chlorthalidone and metoprolol

chlorthalidone has been researched along with metoprolol in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (66.67)	18.7374
1990's	4 (7.84)	18.2507
2000's	6 (11.76)	29.6817
2010's	5 (9.80)	24.3611
2020's	2 (3.92)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Ebbutt, A; John, V; Kendall, M; Kubik, M	1
Dirix, R; Savoye, D; Tyberghein, JM	1
Jäättelä, A; Pyörälä, K	2
Durel, LA; Hayashi, PJ; Schneiderman, N; Weidler, DJ	1
Bielmann, P; Davignon, J; Leduc, G; Lepage, J; Thibault, G	1
Goldbourt, U; Holtzman, E; Rosenthal, T; Segal, P	2
Bentivoglio, M; Bichisao, E; Corea, L; Valori, C; Verdecchia, P	1
Dal Negro, RW; Pomari, C; Trevisan, F; Turco, P; Zoccatelli, O	1
Contursi, V; Di Lecce, G; Maiorano, G; Ricapito, M; Saracino, E	1
Antiga, F; Beltrami, M; Bola, U; Caponi, S; De Ranieri, P; Galli, G; Gasparotti, G; Guidicelli, N; Natali, P; Panvini, F	1
Black, DM; Furberg, CD	1
Acquarone, N; Crisalli, MP; Vinciguerra, G	1
Bovenzi, F; Contursi, V; Loiacono, N; Maiorano, G; Petrelli, G; Ricapito, M	1
Alberti, D; Bafico, GL; Bertulla, A; Camerieri, A; Caponnetto, S; Francucci, BM; Gatto, E; Gentile, A; Livi, S; Mereto, PE	1
De Dominicis, E; Lazzaretto, R; Mattiello, M; Onza, I; Vincenzi, M	1
Cocco, F; Dessì Fulgheri, P; Dettori, S; Fiori, C; Glorioso, N; Madeddu, P; Rappelli, A; Sanna, G	1
Floris, B; Franchetta, G; Palestini, N; Sonaglioni, G; Verdecchia, P	1
Altman, DG; Gould, BA; Hornung, RS; Kieso, HA; Mann, S; Raftery, EB	1
Dunning, AJ; Erwteman, TM; Koster, M; Lubsen, J; Nagelkerke, N	1
Mancia, G; Motolese, M; Parati, G; Pomidossi, G; Zanchetti, A	1
Dolce, E; Misceo, N; Pirrelli, A	1
Candau, LA; Pereira, LS; Scherr, C	1
Agabiti-Rosei, E; Carotti, A; Corea, L; Innocenti, P; Montervino, C; Motolese, M; Muiesan, G; Prezioso, R; Romanelli, G; Toso, M	1
Bichisao, E; Floris, B; Franchetta, G; Palestini, N; Sonaglioni, G; Verdecchia, P	1
Franco Manera, R; López-Vidriero, E; Paumard Fraguas, A; Petersen Guitarte, G; Rodríguez Rodríguez, FJ	1
Boddy, K; East, W; Gray, JM; Lawson, DH	1
Gerardin, A; Godbillon, J; John, VA; Theobald, W	1
Govind, U; Munro, BF; Robertson, LI	1
Checchi, M; Galeone, F; Giuntoli, F; Guidi, G; Locci, P; Saba, GC; Saba, P	1
Chadha, DR; Houtzagers, JJ	1
Centritto, V	1
Chequer, CV; Fernandes, EO; Latreca, CE; Reis, NB; Talberg, J	1
John, VA; Kendall, MJ; Lambert, L; Quarterman, CP	1
Cinotti, GA; De Martino, A; Filabozzi, P; Greco, V; Manzi, M; Matteoli, S; Simonetti, BM; Stirati, G	1
Huysmans, FT; Kloke, HJ; Koene, RA; van Hamersvelt, HW; Wetzels, JF	1
Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV	1
Li, Y; Liu, HW	1
Chandurkar, NB; Karnik, ND; Pareek, A; Salagre, SB; Zawar, SD	1
Beitelshees, AL; Chapman, AB; Cooper-DeHoff, RM; Gong, Y; Gums, JG; Johnson, JA; McDonough, CW; Mehanna, M; Schwartz, GL; Turner, ST	1
Bailey, KR; Beitelshees, AL; Chapman, AB; Cooper-DeHoff, RM; Gong, Y; Gums, JG; Johnson, JA; McDonough, CW; Mehanna, M; Schwartz, GL; Turner, ST; Wang, Z	1
Agrawal, S; Anand, J; Bachani, D; Doshi, M; Gaikwad, VB; Halder, SK; Kinholkar, B; Kumar, DA; Kumbhar, A; Mathur, R; Mehta, S; Sarkar, G; Sharma, A	1
Cassola, N; Clezar, CN; Flumignan, CD; Flumignan, RL; Nakano, LC; Trevisani, VF	1

