chlorpromazine has been researched along with verapamil in 155 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (25.16) | 18.7374 |
| 1990's | 28 (18.06) | 18.2507 |
| 2000's | 37 (23.87) | 29.6817 |
| 2010's | 45 (29.03) | 24.3611 |
| 2020's | 6 (3.87) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Batra, S; Bhaduri, AP; Pandey, VC; Roy, K; Srivastava, P | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Pajeva, IK; Wiese, M | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Keserü, GM | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
| Cushman, M; Kim, HY; Kuhn, RJ; Patkar, C; Warrier, R | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Briand, X; Faller, B; Lázaro, E; Lowe, PJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Bucar, F; Gröblacher, B; Kunert, O | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Peters, JU | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, J; Chen, X; Huang, L; Li, X; Sun, Y | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Huang, L; Li, X; Meng, F; Miao, H; Sun, Y | 1 |
| Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bassetto, M; Brancale, A; Ferla, S; Kandil, S; McGuigan, C; Pertusati, F; Westwell, AD | 2 |
| Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL | 1 |
| Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Barreca, ML; Cannalire, R; Cecchetti, V; Couto, I; Felicetti, T; Machado, D; Manfroni, G; Massari, S; Sabatini, S; Santos Costa, S; Tabarrini, O; Viveiros, M | 1 |
| Chreifi, G; Do, HT; Li, H; Poulos, TL; Silverman, RB; Wang, HY | 1 |
| Ganeshpurkar, A; Gupta, SK; Gutti, G; Krishnamurthy, S; Kumar, D; Modi, G; Singh, SK | 1 |
| Rai, SN; Shankar, S; Sharma, P; Shrivastava, SK; Singh, SP; Srivastava, P; Srivastava, RK; Tripathi, PN | 1 |
| An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T | 1 |
| Sharma, P; Shrivastava, SK; Srivastava, P; Tripathi, PN | 1 |
| Chreifi, G; Cinelli, MA; Li, H; Poulos, TL; Reidl, CT; Silverman, RB | 1 |
| Chen, Y; Feng, F; He, S; Li, Q; Liao, Q; Liu, W; Liu, Y; Lu, W; Sun, H; Xing, S; Xiong, B; Yang, H | 1 |
| Chen, L; Chen, Y; Duan, Y; Feng, F; Huang, J; Jiang, X; Liu, C; Liu, W; Qu, W; Sun, H; Wang, Y; Zhou, J | 1 |
| Chen, T; Chen, Y; Feng, F; Jiang, X; Li, Q; Liu, C; Liu, W; Lyu, W; Sun, H; Wang, S; Wang, Y; Xing, C | 1 |
| Du, C; Du, K; Feng, C; Lv, W; Shen, R; Sun, H; Xi, M | 1 |
| Hardy, CD; Li, H; Poulos, TL; Silverman, RB; Vasu, D | 1 |
| Haye, B; Jacquemin, C; Marcy, G | 1 |
| Crankshaw, DJ; Daniel, EE; Janis, RA | 1 |
| Baldenkov, GN; Ratner, EI; Tkachuk, VA | 1 |
| Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M | 1 |
| Belzer, FO; Kim, SK; Southard, JH | 1 |
| Misík, V; Ondrias, K; Reguli, J; Stasko, A; Svajdlenka, E | 1 |
| DeCoursey, TE; Jacobs, ER | 1 |
| Belzer, FO; Claesson, K; Lindell, S; Southard, JH | 1 |
| Bryson, YJ; Kesson, AM | 1 |
| Hirai, H; Natori, S; Sekimizu, K | 1 |
| Krishan, A | 3 |
| Gurman, EG | 1 |
| Forsyth, GW; Maenz, DD; Wong, PH | 1 |
| Dell'Osa, D; Temple, DM | 1 |
| Campbell, RM; Scanes, CG | 1 |
| Johnsson, R; Saris, NE | 1 |
| Cahill, D; Schlesinger, MJ | 1 |
| Enyeart, JJ; Hinkle, PM; Phillips, WJ | 1 |
| Gross, GW; Lucas, JH; Shi, RY; Wolf, A | 1 |
| Safa, AR; Spearman, T; Van Dyke, K; Ye, ZG | 1 |
| Cools, V; Cox, E; Houvenaghel, A | 1 |
| Beyer, HK; Kiricuta, IC; Schmitt, WG | 1 |
| Angel, MF; Mahoney, JE; Mitchell, GM; Morrison, WA; O'Brien, BM; Pederson, WC; Singer, DI | 1 |
| Asano, M | 1 |
| Askri, H; Scheftel, JM | 1 |
| Chen, IJ; Teng, CM; Yeh, HI | 1 |
| Grignani, G; Pacchiarini, L; Zucchella, M | 1 |
