chlorpromazine and theophylline

chlorpromazine has been researched along with theophylline in 85 studies

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-199046 (54.12)18.7374
1990's4 (4.71)18.2507
2000's11 (12.94)29.6817
2010's21 (24.71)24.3611
2020's3 (3.53)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Caron, G; Ermondi, G1
Abraham, MH; Acree, WE; Ibrahim, A1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, J; Chen, X; Huang, L; Li, X; Sun, Y1
Huang, L; Li, X; Meng, F; Miao, H; Sun, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Aitken, L; Benek, O; Dohnal, V; Dolezal, R; Guest, P; Gunn-Moore, F; Hroch, L; Janockova, J; Kuca, K; Musil, K; Musilek, K; Smith, TK; Soukup, O1
Bajda, M; Gobec, S; Godyń, J; Janockova, J; Jończyk, J; Knez, D; Korabecny, J; Malawska, B; Mika, K; Panek, D; Soukup, O; Wichur, T; Więckowska, A1
Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL1
Andrisano, V; Apperley, KYP; Bartolini, M; Baschieri, A; Basso, M; Chen, HH; De Simone, A; Guardigni, M; Keillor, JW; Kobrlova, T; Milelli, A; Montanari, S; Soukup, O; Valgimigli, L1
Chreifi, G; Do, HT; Li, H; Poulos, TL; Silverman, RB; Wang, HY1
An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T1
Cheng, M; Guo, J; Jiang, N; Li, Q; Liang, N; Liu, J; Nong, X; Pang, C; Qin, Y; Tang, C; Tang, W; Xie, SS; Zhang, Z1
Cheng, M; Fang, Y; Guo, J; Jin, Y; Liu, J; Wan, Y; Wang, R; Xie, SS; Zhang, Z; Zhou, W1
Hardy, CD; Li, H; Poulos, TL; Silverman, RB; Vasu, D1
Mori, J; Shimomura, K; Tomoi, M1
Fujiwara, M; Oishi, R; Razzak, A; Ueki, S1
Passonneau, JV; Watanabe, H1
Gárdos, G; Sarkadi, B; Szász, I1
Garrettson, LK; Lee, AJ; Wood, JH1
Borowitz, JL; Peyton, JC1
Jhamandas, K; Sawynok, J; Sutak, M1
Frølich, KW; Holmsen, H; Steen, VM; Tysnes, OB1
Forsyth, GW; Maenz, DD; Wong, PH1
Botana, LM; Espinosa, J; Fernández-Otero, MP1
Fujita, K; Fujita, Y; Mori, I; Nakahashi, Y; Tanaka, T1
Barboza, R; Chacín, J1
Crepaldi, G; Jemmolo, RM; Lirussi, F; Muraca, M; Nassuato, G; Okolicsanyi, L; Orlando, R; Strazzabosco, M1
French, SW1
Georgi, H; Gey, KF1
Bounameaux, Y1
Molnár, J; Prágai, B1
Massey, KL; Yamamoto, M1
Williams, JA; Wolff, J1
Roberts, E; Simonsen, DG1
Horlington, M; Watson, PA1
Kodama, T; Matsukado, Y; Shimizu, H; Suzuki, T; Tanaka, S1
Born, GV1
Williams, JA1
Reid, L; Whimster, WF1
Berndt, S; Schwabe, U1
Kakác, B; Malý, V; Protiva, J; Sarsúnová, M; Schwarz, V1
Kakiuchi, S; McIlwain, H; Rall, TW1
Chibanguza, G1
Hellman, B; Lernmark, A; Sehlin, J; Täljedal, IB1
Bärmig, H; Rasche, P1
Bligh, J; Cremer, JE1
Castelli, G; Nardini, L1
Laplace, JP; Ruckebusch, Y1
Burgison, RM; Dietz, AJ1
Hyun, CS; Kimmich, GA1
Luczynska, C; Wilson, K1
Farack, UM; Nell, G; Rummel, W1
Bárány, K; Bárány, M; Barron, JT; Storti, RV1
Thomas, G; Voigt, R1
Bunce, KT; Spraggs, CF1
Doutlík, S; Hanzl, M; Pekárek, J; Rybnícek, A; Svejcar, J; Vacek, Z1
Kostyuk, PG; Lukyanetz, EA1
Aungst, BJ; Saitoh, H1
Du Souich, P; El-Kadi, A; Haddad, P; Serrar, H1
FREY, HH; HOLTZ, G; SOEHRING, K1
COLE, SL; GRIFFITH, GC; KAYE, H1
CERRA, R; PERCESEPE, E1
SPIERS, AS1
Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W1

