Compounds > chlorthalidone

chlorthalidone and prazosin

chlorthalidone has been researched along with prazosin in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (56.25)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (25.00)	29.6817
2010's	3 (18.75)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hammond, JJ; Kirkendall, WM; Overturf, ML; Thomas, JC; Zama, A	1
Farsang, C; Kapocsi, J; Vizi, ES	1
Hengeveld, WL; Schouten, JA; Westerman, RF	1
Cocco, F; Dessì Fulgheri, P; Dettori, S; Fiori, C; Glorioso, N; Madeddu, P; Rappelli, A; Sanna, G	1
Lowenstein, J	1
Hernández-Pieretti, O; Morillo, J; Pellicer, R; Silva, H; Urbina-Quintana, A; Velasco, M	1
Drayer, JI; Hubbell, FA; Rose, DE; Weber, MA	1
de Lima, JJ; Macruz, R; Pileggi, F; Saldanha, RV; Santana, PC; Zalc, S	1
Mauersberger, H	1

Reviews

1 review(s) available for chlorthalidone and prazosin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for chlorthalidone and prazosin

Article	Year
Prazosin and clonidine for moderately severe hypertension. JAMA, 1978, Dec-01, Volume: 240, Issue:23 Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Polythiazide; Prazosin; Quinazolines	1978
Prazosin once or twice daily? European journal of clinical pharmacology, 1985, Volume: 28, Issue:1 Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Posture; Prazosin; Propranolol; Quinazolines	1985
Comparative antihypertensive and endocrinologic effects of clonidine and prazosin in patients with essential hypertension. Southern medical journal, 1984, Volume: 77, Issue:10 Topics: Adult; Blood Pressure; Catecholamines; Chlorthalidone; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Posture; Prazosin; Quinazolines; Random Allocation; Renin-Angiotensin System; Time Factors	1984

Other Studies

12 other study(ies) available for chlorthalidone and prazosin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21 Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship	2003
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Prazosin partly blocks clonidine-induced hypotension in patients with essential hypertension. European journal of clinical pharmacology, 1987, Volume: 32, Issue:4 Topics: Adult; Blood Pressure; Chlorthalidone; Clonidine; Drug Therapy, Combination; Heart Rate; Humans; Hypertension; Prazosin; Receptors, Adrenergic, alpha	1987
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Metoprolol; Middle Aged; Prazosin; Renin; Sotalol; Spironolactone	1981
Effects of prazosin on serum lipids in patients with essential hypertension: a review of the findings presented at the Satellite Symposium on coronary heart disease: hypertension and other risk factors, Milan, 1983. The American journal of cardiology, 1984, Jan-27, Volume: 53, Issue:3 Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Chlorthalidone; Cholesterol; Cholesterol, HDL; Coronary Disease; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Lipids; Lipoproteins, HDL; Prazosin; Quinazolines; Risk; Sodium Chloride Symporter Inhibitors; Triglycerides	1984
Effect of prazosin on blood lipids and on thyroid function in hypertensive patients. Journal of cardiovascular pharmacology, 1982, Volume: 4 Suppl 2 Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Heart Rate; Humans; Hypertension; Lipids; Lipoproteins; Middle Aged; Prazosin; Quinazolines; Thyroid Hormones	1982
[Prazosin in moderate or severe essential arterial hypertension not controlled with chlorthalidone. A multicenter study]. Arquivos brasileiros de cardiologia, 1983, Volume: 40, Issue:6 Topics: Adult; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Propranolol; Quinazolines	1983
Effect of prazosin on blood pressure and plasma lipids in patients receiving a beta-blocker and diuretic regimen. The American journal of medicine, 1984, Feb-27, Volume: 76, Issue:2A Topics: Aged; Blood Pressure; Chlorthalidone; Cholesterol; Drug Therapy, Combination; Female; Humans; Hypertension; Lipoproteins; Male; Oxprenolol; Prazosin; Quinazolines; Triglycerides	1984