chlorpromazine and quinidine

chlorpromazine has been researched along with quinidine in 84 studies

Research

Studies (84)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (35.71)	18.7374
1990's	8 (9.52)	18.2507
2000's	27 (32.14)	29.6817
2010's	18 (21.43)	24.3611
2020's	1 (1.19)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Chiang, GH; Unger, SH	1
Guengerich, FP; Stöckigt, J; Strobl, GR; von Kruedener, S; Wolff, T	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Pajeva, IK; Wiese, M	1
Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Dalvie, D; Loi, CM; Smith, DA	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Romankiewicz, JA	1
Stossel, TP; Weitzman, SA	1
Briggs, FN; Pang, DC	2
Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M	1
DeCoursey, TE; Jacobs, ER	1
Burlingame, RW; Rubin, RL	1
Wood, M	1
Constantinides, PP; Inouchi, N; Sartorelli, AC; Sturtevant, JM; Tritton, TR	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Balzer, H; Hellenbrecht, D	1
Hellenbrecht, D	1
Keresztes-Nagy, S; Mais, RF; Oester, YT; Zaroslinski, JF	1
Wosilait, WD	1
Andersson, KE	2
Batra, S	1
Bhargava, KP; Dhawan, KN; Kulshrestha, VK; Shamsi, MA	1
Briggs, FN; Gertz, EW; Solaro, RJ	1
Mason, RG; Read, MS; Saba, SR; Shermer, RW	1
Jacobsen, CD	1
Fairhurst, AS; Hasselbach, W	1
Peter, JB; Worsfold, M	1
Blount, AW; Miller, DS	1
Ciofalo, FR	1
Richardson, BC; Yung, RL	1
Jiang, X; Khursigara, G; Rubin, RL	1
Cooper, JK; Hawes, EM; Korchinski, ED; Midha, KK; Muralidharan, G	1
Bolton, JL; Nikolic, D; van Breemen, RB	1
Ma, Y; Tang, X; Yang, X	1
Brozmanová, H; Fendrich, Z; Grundmann, M; Láznícek, M; Malákova, J; Palicka, V; Pávek, P; Semecký, V; Staud, F	1
Fendrich, Z; Kopecky, M; Libra, A; Nobilis, M; Novotna, M; Pavek, P; Semecky, V; Sklenarova, H; Staud, F	1
HUANG, TF	1
MAEKAWA, M; NOHARA, Y	1
BONAMOUR, G; DIDIER-LAURENT, A	1
CLARKE, RS; DUNDEE, JW	1
BEAULNES, A; LAVALLEE, M	1
Bhoopathy, S; Karnes, HT; Unger, SE; Xin, B	1
Banach, T; Bonior, J; Kogut, P; Zarow, R	1
Wen, B; Zhou, M	1
Chen, Y; Subramanian, R; Zhu, X	1

Reviews

4 review(s) available for chlorpromazine and quinidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Plasma drug binding: implications for anesthesiologists. Anesthesia and analgesia, 1986, Volume: 65, Issue:7 Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Cardiac Surgical Procedures; Chlorpromazine; Dipyridamole; Disopyramide; Etidocaine; Female; Fentanyl; Half-Life; Humans; Imipramine; Kidney Diseases; Lidocaine; Liver; Mathematics; Meperidine; Methadone; Myocardial Infarction; Orosomucoid; Prazosin; Pregnancy; Propranolol; Protein Binding; Quinidine; Serum Albumin; Sex Factors	1986
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
Drug-induced lupus. Rheumatic diseases clinics of North America, 1994, Volume: 20, Issue:1 Topics: Anticonvulsants; Chlorpromazine; Complement System Proteins; DNA; HLA Antigens; Humans; Interferons; Isoniazid; Lupus Erythematosus, Systemic; Penicillamine; Quinidine	1994

Trials

1 trial(s) available for chlorpromazine and quinidine

Article	Year
Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine. European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2 Topics: Adult; Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Depression, Chemical; Enzyme Inhibitors; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Quinidine	1996

Article

Year

Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine.