Reviews

5 review(s) available for chlorpromazine and theophylline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The effect of drugs on bile flow and composition. An overview.
    Drugs, 1986, Volume: 31, Issue:5

    Topics: Animals; Bile; Bile Acids and Salts; Cats; Chlorpromazine; Cholagogues and Choleretics; Cholesterol; Clofibrate; Colchicine; Cricetinae; Dehydrocholic Acid; Diuretics; Dogs; Enterohepatic Circulation; Estrogens; Glucagon; Guinea Pigs; Humans; Insulin; Liver; Macaca mulatta; Phospholipids; Rabbits; Rats; Rifampin; Rifamycins; Somatostatin; Theophylline; Ursodeoxycholic Acid

1986
Role of canalicular contraction in bile flow.
    Laboratory investigation; a journal of technical methods and pathology, 1985, Volume: 53, Issue:3

    Topics: Bile; Bile Canaliculi; Bile Ducts, Intrahepatic; Calcium; Chlorpromazine; Cyclic AMP; Cytochalasin B; Cytochalasin D; Cytochalasins; Cytoskeleton; Ethanol; Humans; Microtubules; Models, Biological; Movement; Sodium-Potassium-Exchanging ATPase; Theophylline

1985
Body-temperature and responses to drugs.
    British medical bulletin, 1969, Volume: 25, Issue:3

    Topics: Acetylcholine; Anesthetics; Animals; Body Temperature; Body Temperature Regulation; Cats; Chlorpromazine; Dinitrophenols; Dogs; Humans; Hypothalamus; Infant, Newborn; Metabolism; Muscle Contraction; Norepinephrine; Pyrogens; Rabbits; Rats; Salicylates; Serotonin; Theophylline

1969
The clinical significance of the effects of cigarette smoking on drug disposition.
    Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:7

    Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin

1983

Other Studies

80 other study(ies) available for chlorpromazine and theophylline

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
    Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

    Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine

2013
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates

2014
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.
    Bioorganic & medicinal chemistry letters, 2016, 08-01, Volume: 26, Issue:15

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Urea

2016
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Amines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Binding Sites; Blood-Brain Barrier; Cholinesterases; Drug Delivery Systems; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregation, Pathological; Protein Binding; Saccharin

2017
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species

2017
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: Alzheimer Disease; Animals; Cinnamates; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycogen Synthase Kinase 3 beta; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2017
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
    Journal of medicinal chemistry, 2017, 11-22, Volume: 60, Issue:22

    Topics: Aminopyridines; Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Fluorobenzenes; Humans; Mice; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Structure-Activity Relationship; Swine; Theophylline; Verapamil

2017
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2019, Feb-01, Volume: 163

    Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram

2019
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Clorgyline; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Male; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2020
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzothiazoles; Benzylamines; Biphenyl Compounds; Butyrylcholinesterase; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neuroprotective Agents; Picrates; Rats; Structure-Activity Relationship; Sulfonic Acids; Xanthones

2021
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
    Bioorganic & medicinal chemistry, 2022, 09-01, Volume: 69

    Topics: Aminopyridines; Animals; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Isoforms; Rats

2022
The role of caudate nucleus dopamine and cyclic AMP in the hyperpyrexia induced by LiCl plus tranylcypromine in rats.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Caudate Nucleus; Chlorpromazine; Cyclic AMP; Dopamine; Fever; Hypothalamus; Lithium; Male; Phenoxybenzamine; Phentolamine; Rats; Rectum; Theophylline; Tranylcypromine

1979
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline

1977
Cyclic adenosine monophosphate in cerebral cortex. Alterations following trauma.
    Archives of neurology, 1975, Volume: 32, Issue:3

    Topics: Animals; Cerebral Cortex; Chlorpromazine; Craniocerebral Trauma; Cyclic AMP; Diphenhydramine; Ethanolamines; Hypothermia, Induced; Isoproterenol; Male; Mice; Reserpine; Theophylline; Time Factors; Trifluoperazine

1975
Effect of drugs on the calcium-dependent rapid potassium transport in calcium-loaded intact red cells.
    Acta biochimica et biophysica; Academiae Scientiarum Hungaricae, 1978, Volume: 13, Issue:3

