chlorpromazine and orphenadrine

chlorpromazine has been researched along with orphenadrine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199028 (73.68)18.7374
1990's1 (2.63)18.2507
2000's4 (10.53)29.6817
2010's5 (13.16)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Bailey, AM; Paulsen, IT; Piddock, LJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sen, S; Sinha, N1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lader, MH1
Bartlett, W; Bourne, RC; Cotes, PM; Crow, TJ; Johnstone, EC1
Curry, S; Lader, M; Loga, S1
Ballatori, E; Basurto, C; Minotti, V; Roila, F; Tonato, M1
Bowers, MB; Roth, RH1
Bamji, AN; Bender, DA1
Bennett, JM1
Dols, LC; van Praag, HM1
Andersen, PR; Gibbs, P; Kubinski, H1
Beall, JR1
Bhargava, KP; Dixit, KS; Sinha, JN; Srimal, RC1
Ban, T; Hojo, M1
Bertuzzi, F; Dogliani, P; Senini, G1
Schipper, JA1
Roberts, E; Varon, S; Weinstein, H1
Castelli, G; Nardini, L1
Osuide, G1
Boersma, L; van Riezen, H1
Ginzel, KH; Kimison, R1
Ekdawi, MY; Fowke, R1
Buckle, RM; Guillebaud, J1
Pigache, RM1
Catalán Arlandis, JL; Jiménez Torres, NV1
BEGHI, Q1
PERRIN, J; SCHNEIDER, J; SIFFERMANN, A; THOMALSKE, G1
FROGEL, M1
TAIT, AC; TODRICK, A; YATES, CM1
DEMEL, RA1
GOLDSTEIN, L; MURPHREE, HB; PFEIFFER, CC; SUGERMAN, AA1

Reviews

1 review(s) available for chlorpromazine and orphenadrine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

5 trial(s) available for chlorpromazine and orphenadrine

ArticleYear
Neuroendocrine changes in acute schizophrenia as a function of clinical state and neuroleptic medication.
    Psychological medicine, 1978, Volume: 8, Issue:4

    Topics: Acute Disease; Chlorpromazine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Flupenthixol; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing Hormone; Orphenadrine; Prolactin; Receptors, Dopamine; Schizophrenia; Testosterone; Thioxanthenes

1978
Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:3

    Topics: Adult; Antipyrine; Chlorpromazine; Clinical Trials as Topic; Drug Interactions; Female; Half-Life; Humans; Male; Orphenadrine; Phenobarbital; Psychotic Disorders

1975
Fluphenazine enanthate and fluphenazine decanoate: a comparison of their duration of action and motor side effects.
    The American journal of psychiatry, 1973, Volume: 130, Issue:7

    Topics: Acute Disease; Adult; Aged; Chlorpromazine; Clinical Trials as Topic; Esters; Female; Fluphenazine; Humans; Injections, Intramuscular; Male; Middle Aged; Movement Disorders; Orphenadrine; Placebos; Psychiatric Status Rating Scales; Psychotic Disorders; Time Factors

1973
[Depot-neuroleptics in the treatment of schizophrenia].
    Nederlands tijdschrift voor geneeskunde, 1971, Apr-17, Volume: 115, Issue:16

    Topics: Adult; Chlorpromazine; Delayed-Action Preparations; Female; Fluphenazine; Haloperidol; Humans; Middle Aged; Orphenadrine; Perphenazine; Schizophrenia; Thioridazine

1971
Effects of placebo, orphenadrine, and rising doses of chlorpromazine, on PAT performance in chronic schizophrenia. A two year longitudinal study.
    Schizophrenia research, 1993, Volume: 10, Issue:1

    Topics: Adult; Attention; Chlorpromazine; Chronic Disease; Dominance, Cerebral; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Humans; Length of Stay; Longitudinal Studies; Male; Middle Aged; Orphenadrine; Psychiatric Status Rating Scales; Reaction Time; Recurrence; Schizophrenia; Schizophrenic Psychology; Speech Perception

