chlorthalidone and amiloride

chlorthalidone has been researched along with amiloride in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199015 (42.86)18.7374
1990's3 (8.57)18.2507
2000's5 (14.29)29.6817
2010's10 (28.57)24.3611
2020's2 (5.71)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Amadeo, A; Currò, F; de Pasquale, C1
Esch, I; Gaul, G; Placheta, P1
Canavese, JC; Fabre, J1
Nádvorníková, H; Schück, O1
Hengeveld, WL; Schouten, JA; Westerman, RF1
Espiner, EA; Ikram, H; Nicholls, MG; Stewart, DE1
Distler, A1
Kakác, B; Matousová, O; Peterková, M1
Beermann, B1
Cepelák, V; Mayer, O; Suchová, H1
Bhigjee, AI; Hoosen, S; Naidoo, K; Neerahoo, RM; Seedat, YK1
van Soeren, F1
Borba, P; Didier, M; França, P; Santos, A; Tenório, J1
Albanesi Filho, FM; Brandão, AP; Oigman, W1
Danĕková, H; Dzúrik, R; Fedelesová, V1
Alli, C; Avanzini, F; Bettelli, G; Colombo, F; Corso, R; Mariotti, G; Radice, M; Tognoni, G; Torri, V1
Bonet-Domingo, E; Garcia-Alvarez-Coque, MC; Medina-Hernandez, MJ1
Haris, A; Radó, JP1
Asplin, J; Blowey, D; D'mello, RG; Goodyer, P; Ploutz-Snyder, RJ; Raja, KA; Scheinman, SJ; Schurman, S; Van Why, S1
Huysmans, FT; van der Heijden, AG; van Hamersvelt, HW1
El-Gindy, A; Emara, S; Mostafa, A1
Mohamed, Ael-M; Salem, H1
Aboul-Enein, HY; Al Azzam, KM; Saad, B1
Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, L; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; Coelho, EB; Consolim-Colombo, F; de Mello, RB; de Sousa, MR; Figueiredo Neto, JA; Franco, R; Fuchs, FD; Fuchs, SC; Ghizzoni, F; Gus, M; Irigoyen, MC; Jardim, PC; Mion, D; Moreira, LB; Moreno, H; Mosele, F; Mota, M; Nobre, F; Nóbrega, AC; Pereira e Silva, R; Poli-de-Figueiredo, CE; Ribeiro, AL; Scala, LC; Schlatter, R; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF1
Alves, JG; Berwanger, O; Bortoloto, L; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; Coelho, EB; Consolim-Colombo, F; de Mello, RB; de Sousa, MR; Filho, DC; Franco, R; Fuchs, FD; Fuchs, SC; Ghizzoni, F; Gus, M; Irigoyen, MC; Jardim, PC; Mion, D; Moreira, LB; Moreno, H; Mosele, F; Mota, M; Neto, AA; Neto, JA; Nobre, F; Nóbrega, AC; Pereira e Silva, R; Poli-de-Figueiredo, CE; Ribeiro, AL; Scala, LC; Schlatter, R; Steffens, AA; Vilela-Martin, JF1
Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; de Alencastro, PR; de Mello, RB; de Sousa, MR; E Silva, RP; Filho, DC; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gomes, MM; Gus, M; Jardim, PC; Moreira, LB; Mosele, F; Neto, AA; Neto, JA; Nobre, F; Nóbrega, AC; Poli-de-Figueiredo, CE; Scala, LC; Schlatter, R; Steffens, AA; Vilela-Martin, JF; Whelton, PK1
Alves, JG; Berwanger, O; Bordignon, A; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; Consolim-Colombo, FM; de Alencastro, PR; de Mello, RB; de Sousa, MR; Figueiredo Neto, JA; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gus, M; Jardim, PC; Moreira, LB; Mosele, F; Mota Gomes, M; Neto, AA; Nobre, F; Nóbrega, AC; Poli-de-Figueiredo, CE; Scala, LC; Schlatter, R; Silva, RP; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF; Whelton, PK1
Bertoluci, C; Branchi, TV; Foppa, M; Fuchs, FD; Fuchs, SC; Santos, ABS1
Moreno, B; Moreno, H; Vilela-Martin, JF; Yugar, LBT; Yugar-Toledo, JC1
Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; De David, CN; de Sousa, MR; Figueiredo Neto, JA; Franco, RS; Fuchs, FD; Fuchs, SC; Gus, M; Moreira, LB; Mota Gomes, M; Nobre, F; Nóbrega, AC; Poli-de-Figueiredo, CE; Rafaelli, L; Scala, LCN; Schlatter, R; Sesin, GP; Silva, RPE; Sobral Filho, DC; Sousa, ALL; Steffens, AA; Vilela-Martin, JF; Whelton, PK1
Bottino, LG; Ferrari, F; Fuchs, FD; Fuchs, SC; Helal, L; Martins, VM1
Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, JE; Chaves, H; Consolim-Colombo, FM; de Sousa, MR; Figueiredo Neto, JA; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gomes, MM; Gus, M; Jardim, PC; Moreira, LB; Nobre, F; Nóbrega, AC; Pereira E Silva, R; Poli-de-Figueiredo, CE; Scala, LCN; Schlatter, RP; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF; Whelton, PK1
Borges, RB; Cichelero, FT; Fuchs, FD; Fuchs, SC; Hirakata, VN; Jorge, JA; Lucca, MB; Martinez, D1

