chlorthalidone and tak 491

chlorthalidone has been researched along with tak 491 in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's22 (88.00)24.3611
2020's3 (12.00)2.80

Authors

AuthorsStudies
Bakris, GL; Cushman, WC; Huang, P; Kupfer, S; Roberts, A; Sica, D; Weber, MA; White, WB1
Bakris, GL; Cushman, WC; Kupfer, S; Lloyd, E; Roberts, A; Sica, D; Weber, MA; White, WB2
Bakris, GL; Cushman, WC; Handley, A; Kupfer, S; Sica, D; Song, E; Weber, MA; White, WB1
Anderson, KV; Pierini, D1
Baker, WL; Nigro, SC; White, WB1
Ebeid, WM; El-Bagary, RI; El-Zaher, AA; Elkady, EF; Patonay, G1
Barger, B; Handley, A; Kipnes, MS; Lloyd, E; Roberts, A1
Kupfer, S; Tsai, MC; Vakilynejad, M; Wu, J1
Barger, B; Handley, A; Lloyd, E; Roberts, A1
Dudkowski, C; Karim, A; Munsaka, M1
Dargad, RR; Kukrety, S; Parekh, JD1
Bhateria, M; Bhatta, RS; Hanif, K; Jain, M; Kumar Puttrevu, S; Ramakrishna, R1
Barger, B; Cushman, WC; Handley, A; Lloyd, E; Neutel, JM1
Thomopoulos, C1
Kobalava, ZD; Kulakov, VV; Villevalde, SV1
van der Merwe, WM1
Bakris, GL; Hisada, M; Juhasz, A; Kupfer, S; Lloyd, E; Oparil, S; Zhao, L1
Bakris, GL; Cushman, WC; Ferdinand, KC; Lloyd, E; Weber, MA; White, WB; Wu, J1
Agabiti-Rosei, E; Caulfield, MJ; Collier, DJ; Hisada, M; Juhasz, A; Kupfer, S; Lloyd, E; Zhao, L1
Hussein, LA; Ibrahim, MA; Magdy, NN1
Amer, SM; Gad, MA; Hassan, SA; Zaazaa, HE1
Kim, GH; Kwon, A1
Antonopoulos, AS; Katsi, V; Michalakeas, C; Soulaidopoulos, S; Tousoulis, D; Tsioufis, K; Vlachopoulos, C1

Reviews

4 review(s) available for chlorthalidone and tak 491

ArticleYear
Edarbyclor: an ARB/chlorthalidone combination for hypertension.
    The Medical letter on drugs and therapeutics, 2012, Mar-05, Volume: 54, Issue:1385

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Humans; Hypertension; Oxadiazoles

2012
Efficacy of azilsartan medoxomil with chlorthalidone in hypertension.
    Expert review of cardiovascular therapy, 2014, Volume: 12, Issue:7

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Blood Pressure; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Oxadiazoles; Randomized Controlled Trials as Topic; Treatment Outcome

2014
Single-pill Combination Therapy of Azilsartan Medoxomil/Chlorthalidone for Treatment of Hypertension: A Systematic Review.
    Clinical therapeutics, 2020, Volume: 42, Issue:7

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Drug Combinations; Humans; Hypertension; Oxadiazoles

2020
Evaluating the Safety and Tolerability of Azilsartan Medoxomil Alone or in Combination With Chlorthalidone in the Management of Hypertension: A Systematic Review.
    Current hypertension reviews, 2021, Volume: 17, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Humans; Hypertension; Oxadiazoles; Treatment Outcome; Uric Acid

2021

Trials

12 trial(s) available for chlorthalidone and tak 491

ArticleYear
Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study.
    Journal of clinical hypertension (Greenwich, Conn.), 2012, Volume: 14, Issue:5

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Black People; Blood Pressure; Chlorthalidone; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Oxadiazoles; Treatment Outcome; White People

2012
Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:2

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Black People; Blood Pressure; Chlorthalidone; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Male; Middle Aged; Oxadiazoles; Severity of Illness Index; Tetrazoles; Treatment Outcome; White People

2012
Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil.
    The American journal of medicine, 2012, Volume: 125, Issue:12

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Blood Pressure Monitoring, Ambulatory; Chlorthalidone; Creatinine; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Oxadiazoles; Potassium; Systole

2012
Safety, tolerability, and efficacy of azilsartan medoxomil with or without chlorthalidone during and after 8 months of treatment for hypertension.
    Journal of clinical hypertension (Greenwich, Conn.), 2015, Volume: 17, Issue:3

    Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Follow-Up Studies; Humans; Hypertension; Longitudinal Studies; Male; Mass Screening; Middle Aged; Oxadiazoles; Treatment Outcome

2015
Population Pharmacokinetics and Exposure-Response of a Fixed-Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With Stage 2 Hypertension.
    Journal of clinical pharmacology, 2016, Volume: 56, Issue:8

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Oxadiazoles; Treatment Outcome

2016
Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2016, Volume: 38, Issue:2

    Topics: Adult; Aged; Benzimidazoles; Chlorthalidone; Cohort Studies; Dizziness; Drug Therapy, Combination; Essential Hypertension; Fatigue; Female; Headache; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Oxadiazoles; Sodium Chloride Symporter Inhibitors; Treatment Outcome