European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2

Topics: Adult; Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Depression, Chemical; Enzyme Inhibitors; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Quinidine

1996

Other Studies

79 other study(ies) available for chlorpromazine and quinidine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. Journal of medicinal chemistry, 1993, Apr-30, Volume: 36, Issue:9 Topics: Alkaloids; Computer Simulation; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Ethanolamines; Humans; Indoles; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Conformation; Molecular Structure; Quinidine; Quinolines; Secologanin Tryptamine Alkaloids; Yohimbine	1993
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine	2002
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Molecular pharmacology, 2003, Volume: 63, Issue:3 Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection	2003
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Effects of antacids on gastrointestinal absorption of drugs. Primary care, 1976, Volume: 3, Issue:3 Topics: Animals; Antacids; Aspirin; Chlordiazepoxide; Chlorpromazine; Dicumarol; Digitoxin; Digoxin; Ephedrine; Guinea Pigs; Humans; Intestinal Absorption; Iron; Isoniazid; Levodopa; Naproxen; Pentobarbital; Pharmaceutical Preparations; Quinidine; Quinine; Rats; Sulfadiazine; Tetracyclines; Warfarin	1976
Drug-induced immunological neutropenia. Lancet (London, England), 1978, May-20, Volume: 1, Issue:8073 Topics: Adolescent; Adult; Aged; Agranulocytosis; Chlorothiazide; Chlorpromazine; Complement C3; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Immunoglobulin M; Male; Methimazole; Middle Aged; Neutropenia; Neutrophils; Opsonin Proteins; Penicillins; Quinidine	1978
Mechanism of quinidine and chlorpromazine inhibition of sarcotubular ATPase activity. Biochemical pharmacology, 1976, Volume: 25, Issue:1 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Chlorpromazine; Dogs; Kinetics; Magnesium; Myocardium; Quinidine; Sarcoplasmic Reticulum	1976
The mechanism of chlorpromazine and quinidine inhibition of cardiac sarcotubular ATPase. Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 7 Topics: Adenosine Triphosphatases; Animals; Chlorpromazine; Dogs; In Vitro Techniques; Kinetics; Mathematics; Myocardium; Quinidine; Sarcoplasmic Reticulum	1975
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes. Pharmaceutical research, 1992, Volume: 9, Issue:9 Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil	1992
Mechanisms of potassium channel block in rat alveolar epithelial cells. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2 Topics: Animals; Calcium; Calcium Channels; Capsaicin; Cells, Cultured; Charybdotoxin; Chlorpromazine; Epithelium; Gallopamil; Kinetics; Nifedipine; Phencyclidine; Potassium Channels; Pulmonary Alveoli; Quinidine; Rats; Scorpion Venoms; Tacrine; Tetraethylammonium Compounds; Verapamil	1990
Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin. The Journal of clinical investigation, 1991, Volume: 88, Issue:2 Topics: Autoantibodies; Chlorpromazine; Chromatin; DNA; Enzyme-Linked Immunosorbent Assay; Histones; Humans; Hydralazine; Immunoglobulin G; Immunoglobulin M; Lupus Vulgaris; Procainamide; Quinidine	1991
A scanning calorimetric study of the interaction of anthracyclines with neutral and acidic phospholipids alone and in binary mixtures. The Journal of biological chemistry, 1986, Aug-05, Volume: 261, Issue:22 Topics: Antibiotics, Antineoplastic; Calorimetry, Differential Scanning; Chlorpromazine; Doxorubicin; Hydrogen-Ion Concentration; Lipid Bilayers; Liposomes; Naphthacenes; Osmolar Concentration; Phosphatidylglycerols; Phospholipids; Pulmonary Surfactants; Quinidine	1986
Effect of reserpine and chlorpromazine on the resting potential and membrane resistance of the frog sartorius muscle after potassium depolarization. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4 Topics: Animals; Anura; Cell Membrane; Chlorpromazine; In Vitro Techniques; Membrane Potentials; Muscles; Potassium; Quinidine; Reserpine; Tetracaine	1970