    Topics: Biological Transport, Active; Calcimycin; Calcium; Chlorpromazine; Dipyridamole; Erythrocytes; Histamine; Humans; Kinetics; Lanthanum; Norepinephrine; Potassium; Propranolol; Serotonin; Theophylline

1978
Periodicity during the distributive phase for drugs administered intravenously to humans.
    Drug metabolism reviews, 1979, Volume: 9, Issue:1

    Topics: Chlorpromazine; Computers; Humans; Infusions, Parenteral; Models, Biological; Pharmaceutical Preparations; Theophylline; Time Factors

1979
Chlordiazepoxide and theophylline alter calcium levels in subcellular fractions of rat brain cortex.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 161, Issue:2

    Topics: Animals; Calcium; Cerebral Cortex; Chlordiazepoxide; Chlorpromazine; Male; Microsomes; Mitochondria; Rats; Subcellular Fractions; Synaptosomes; Theophylline

1979
Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium.
    European journal of pharmacology, 1978, Jun-01, Volume: 49, Issue:3

    Topics: Acetylcholine; Animals; Brain; Caffeine; Calcium; Chlorpromazine; Morphine; Rats; Theophylline; Xanthines

1978
Evidence that chlorpromazine and prostaglandin E1 but not neomycin interfere with the inositol phospholipid metabolism in intact human platelets.
    FEBS letters, 1990, May-07, Volume: 264, Issue:1

    Topics: Alprostadil; Blood Platelets; Chlorpromazine; Humans; In Vitro Techniques; Inositol Phosphates; Kinetics; Neomycin; Phosphates; Phosphorus Radioisotopes; Theophylline

1990
Calcium mediation of the pig jejunal secretory response.
    Canadian journal of comparative medicine : Revue canadienne de medecine comparee, 1985, Volume: 49, Issue:2

    Topics: Animals; Bacterial Toxins; Calcimycin; Calcium; Cell Membrane Permeability; Chlorpromazine; Dantrolene; Egtazic Acid; Enterotoxins; Escherichia coli Proteins; Intestinal Mucosa; Ion Channels; Jejunum; Membrane Potentials; Swine; Theophylline; Verapamil

1985
[Response of pleural and peritoneal mastocyte populations in the rat to agents with different mechanisms of action].
    Revista espanola de fisiologia, 1986, Volume: 42, Issue:4

    Topics: Animals; Chlorpromazine; Female; Histamine Release; Male; Mast Cells; Peritoneal Cavity; Pleura; Propranolol; Rats; Ruthenium Red; Sodium Fluoride; Theophylline

1986
Determination of chlorpromazine, thiamine, lincomycin, ofloxacin and theophylline by ternary complex formation with eosin and palladium(II).
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:12

    Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Eosine Yellowish-(YS); Lincomycin; Ofloxacin; Oxazines; Palladium; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Thiamine

1987
Effects of phenothiazines on acid secretion in the toad gastric mucosa.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 81, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Bufo marinus; Carbachol; Chlorpromazine; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Histamine; Kinetics; Microsomes; Protein Kinases; Theophylline; Trifluoperazine

1985
Effect of neurotropic agents on total pyridoxal phosphate and on the activity of the decarboxylose of aromatic amino acids as well as of other pyridoxal phosphate-dependent enzymes in rat brains.
    Journal of neurochemistry, 1974, Volume: 23, Issue:4

    Topics: Acetates; Amphetamine; Animals; Anti-Anxiety Agents; Atropine; Benzodiazepines; Brain; Carbon Radioisotopes; Carboxy-Lyases; Chloroform; Chlorpromazine; Cocaine; Dihydroxyphenylalanine; Ether; Female; Glutamates; Haloperidol; Hydroxylamines; Methylphenidate; Oxotremorine; Pentobarbital; Pentylenetetrazole; Pyridoxal Phosphate; Quinolines; Rats; Reserpine; Scopolamine; Semicarbazides; Theophylline; Tranylcypromine; Tyrosine Transaminase

1974
[Studies on the effect of various substances on platelet function with several methods].
    Die Medizinische Welt, 1973, Feb-02, Volume: 24, Issue:5

    Topics: Amphetamine; Anti-Anxiety Agents; Blood Platelets; Caffeine; Chlorpromazine; Debrisoquin; Dibenzazepines; Flurazepam; Guanethidine; Humans; Oxazoles; Papaverine; Phenytoin; Platelet Aggregation; Pyridines; Theophylline