| Bennett, AJ; Brindley, DN; Graham, A; McLean, AA; Zammit, VA | 1 |
| FitzGerald, DJ; Pastan, I; Pirker, R; Willingham, MC | 1 |
| Brockelman, CR; Bunnag, D; Satayavivad, J; Tan-ariya, P; Wongsawatkul, O | 1 |
| Dill, PL; Duarte, TE; Nagourney, RA; Su, YZ; Weisenthal, LM | 1 |
| Bonventre, JV; Cheung, JY; Leaf, A; Malis, CD | 1 |
| Brostrom, CO; Brostrom, MA; Wolfe, SE | 1 |
| Anno, T; Kodama, I; Shibata, S; Toyama, J; Yamada, K | 1 |
| Ballejo, G; Calixto, JB; Medeiros, YS | 1 |
| Adkinson, NF; Farrukh, IS; Gurtner, GH; Michael, JR; Summer, WR | 1 |
| Gordon, K; Krishan, A; Sauerteig, A; Swinkin, C | 1 |
| Borowitz, JL; Hadley, R; Stebbins, G | 1 |
| Greig, R; Poste, G; Wright, B; Zeidman, I | 1 |
| Izawa, T; Komabayashi, T; Nakamura, T; Nakano, K; Tsuboi, M | 1 |
| Cain, CA; Fan, S; Tompkins, WA; Weltzin, R | 1 |
| Jaiswal, RK; Landon, EJ; Naukam, RJ; Sastry, BV | 1 |
| Hepler, PK; Saunders, MJ | 1 |
| Bianchi, RG; Dajani, EZ; Gullikson, GW | 1 |
| Minakuchi, R; Mori, T; Nishizuka, Y; Takai, Y; Yu, B | 1 |
| Bottomley, PA; Nunnally, RL | 1 |
| Maroko, PR | 1 |
| Churchill, TA; Fuller, BJ; Green, CJ | 1 |
| Cassano, GB; Lenzi, A; Marazziti, D; Raffaelli, S | 1 |
| Phung-Ba, V; Scherman, D; Warnery, A; Wils, P | 1 |
| Danova, ST; Ivanova, IV; Khristova, KR; Moncheva, PA | 1 |
| Guo, ZJ; Zhu, YJ; Zhu, YL | 1 |
| Sakata, A; Tamai, I; Tenda, Y; Terasaki, T; Tsuji, A | 1 |
| Deng, Y; Zhang, ZS | 1 |
| Kyle, DE; Milhous, WK; Rossan, RN | 1 |
| Corcoran, GB; Gurule, MW; Kamendulis, LM; Ray, SD; Yorkin, RD | 1 |
| Aungst, BJ; Saitoh, H | 1 |
| Anene, BM; Anika, SM; Chukwu, CC; Ross, CA | 1 |
| Balakumaran, A; Campbell, GA; Moslen, MT | 1 |
| Batrak, GN; Degtiar, VY; Hawryluk, BR; Luik, AI; Mogilevich, SE; Naydyenova, IY; Prokopenko, RA | 1 |
| Gilani, AH; Rashid, F; Saeed, SA; Shah, BH | 1 |
| Bernard, A; Lermioglu, F | 1 |
| Karlsson, A; Lennernäs, H; Sandström, R | 1 |
| Cao, W; Guo, Z; Luo, W; Zeng, Z; Zhu, Y | 1 |
| Guo, YJ; He, P; Li, LF; Wu, MC; Yan, ZL | 1 |
| Prithiviraj, B; Sarma, BK; Singh, UP | 1 |
| Bebawy, M; Morris, MB; Roufogalis, BD | 1 |
| Doi, K; Harada, K; Itagaki, S; Karaki, H; Kawamura, S; Tsutsui, S; Yoshikawa, Y | 1 |
| Amaral, L; Kristiansen, JE; Kristiansen, MM; Leandro, C; Martins, M; Ordway, D; Pacheco, T; Viveiros, M | 1 |
| Da, SL; Feng, YQ; He, HB; Hu, ZX; Qu, L | 1 |
| Amaral, L; Couto, I; Kern, WV; Rodrigues, L; Sampaio, D; Vavra, M; Viveiros, M; Wagner, D | 1 |
| Deng, Y; Xu, B; Xu, ZF; Yang, JH | 1 |
| Amaral, L; Couto, I; Kern, WV; Machado, D; Rodrigues, L; Sampaio, D; Viveiros, M | 1 |
| Alderton, W; Berghmans, S; Butler, P; Chassaing, H; Fleming, A; Gardner, I; Golder, Z; Richards, F | 1 |
| Guo, N; Jin, J; Li, L; Li, Y; Liang, JC; Liu, MY; Sheng, H; Wang, XL; Wu, XP; Yu, L; Zhang, JY | 1 |
| Amaral, L; Baptista, P; Couto, I; Machado, D; Perdigão, J; Portugal, I; Rodrigues, L; Veigas, B; Viveiros, M | 1 |
| Audéon, C; Duplaix, C; Fillinger, S; Lanen, C; Omrane, S; Sghyer, H; Walker, AS | 1 |
| Andreev, SL; Dronova, IV; Eremenko, KV; Gusakova, SV; Kovalev, IV; Vecherskiĭ, IuIu; Zatolokin, VV | 1 |
| Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M | 1 |
| Guo, Q; Jiang, Y; Li, C; Li, G; Lu, J; Qiu, Y; Wan, K; Wei, J; Zhang, J; Zhao, LL; Zhao, X | 1 |
| Beeram, S; Bi, C; Hage, DS; Zheng, X | 1 |
| Badaoui, M; Dickson, CJ; Hornak, V; Kells, A; Molteni, C; Rosta, E | 1 |
| Bae, EJ; Lee, MK; Xu, W | 1 |
4 review(s) available for chlorpromazine and verapamil
| Article | Year |
|---|---|
Polypharmacology - foe or friend?
Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Possibilities of phosphorus 31 spectroscopy in assessing the therapeutic effects on cellular energy metabolism of the myocardium].
Topics: Acebutolol; Cardioplegic Solutions; Chlorpromazine; Energy Metabolism; Humans; Magnetic Resonance Spectroscopy; Myocardial Infarction; Myocardium; Phosphates; Propranolol; Tiopronin; Verapamil | 1989 |
Calcium and ischemic injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Chlorpromazine; Cytosol; Extracellular Space; Homeostasis; Humans; In Vitro Techniques; Ischemia; Models, Biological; Myocardial Infarction; Myocardium; Nifedipine; Oxygen; Vasodilation; Verapamil | 1986 |
1 trial(s) available for chlorpromazine and verapamil
| Article | Year |
|---|---|
Effectiveness of the combination verapamil and chlorpromazine in the treatment of severe manic or mixed patients.
Topics: Adolescent; Adult; Bipolar Disorder; Chlorpromazine; Drug Administration Schedule; Drug Therapy, Combination; Female; Hospitalization; Humans; Middle Aged; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome; Verapamil | 1995 |
150 other study(ies) available for chlorpromazine and verapamil
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
A new class of potential chloroquine-resistance reversal agents for Plasmodia: syntheses and biological evaluation of 1-(3'-diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Mice; Plasmodium; Pyrrolidines; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results | 2006 |
Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication.
Topics: Animals; Antiviral Agents; Capsid Proteins; Cell Line; Cell Survival; Cricetinae; Crystallography, X-Ray; Dioxanes; Glycoproteins; Indicators and Reagents; Ligands; Models, Molecular; Molecular Conformation; Sindbis Virus; Virus Replication | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.
Topics: Alpinia; Antibiotics, Antitubercular; Antitubercular Agents; Diarylheptanoids; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium smegmatis; Plant Extracts; Seeds | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates | 2014 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine | 2015 |
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
Topics: Anilides; Antineoplastic Agents; Benzamides; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Drug Resistance, Neoplasm; Humans; Male; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Permeability; Phenylthiohydantoin; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Tosyl Compounds | 2016 |
Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Male; Molecular Docking Simulation; Molecular Structure; Prostatic Neoplasms; Structure-Activity Relationship; Xylenes | 2016 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species | 2017 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques | 2017 |
Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium.
Topics: Anti-Bacterial Agents; Drug Design; Genistein; Mycobacterium avium; Quinolones | 2017 |
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Topics: Aminopyridines; Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Fluorobenzenes; Humans; Mice; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Structure-Activity Relationship; Swine; Theophylline; Verapamil | 2017 |
Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Diketopiperazines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Matrix Metalloproteinase 2; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship | 2018 |
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
Topics: Antioxidants; Benzoxazoles; Cholinesterase Inhibitors; Drug Design; Humans; Learning; Memory; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2019 |
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram | 2019 |
Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, β-amyloid aggregation and oxidative stress to treat Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Drug Design; Humans; Oxidative Stress | 2019 |
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
Topics: Aminoquinolines; Animals; Aspartic Acid; Blood-Brain Barrier; Catalytic Domain; Crystallography, X-Ray; Enzyme Assays; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Molecular Structure; Mutagenesis, Site-Directed; Mutation; Nitric Oxide Synthase Type I; Permeability; Protein Binding; Rats; Structure-Activity Relationship | 2020 |
Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor.
Topics: Aminoquinolines; Animals; Benzimidazoles; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Female; Humans; Male; Mice, Inbred ICR; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuroprotective Agents; Protein Binding; Small Molecule Libraries | 2020 |
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Glycogen Synthase Kinase 3; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Morris Water Maze Test; Phosphorylation; Protein Conformation; tau Proteins; Thiazoles | 2020 |
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Glycogen Synthase Kinase 3 beta; Humans; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Pyridines; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2021 |
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2022 |
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Topics: Aminopyridines; Animals; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Isoforms; Rats | 2022 |
Relationship between the "phospholipid effect" and calcium in the thyroid. I. - Effects of calcium ions, E.G.T.A., ionophore A 23187, verapamil and chlorpromazine on resting and stimulate thyroid slices.
Topics: Animals; Calcimycin; Calcium; Cattle; Chlorpromazine; Edetic Acid; Egtazic Acid; In Vitro Techniques; Phosphatidylinositols; Swine; Thyroid Gland; Thyrotropin; Verapamil | 1979 |
The effects of Ca2+ antagonists on Ca2+ accumulation by subcellular fractions of rat myometrium.
Topics: Animals; Biological Transport, Active; Calcium; Cations, Divalent; Chlorpromazine; Female; Gallopamil; Lanthanum; Myometrium; Potassium; Rats; Sodium; Subcellular Fractions; Uterus; Verapamil | 1977 |
Effect of moracizine and ethacizine on receptors of potential-operated calcium channels and calcium-binding proteins.