Stabilizing-labilizing effects of reserpine, chlorpromazine, tetracaine, and quinidine on frog skeletal muscle fibers. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1971, Volume: 271, Issue:2 Topics: Animals; Anura; Cell Membrane; Chlorides; Chlorpromazine; Membrane Potentials; Muscle Contraction; Myofibrils; Organ Size; Potassium; Quinidine; Reserpine; Tetracaine; Time Factors	1971
Drug allergy. II. British medical journal, 1971, Apr-10, Volume: 2, Issue:5753 Topics: Aged; Anemia, Hemolytic; Antigen-Antibody Reactions; Blood Platelets; Chlorpromazine; Dermatitis, Contact; Drug Hypersensitivity; Female; Hemolysis; Histamine H1 Antagonists; Humans; Hypersensitivity, Delayed; Leukopenia; Methyldopa; Middle Aged; Penicillins; Photosensitivity Disorders; Protein Binding; Purpura; Quinidine; Sulfonamides	1971
Interpretation of protein-drug interaction through fraction bound and relative contribution of secondary sites. Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:9 Topics: Binding Sites; Carbon Radioisotopes; Chlorpromazine; Chromatography, Gel; Computers; Humans; In Vitro Techniques; Kinetics; Ligands; Mathematics; Models, Biological; Pharmaceutical Preparations; Protein Binding; Quinidine; Salicylates; Serum Albumin; Spectrophotometry; Warfarin	1974
An analysis of the effect of hypoalbuminemia on the amount of free drug in plasma for drugs bound at two sets of sites. Research communications in chemical pathology and pharmacology, 1974, Volume: 9, Issue:4 Topics: Binding Sites; Carbenoxolone; Chlorpromazine; Chlorpropamide; Computers; Dose-Response Relationship, Drug; Humans; Iopanoic Acid; Pharmaceutical Preparations; Phenylbutazone; Protein Binding; Quinidine; Salicylates; Serum Albumin; Sulfadiazine; Tolbutamide	1974
Effects of chlorpromazine, imipramine, and quinidine on the mechanical activity of single skeletal muscle fibres of the frog. Acta physiologica Scandinavica, 1972, Volume: 85, Issue:4 Topics: Animals; Anura; Caffeine; Chlorpromazine; Drug Synergism; Electric Stimulation; Imipramine; Methods; Muscle Contraction; Myofibrils; Potassium; Quinidine; Rana temporaria; Tendons	1972
The effects of drugs on calcium uptake and calcium release by mitochondria and sarcoplasmic reticulum of frog skeletal muscle. Biochemical pharmacology, 1974, Jan-01, Volume: 23, Issue:1 Topics: Animals; Anura; Biological Transport; Brain; Caffeine; Calcium; Chlorpromazine; Imidazoles; In Vitro Techniques; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Muscles; Myocardium; Quinidine; Rana temporaria; Sarcoplasmic Reticulum; Time Factors	1974
Effects of chlorpromazine, imipramine, and quinidine on action potential and tension development in single skeletal muscle fibres of the frog. Acta physiologica Scandinavica, 1973, Volume: 88, Issue:3 Topics: Action Potentials; Animals; Anura; Chlorpromazine; Dose-Response Relationship, Drug; Electric Stimulation; Imipramine; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle Tonus; Quinidine; Urea	1973
Correlation of chemical structure of phenothiazines with their coronary dilator and antiarrhythmic activities. Japanese journal of pharmacology, 1971, Volume: 21, Issue:6 Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chlorpromazine; Coronary Vessels; Dogs; In Vitro Techniques; Ligation; Nitroglycerin; Perphenazine; Phenothiazines; Promazine; Promethazine; Quinidine; Rabbits; Strophanthins; Structure-Activity Relationship; Thioridazine; Trifluoperazine; Triflupromazine; Vasodilator Agents	1971
Sucrose antagonism of drug and temperature effects on cardiac sarcoplasmic reticulum. Biochimica et biophysica acta, 1972, Mar-17, Volume: 255, Issue:3 Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Isotopes; Carbohydrates; Chloroform; Chlorpromazine; Dogs; Female; Fructose; Heart; Male; Myocardium; Propranolol; Quinidine; Sarcoplasmic Reticulum; Sucrose; Sulfur Isotopes; Temperature	1972