1993

Other Studies

32 other study(ies) available for chlorpromazine and orphenadrine

ArticleYear
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Anti-Bacterial Agents; Antipsychotic Agents; Bacterial Proteins; Base Sequence; Chlorpromazine; DNA Primers; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Synergism; Ethidium; Gene Expression; Genes, Bacterial; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Oligonucleotide Array Sequence Analysis; Phenothiazines; Salmonella typhimurium; Trans-Activators

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
[Rational utilization of the major tranquilizers].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:9

    Topics: Adult; Antipsychotic Agents; Antipyrine; Chlorpromazine; Drug Interactions; Drug Therapy, Combination; Drug Utilization; Electroencephalography; Half-Life; Humans; Liver; Male; Orphenadrine; Phenobarbital; Psychotic Disorders; Theta Rhythm; Time Factors

1975
A phase II antiemetic combination (COMD) for cisplatin-induced nausea and vomiting.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:1

    Topics: Adult; Aged; Antiemetics; Chlorpromazine; Dexamethasone; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Metoclopramide; Middle Aged; Orphenadrine

1986
Interaction of atropine-like drugs with dopamine-containing neurones in rat brain.
    British journal of pharmacology, 1972, Volume: 44, Issue:2

    Topics: Animals; Atropine; Benztropine; Brain; Chlorpromazine; Dopamine; Homovanillic Acid; Male; Methyltyrosines; Neurons; Orphenadrine; Phenothiazines; Procyclidine; Rats; Time Factors; Trihexyphenidyl

1972
Serum tryptophan binding in chlorpromazine-treated chronic schizophrenics.
    Journal of neurochemistry, 1974, Volume: 22, Issue:5

    Topics: Chlorpromazine; Chronic Disease; Diffusion; Fatty Acids, Nonesterified; Humans; Liver; Male; Orphenadrine; Protein Binding; Schizophrenia; Serum Albumin; Time Factors; Tryptophan; Tryptophan Oxygenase

1974
Modification of strychnine-induced convulsions by anticonvulsants in the frog.
    Neuropharmacology, 1972, Volume: 11, Issue:2

    Topics: Animals; Anticonvulsants; Anura; Chlorpromazine; Mephenesin; Muscle Contraction; Orphenadrine; Rana temporaria; Reserpine; Seizures; Strychnine

1972
Effects of neuropharmacological agents on in vitro formation of complexes between nucleic acids and proteins.
    Neuropharmacology, 1974, Volume: 13, Issue:2

    Topics: Animals; Benztropine; Cattle; Chlorpromazine; Codeine; Desipramine; DNA, Bacterial; Escherichia coli; Histones; Lysergic Acid Diethylamide; Morphine; Neostigmine; Nucleic Acids; Orphenadrine; Phenytoin; Protein Binding; Proteins; RNA, Bacterial; RNA, Ribosomal; Serum Albumin, Bovine; Sodium Dodecyl Sulfate; Trihexyphenidyl

1974
A teratogenic study of chlorpromazine, orphenadrine, perphenzaine, and LSD-25 in rats.
    Toxicology and applied pharmacology, 1972, Volume: 21, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Chlorpromazine; Embryo Implantation; Evaluation Studies as Topic; Female; Gestational Age; Lysergic Acid Diethylamide; Male; Orphenadrine; Perphenazine; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Reproduction

1972
Central muscle relaxant activity of a dozen CNS active agents and a correlation with their psychotropic activity.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:1

    Topics: Amphetamine; Animals; Antidepressive Agents; Blood Pressure; Cats; Central Nervous System; Chlorpromazine; Desipramine; Dibenzothiazepines; Ephedrine; Female; Imipramine; Iproniazid; Male; Mephenesin; Monoamine Oxidase Inhibitors; Muscles; Orphenadrine; Phenelzine; Reflex; Thioridazine; Tranquilizing Agents