Topics: Adenosine Triphosphatases; Animals; Anti-Arrhythmia Agents; Calcium Channels; Calcium-Binding Proteins; Chlorpromazine; Electrophysiology; In Vitro Techniques; Ligands; Membrane Potentials; Moricizine; Phenothiazines; Phosphoric Diester Hydrolases; Protein Binding; Rabbits; Receptors, Nicotinic; Verapamil | 1992 |
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes.
Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil | 1992 |
Loss of mitochondrial respiratory function and its suppression during cold ischemic preservation of rat livers with University of Wisconsin solution.
Topics: Adenosine; Allopurinol; Animals; Chlorpromazine; Cryopreservation; Fatty Acids, Nonesterified; Glutathione; Insulin; Liver; Male; Mitochondria, Liver; Oligomycins; Organ Preservation; Organ Preservation Solutions; Oxygen Consumption; Raffinose; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Solutions; Time Factors; Verapamil | 1992 |
Comparison of perturbation effect of propranolol, verapamil, chlorpromazine and carbisocaine on lecithin liposomes and brain total lipid liposomes. An EPR spectroscopy study.
Topics: Animals; Brain; Carbamates; Chlorpromazine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Liposomes; Molecular Weight; Phosphatidylcholines; Phospholipids; Propranolol; Rats; Verapamil | 1991 |
Mechanisms of potassium channel block in rat alveolar epithelial cells.
Topics: Animals; Calcium; Calcium Channels; Capsaicin; Cells, Cultured; Charybdotoxin; Chlorpromazine; Epithelium; Gallopamil; Kinetics; Nifedipine; Phencyclidine; Potassium Channels; Pulmonary Alveoli; Quinidine; Rats; Scorpion Venoms; Tacrine; Tetraethylammonium Compounds; Verapamil | 1990 |
Chlorpromazine, quinacrine, and verapamil as donor pretreatment in liver preservation, tested in the isolated perfused rat liver.
Topics: Animals; Bile; Chlorpromazine; Cold Temperature; Cryoprotective Agents; Drug Evaluation, Preclinical; Enzymes; In Vitro Techniques; Liver; Male; Organ Preservation; Perfusion; Quinacrine; Rats; Rats, Inbred Strains; Tissue Donors; Verapamil | 1991 |
Induction of interferon-gamma by cord blood mononuclear cells is calcium dependent.
Topics: Calcium; Calmodulin; Cell Line; Chlorides; Chlorpromazine; Fetal Blood; Humans; In Vitro Techniques; Interferon-gamma; Leukocytes, Mononuclear; Macrophages; Manganese; Manganese Compounds; Phytohemagglutinins; Verapamil | 1991 |
Inhibitory action of phospholipid-interacting drugs on transcription initiation in a nuclear extract of Ehrlich ascites tumor cells.
Topics: Adenoviruses, Human; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Chlorpromazine; HeLa Cells; Humans; Imipramine; Kinetics; Mice; Phospholipases A; Phospholipases A2; Phospholipids; Promoter Regions, Genetic; RNA Polymerase II; Tetracaine; Transcription Factors; Transcription, Genetic; Verapamil | 1991 |
Rapid determination of cellular resistance-related drug efflux in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Doxorubicin; Drug Resistance; Flow Cytometry; Humans; Leukemia P388; Mice; Trifluoperazine; Tumor Cells, Cultured; Verapamil | 1990 |
[The characteristics of the action of calcium antagonists on glucose transport in the rat small intestine].
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Depression, Chemical; Glucose; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Male; Perfusion; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil | 1990 |
Calcium mediation of the pig jejunal secretory response.
Topics: Animals; Bacterial Toxins; Calcimycin; Calcium; Cell Membrane Permeability; Chlorpromazine; Dantrolene; Egtazic Acid; Enterotoxins; Escherichia coli Proteins; Intestinal Mucosa; Ion Channels; Jejunum; Membrane Potentials; Swine; Theophylline; Verapamil | 1985 |
Inhibitory action of verapamil and chlorpromazine on the release of slow-reacting substance of anaphylaxis from cat lung.
Topics: Animals; Ascaris; Calcimycin; Cats; Chlorpromazine; Female; Histamine Release; In Vitro Techniques; Lung; Male; SRS-A; Verapamil | 1986 |
Pharmacological investigations on the lipolytic and antilipolytic effects of growth hormone (GH) in chicken adipose tissue in vitro: evidence for involvement of calcium and polyamines.
Topics: Adipose Tissue; Animals; Calcimycin; Calcium; Chickens; Chlorpromazine; Cycloheximide; Dactinomycin; Eflornithine; Growth Hormone; Lipolysis; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Synthesis Inhibitors; RNA; Spermidine; Verapamil | 1988 |
Ca2+ influx in normal and spherocytic red cells.
Topics: Adult; Calcium; Chlorpromazine; Erythrocytes; Erythrocytes, Abnormal; Female; Humans; Ion Channels; Male; Middle Aged; Spherocytes; Spherocytosis, Hereditary; Splenectomy; Vanadates; Verapamil | 1988 |
Verapamil and chlorpromazine inhibit the budding of Sindbis and vesicular stomatitis viruses from infected chicken embryo fibroblasts.
