chlorpromazine and probenecid

chlorpromazine has been researched along with probenecid in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (30.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (26.67)	29.6817
2010's	12 (40.00)	24.3611
2020's	1 (3.33)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Bowers, MB; Study, RE	1
Bovell, M; Chung, T; Leake, J; MacMillan, V	1
Kikkert, RJ; Westerink, BH	1
Hahn, I; Krieglstein, G; Krieglstein, J; Tschentscher, K	1
Gessa, GL; Perez-Cruet, J; Stern, S; Tagliamonte, A; Tagliamonte, P	1
Bowers, MB; Extein, I; Roth, RH	1
Bowers, MB	1
Roth, RH	1
Sharman, DF	1
Jo, OD; Said, HM; Shih, RN; Yanagawa, N	1

Reviews

2 review(s) available for chlorpromazine and probenecid

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

28 other study(ies) available for chlorpromazine and probenecid

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients. Psychopharmacology, 1979, Mar-29, Volume: 62, Issue:1 Topics: Adolescent; Adult; Aged; Biogenic Amines; Chlorpromazine; Cyclic AMP; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Mental Disorders; Middle Aged; Probenecid; Schizophrenia	1979
The effect of valproic acid on the 5-hydroxyindoleacetic, homovanillic and lactic acid levels of cerebrospinal fluid. Brain research, 1987, Sep-15, Volume: 420, Issue:2 Topics: Animals; Anticonvulsants; Brain; Chlorpromazine; Dose-Response Relationship, Drug; Homovanillic Acid; Hydroxyindoleacetic Acid; Lactates; Lactic Acid; Male; Probenecid; Rats; Rats, Inbred Strains; Valproic Acid	1987
Effect of various centrally acting drugs on the efflux of dopamine metabolites from the rat brain. Journal of neurochemistry, 1986, Volume: 46, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Biological Transport, Active; Brain; Brain Stem; Central Nervous System Agents; Chloral Hydrate; Chlorpromazine; Corpus Striatum; Dopamine; Frontal Lobe; Haloperidol; Homovanillic Acid; Kainic Acid; Male; Olfactory Bulb; Oxotremorine; Pargyline; Phenylacetates; Probenecid; Rats	1986
Distribution of chlorpromazine in a simplified blood influenced by various drugs. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 278, Issue:1 Topics: Acetazolamide; Animals; Antidepressive Agents; Benzoates; Binding Sites; Binding, Competitive; Cattle; Chlorothiazide; Chlorpromazine; Coumarins; Deoxycholic Acid; Erythrocytes; Fatty Acids; Indomethacin; Phenylbutazone; Phenytoin; Probenecid; Protein Binding; Quinine; Salicylates; Serum Albumin, Bovine; Solubility; Sulfonamides; Suramin; Tetracycline; Thiopental	1973
Effect of psychotropic drugs on tryptophan concentration in the rat brain. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 177, Issue:3 Topics: Alkaloids; Animals; Apomorphine; Aporphines; Body Temperature; Brain Chemistry; Butyrates; Chlorpromazine; Cold Temperature; Cyclic AMP; Dextroamphetamine; Fenclonine; Fenfluramine; Haloperidol; Hot Temperature; Hydroxybutyrates; Hydroxyindoleacetic Acid; Lithium; Male; Methyltyrosines; Morphine; Nucleosides; Phenelzine; Phenmetrazine; Probenecid; Rats; Reserpine; Serotonin; Tryptophan; Tyrosine	1971
Accumulation of 3H-homovanillic acid in rabbit brain and cerebrospinal fluid following intravenous 3H-L-dopa. Biological psychiatry, 1974, Volume: 9, Issue:2 Topics: Animals; Brain; Brain Chemistry; Carboxy-Lyases; Cerebrospinal Fluid; Chlorpromazine; Chromatography, Thin Layer; Deamination; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Injections, Intravenous; Male; Methylation; Neurons; Phenylacetates; Probenecid; Rabbits; Stimulation, Chemical; Time Factors; Tritium	1974
Central dopamine turnover in schizophrenic syndromes. Archives of general psychiatry, 1974, Volume: 31, Issue:1 Topics: Affective Symptoms; Chlorpromazine; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Probenecid; Schizophrenia; Syndrome; Time Factors; Trifluoperazine	1974
Effect of anesthetic doses of hydroxybutyrate on subcortical concentrations of homovanillic acid. European journal of pharmacology, 1971, Volume: 15, Issue:1 Topics: Animals; Brain; Brain Chemistry; Chloral Hydrate; Chlorpromazine; Dopamine; Glycols; Hydroxybutyrates; Lactones; Male; Norepinephrine; Phenylacetates; Probenecid; Rats; Rats, Inbred Strains; Sleep; Time Factors	1971
A discussion of the modes of action of drugs which increase the concentration of 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid) in the striatum of the mouse. British journal of pharmacology and chemotherapy, 1967, Volume: 30, Issue:3 Topics: Alkaloids; Animals; Brain; Chlorpromazine; Female; Mice; Naphthalenes; Phenylacetates; Probenecid; Spiro Compounds	1967
Riboflavin transport by isolated perfused rabbit renal proximal tubules. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6 Topics: Animals; Antipsychotic Agents; Biological Transport; Calcium; Calmodulin; Carcinogens; Chlorpromazine; Cyclic AMP; Dose-Response Relationship, Drug; Flavins; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Phorbol Esters; Probenecid; Rabbits; Riboflavin; Temperature; Trifluoperazine; Uricosuric Agents	2000