1973
Repression of alkaline phosphatase synthesis by adenine, adenosine and adenine nucleotides in an adenine auxotroph of Bacillus anthracis.
    Acta microbiologica Academiae Scientiarum Hungaricae, 1973, Volume: 20, Issue:3

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Alkaline Phosphatase; Bacillus anthracis; Caffeine; Chlorpromazine; Culture Media; Dinitrophenols; Enzyme Repression; Inosine Nucleotides; Lyases; Mutation; Phosphates; Theophylline

1973
Cyclic 3',5'-nucleotide phosphodiesterase of fish (Salmo gairdnerii) brain.
    Comparative biochemistry and physiology, 1969, Sep-01, Volume: 30, Issue:5

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Brain; Chlorpromazine; Citrates; Cyclic AMP; Diphosphates; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Limbic System; Magnesium; Manganese; Medulla Oblongata; Microscopy, Electron; Myocardium; Organ Specificity; Phosphates; Phosphoric Monoester Hydrolases; Plants; Reserpine; Salmonidae; Synapses; Temperature; Theophylline

1969
Thyroid secretion in vitro: multiple actions of agents affecting secretion.
    Endocrinology, 1971, Volume: 88, Issue:1

    Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Cell Membrane; Chlorpromazine; Cyclic AMP; Detergents; Fluorides; In Vitro Techniques; Iodine; Iodine Isotopes; Iodoproteins; Lysosomes; Male; Mice; Proteins; Pyridinium Compounds; Stimulation, Chemical; Theophylline; Thyroid Gland; Thyrotropin

1971
Some properties of cyclic 3',5'-nucleotide phosphodiesterase of mouse brain: effects of imidazole-4-acetic acid, chlorpromazine, cyclic 3',5'-GMP, and other substances.
    Brain research, 1970, Nov-11, Volume: 24, Issue:1

    Topics: Acetates; Animals; Brain; Chlorpromazine; Cyclic AMP; Guanine Nucleotides; Imidazoles; Magnesium; Mice; Nortriptyline; Nucleosides; Phosphates; Phosphoric Monoester Hydrolases; Purines; Pyrimidines; Theophylline

1970
Inhibition of 3'5'-cyclic-AMP phosphodiesterase by some platelet aggregation inhibitors.
    Biochemical pharmacology, 1970, Volume: 19, Issue:3

    Topics: Animals; Blood Platelets; Cattle; Cell Aggregation; Chlorine; Chlorpromazine; Cyclic AMP; Esterases; Female; Nucleosides; Phenothiazines; Promethazine; Theophylline

1970
Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices.
    Biochimica et biophysica acta, 1971, Volume: 252, Issue:1

    Topics: Adenine; Adenosine Triphosphate; Amitriptyline; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cyclic AMP; Desipramine; Guinea Pigs; Histamine; Imipramine; Male; Norepinephrine; Perphenazine; Phentolamine; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Theophylline; Tritium; Veratrine

1971
Inhibition of platelet aggregation by chemicals and drugs.
    Acta medica Scandinavica. Supplementum, 1971, Volume: 525

    Topics: Adenosine; Amitriptyline; Blood Coagulation; Blood Platelets; Chlorpromazine; Cyclic AMP; Fibrinogen; Imipramine; Prostaglandins; Theophylline

1971
Cyclic AMP formation and thyroid secretion by incubated mouse thyroid lobes.
    Endocrinology, 1972, Volume: 91, Issue:6

    Topics: Animals; Calcium; Chlorpromazine; Colchicine; Cyclic AMP; Cytochalasin B; In Vitro Techniques; Iodine; Iodine Isotopes; Lithium; Male; Mice; Ouabain; Sodium; Stimulation, Chemical; Theophylline; Thyroid Gland; Thyrotropin; Time Factors

1972
The influence of dibutyryl cyclic adenosine monophosphate and other substances on human bronchial mucous gland discharge.
    Experimental and molecular pathology, 1973, Volume: 18, Issue:2

    Topics: Bronchi; Butyrates; Chlorpromazine; Culture Techniques; Cyclic AMP; Glucose; Humans; Lithium; Mucous Membrane; Mucus; Opipramol; Stimulation, Chemical; Theophylline; Tritium

1973
Effect of psychotropic drugs on phosphodiesterase and cyclic AMP level in rat brain in vivo.
    Brain research, 1973, Dec-07, Volume: 63

    Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlorpromazine; Chlorprothixene; Cyclic AMP; Desipramine; Haloperidol; Imipramine; Male; Phosphoric Diester Hydrolases; Rats; Theophylline; Tranquilizing Agents; Triflupromazine; Tritium