Topics: Animals; Capsid; Cells, Cultured; Chick Embryo; Chlorpromazine; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Membrane Glycoproteins; Sindbis Virus; Verapamil; Vesicular stomatitis Indiana virus; Viral Core Proteins; Viral Proteins; Virus Replication | 1989 |
Pituitary thyrotropin-releasing hormone receptors: local anesthetic effects on binding and responses.
Topics: Anesthetics, Local; Animals; Benzocaine; Chlordiazepoxide; Chlorpromazine; Dibucaine; Hydrogen-Ion Concentration; Imipramine; Lidocaine; Pituitary Gland; Procaine; Prolactin; Propranolol; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Tetracaine; Thyrotropin-Releasing Hormone; Trifluoperazine; Verapamil | 1989 |
Calcium antagonists fail to protect mammalian spinal neurons after physical injury.
Topics: Animals; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Chlorpromazine; In Vitro Techniques; Mice; Nifedipine; Spinal Cord; Spinal Cord Injuries; Verapamil | 1989 |
3H-azidopine photoaffinity labeling of high molecular weight proteins in chloroquine resistant falciparum malaria.
Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Chloroquine; Chlorpromazine; Dihydropyridines; Drug Resistance; Glycoproteins; Molecular Weight; Nicardipine; Photochemistry; Plasmodium falciparum; Proteins; Quinacrine; Reserpine; Trifluoperazine; Verapamil | 1989 |
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets.
Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia coli Infections; Female; Gastroenteritis, Transmissible, of Swine; Propranolol; Swine; Swine Diseases; Verapamil | 1989 |
Hydrostatic distention and pharmacological treatment of epinephrine-induced microarterial spasm.
Topics: Animals; Chlorpromazine; Constriction, Pathologic; Epinephrine; Femoral Artery; Isotonic Solutions; Lidocaine; Rabbits; Sodium Chloride; Vasodilator Agents; Verapamil | 1989 |
Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea
Topics: Animals; Atropine; Calmodulin; Carbachol; Cattle; Chlorpromazine; Imidazoles; In Vitro Techniques; Muscle Contraction; Myosins; Phosphorylation; Potassium Chloride; Sulfonamides; Trachea; Verapamil | 1989 |
Effects of chlorpromazine, berberine and verapamil on Escherichia coli heat-labile enterotoxin-induced intestinal hypersecretion in rabbit ileal loops.
Topics: Adenylyl Cyclase Inhibitors; Animals; Bacterial Toxins; Berberine; Berberine Alkaloids; Chlorpromazine; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Intestinal Secretions; Jejunum; Rabbits; Verapamil | 1988 |
Cyclooxygenase--independent pathway of phospholipase activation in carrageenan--induced platelet aggregation.
Topics: Animals; Calcium; Carrageenan; Chlorpromazine; Drug Synergism; Enzyme Activation; Indomethacin; Nitroprusside; Phospholipases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rabbits; Tetracaine; Verapamil | 1987 |
[Effect of chlorpromazine, dipyridamole and verapamil on platelet aggregation on the arachidonic acid metabolism].
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Calcium; Chlorpromazine; Dipyridamole; Humans; Platelet Aggregation; Verapamil | 1987 |
Factors regulating the secretion of lysophosphatidylcholine by rat hepatocytes compared with the synthesis and secretion of phosphatidylcholine and triacylglycerol. Effects of albumin, cycloheximide, verapamil, EGTA and chlorpromazine.
Topics: Albumins; Animals; Cells, Cultured; Chlorpromazine; Choline; Cycloheximide; Egtazic Acid; Glycerol; Liver; Lysophosphatidylcholines; Oleic Acid; Oleic Acids; Phosphatidylcholines; Rats; Triglycerides; Verapamil | 1988 |
Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines.
Topics: ADP Ribose Transferases; Bacterial Toxins; Cadaverine; Calmodulin; Carcinoma, Squamous Cell; Cell Line; Chlorpromazine; Drug Synergism; Exotoxins; Female; Humans; Immunotoxins; Ovarian Neoplasms; Pseudomonas aeruginosa Exotoxin A; Ricin; Trifluoperazine; Verapamil; Virulence Factors | 1988 |
Flunarizine and verapamil inhibit chloroquine-resistant Plasmodium falciparum growth in vitro.
Topics: Animals; Antimalarials; Chloroquine; Chlorpromazine; Drug Resistance; Flunarizine; Mefloquine; Plasmodium falciparum; Quinine; Quinolines; Regression Analysis; Verapamil | 1987 |
Flow cytometric monitoring of anthracycline transport in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Daunorubicin; Flow Cytometry; Humans; Lasers; Leukemia P388; Leukemia, Experimental; Mice; Naphthacenes; Verapamil | 1986 |
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.
Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Lidocaine; Protein Kinase C; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1987 |
Mechanisms of action of inhibitors of prolactin secretion in GH3 pituitary cells. I. Ca2+-dependent inhibition of amino acid incorporation.
Topics: Acetylcholine; Amino Acids; Animals; Bromocriptine; Calcium; Carbachol; Cell Line; Chlorpromazine; Imidazoles; Magnesium; Nifedipine; Pituitary Neoplasms; Prolactin; Protein Processing, Post-Translational; Rats; Trifluoperazine; Verapamil | 1986 |
Effects of calcium, calcium entry blockers and calmodulin inhibitors on atrioventricular conduction disturbances induced by hypoxia.