Reviews

3 review(s) available for chlorthalidone and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Enantiomer separation by capillary electrochromatography]. Se pu = Chinese journal of chromatography, 2000, Volume: 18, Issue:3 Topics: Adrenergic beta-Antagonists; Chlorthalidone; Chromatography, High Pressure Liquid; Diuretics; Electrophoresis, Capillary; Metoprolol; Propranolol; Stereoisomerism	2000
Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews, 2023, 08-04, Volume: 8 Topics: Aspirin; Atherosclerosis; Atorvastatin; Carotid Stenosis; Chlorthalidone; Fluvastatin; Hemorrhage; Humans; Ischemic Stroke; Metoprolol; Pravastatin; Probucol; Rosuvastatin Calcium; Stroke; Warfarin	2023

Trials

20 trial(s) available for chlorthalidone and metoprolol

Article	Year
Metoprolol with and without chlorthalidone in hypertension. Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:1 Topics: Adult; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Pulse	1979
A controlled study on the anti-hypertensive effect of a new beta-adrenoreceptor-blocking drug, metoprolol, in combination with chlorthalidone. Clinical science and molecular medicine. Supplement, 1976, Volume: 3 Topics: Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Heart Rate; Humans; Hypertension; Metoprolol; Propanolamines	1976
Effectiveness of antihypertensive medications in office and ambulatory settings: a placebo-controlled comparison of atenolol, metoprolol, chlorthalidone, verapamil, and an atenolol-chlorthalidone combination. Journal of clinical pharmacology, 1992, Volume: 32, Issue:6 Topics: Adult; Ambulatory Care; Antihypertensive Agents; Atenolol; Blood Pressure; Blood Pressure Determination; Chlorthalidone; Double-Blind Method; Drug Combinations; Humans; Hypertension; Metoprolol; Middle Aged; Monitoring, Physiologic; Office Visits; Verapamil	1992
Effects of chlorthalidone and metoprolol alone or in combination (logroton) on blood pressure, lipids, lipoproteins and circulating plasma ANF levels in essential hypertension. International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:12 Topics: Atrial Natriuretic Factor; Blood Pressure; Chlorthalidone; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Double-Blind Method; Drug Combinations; Female; Humans; Hypertension; Lipids; Lipoproteins; Male; Metoprolol; Single-Blind Method	1991
Age and responses to isometric exercise in hypertension: possible predictors of the antihypertensive effect of diuretics and beta-blockers. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:10 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Diuretics; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Physical Exertion; Random Allocation	1985
Respiratory effects of four adrenergic blocking agents combined with a diuretic in treating hypertension with concurrent chronic obstructive lung disease. International journal of clinical pharmacology research, 1986, Volume: 6, Issue:4 Topics: Adrenergic beta-Antagonists; Airway Resistance; Atenolol; Chlorthalidone; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Hypertension; Labetalol; Lung Diseases, Obstructive; Male; Maximal Midexpiratory Flow Rate; Metoprolol; Oxprenolol; Random Allocation	1986
[Antihypertensive effectiveness and tolerance of slow-release metoprolol in fixed combination with chlorthalidone. Multicenter study on 93 patients]. La Clinica terapeutica, 1987, Feb-28, Volume: 120, Issue:4 Topics: Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Hypertension; Male; Metoprolol	1987
The systolic hypertension in the elderly pilot program: methodological issues. European heart journal, 1988, Volume: 9, Issue:2 Topics: Age Factors; Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Feasibility Studies; Female; Humans; Hydralazine; Hypertension; Male; Metoprolol; Middle Aged; Patient Compliance; Pilot Projects; Random Allocation; Reserpine; Sex Factors; Systole	1988