1973
[Thin layer chromatography without binding agent in drug analysis. 8. Separation and quantitative determination of antihistaminics and ataraxics].
    Die Pharmazie, 1966, Volume: 21, Issue:12

    Topics: Aluminum; Anti-Arrhythmia Agents; Benactyzine; Chlorpromazine; Chromatography, Thin Layer; Guaiacol; Histamine H1 Antagonists; Imidazoles; Infrared Rays; Iodine; Meprobamate; Methods; Oxides; Parasympatholytics; Phenmetrazine; Promethazine; Spectrophotometry; Theophylline; Tranquilizing Agents; Ultraviolet Rays

1966
The effect of electrical stimulation upon the accumulation of adenosine 3',5'-phosphate in isolated cerebral tissue.
    Journal of neurochemistry, 1969, Volume: 16, Issue:4

    Topics: Adenine Nucleotides; Animals; Centrifugation; Cerebral Cortex; Chlorpromazine; Chromatography; Cyclic AMP; Diphenhydramine; Electric Stimulation; Freeze Drying; Guinea Pigs; Histamine; Histamine Antagonists; In Vitro Techniques; Isoproterenol; Norepinephrine; Photometry; Theophylline; Tritium

1969
[The emetic action of theophylline in the dog].
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 212, Issue:1

    Topics: Animals; Chlorpromazine; Dogs; Dose-Response Relationship, Drug; Emetics; Haloperidol; Myotonia; Nausea; Reaction Time; Reserpine; Theophylline; Time Factors; Tremor

1974
The pancreatic -cell recognition of insulin secretagogues. V. Binding and stimulatory action of phlorizin.
    Molecular pharmacology, 1972, Volume: 8, Issue:6

    Topics: Animals; Antimycin A; Arginine; Carbon Isotopes; Chloromercuribenzoates; Chlorpromazine; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Heptoses; Hyperglycemia; Insulin; Insulin Secretion; Iodine Isotopes; Islets of Langerhans; Ketones; Mice; Obesity; Organ Size; Phloretin; Phlorhizin; Sucrose; Theophylline; Time Factors; Tritium

1972
[Atypical course in postpartum eclampsia? A case report].
    Zentralblatt fur Gynakologie, 1972, Dec-02, Volume: 94, Issue:48

    Topics: Adult; Chlorpromazine; Diazepam; Eclampsia; Female; Humans; Hypertension; Infant, Newborn; Infant, Premature; Ischemic Attack, Transient; Nicotinic Acids; Pregnancy; Pressure Ulcer; Promethazine; Puerperal Disorders; Theophylline; Twins

1972
[Statistical reports of the psychopharmacological agents used in the past 10 years in the Ospedale Neuropsichiatrico Provinciale of Mantua].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1967, Oct-31, Volume: 91, Issue:5

    Topics: Chlorpromazine; Chlorprothixene; Humans; Mental Disorders; Orphenadrine; Pentylenetetrazole; Phenelzine; Phenothiazines; Reserpine; Theophylline; Thioridazine; Tranquilizing Agents

1967
[Pharmacologic changes in feeding behavior: food intake and rumination in sheep].
    Psychopharmacologia, 1968, Volume: 12, Issue:2

    Topics: Amphetamine; Animals; Apomorphine; Atropine; Behavior, Animal; Cerebral Cortex; Chlorpromazine; Digestion; Digitalis Glycosides; Eating; Imipramine; Iproniazid; Lanatosides; Mescaline; Methylphenidate; Morphine; Ouabain; Pentobarbital; Psychopharmacology; Reticulum; Rumen; Sheep; Theophylline

1968
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
    Toxicology and applied pharmacology, 1968, Volume: 12, Issue:2

    Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental

1968
Effect of cholera toxin on cAMP levels and Na+ influx in isolated intestinal epithelial cells.
    The American journal of physiology, 1982, Volume: 243, Issue:3

    Topics: Animals; Bucladesine; Calcitonin; Chickens; Chlorpromazine; Cholera Toxin; Cyclic AMP; Intestine, Small; Sodium; Theophylline; Time Factors

1982
Differentiation of secretagogue drugs by chlorpromazine in rat intestine in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 324, Issue:1

    Topics: Animals; Body Water; Chlorpromazine; Cholera Toxin; Deoxycholic Acid; Female; Intestinal Mucosa; Intestines; Oxyphenisatin Acetate; Rats; Rats, Inbred Strains; Theophylline