Topics: Animals; Atrioventricular Node; Calcium; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Heart; Heart Conduction System; Hypoxia; In Vitro Techniques; Nifedipine; Rabbits; Sulfonamides; Time Factors; Verapamil | 1986 |
In vitro effects of calcium entry blockers, chlorpromazine and fenoterol upon human pregnant myometrium contractility.
Topics: Adult; Calcium Channel Blockers; Chlorpromazine; Cinnarizine; Female; Fenoterol; Humans; In Vitro Techniques; Nifedipine; Potassium Chloride; Pregnancy; Uterine Contraction; Verapamil | 1986 |
Thromboxane-induced pulmonary vasoconstriction: involvement of calcium.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Cyclooxygenase Inhibitors; Male; Nitroglycerin; Peroxides; Phentolamine; Potassium Chloride; Pulmonary Circulation; Rabbits; tert-Butylhydroperoxide; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction; Verapamil | 1985 |
Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.
Topics: Animals; Biological Transport; Cell Line; Chlorpromazine; Daunorubicin; Doxorubicin; Flow Cytometry; Fluorometry; Leukemia P388; Leukemia, Experimental; Mice; Monitoring, Physiologic; Trifluoperazine; Tumor Stem Cell Assay; Verapamil | 1986 |
Effects of calcium and verapamil on normal and tumor murine leukocytes.
Topics: Animals; Calcium; Chlorpromazine; Ethanol; Leukemia P388; Leukemia, Experimental; Leukocytes; Mice; Verapamil | 1985 |
Inhibition of macrophage activation by calcium channel blockers and calmodulin antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Calmodulin; Cell Membrane; Cell Survival; Chlorpromazine; Female; Imidazoles; Macrophage Activation; Macrophages; Mice; Sulfonamides; Verapamil | 1985 |
Effects of Ca2+ and calmodulin antagonists on the oxygen uptake induced by acetylcholine or substance P in rat submandibular gland slices.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Diltiazem; In Vitro Techniques; Lanthanum; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Submandibular Gland; Substance P; Sulfonamides; Trifluoperazine; Vasodilator Agents; Verapamil | 1984 |
A role for calcium-activated calmodulin in murine nonspecific cell-mediated cytotoxicity.
Topics: Animals; Calcimycin; Calcium; Calcium-Binding Proteins; Calmodulin; Chlorpromazine; Cyclic AMP; Cytotoxicity, Immunologic; Mice; Mice, Inbred BALB C; Spleen; Verapamil | 1983 |
Effects of calcium channel blocking agents on membrane microviscosity and calcium in the liver of the carbon tetrachloride treated rat.
Topics: Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride Poisoning; Cell Membrane; Chlorpromazine; Kinetics; Liposomes; Liver; Male; Membrane Lipids; Microsomes, Liver; Nifedipine; Rats; Rats, Inbred Strains; Verapamil; Viscosity | 1984 |
Calcium antagonists and calmodulin inhibitors block cytokinin-induced bud formation in Funaria.
Topics: Calcium; Calmodulin; Cell Division; Cells, Cultured; Chlorpromazine; Cytokinins; Gallic Acid; Gallopamil; Lanthanum; Plant Growth Regulators; Plants; Trifluoperazine; Verapamil | 1983 |
Inhibition of intestinal secretion in the dog: a new approach for the management of diarrheal states.
Topics: Animals; Antidiarrheals; Body Water; Chlorpromazine; Deoxycholic Acid; Diarrhea; Dogs; Electrolytes; Intestinal Mucosa; Phenylurea Compounds; Propranolol; Verapamil | 1981 |
Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.
Topics: Animals; Brain; Calcium; Chlorpromazine; Cytosol; Dibucaine; Enzyme Activation; Imipramine; Kinetics; Phentolamine; Phospholipids; Protein Kinases; Rats; Tetracaine; Verapamil | 1980 |
Assessment of pharmacological treatment of myocardial infarction by phosphorus-31 NMR with surface coils.
Topics: Animals; Chlorpromazine; Coronary Circulation; Disease Models, Animal; Magnetic Resonance Spectroscopy; Myocardial Infarction; Phosphorus; Phosphorus Isotopes; Rabbits; Verapamil | 1981 |
Experimental infarction studies.
Topics: Animals; Chlorpromazine; Dogs; Heart Rate; Ibuprofen; Morphine; Myocardial Infarction; Myocardium; Propranolol; Time Factors; Verapamil | 1980 |
The importance of calcium-related effects on energetics at hypothermia: effects of membrane-channel antagonists on energy metabolism of rat liver.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Chlorpromazine; Cryopreservation; Energy Metabolism; In Vitro Techniques; Ion Channels; Ion Transport; Liver; Male; Nifedipine; Nisoldipine; Organ Preservation; Prenylamine; Rats; Rats, Sprague-Dawley; Verapamil | 1995 |
Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Chlorpromazine; Epithelium; Humans; Intestinal Mucosa; Reserpine; Verapamil; Vinblastine; Virginiamycin | 1995 |
[Effect of calcium ions on the differentiation of actinomycetes].