Reviews

3 review(s) available for chlorthalidone and amiloride

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Importance of the continuity of anti-hypertension treatment in prevention of ischemic cardiovascular diseases: preliminary note. Controlled study of hypertensive patients treated with amiloride associated with hydrochlorothiazide and chlorthalidone].
    Minerva medica, 1978, Jun-23, Volume: 69, Issue:31

    Topics: Adult; Aged; Amiloride; Chlorthalidone; Coronary Disease; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines

1978
Aspects on pharmacokinetics of some diuretics.
    Acta pharmacologica et toxicologica, 1984, Volume: 54 Suppl 1

    Topics: Amiloride; Bendroflumethiazide; Bumetanide; Chlorthalidone; Diuretics; Furosemide; Humans; Hydrochlorothiazide; Kinetics; Sodium Chloride Symporter Inhibitors; Spironolactone

1984

Trials

18 trial(s) available for chlorthalidone and amiloride

ArticleYear
[Plasma renin activity in essential hypertension: different short- und long-term effects of diuretics (author's transl)].
    Wiener klinische Wochenschrift, 1976, Jun-25, Volume: 88, Issue:13

    Topics: Adult; Amiloride; Canrenoic Acid; Chlorthalidone; Clinical Trials as Topic; Diuresis; Diuretics; Female; Humans; Hypertension; Long-Term Care; Male; Middle Aged; Renin; Spironolactone; Time Factors

1976
Prazosin once or twice daily?
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:1

    Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Posture; Prazosin; Propranolol; Quinazolines

1985
[Report on the clinical evaluation of the antihypertensive effects of Urandil A VUFB].
    Vnitrni lekarstvi, 1984, Volume: 30, Issue:2

    Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hypertension; Isoindoles; Male; Middle Aged; Pyrazines

1984
Biochemical changes in black and Indian hypertensive patients on diuretic therapy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, Dec-10, Volume: 64, Issue:25

    Topics: Adult; Amiloride; Blood Glucose; Blood Pressure; Chlorthalidone; Creatinine; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indapamide; Male; Middle Aged; Potassium; Triamterene

1983
The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone.
    The Journal of international medical research, 1980, Volume: 8, Issue:2

    Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines

1980
Antihypertensive efficacy and tolerability of different drug regimens in isolated systolic hypertension in the elderly.
    European heart journal, 1994, Volume: 15, Issue:2

    Topics: Aged; Aged, 80 and over; Amiloride; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Delayed-Action Preparations; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Nifedipine; Patient Satisfaction; Treatment Outcome

1994
Patterns of potassium wasting in response to stepwise combinations of diuretics in nephrotic syndrome.
    International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:7

    Topics: Aged; Amiloride; Body Weight; Chlorthalidone; Diuresis; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Male; Middle Aged; Nephrotic Syndrome; Potassium; Regression Analysis; Sodium; Spironolactone; Triamterene