Effects of two doses of the fixed-combination chlorthalidone and slow-release metoprolol on blood pressure at rest and during exercise: a multicenter study. International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:10 Topics: Adult; Aged; Chlorthalidone; Double-Blind Method; Drug Combinations; Exercise Test; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged	1986
Effect on intra-arterial blood pressure of slow release metoprolol combined with placebo or chlorthalidone. British medical journal (Clinical research ed.), 1983, Sep-10, Volume: 287, Issue:6394 Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Physical Exertion; Pulse; Random Allocation; Urea; Uric Acid	1983
Beta blockade, diuretics, and salt restriction for the management of mild hypertension: a randomised double blind trial. British medical journal (Clinical research ed.), 1984, Aug-18, Volume: 289, Issue:6442 Topics: Adult; Aged; Chlorthalidone; Clinical Trials as Topic; Diet, Sodium-Restricted; Double-Blind Method; Drug Combinations; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Random Allocation	1984
[Comparative study of the combination of chlorthalidone with verapamil and metoprolol in arterial hypertension: evaluation by cycloergometrics]. Arquivos brasileiros de cardiologia, 1981, Volume: 37, Issue:2 Topics: Adult; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Exercise Test; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil	1981
Antihypertensive activity of once daily metoprolol alone and with chlorthalidone and comparison with a twice daily regimen. European journal of clinical pharmacology, 1982, Volume: 23, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines	1982
A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Dec-12, Volume: 60, Issue:24 Topics: Adult; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Fundus Oculi; Humans; Hypertension; Male; Metoprolol; Middle Aged; Potassium; Propanolamines; Pulse	1981
[Double-blind comparative study of the hypotensive effect of combination therapy with chlorthalidone and metoprolol or alpha-methyldopa]. Giornale di clinica medica, 1981, Volume: 62, Issue:8 Topics: Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Methyldopa; Metoprolol; Middle Aged; Propanolamines	1981
Once-daily penbutolol or atenolol can replace combination therapy in essential hypertension. The Journal of international medical research, 1982, Volume: 10, Issue:1 Topics: Atenolol; Blood Pressure; Chlorthalidone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Metoprolol; Penbutolol; Propanolamines; Propranolol; Pulse	1982
Angiotensin-converting enzyme inhibition and the combination of a beta blocker and a diuretic are equally effective in lowering proteinuria in patients with glomerulonephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1993, Volume: 8, Issue:9 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Chlorthalidone; Drug Combinations; Female; Glomerulonephritis; Hemodynamics; Humans; Kidney; Male; Metoprolol; Middle Aged; Proteinuria	1993
Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in indian patients with mild-to-moderate essential hypertension. European journal of medical research, 2009, Jul-22, Volume: 14, Issue:7 Topics: Adult; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Time Factors; Treatment Outcome	2009
A controlled study on the antihypertensive effect of a new beta-adrenergic receptor blocking drug, metoprolol, in combination with chlorthalidone. British journal of clinical pharmacology, 1976, Volume: 3, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Chlorthalidone; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged	1976
Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study. Advances in therapy, 2022, Volume: 39, Issue:2 Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Coronary Artery Disease; Drug Therapy, Combination; Essential Hypertension; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Metoprolol; Telmisartan; Tetrazoles	2022

