; Antifungal Agents; Bacterial Proteins; Candida albicans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cryptococcus neoformans; Helicobacter pylori; Humans; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Sequence Alignment; Structure-Activity Relationship; Sulfonamides

2009
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
    Bioorganic & medicinal chemistry letters, 2009, Dec-01, Volume: 19, Issue:23

    Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Drug Design; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship

2009
Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.
    Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brucella suis; Brucellosis; Carbonic Anhydrases; Cloning, Molecular; DNA, Bacterial; Humans; Kinetics; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Sequence Alignment; Sequence Analysis, DNA; Structure-Activity Relationship; Sulfonamides

2010
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
    Bioorganic & medicinal chemistry, 2011, Feb-01, Volume: 19, Issue:3

    Topics: Anti-Bacterial Agents; Brucella suis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Drug Design; Drug Discovery; Inhibitory Concentration 50; Kinetics; Sulfonamides; Sulfonic Acids

2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
    Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16

    Topics: Anti-Bacterial Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Salmonella Infections; Salmonella typhimurium; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids

2011
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
    Bioorganic & medicinal chemistry, 2012, Feb-15, Volume: 20, Issue:4

    Topics: Amino Acid Sequence; Animals; Carbonic Anhydrases; Cloning, Molecular; Fossils; Humans; Molecular Sequence Data; Porifera; Protein Binding; Sequence Alignment; Sulfonamides; Sulfonic Acids

2012
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: Amino Acid Sequence; Animals; Antifungal Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Dermatomycoses; Fungal Proteins; Humans; Isoenzymes; Malassezia; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Recombinant Fusion Proteins; Scalp Dermatoses; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids

2012
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
    Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23

    Topics: Amino Acid Sequence; Biocatalysis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; DNA; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Phylogeny; Sequence Homology, Amino Acid; Vibrio cholerae

2012
Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.
    Bioorganic & medicinal chemistry letters, 2013, May-01, Volume: 23, Issue:9

    Topics: Acetazolamide; Amino Acid Sequence; Antifungal Agents; Candida glabrata; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Kinetics; Molecular Sequence Data; Phylogeny; Protein Binding; Sequence Alignment; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids

2013
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Anti-Bacterial Agents; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Gammaproteobacteria; Molecular Docking Simulation; Sulfonamides

2016