Compounds > chlorthalidone

chlorthalidone and tolbutamide

chlorthalidone has been researched along with tolbutamide in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (37.50)	18.7374
1990's	1 (6.25)	18.2507
2000's	4 (25.00)	29.6817
2010's	5 (31.25)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Koene, R; Wijdeveld, P	1
Bonardi, G; Coppi, G	1
Juhl, F; Persson, I	1
Bleicher, SJ; Chowdhury, FR	1
Königstein, RP	1
Andersen, OO; Persson, I	1
Engelhardt, G; Homma, D; Schlegel, K; Schnitzler, C; Utzmann, R	1

Reviews

1 review(s) available for chlorthalidone and tolbutamide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for chlorthalidone and tolbutamide

Article	Year
Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid. British medical journal, 1968, Jun-29, Volume: 2, Issue:5608 Topics: Aged; Blood Glucose; Carbohydrate Metabolism; Chlorthalidone; Cortisone; Diabetes Mellitus; Ethacrynic Acid; Female; Glucose Tolerance Test; Humans; Hypertension; Male; Middle Aged; Tolbutamide	1968

Other Studies

14 other study(ies) available for chlorthalidone and tolbutamide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
[Diazoxide: new way in treatment of hypertension]. Nederlands tijdschrift voor geneeskunde, 1975, Mar-15, Volume: 119, Issue:11 Topics: Adult; Chlorthalidone; Diazoxide; Diet, Sodium-Restricted; Female; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; Propranolol; Tolbutamide; Water-Electrolyte Balance	1975
[Action of tolbutamide, chlorpropamide and insulin on hyperglycemia induced by non-thiazide diuretics in rats]. Bollettino della Societa italiana di biologia sperimentale, 1969, Jan-31, Volume: 45, Issue:2 Topics: Animals; Chlorpropamide; Chlorthalidone; Diuretics; Ethacrynic Acid; Female; Furosemide; Hyperglycemia; Insulin; Rats; Tolbutamide; Triamterene	1969
[Carbohydrate metabolism during treatment with chlorthalidone and cyclothiazide]. Ugeskrift for laeger, 1970, Jan-29, Volume: 132, Issue:5 Topics: Aged; Antihypertensive Agents; Benzothiadiazines; Carbohydrate Metabolism; Chlorthalidone; Cortisone; Cyclic S-Oxides; Diuretics; Female; Glucose Tolerance Test; Humans; Hypertension; Male; Middle Aged; Time Factors; Tolbutamide	1970
Chlorthalidone--induced hypokalemia and abnormal carbohydrate metabolism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1970, Volume: 2, Issue:1 Topics: Administration, Oral; Adult; Blood Glucose; Carbohydrate Metabolism; Chlorthalidone; Depression, Chemical; Drug Tolerance; Female; Gluconates; Glucose Tolerance Test; Humans; Hypokalemia; Injections, Intravenous; Insulin; Potassium; Stimulation, Chemical; Tolbutamide	1970
[Iatrogenic diabetes mellitus and some important iatrogenic complications in diabetes]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1967, Volume: 48, Issue:12 Topics: Aged; Benzothiadiazines; Blood Glucose; Chlorthalidone; Diabetes Complications; Diabetes Mellitus; Diuretics; Female; Furosemide; Glucocorticoids; Humans; Hypoglycemia; Male; Middle Aged; Pancreatectomy; Phenylbutazone; Tolbutamide	1967
General pharmacology of meloxicam--Part II: Effects on blood pressure, blood flow, heart rate, ECG, respiratory minute volume and interactions with paracetamol, pirenzepine, chlorthalidone, phenprocoumon and tolbutamide. General pharmacology, 1996, Volume: 27, Issue:4 Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Blood Pressure; Cats; Chlorthalidone; Diuretics; Dogs; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Rate; Hemodynamics; Hypoglycemic Agents; Meloxicam; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Phenprocoumon; Pirenzepine; Rabbits; Rats; Rats, Inbred Strains; Regional Blood Flow; Respiratory Mechanics; Thiazines; Thiazoles; Tolbutamide	1996