Other Studies

28 other study(ies) available for chlorthalidone and metoprolol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Drug treatment of essential hypertension. Practical guidelines. The Practitioner, 1979, Volume: 222, Issue:1331 Topics: Adult; Aged; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines	1979
Do beta-blockers alter lipids and what are the consequences? Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 2 Topics: Adrenergic beta-Antagonists; Blood Pressure; Chlorthalidone; Diuretics; Female; Humans; Hypertension; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Metoprolol; Middle Aged	1987
[Cardiovascular response to isometric exercise test during beta blocker and diuretic treatment in essential arterial hypertension]. La Clinica terapeutica, 1988, Mar-31, Volume: 124, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Chlorthalidone; Diuretics; Drug Evaluation; Drug Therapy, Combination; Exercise Test; Female; Heart Rate; Humans; Hypertension; Isometric Contraction; Male; Metoprolol; Middle Aged; Time Factors	1988
[Hypokalemic rhabdomyolysis associated with diuretic and beta blockader therapy]. Recenti progressi in medicina, 1987, Volume: 78, Issue:1 Topics: Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Hypokalemia; Metoprolol; Middle Aged; Rhabdomyolysis	1987
[Clinico-therapeutic evaluation of the hypertensive patient by the isometric exertion test]. Minerva cardioangiologica, 1986, Volume: 34, Issue:3 Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Clonidine; Female; Humans; Hypertension; Isometric Contraction; Male; Metoprolol; Middle Aged; Muscle Contraction	1986
[Echocardiographic changes in hypertensive patients treated with a fixed combination of metoprolol and chlorthalidone]. Minerva cardioangiologica, 1986, Volume: 34, Issue:10 Topics: Adult; Chlorthalidone; Delayed-Action Preparations; Drug Combinations; Echocardiography; Female; Heart; Humans; Hypertension; Male; Metoprolol; Middle Aged	1986
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Metoprolol; Middle Aged; Prazosin; Renin; Sotalol; Spironolactone	1981
[Regression of left ventricular hypertrophy by a prolonged anti-hypertensive treatment]. Giornale italiano di cardiologia, 1982, Volume: 12, Issue:6 Topics: Aged; Antihypertensive Agents; Cardiomegaly; Chlorthalidone; Female; Humans; Male; Metoprolol; Middle Aged; Propanolamines	1982
Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status. Israel journal of medical sciences, 1984, Volume: 20, Issue:12 Topics: Body Weight; Chlorthalidone; Cholesterol; Coronary Disease; Female; Heart Rate; Humans; Hypertension; Lipoproteins; Male; Metoprolol; Middle Aged; Triglycerides	1984
Hemodynamic effects of once a day administration of combined chlorthalidone and metoprolol slow-release in essential hypertension. International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:12 Topics: Administration, Oral; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Isometric Contraction; Male; Metoprolol; Middle Aged; Physical Exertion; Time Factors	1984
[Effect of a metoprolol-chlorthalidone combination on arterial pressure and respiratory function]. Cardiologia (Rome, Italy), 1983, Volume: 28, Issue:1 Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Lung Diseases, Obstructive; Male; Metoprolol; Middle Aged; Respiration	1983
A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension. The Journal of international medical research, 1982, Volume: 10, Issue:2 Topics: Adult; Aged; Arteries; Chlorthalidone; Drug Therapy, Combination; Humans; Hypertension; Long-Term Care; Metoprolol; Middle Aged; Propanolamines	1982
[Antihypertensive effect of metoprolol in essential hypertension]. Medicina clinica, 1983, Mar-12, Volume: 80, Issue:8 Topics: Adult; Antihypertensive Agents; Chlorthalidone; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines	1983
Total body potassium in patients receiving chlorthalidone and metoprolol for hypertension. Scottish medical journal, 1983, Volume: 28, Issue:2 Topics: Adult; Chlorthalidone; Female; Humans; Hyperkalemia; Hypertension; Male; Metoprolol; Middle Aged; Potassium; Propanolamines	1983
Comparative pharmacokinetic profiles of metoprolol and chlorthalidone administered alone or in combination to healthy volunteers. European journal of clinical pharmacology, 1983, Volume: 24, Issue:5 Topics: Chlorthalidone; Drug Combinations; Drug Interactions; Half-Life; Humans; Kinetics; Metoprolol; Propanolamines	1983
[Use of metoprolol and atenolol, singly or in combination with a diuretic, in the treatment of arterial hypertension]. Bollettino della Societa italiana di cardiologia, 1980, Volume: 25, Issue:5 Topics: Adult; Atenolol; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines	1980
[Verapamil as a hypotensive agent. Clinical, laboratory, electro- and echocardiographic study]. Arquivos brasileiros de cardiologia, 1981, Volume: 36 Suppl 1 Topics: Adult; Aged; Chlorthalidone; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Liver; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil	1981
A pharmacokinetic and pharmacodynamic assessment of a combined slow-release metoprolol-chlorthalidone preparation. Journal of clinical and hospital pharmacy, 1981, Volume: 6, Issue:4 Topics: Adult; Chlorthalidone; Delayed-Action Preparations; Drug Combinations; Hemodynamics; Humans; Kinetics; Male; Metoprolol; Propanolamines; Time Factors	1981
[Evaluation of the antihypertensive effectiveness of the combination of metoprolol and chlorthalidone, using the ergometric test]. Bollettino della Societa italiana di cardiologia, 1981, Volume: 26, Issue:10 Topics: Adult; Chlorthalidone; Drug Evaluation; Drug Therapy, Combination; Exercise Test; Humans; Hypertension; Metoprolol; Middle Aged; Propanolamines	1981
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose. Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:8 Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol	1999
Blood pressure response to metoprolol and chlorthalidone in European and African Americans with hypertension. Journal of clinical hypertension (Greenwich, Conn.), 2017, Volume: 19, Issue:12 Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Black or African American; Blood Pressure; Chlorthalidone; Ethnopharmacology; Female; Humans; Hypertension; Male; Medication Therapy Management; Metoprolol; Middle Aged; United States; White People	2017
Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension. American journal of hypertension, 2019, 06-11, Volume: 32, Issue:7 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Biomarkers; Black or African American; Blood Pressure; Chlorthalidone; Clinical Decision-Making; Essential Hypertension; Female; Humans; Male; Metoprolol; Middle Aged; Patient Selection; Predictive Value of Tests; Randomized Controlled Trials as Topic; Renin; Treatment Outcome; United States; White People; Young Adult	2019