chlorpromazine and primaquine

chlorpromazine has been researched along with primaquine in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199015 (48.39)18.7374
1990's0 (0.00)18.2507
2000's5 (16.13)29.6817
2010's11 (35.48)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Fitos, I; Mády, G; Visy, J; Zsila, F1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Johnson, M; Junga, I; Krueger, J; Schrier, SL2
Rinehart, J; Zarkowsky, H1
Bensch, KG; Hardy, B; Schrier, SL1
Garfinkel, E; Hirschman, SZ1
Greenwalt, TJ; Lau, FO; Swierk, EM; Williams, RE1
Allison, RG; Hahn, FE1
Junga, I; Ma, L; Schrier, SL1
Akintonwa, DA1
Junga, IG; Matovcik, LM; Schrier, SL1
Ben-Bassat, I; Bensch, KG; Schrier, SL1
Curry, MC; Dustin, R; Kahn, G1
Fujii, T; Nakanishi, K; Sato, T1
Goldschmidt, L1
Chiu, DT; Lubin, B; Schrier, SL; Sizer, K; Yee, M1
Bhoopathy, S; Karnes, HT; Unger, SE; Xin, B1
Ahting, U; Bader, B; Danek, A; Gregory, A; Hamminger, P; Hartig, M; Hayflick, S; Hermann, A; Jank, H; Prohaska, R; Prokisch, H; Salzer, U; Sammler, EM; Siegl, C; Yapici, Z1
Chen, S; Guo, L; Ning, B; Tolleson, WH; Xuan, J1

Reviews

1 review(s) available for chlorpromazine and primaquine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for chlorpromazine and primaquine

ArticleYear
Studies on the effect of clinical dosages of chlorpromazine and other neurotropics on primaquine-sensitive Negro mental patients.
    The Journal of nervous and mental disease, 1966, Volume: 143, Issue:1

    Topics: Adult; Anemia, Hemolytic; Black or African American; Chlorpromazine; Clinical Trials as Topic; Dementia; Female; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Hematocrit; Hemoglobinometry; Humans; Male; Neurotic Disorders; Primaquine; Psychopharmacology; Psychoses, Alcoholic; Schizophrenia

1966

Other Studies

29 other study(ies) available for chlorpromazine and primaquine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein.
    Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7

    Topics: Antimalarials; Binding Sites; Chromatography, Affinity; Circular Dichroism; Humans; Molecular Structure; Orosomucoid; Protein Binding; Serum Albumin; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Requirements of drug-induced endocytosis by intact human erythrocytes.
    Blood cells, 1978, Volume: 4, Issue:1-2

    Topics: Calcium; Chlorpromazine; Cyclic AMP; Cyclic GMP; Cytochalasin B; Endocytosis; Erythrocytes; Humans; Primaquine; Vinblastine

1978
Endocytosis in adenosine triphosphate-depleted erythrocytes.
    Biochimica et biophysica acta, 1979, May-01, Volume: 584, Issue:2

    Topics: Adenosine Triphosphate; Chlorpromazine; Endocytosis; Erythrocytes; Humans; Primaquine

1979
Endocytosis in erythrocytes and their ghosts.
    Progress in clinical and biological research, 1979, Volume: 30

    Topics: Adenosine Triphosphate; Calcium; Chlorpromazine; Cytochalasins; Diamide; Endocytosis; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Primaquine; Spectrin; Vinblastine

1979
Inhibition of hepatitis B DNA polymerase by intercalating agents.
    Nature, 1978, Feb-16, Volume: 271, Issue:5646

    Topics: Chloroquine; Chlorpromazine; Drug Synergism; Ethidium; Hepatitis B; Hepatitis B virus; Humans; Indicators and Reagents; Methylene Blue; Nucleic Acid Synthesis Inhibitors; Primaquine; Quinacrine

1978
Studies of erythrocyte membrane loss produced by amphipathic drugs and in vitro storage.
    British journal of haematology, 1978, Volume: 39, Issue:4

    Topics: Adenosine Triphosphate; Blood Preservation; Chlorpromazine; Endocytosis; Erythrocyte Aging; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Microscopy, Electron, Scanning; Primaquine; Propranolol; Tetracaine; Tolonium Chloride

1978
Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine.
    Antimicrobial agents and chemotherapy, 1977, Volume: 11, Issue:2

    Topics: Acridines; Chemical Phenomena; Chemistry; Chloroquine; Chlorpromazine; DNA, Circular; Ethidium; Extrachromosomal Inheritance; Methylene Blue; Plasmids; Primaquine; Pseudomonas; Quinine