1999
Responsiveness of hypercalciuria to thiazide in Dent's disease.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:12

    Topics: Adolescent; Adult; Amiloride; Calcium; Calcium Oxalate; Child; Chlorthalidone; Chromosomes, Human, X; Cross-Over Studies; Diuretics; Drug Combinations; Genetic Linkage; Humans; Kidney Calculi; Male; Middle Aged; Osmolar Concentration

2002
Foot volume increase on nifedipine is not prevented by pretreatment with diuretics.
    Journal of hypertension, 2004, Volume: 22, Issue:2

    Topics: Adult; Amiloride; Ankle; Body Weight; Calcium Channel Blockers; Chlorthalidone; Diuretics; Edema; Female; Foot Diseases; Hematocrit; Humans; Male; Natriuresis; Nifedipine; Osmotic Pressure; Premedication

2004
A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial.
    Trials, 2011, Feb-24, Volume: 12

    Topics: Adult; Aged; Amiloride; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Research Design; Severity of Illness Index; Time Factors; Treatment Outcome

2011
Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial.
    Trials, 2011, Mar-05, Volume: 12

    Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Diuretics; Double-Blind Method; Drug Combinations; Female; Humans; Hypertension; Male; Middle Aged; Placebo Effect; Prehypertension; Research Design; Treatment Outcome

2011
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension: results from the PREVER-treatment randomized trial.
    Journal of hypertension, 2016, Volume: 34, Issue:4

    Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Humans; Hypertension; Losartan; Middle Aged

2016
Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER-Prevention Randomized Clinical Trial.
    Journal of the American Heart Association, 2016, 12-13, Volume: 5, Issue:12

    Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Diuretics; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Treatment Outcome

2016
Echocardiographic Left Ventricular Reverse Remodeling After 18 Months of Antihypertensive Treatment in Stage I Hypertension. Results From the Prever-Treatment Study.
    American journal of hypertension, 2018, 02-09, Volume: 31, Issue:3

    Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Atrial Function, Left; Atrial Remodeling; Blood Pressure; Chlorthalidone; Double-Blind Method; Echocardiography, Doppler; Female; Heart Ventricles; Humans; Hypertension; Losartan; Male; Middle Aged; Predictive Value of Tests; Time Factors; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling

2018
Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: a randomized clinical trial.
    Journal of hypertension, 2018, Volume: 36, Issue:4

    Topics: Adult; Amiloride; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Diastole; Disease Progression; Diuretics; Double-Blind Method; Female; Humans; Male; Middle Aged; Prehypertension; Systole

2018
Efficacy of chlorthalidone and hydrochlorothiazide in combination with amiloride in multiple doses on blood pressure in patients with primary hypertension: a protocol for a factorial randomized controlled trial.
    Trials, 2019, Dec-16, Volume: 20, Issue:1

    Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Time Factors; Treatment Outcome

2019
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial.
    Acta diabetologica, 2021, Volume: 58, Issue:2

    Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Severity of Illness Index; Treatment Outcome

2021
Effects of chlorthalidone plus amiloride compared with amlodipine on short-term blood pressure variability in individuals with hypertension and obstructive sleep apnea: a randomized controlled trial.
    Blood pressure monitoring, 2023, Dec-01, Volume: 28, Issue:6

    Topics: Adult; Amiloride; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chlorthalidone; Female; Humans; Hypertension; Male; Middle Aged; Sleep Apnea, Obstructive

2023

Other Studies

14 other study(ies) available for chlorthalidone and amiloride

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
[The diuretics in the treatment of arteriol hypertension].
    Therapeutische Umschau. Revue therapeutique, 1976, Volume: 33, Issue:5

    Topics: Amiloride; Benzothiadiazines; Chlorthalidone; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertension; Kidney Failure, Chronic; Potassium; Sodium; Sodium Chloride Symporter Inhibitors

1976
[Long-term study of the effects of chlorthalidone and amiloride on the renal excretion of electrolytes in patients with vascular hypertension].
    Vnitrni lekarstvi, 1986, Volume: 32, Issue:1

    Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Electrolytes; Female; Humans; Hypertension; Male; Middle Aged

1986
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.
    British heart journal, 1985, Volume: 54, Issue:3