1968
Comparison of the electroencephalographic and motor effects of orphenadrine, an antiparkinson agent.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Animals; Arousal; Atropine; Brain; Chlorpromazine; Depression, Chemical; Electric Stimulation; Electroencephalography; Injections, Intravenous; Male; Mephenesin; Motor Activity; Orphenadrine; Pentobarbital; Rabbits; Scopolamine; Stimulation, Chemical; Tectum Mesencephali

1968
Clinical observations on the therapeutic activity of flupentixol in the treatment of chronic schizophrenia.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:8

    Topics: Adult; Aged; Blood; Body Weight; Chlorpromazine; Chronic Disease; Delusions; Depression, Chemical; Female; Hallucinations; Humans; Hypnotics and Sedatives; Male; Middle Aged; Orphenadrine; Parkinson Disease, Secondary; Piperazines; Psychomotor Disorders; Psychopharmacology; Schizophrenia; Social Behavior; Stimulation, Chemical; Transaminases; Xanthenes

1970
Effects of imipramine on the Na+-dependent exchange and retention of gamma-aminobutyric acid by mouse brain subcellular particles.
    Biochemical pharmacology, 1971, Volume: 20, Issue:1

    Topics: Adsorption; Aminobutyrates; Animals; Biological Transport; Brain; Carbon Isotopes; Chlorpromazine; Imipramine; In Vitro Techniques; Kinetics; Mathematics; Membranes; Mice; Orphenadrine; Potassium Chloride; Receptors, Drug; Sodium Chloride; Time Factors; Tritium

1971
Hiccup.
    British medical journal, 1971, May-01, Volume: 2, Issue:5756

    Topics: Amides; Amitriptyline; Benzoates; Catheterization; Chlorpromazine; Digestive System; Hiccup; Humans; Orphenadrine; Pharynx; Respiratory System

1971
[Statistical reports of the psychopharmacological agents used in the past 10 years in the Ospedale Neuropsichiatrico Provinciale of Mantua].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1967, Oct-31, Volume: 91, Issue:5

    Topics: Chlorpromazine; Chlorprothixene; Humans; Mental Disorders; Orphenadrine; Pentylenetetrazole; Phenelzine; Phenothiazines; Reserpine; Theophylline; Thioridazine; Tranquilizing Agents

1967
Effects of some centrally-acting drugs in conscious chicks and on spinal reflexes.
    European journal of pharmacology, 1968, Volume: 3, Issue:4

    Topics: Animals; Carbamates; Chickens; Chlorpromazine; Male; Mephenesin; Meprobamate; Orphenadrine; Pentylenetetrazole; Picrotoxin; Reflex; Spinal Nerves; Strychnine; Triazines

1968
A new method for quantitative grip strength evaluation.
    European journal of pharmacology, 1969, Volume: 6, Issue:3

    Topics: Animals; Chlormezanone; Chlorpromazine; Diazepam; Fatigue; Meprobamate; Methods; Mice; Muscles; Orphenadrine; Pharmacology

1969
The effect of orphenadrine on neuromuscular transmission.
    Proceedings of the Western Pharmacology Society, 1965, Volume: 8

    Topics: Animals; Cats; Chlorpromazine; Decerebrate State; Diaphragm; Muscles; Neuromuscular Junction; Orphenadrine; Phrenic Nerve; Poultry; Rats; Sciatic Nerve

1965
A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism.
    The British journal of psychiatry : the journal of mental science, 1966, Volume: 112, Issue:487

    Topics: Adolescent; Adult; Chlorpromazine; Haloperidol; Humans; Middle Aged; Orphenadrine; Parasympatholytics; Parkinson Disease; Parkinson Disease, Secondary; Perphenazine; Schizophrenia; Tranquilizing Agents; Trifluoperazine

1966
Hypoglycaemic coma occurring during treatment with chlorpromazine and orphenadrine.
    British medical journal, 1967, Dec-09, Volume: 4, Issue:5579

    Topics: Blood Glucose; Chlorpromazine; Coma; Female; Humans; Hypoglycemia; Mental Disorders; Middle Aged; Orphenadrine; Tolbutamide

1967
Anthropometric and pharmacotherapeutic variables on acute emesis induced by cisplatin-containing chemotherapy.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:5