1977
Studies on the effect of vanadate on endocytosis and shape changes in human red blood cells and ghosts.
    Blood, 1986, Volume: 68, Issue:5

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Chlorpromazine; Endocytosis; Erythrocyte Membrane; Erythrocytes; Humans; Primaquine; Vanadium; Vinblastine

1986
The derivation of nitrosamines from some therapeutic amines in the human environment.
    Ecotoxicology and environmental safety, 1985, Volume: 9, Issue:1

    Topics: Amines; Carcinogens; Chemical Phenomena; Chemistry; Chloroquine; Chlorpromazine; Humans; Methadone; Mixed Function Oxygenases; Nitrosamines; Pharmaceutical Preparations; Phenacetin; Primaquine

1985
Drug-induced endocytosis of neonatal erythrocytes.
    Blood, 1985, Volume: 65, Issue:5

    Topics: Adenosine Triphosphate; Adult; Age Factors; Aspartate Aminotransferases; Chlorpromazine; Densitometry; Endocytosis; Erythrocyte Aging; Erythrocyte Indices; Erythrocyte Membrane; Erythrocytes; Glucosephosphate Dehydrogenase; Humans; Infant, Newborn; Primaquine; Vinblastine

1985
Drug-induced erythrocyte membrane internalization.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:7

    Topics: Adenosine Triphosphate; Calcium; Chlorpromazine; Cytoplasm; Erythrocyte Aging; Erythrocytes; Ethylmaleimide; Fluorides; Humans; Hydrocortisone; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; Membranes; Microscopy, Electron; Microscopy, Phase-Contrast; Primaquine; Sulfonic Acids; Vinblastine

1972
New approaches to investigating UVL photo protective substances in vitro.
    Archiv fur dermatologische Forschung, 1973, Volume: 248, Issue:3

    Topics: 1-Propanol; Aminobenzoates; Aniline Compounds; beta-Aminoethyl Isothiourea; Candida albicans; Chlorpromazine; Dithiothreitol; Erythrocytes; Gallic Acid; Hemolysis; Mercaptoethylamines; Oxygen; Partial Pressure; Primaquine; Radiation Effects; Radiation-Protective Agents; Sulfoxides; Thiram; Tuberculin; Ultraviolet Rays

1973
In vitro shape changes of human erythrocyte membranes.
    Physiological chemistry and physics, 1973, Volume: 5, Issue:5

    Topics: Adenosine Triphosphate; Aluminum; Cell Membrane; Chloromercuribenzoates; Chlorpromazine; Erythrocytes; Ethanol; Ethylmaleimide; Hot Temperature; Humans; Microscopy, Electron, Scanning; Nitrobenzenes; Osmolar Concentration; Osmotic Fragility; Phosphatidylcholines; Primaquine; Saponins; Sodium Chloride; Spectrophotometry; Sulfonic Acids; Surface-Active Agents

1973
Alteration of membrane phospholipid bilayer organization in human erythrocytes during drug-induced endocytosis.
    The Journal of clinical investigation, 1983, Volume: 72, Issue:5

    Topics: Chlorpromazine; Endocytosis; Erythrocyte Membrane; Erythrocytes; Humans; Lipid Bilayers; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Phospholipids; Primaquine; Sphingomyelin Phosphodiesterase; Vinblastine

1983
Calcium distribution within human erythrocytes during endocytosis.
    Blood, 1980, Volume: 56, Issue:4

    Topics: Adenosine Triphosphate; Calcium; Chlorpromazine; Endocytosis; Erythrocytes; Humans; Primaquine; Vinblastine

1980
A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.
    Journal of pharmaceutical and biomedical analysis, 2005, Apr-01, Volume: 37, Issue:4

    Topics: Algorithms; Animals; Antitussive Agents; Chlorpromazine; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Half-Life; Humans; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Microsomes, Liver; Midazolam; Pharmaceutical Preparations; Primaquine; Quinidine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2005
Alterations of red cell membrane properties in neuroacanthocytosis.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Acanthocytes; Adolescent; Adult; Basal Ganglia; Calcium; Case-Control Studies; Cations, Divalent; Child; Chlorpromazine; Endocytosis; Erythrocyte Membrane; Female; Humans; Imipramine; Ion Transport; Lysophospholipids; Male; Middle Aged; Neuroacanthocytosis; Pantothenate Kinase-Associated Neurodegeneration; Phosphatidylserines; Primaquine

2013
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.
    Chemico-biological interactions, 2016, Aug-05, Volume: 255

    Topics: Amiodarone; Antimalarials; Antipsychotic Agents; Cell Line; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Gene Expression; Hep G2 Cells; Humans; Liver; Primaquine; Protein Isoforms; RNA, Messenger

2016