2016
Effects of Food Intake on the Pharmacokinetics of Azilsartan Medoxomil and Chlorthalidone Alone and in Fixed-Dose Combination in Healthy Adults.
    Clinical pharmacology in drug development, 2016, Volume: 5, Issue:5

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Cohort Studies; Dietary Fats; Drug Combinations; Fasting; Female; Food-Drug Interactions; Humans; Male; Oxadiazoles; Tablets; Young Adult

2016
Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide.
    Journal of clinical hypertension (Greenwich, Conn.), 2017, Volume: 19, Issue:9

    Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Male; Middle Aged; Olmesartan Medoxomil; Oxadiazoles; Treatment Outcome

2017
A randomized titrate-to-target study comparing fixed-dose combinations of azilsartan medoxomil and chlorthalidone with olmesartan and hydrochlorothiazide in stage-2 systolic hypertension.
    Journal of hypertension, 2018, Volume: 36, Issue:4

    Topics: Aged; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Diuretics; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Male; Middle Aged; Oxadiazoles; Tetrazoles

2018
Long-term efficacy and tolerability of azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in chronic kidney disease.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:4

    Topics: Aged; Benzimidazoles; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Olmesartan Medoxomil; Oxadiazoles; Renal Insufficiency, Chronic; Treatment Outcome

2018
Comparison of Effectiveness of Azilsartan Medoxomil and Olmesartan in Blacks Versus Whites With Systemic Hypertension.
    The American journal of cardiology, 2018, 11-01, Volume: 122, Issue:9

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Black or African American; Chlorthalidone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Male; Middle Aged; Oxadiazoles; Tetrazoles; United States; White People

2018
Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:10

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chlorthalidone; Drug Therapy, Combination; Essential Hypertension; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Oxadiazoles; Sodium Chloride Symporter Inhibitors; Systole

2018

Other Studies

9 other study(ies) available for chlorthalidone and tak 491

ArticleYear
Azilsartan medoxomil/chlorthalidone: a new fixed-dose combination antihypertensive.
    The Annals of pharmacotherapy, 2013, Volume: 47, Issue:5

    Topics: Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Drug Combinations; Drug Interactions; Humans; Hypertension; Oxadiazoles; Randomized Controlled Trials as Topic

2013
Stability-indicating RP-LC method for determination of azilsartan medoxomil and chlorthalidone in pharmaceutical dosage forms: application to degradation kinetics.
    Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:26

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Stability; Hydrolysis; Limit of Detection; Oxadiazoles; Oxidation-Reduction; Tablets

2014
Azilsartan: Novel Angiotensin Receptor Blocker.
    The Journal of the Association of Physicians of India, 2016, Volume: 64, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Drug Interactions; Humans; Hypertension; Oxadiazoles; Treatment Outcome; United States; United States Food and Drug Administration

2016
Pharmacokinetic-pharmacodynamic modeling of the antihypertensive interaction between azilsartan medoxomil and chlorthalidone in spontaneously hypertensive rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:5

    Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Chromatography, Liquid; Computer Simulation; Disease Models, Animal; Drug Monitoring; Drug Synergism; Drug Therapy, Combination; Hypertension; Models, Biological; Oxadiazoles; Rats, Inbred SHR; Sodium Chloride Symporter Inhibitors; Tandem Mass Spectrometry

2017
Long-term safety of different antihypertensive regimens: The risk of unfair comparisons.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:1

    Topics: Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Humans; Hydrochlorothiazide; Hypertension; Olmesartan Medoxomil; Oxadiazoles

2018
[Antihypertensive Efficacy of Fixed Combination Azilsartan Medoxomil / Chlorthalidone in Patients With Uncontrolled Arterial Hypertension].
    Kardiologiia, 2017, Volume: 57, Issue:11

    Topics: Antihypertensive Agents; Benzimidazoles; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Humans; Hypertension; Oxadiazoles; Tetrazoles; Treatment Outcome

2017
Treatment of hypertension in CKD patients with azilsartan/chlorthalidone vs olmesartan/hydrochlorothiazide.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:4

    Topics: Antihypertensive Agents; Benzimidazoles; Chlorthalidone; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Olmesartan Medoxomil; Oxadiazoles; Renal Insufficiency, Chronic; Tetrazoles

2018
Stability-Indicating RP-UPLC Method for Simultaneous Determination of Azilsartan Medoxomil and Chlorthalidone in Tablets in the Presence of Its Degradation Products.
    Journal of chromatographic science, 2019, Mar-01, Volume: 57, Issue:3

    Topics: Benzimidazoles; Chlorthalidone; Chromatography, High Pressure Liquid; Drug Stability; Linear Models; Oxadiazoles; Reproducibility of Results; Sensitivity and Specificity; Tablets

2019
Strategies for stabilizing formulation and QbD assisted development of robust stability indicating method of azilsartan medoxomil/chlorthalidone.
    Journal of pharmaceutical and biomedical analysis, 2020, Jan-30, Volume: 178

    Topics: Acetonitriles; Benzimidazoles; Chemistry, Pharmaceutical; Chlorthalidone; Chromatography, High Pressure Liquid; Drug Stability; Oxadiazoles; Tablets

2020