    Topics: Amiloride; Arrhythmias, Cardiac; Chlorthalidone; Coronary Disease; Cyclopenthiazide; Diuretics; Female; Hormones; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Spironolactone

1985
[Is essential hypertension still a disease entity? Definition of hyporeninemic hypertension].
    Der Internist, 1974, Volume: 15, Issue:3

    Topics: Aldosterone; Amiloride; Chlorthalidone; Diagnosis, Differential; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Mineralocorticoids; Prognosis; Renin; Sodium Chloride; Spironolactone; Sympathetic Nervous System

1974
[Determination of trimepranol, chlorthalidone, DH-ergocristine and amiloride simultaneously].
    Ceskoslovenska farmacie, 1980, Volume: 29, Issue:7

    Topics: Amiloride; Chlorthalidone; Chromatography, Thin Layer; Drug Combinations; Ergolines; Metipranolol; Propanolamines; Pyrazines; Spectrophotometry

1980
[Comparative study of the association of propranolol-chlorthalidone and the fixed combination of timolol-hydrochlorothiazide-amiloride in the treatment of arterial hypertension].
    Arquivos brasileiros de cardiologia, 1981, Volume: 36, Issue:1

    Topics: Amiloride; Antihypertensive Agents; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Propranolol; Timolol

1981
[Treatment of arterial hypertension: comparative study of atenolol + chlorthalidone vs. timolol maleate-hydrochlorthiazide-amiloride association].
    Arquivos brasileiros de cardiologia, 1981, Volume: 37, Issue:6

    Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol

1981
[Value of combining amiloride with furosemide chlorthalidone in diuretic treatment].
    Bratislavske lekarske listy, 1980, Volume: 73, Issue:1

    Topics: Amiloride; Chlorthalidone; Diuresis; Drug Combinations; Furosemide; Humans; Pyrazines

1980
A micellar liquid chromatographic procedure for the determination of amiloride, bendroflumethiazide, chlorthalidone, spironolactone and triamterene in pharmaceuticals.
    Journal of pharmaceutical and biomedical analysis, 1993, Volume: 11, Issue:8

    Topics: Amiloride; Bendroflumethiazide; Chemistry, Pharmaceutical; Chlorthalidone; Chromatography, High Pressure Liquid; Diuretics; Micelles; Spironolactone; Tablets; Triamterene

1993
HPLC and chemometric-assisted spectrophotometric methods for simultaneous determination of atenolol, amiloride hydrochloride and chlorthalidone.
    Farmaco (Societa chimica italiana : 1989), 2005, Volume: 60, Issue:3

    Topics: Acetonitriles; Amiloride; Antihypertensive Agents; Atenolol; Chemistry, Pharmaceutical; Chlorthalidone; Chromatography, High Pressure Liquid; Heptanes; Least-Squares Analysis; Regression Analysis; Salts; Solutions; Spectrophotometry, Ultraviolet; Sulfonic Acids

2005
Determination of antihypertensive mixtures by use of a chemometrics-assisted spectrophotometric method.
    Analytical and bioanalytical chemistry, 2005, Volume: 382, Issue:4

    Topics: Amiloride; Antihypertensive Agents; Atenolol; Chlorthalidone; Least-Squares Analysis; Molecular Structure; Multivariate Analysis; Regression Analysis; Sensitivity and Specificity; Spectrophotometry

2005
Simultaneous determination of atenolol, chlorthalidone and amiloride in pharmaceutical preparations by capillary zone electrophoresis with ultraviolet detection.
    Biomedical chromatography : BMC, 2010, Volume: 24, Issue:9

    Topics: Amiloride; Atenolol; Chlorthalidone; Electrophoresis, Capillary; Molecular Structure; Pharmaceutical Preparations; Reproducibility of Results; Spectrophotometry, Ultraviolet

2010
Do thiazide diuretics reduce central systolic blood pressure in hypertension?
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:1

    Topics: Amiloride; Antihypertensive Agents; Arterial Pressure; Blood Pressure; Chlorthalidone; Diuretics; Drug Combinations; Humans; Hypertension; Treatment Outcome; Vascular Stiffness

2018