1983
Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.
    The Journal of biological chemistry, 1980, Jul-10, Volume: 255, Issue:13

    Topics: Animals; Calcium; Carotid Arteries; Chlorpromazine; Egtazic Acid; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosins; Norepinephrine; Phosphates; Phosphorylation; Potassium Chloride; Swine; Theophylline; Trifluoperazine

1980
[Effects of the pH value and of drug-adjuvant interactions on the dissolution rate and the liberation of drugs].
    Die Pharmazie, 1983, Volume: 38, Issue:3

    Topics: Adjuvants, Pharmaceutic; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Chlorpromazine; Hydrogen-Ion Concentration; Kinetics; Solubility; Theophylline

1983
The effect of chlorpromazine on the function of colonic and ileal mucosa in the anaesthetized rat.
    British journal of pharmacology, 1982, Volume: 77, Issue:3

    Topics: Alprostadil; Anesthesia; Animals; Chlorpromazine; Colon; Ileum; Intestinal Mucosa; Intestinal Secretions; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Theophylline

1982
[Drug-controlled macrophage migration inhibition test (author's transl)].
    Casopis lekaru ceskych, 1980, Volume: 119, Issue:11

    Topics: Cell Migration Inhibition; Chlorpromazine; Diazepam; Humans; Macrophages; Meperidine; Theophylline

1980
Mechanisms of antagonistic action of internal Ca2+ on serotonin-induced potentiation of Ca2+ currents in Helix neurones.
    Pflugers Archiv : European journal of physiology, 1993, Volume: 424, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Calmodulin; Chlorpromazine; Cyclic AMP; Egtazic Acid; Electric Conductivity; Enzyme Activation; Ethers, Cyclic; Helix, Snails; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoric Diester Hydrolases; Serotonin; Theophylline; Trifluoperazine

1993
Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine.
    Pharmaceutical research, 1995, Volume: 12, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Biological Transport, Active; Cefazolin; Chlorpromazine; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Male; Propantheline; Rats; Rats, Sprague-Dawley; Theophylline; Verapamil

1995
Cytochrome P-450 content and activity after cold storage of rat hepatocytes in university of wisconsin and sodium-lactobionate-sucrose solutions.
    Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1999, Volume: 5, Issue:2

    Topics: Adenosine; Allopurinol; Animals; Cell Survival; Chlorpromazine; Cryopreservation; Cytochrome P-450 Enzyme System; Disaccharides; Glutathione; Insulin; Liver; Male; Organ Preservation Solutions; Raffinose; Rats; Rats, Sprague-Dawley; Sucrose; Theophylline

1999
[Influence of drugs on pyrogene reactions; practical testing of injection solutions with pyrogene substances].
    Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1956, Volume: 289, Issue:1

    Topics: Biological Factors; Biological Products; Chlorpromazine; Humans; Myocardium; Pharmaceutical Solutions; Theophylline

1956
Assay of anti-anginal agents. I. A curve analysis with multiple control periods.
    Circulation, 1957, Volume: 15, Issue:3

    Topics: Angina Pectoris; Cardiovascular Agents; Chlorpromazine; Nitrites; Theophylline

1957
[Clinical study of the use of a drug containing a combination of chlorpromazine, gardenal and theophylline-ethylenediamine in patients of malignant neoplasms].
    Rassegna internazionale di clinica e terapia, 1958, Jun-30, Volume: 38, Issue:12

    Topics: Aminophylline; Biomedical Research; Chlorpromazine; Electroencephalography; Humans; Neoplasms; Phenobarbital; Theophylline

1958
THE MANAGEMENT OF ASTHMATIC PATIENTS IN A CASUALTY DEPARTMENT.
    The Medical journal of Australia, 1964, Apr-18, Volume: 1

    Topics: Adrenal Cortex Hormones; Aminophylline; Amobarbital; Anti-Bacterial Agents; Antibiotics, Antitubercular; Asthma; Bronchodilator Agents; Chlorpromazine; Choline; Diuretics; Emergency Service, Hospital; Ephedrine; Epinephrine; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Norepinephrine; Organomercury Compounds; Oxygen Inhalation Therapy; Phenobarbital; Posture; Theophylline

1964
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
    Neurotoxicology, 2012, Volume: 33, Issue:1

    Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reaction Time; Seizures; Theophylline; Time Factors; Tramadol

2012