Topics: Actinomycetales; Calcium; Chlorpromazine; Egtazic Acid; Nifedipine; Spores, Bacterial; Streptomyces; Verapamil | 1994 |
[Effects of calcium blockers and calmodulin inhibitors on the proliferation of fibroblast in alveolar macrophage condition medium].
Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Cell Division; Chlorpromazine; Culture Media, Conditioned; Diltiazem; Fibroblasts; Humans; Lung Neoplasms; Macrophages, Alveolar; Pulmonary Fibrosis; Sarcoidosis; Verapamil | 1993 |
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carrier Proteins; Cattle; Cells, Cultured; Chlorpromazine; Cyclosporine; Membrane Glycoproteins; Progesterone; Tritium; Verapamil; Vincristine | 1993 |
[Protective effects of combination of chlorpromazine and verapamil on ischemia-reperfusion induced injury in rat myocardium].
Topics: Animals; Chlorpromazine; Drug Therapy, Combination; Female; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation; Verapamil | 1993 |
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; Disease Models, Animal; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Ketotifen; Malaria, Falciparum; Plasmodium falciparum; Prochlorperazine; Propylamines; Verapamil | 1993 |
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Calcium Channel Blockers; Cell Death; Chlorpromazine; DNA Damage; Liver; Male; Mice; Necrosis; Verapamil | 1993 |
Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Biological Transport, Active; Cefazolin; Chlorpromazine; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Male; Propantheline; Rats; Rats, Sprague-Dawley; Theophylline; Verapamil | 1995 |
Trypanocidal resistance in Trypanosoma evansi in vitro: effects of verapamil, cyproheptidine, desipramine and chlorpromazine alone and in combination with trypanocides.
Topics: Animals; Calcium Channel Blockers; Chlorpromazine; Cyproheptadine; Desipramine; Diminazene; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Melarsoprol; Suramin; Trypanocidal Agents; Trypanosoma; Verapamil | 1996 |
Calcium channel blockers induce thymic apoptosis in vivo in rats.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Chlorpromazine; Diltiazem; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Hydrocortisone; Hypotension; Image Processing, Computer-Assisted; Injections, Intraperitoneal; Male; Microscopy, Electron; Nicardipine; Nifedipine; Nitroprusside; Organ Size; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; T-Lymphocytes; Thymus Gland; Verapamil | 1996 |
Effects of haloperidol and chlorpromazine on smooth muscle contractility, platelet aggregation and neuronal calcium current.
Topics: Animals; Antipsychotic Agents; Butyrophenones; Calcium Channel Blockers; Calcium Channels; Calmodulin; Chlorpromazine; Droperidol; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neurons; Phenothiazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prazosin; Rats; Rats, Wistar; Snails; Sulpiride; Thrombin; Ureter; Verapamil | 1995 |
Dopamine potentiation of calcium ionophore, A-23187-induced platelet aggregation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Androstadienes; Aspirin; Benzophenanthridines; Calcimycin; Calcium; Chlorpromazine; Diltiazem; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; GTP-Binding Proteins; Haloperidol; Homovanillic Acid; Humans; Indomethacin; Ion Transport; Ionophores; Phenanthridines; Phentolamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Dopamine; Serotonin; Signal Transduction; Verapamil; Wortmannin | 1997 |
Effect of calmodulin-inhibitors and verapamil on the nephrotoxicity of cadmium in rat.
Topics: Animals; Cadmium Chloride; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Dopamine Antagonists; Drug Synergism; Enzyme Inhibitors; Female; Injections, Subcutaneous; Kidney Diseases; Kidney Tubules; Proteins; Proteinuria; Rats; Rats, Sprague-Dawley; Trifluoperazine; Uteroglobin; Verapamil | 1998 |
The absence of stereoselective P-glycoprotein-mediated transport of R/S-verapamil across the rat jejunum.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorpromazine; Intestinal Absorption; Jejunum; Male; Rats; Stereoisomerism; Vasodilator Agents; Verapamil | 1998 |
[Effects of calcium channel blockers and calmodulin inhibitors on the secretion of endothelin-1 in cultured endothelial cells].
Topics: Alkaloids; Benzylisoquinolines; Calcium Channel Blockers; Calmodulin; Cells, Cultured; Chlorpromazine; Diltiazem; Endothelin-1; Endothelium, Vascular; Humans; Nitroglycerin; Umbilical Veins; Verapamil | 1997 |
Monitoring of cellular resistance to cancer chemotherapy: drug retention and efflux.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Calcium Channel Blockers; Cell Membrane Permeability; Chlorpromazine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Mice; Rhodamine 123; Staining and Labeling; Tumor Cells, Cultured; Verapamil | 2001 |
Chlorpromazine inhibits hepatocyte apoptosis caused by withdrawal of phenobarbital in mice.
Topics: Animals; Apoptosis; Aspirin; Calcium Channel Blockers; Calmodulin; Cell Division; Chlorpromazine; Cyclooxygenase Inhibitors; Liver; Male; Mice; Phenobarbital; Random Allocation; Verapamil | 1999 |
Effect of calcium and calmodulin modulators on the development of Erysiphe pisi on pea leaves.
