chlorpromazine and paclitaxel

chlorpromazine has been researched along with paclitaxel in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's0 (0.00)18.2507
2000's10 (50.00)29.6817
2010's9 (45.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Maccioni, RB1
Avery, W; Borisy, AA; Elliott, P; Johansen, L; Keegan, M; Keith, CT; Lee, MS; Wilson, A; Zhang, Y1
Dewhurst, S; Rodrigo, WW; Sapinoro, R; Schlesinger, JJ; Volcy, K1
Khong, A; McHardy, LM; Riffell, JL; Roberge, M; Zimmerman, C1
Ayesta, C; Dagger, F; Marcano, AK; Valdivieso, E1
Bae, EJ; Lee, MK; Xu, W1

Reviews

2 review(s) available for chlorpromazine and paclitaxel

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Molecular cytology of microtubules.
    Revisiones sobre biologia celular : RBC, 1986, Volume: 8

    Topics: Alkaloids; Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Cell Differentiation; Chlorpromazine; Colchicine; Cytoskeleton; Gene Expression Regulation; Griseofulvin; Guanosine Triphosphate; Humans; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Phosphorylation; Structure-Activity Relationship; Tubulin; Vinblastine

1986

Other Studies

18 other study(ies) available for chlorpromazine and paclitaxel

ArticleYear
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
    Pharmaceutical research, 2003, Volume: 20, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans

2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.
    Cancer research, 2007, Dec-01, Volume: 67, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiprotozoal Agents; Antipsychotic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Fluorescent Antibody Technique; HCT116 Cells; Humans; Kinesins; Lung Neoplasms; Male; Mice; Mice, SCID; Microtubules; Mitosis; Paclitaxel; Pentamidine; Spindle Apparatus; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays

2007
Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells.
    Virology, 2008, Apr-10, Volume: 373, Issue:2

    Topics: Actins; Animals; Antibodies, Viral; Bacteriophage lambda; Bridged Bicyclo Compounds, Heterocyclic; Capsid Proteins; Cell Line; Chlorocebus aethiops; Chlorpromazine; COS Cells; Endocytosis; Gene Transfer Techniques; Glycoproteins; Humans; Luciferases; Mice; Microtubules; Models, Biological; Nocodazole; Paclitaxel; Receptors, IgG; Recombinant Proteins; Thiazolidines; Transduction, Genetic; Transfection

2008
Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation.
    Cell cycle (Georgetown, Tex.), 2009, Sep-15, Volume: 8, Issue:18

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlorpromazine; Cysteine; Flavones; Humans; Indoles; Microtubules; Mitosis; Paclitaxel; Sulfonamides; Triflupromazine; Vinblastine

2009
Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs.
    Memorias do Instituto Oswaldo Cruz, 2013, Volume: 108, Issue:1

    Topics: Animals; Chlorpromazine; Cytoskeleton; Leishmania mexicana; Macrolides; Maytansine; Mice; Paclitaxel; Trifluoperazine; Tubulin Modulators

2013
Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Death; Cell Line, Tumor; Chlorpromazine; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Female; Humans; Inhibitory Concentration 50; Lipids; Madin Darby Canine Kidney Cells; Nanoparticles; Paclitaxel; Particle Size; Verapamil

2018