    Topics: Acute Disease; Age Factors; Antiemetics; Antineoplastic Agents; Body Weights and Measures; Chlorpromazine; Cisplatin; Cross-Sectional Studies; Dexamethasone; Drug Combinations; Humans; Logistic Models; Metoclopramide; Middle Aged; Multivariate Analysis; Ondansetron; Orphenadrine; Prognosis; Prospective Studies; Sex Factors; Vomiting

2000
[PSYCHIATRIC USE OF SOME PSYCHOPHARMACOLOGICAL DRUGS IN PREGNANCY].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1963, Jun-30, Volume: 87

    Topics: Chlordiazepoxide; Chlorpromazine; Fetus; Haloperidol; Imipramine; Isocarboxazid; Meprobamate; Nialamide; Orphenadrine; Perphenazine; Pharmacology; Pregnancy; Prochlorperazine; Promazine; Psychopharmacology; Reserpine; Thalidomide; Thioridazine

1963
[MODIFICATIONS OF THE EEG DUE TO PSYCHOPHARMACOLOGICAL TREATMENT. LONG-TERM STUDIES ON MENTAL PATIENTS].
    Der Nervenarzt, 1963, Volume: 34

    Topics: Bemegride; Chlormethiazole; Chlorpromazine; Electroencephalography; Haloperidol; Humans; Hypnotics and Sedatives; Imipramine; Mental Disorders; Mentally Ill Persons; Meprobamate; Methotrimeprazine; Orphenadrine; Phenothiazines; Prochlorperazine; Psychopharmacology; Sympathomimetics; Trimeprazine

1963
[EFFECT OF DRUG THERAPY ON REHOSPITALIZATIONS AT THE BEL AIR CLINIC OF PATIENTS WITH CHRONIC PSYCHOSES EXCEPT MANIC-DEPRESSIVE PSYCHOSES].
    Psychiatria et neurologia, 1964, Volume: 147

    Topics: Bipolar Disorder; Chlorpromazine; Chlorprothixene; Convulsive Therapy; Drug Therapy; Haloperidol; Hospitalization; Humans; Insulin; Methotrimeprazine; Orphenadrine; Phenothiazines; Prognosis; Promazine; Psychotic Disorders; Reserpine; Statistics as Topic; Tranquilizing Agents; Trifluperidol

1964
EFFECT OF IMIPRAMINE AND SOME ANALOGUES ON THE UPTAKE OF 5-HYDROXYTRYPTAMINE BY HUMAN BLOOD PLATELETS IN VITRO.
    The Journal of pharmacy and pharmacology, 1964, Volume: 16

    Topics: Amitriptyline; Antidepressive Agents; Blood Platelets; Chlorpromazine; Desipramine; Humans; Imipramine; In Vitro Techniques; Metabolism; Orphenadrine; Pharmacology; Research; Serotonin

1964
PENETRATION OF LIPID MONOLAYERS BY PSYCHOACTIVE DRUGS.
    Biochimica et biophysica acta, 1965, Jan-25, Volume: 94

    Topics: Brain Chemistry; Cell Membrane Permeability; Cerebrosides; Chlorpromazine; Gangliosides; Lecithins; Lipids; Meclizine; Meprobamate; Orphenadrine; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Psychotropic Drugs; Research; Reserpine; Sphingomyelins

1965
TIME-SERIES, FREQUENCY ANALYSIS, AND ELECTROGENESIS OF THE EEGS OF NORMALS AND PSYCHOTICS BEFORE AND AFTER DRUGS.
    The American journal of psychiatry, 1965, Volume: 121

    Topics: Amphetamine; Antidepressive Agents; Barbiturates; Biomedical Research; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Deanol; Drug Therapy; Electroencephalography; Lysergic Acid Diethylamide; Meprobamate; Orphenadrine; Pentobarbital; Perphenazine; Pharmacology; Phenobarbital; Placebos; Schizophrenia; Statistics as Topic; Tranquilizing Agents

1965