Topics: Ascomycota; Calcium; Calcium Channel Blockers; Calmodulin; Chelating Agents; Chlorpromazine; Egtazic Acid; Pisum sativum; Plant Leaves; Ruthenium Red; Verapamil | 2001 |
Selective modulation of P-glycoprotein-mediated drug resistance.
Topics: Allosteric Regulation; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Cell Division; Cell Membrane; Chlorpromazine; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Membrane Lipids; Neoplasm Proteins; Phospholipids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temperature; Tumor Cells, Cultured; Verapamil; Vinblastine | 2001 |
D-galactosamine induced hepatocyte apoptosis is inhibited in vivo and in cell culture by a calcium calmodulin antagonist, chlorpromazine, and a calcium channel blocker, verapamil.
Topics: Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Signaling; Calmodulin; Cells, Cultured; Chlorpromazine; DNA Fragmentation; Galactosamine; Hepatocytes; Male; Mice; Mice, Inbred C57BL; Verapamil | 2003 |
Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro.
Topics: Anti-Bacterial Agents; Biological Transport, Active; Chlorpromazine; Drug Resistance, Bacterial; Methicillin Resistance; Oxacillin; Phenothiazines; Reserpine; Staphylococcus aureus; Thioridazine; Verapamil | 2003 |
High-performance liquid chromatography of some basic drugs on a n-octadecylphosphonic acid modified magnesia-zirconia stationary phase.
Topics: Chlorpromazine; Doxepin; Drug Stability; Hydrogen-Ion Concentration; Indicators and Reagents; Magnesium Oxide; Organic Chemicals; Organophosphonates; Pharmaceutical Preparations; Verapamil; Zirconium | 2005 |
Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis.
Topics: Anti-Bacterial Agents; Automation; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorpromazine; Ethidium; Fluorometry; Membrane Transport Proteins; Mycobacterium avium; Mycobacterium smegmatis; Thioridazine; Time Factors; Verapamil | 2008 |
Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo.
Topics: Animals; Antioxidants; Cadmium; Cadmium Poisoning; Calcium Channel Blockers; Calcium-Transporting ATPases; Chlorpromazine; Female; Kidney; Kidney Cortex; Male; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Verapamil | 2010 |
The role of efflux pumps in macrolide resistance in Mycobacterium avium complex.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Biological Transport, Active; Chlorpromazine; Drug Resistance, Bacterial; Humans; Macrolides; Membrane Transport Proteins; Microbial Sensitivity Tests; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Thioridazine; Uncoupling Agents; Verapamil | 2009 |
Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae.
Topics: Animals; Chlorpromazine; Cisapride; Cytochrome P-450 Enzyme System; Larva; Pharmaceutical Preparations; Pharmacokinetics; Substrate Specificity; Verapamil; Zebrafish | 2010 |
Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis.
Topics: Antitubercular Agents; Bacterial Proteins; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorpromazine; Farnesol; Membrane Transport Proteins; Microbial Sensitivity Tests; Mycobacterium smegmatis; Nitriles; Reserpine; Verapamil | 2010 |
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biological Transport, Active; Carrier Proteins; Catalase; Chlorpromazine; DNA-Directed RNA Polymerases; Drug Resistance, Multiple, Bacterial; Gene Expression; Humans; Isoniazid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Rifampin; Thioridazine; Tuberculosis, Multidrug-Resistant; Verapamil | 2012 |
Fungicide efflux and the MgMFS1 transporter contribute to the multidrug resistance phenotype in Zymoseptoria tritici field isolates.
Topics: Ascomycota; Base Sequence; Chlorpromazine; Drug Resistance, Fungal; Drug Resistance, Multiple; Fungicides, Industrial; Genotype; Membrane Transport Proteins; Molecular Sequence Data; Mutation; Phenotype; Plant Diseases; Plant Leaves; Promoter Regions, Genetic; RNA, Fungal; Sequence Alignment; Sequence Analysis, RNA; Triticum; Verapamil | 2015 |
[In vitro study of the radial artery vasodilatory reactions].
Topics: Chlorpromazine; Dopamine Antagonists; Heparin; Humans; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroglycerin; Papaverine; Radial Artery; Tissue Culture Techniques; Vasodilator Agents; Verapamil | 2014 |
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil | 2015 |
Antimycobacterial activity of five efflux pump inhibitors against Mycobacterium tuberculosis clinical isolates.
Topics: Adult; Antitubercular Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; China; Chlorpromazine; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Reserpine; Thioridazine; Tuberculosis, Pulmonary; Verapamil | 2016 |
Chromatographic studies of drug interactions with alpha
Topics: Chlorpromazine; Chromatography, Affinity; Humans; Imipramine; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Verapamil | 2017 |
Calculating Kinetic Rates and Membrane Permeability from Biased Simulations.
Topics: Cell Membrane Permeability; Chlorpromazine; Desipramine; Domperidone; Kinetics; Labetalol; Lipid Bilayers; Loperamide; Molecular Dynamics Simulation; Molecular Structure; Propranolol; Thermodynamics; Verapamil | 2018 |
Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Death; Cell Line, Tumor; Chlorpromazine; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Female; Humans; Inhibitory Concentration 50; Lipids; Madin Darby Canine Kidney Cells; Nanoparticles; Paclitaxel; Particle Size; Verapamil | 2018 |