Apparent similarity of mechanisms of platelet adhesion and aggregation. Differentiation of these functions from clot retraction. Thrombosis et diathesis haemorrhagica, 1972, Feb-29, Volume: 27, Issue:1 Topics: Amitriptyline; Aspirin; Blood Coagulation Tests; Caffeine; Chloromercuribenzoates; Chlorpromazine; Clot Retraction; Cocaine; Diphenhydramine; Ethacrynic Acid; Guanidines; Humans; Phenothiazines; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Quinacrine; Quinidine; Reserpine; Sulfinpyrazone; Sulfones; Tosyl Compounds	1972
[Drug-induced anemias]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Dec-15, Volume: 90, Issue:24 Topics: Adrenal Cortex Hormones; Anemia; Barbiturates; Bone Marrow; Chloramphenicol; Chlorpromazine; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Gold; Humans; Hypoglycemic Agents; Indomethacin; Isoniazid; Nitrofurantoin; Phenacetin; Phenylbutazone; Phenytoin; Quinidine; Quinine; Salicylates; Sulfonamides	1970
Calcium efflux from a heavy sarcotubular fraction. Effects of ryanodine, caffeine and magnesium. European journal of biochemistry, 1970, Volume: 13, Issue:3 Topics: Alkaloids; Animals; Biological Transport; Caffeine; Calcium; Chlorpromazine; Magnesium; Metabolism; Muscles; Oxalates; Quinidine; Rabbits; Uranium; Zinc	1970
Kinetics of calcium transport by fragmented sarcoplasmic reticulum. The Journal of biological chemistry, 1970, Nov-10, Volume: 245, Issue:21 Topics: Animals; Biological Transport; Calcium; Calcium Isotopes; Chlorpromazine; Endoplasmic Reticulum; Humans; In Vitro Techniques; Kinetics; Muscles; Oxalates; Quinidine; Quinine; Rabbits; Rats	1970
Quinidine-induced recurrent ventricular fibrillation: (quinidine syncope) treated with transvenous pacemaker. Southern medical journal, 1971, Volume: 64, Issue:5 Topics: Adult; Atrial Fibrillation; Atropine; Blood Cell Count; Chlorpromazine; Coumarins; Creatine Kinase; Digitalis Glycosides; Diuretics; Electric Countershock; Electrocardiography; Female; Heart Valve Prosthesis; Humans; L-Lactate Dehydrogenase; Lactates; Lidocaine; Mitral Valve Stenosis; Pacemaker, Artificial; Paranoid Disorders; Pneumonia; Potassium Chloride; Quinidine; Rheumatic Heart Disease; Syncope; Ventricular Fibrillation	1971
Effects of some membrane perturbers on alpha 1-adrenergic receptor binding. Neuroscience letters, 1981, Feb-06, Volume: 21, Issue:3 Topics: Animals; Cattle; Cerebral Cortex; Chlorpromazine; Dibucaine; Dioxanes; Lidocaine; Membranes; Mepivacaine; Phenytoin; Procainamide; Procaine; Propranolol; Quinidine; Receptors, Adrenergic; Receptors, Adrenergic, alpha	1981
Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils. Science (New York, N.Y.), 1994, Nov-04, Volume: 266, Issue:5186 Topics: Animals; Biological Assay; Biotransformation; Cell Death; Chlorpromazine; Humans; Hydralazine; Hydrogen Peroxide; Isoniazid; Lupus Erythematosus, Systemic; Mice; Neutrophil Activation; Neutrophils; Peroxidase; Procainamide; Propylthiouracil; Quinidine; Tumor Cells, Cultured	1994
Metabolic screening using on-line ultrafiltration mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2 Topics: Animals; Automation; Chlorpromazine; Cytochrome P-450 Enzyme System; Female; Flavanones; Flavonoids; Imipramine; Inactivation, Metabolic; Male; Mass Spectrometry; Microsomes, Liver; Oxazines; Quinidine; Rats; Rats, Sprague-Dawley; Ultrafiltration	1998
[The adsorption on attapulgite and cross-linked agar beads entrapped attapulgite(CAA)]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2000, Volume: 17, Issue:4 Topics: Adsorption; Agar; Chlorpromazine; Diazepam; Magnesium Compounds; Phenobarbital; Quinidine; Silicon Compounds	2000
Influence of P-glycoprotein on the transplacental passage of cyclosporine. Journal of pharmaceutical sciences, 2001, Volume: 90, Issue:10 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorpromazine; Cyclosporins; Female; Glucose; In Vitro Techniques; Kinetics; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Quinidine; Rats; Rats, Wistar; Sodium Azide; Time Factors	2001
Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chlorpromazine; Cyclosporins; Drug Interactions; Female; Fluorescent Dyes; Placenta; Pregnancy; Quinidine; Rats; Rats, Wistar; Rhodamine 123; Sodium Azide	2003
Studies on prevention and abolition of fibrillation of the cat's heart by drugs. Archives internationales de pharmacodynamie et de therapie, 1963, Jan-01, Volume: 141 Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Brugada Syndrome; Cardiac Conduction System Disease; Cats; Chlorpromazine; Epinephrine; Felis; Heart Conduction System; Hydroxyzine; Meclizine; Niacinamide; Perphenazine; Prednisolone; Quinidine; Reserpine; Succinates	1963
[DRUGS FOR TREATING ARRHYTHMIA]. [Sogo rinsho] Clinic all-round, 1963, Volume: 12 Topics: Arrhythmias, Cardiac; Chlorpromazine; Digitalis Glycosides; Humans; Pharmacology; Potassium; Procainamide; Quinacrine; Quinidine; Reserpine	1963
[OPHTHALMOLOGICAL COMPLICATIONS OF CERTAIN GENERAL THERAPEUTICS]. Journal de medecine de Lyon, 1964, Mar-05, Volume: 45 Topics: Acetazolamide; Adrenal Cortex Hormones; Anthelmintics; Arsenicals; Barbiturates; Chloroquine; Chlorpromazine; Dinitrophenols; Ophthalmology; Parasympathomimetics; Quinidine; Quinine; Streptomycin; Sulfonamides; Toxicology; Tranquilizing Agents; Vitamin D; Vitamins	1964
PHARMACOLOGY OF HYPOTHERMIA. International anesthesiology clinics, 1964, Volume: 2 Topics: Acetylcholine; Acid-Base Equilibrium; Anesthetics; Anti-Bacterial Agents; Carbohydrate Metabolism; Catecholamines; Chlorpromazine; Citrates; Digitalis Glycosides; Electrolytes; Hibernation; Humans; Hypothermia; Hypothermia, Induced; Meperidine; Neostigmine; Pharmacology; Preanesthetic Medication; Promethazine; Quinidine; Sympatholytics; Ventricular Fibrillation	1964
DIFFERENTIAL EFFECTS OF SOME PHENOTHIAZINE DERIVATIVES AGAINST CALCIUM-INDUCED VENTRICULAR ARRHYTHMIAS IN THE ISOLATED RABBIT HEART. Canadian journal of physiology and pharmacology, 1964, Volume: 42 Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Brugada Syndrome; Calcium; Calcium Chloride; Cardiac Conduction System Disease; Chlorpromazine; Heart Conduction System; Parasympatholytics; Pharmacology; Phenothiazines; Prochlorperazine; Promethazine; Quinidine; Rabbits; Research; Toxicology; Ventricular Fibrillation	1964
A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes. Journal of pharmaceutical and biomedical analysis, 2005, Apr-01, Volume: 37, Issue:4 Topics: Algorithms; Animals; Antitussive Agents; Chlorpromazine; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Half-Life; Humans; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Microsomes, Liver; Midazolam; Pharmaceutical Preparations; Primaquine; Quinidine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization	2005
[Character of patients with paroxysmal atrial fibrillation]. Folia medica Cracoviensia, 2005, Volume: 46, Issue:3-4 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Chlorpromazine; Coronary Artery Disease; Electric Countershock; Female; Humans; Hypertension; Male; Quinidine; Retrospective Studies; Tachycardia, Paroxysmal	2005
Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s. Chemico-biological interactions, 2009, Oct-07, Volume: 181, Issue:2 Topics: Antipsychotic Agents; Biotransformation; Chlorpromazine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; In Vitro Techniques; Microsomes, Liver; Quinidine; Quinones; Tandem Mass Spectrometry; Thioridazine	2009
Comparison of information-dependent acquisition, SWATH, and MS(All) techniques in metabolite identification study employing ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. Analytical chemistry, 2014, Jan-21, Volume: 86, Issue:2 Topics: Algorithms; Animals; Biotransformation; Chlorpromazine; Chromatography, High Pressure Liquid; Ethanolamines; Microsomes, Liver; Midazolam; Oxidation-Reduction; Quinidine; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014