chlorpromazine and opromazine

chlorpromazine has been researched along with opromazine in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199030 (75.00)18.7374
1990's5 (12.50)18.2507
2000's1 (2.50)29.6817
2010's3 (7.50)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Chan, C; Croft, SL; Douglas, KT; Fairlamb, AH; Garforth, J; Jaouhari, R; McKie, JH; Rock, PJ; Speers, P; Yardley, V; Yin, H1
Pajeva, I; Wiese, M1
Chibale, K; Kigondu, EM; Warner, DF; Wasuna, A1
Krzeminska, EC; Tanner, NS; Ward, DJ1
Braun, ID; Hait, WN; Kennedy, KA; Lazo, JS; Meandzija, B1
Beijersbergen van Henegouwen, GM; Schoonderwoerd, SA; van Belkum, S1
de Mol, NJ; Janssen, LH; Kelder, PP1
Di Stasi, AM; Minetti, M1
Balkovetz, DF; Ganapathy, V; Hanano, M; Iwatsubo, T; Leibach, FH; Miyamoto, Y1
Inaba, H; Nakano, H; Nakano, M; Sugioka, K; Takyu, C1
Publicover, SJ; Sahaf, ZY2
Buettner, GR; Chignell, CF; Hall, RD; Motten, AG1
Beijersbergen van Henegouwen, GM; Luijendijk, JJ; Schoonderwoerd, SA1
Hubbard, JW; Korchinski, ED; Midha, KK; Yeung, PK1
Chakraborty, BS; Cooper, JK; Gurnsey, T; Hawes, EM; Hubbard, JW; McKay, G; Midha, KK; Yeung, PK1
Hawes, EM; Hubbard, JW; Martin, M; McKay, G; Midha, KK; Yeung, PK1
Cooper, JK; Hawes, EM; Hubbard, JW; Jenden, DJ; Martin, M; May, PR; McKay, G; Midha, KK; Van Putten, T1
Fasanmade, AA; Fell, AF1
Cooper, JK; Hawes, EM; Hubbard, JW; Martin, M; McKay, G; Midha, KK1
Barabás, K; Molnár, J1
Dahl, SG; Hjorth, M; Hough, E1
Minervini, N; Witman, GB1
Gillette, R; Green, DJ1
Furuya, W; Grinstein, S1
Cooper, JK; Hubbard, JW; Midha, KK; Yeung, PK1
Dascalu, A; Korenstein, R; Nevo, Z; Oron, Y1
Minami, H; Miyahara, A; Nakahara, T; Nakane, Y1
BUTLER, WM; MORAN, NC1
DAVIDSON, JD; SJOERDSMA, A; TERRY, LL1
MILLICAN, RC; RHODES, CJ1
BAART, N; ERDOS, EG; FOLDES, FF; SHANOR, SP1
EADES, CG; MARTIN, WR1
BOCHER, CA; FLANAGAN, TL; LIN, TH; NOVICK, WJ; RONDISH, IM; VAN LOON, EJ1
MARTIN, WR; RIEHL, JL; UNNA, KR1
Hikiji, W; Ikeda, N; Kudo, K; Sato, S; Tsuji, A; Usumoto, Y1
Li, X; Yang, Y; Zhou, K1
Fang, Y; Hammock, BD; Morisseau, C; Rock, DA; Teague, J; Wang, Z; Wong, H1
Fu, T; Guo, Y; Huang, S; Wang, X; Yao, B; Zhang, Y1

Reviews

1 review(s) available for chlorpromazine and opromazine

ArticleYear
Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
    Bioorganic & medicinal chemistry, 2014, Aug-15, Volume: 22, Issue:16

    Topics: Animals; Anti-Bacterial Agents; Antitubercular Agents; Drug Discovery; Fusidic Acid; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Tuberculosis

2014

Other Studies

39 other study(ies) available for chlorpromazine and opromazine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
    Journal of medicinal chemistry, 1998, Jan-15, Volume: 41, Issue:2

    Topics: Animals; Antiprotozoal Agents; Binding Sites; Crithidia fasciculata; Enzyme Inhibitors; Glutathione Disulfide; Glutathione Reductase; Kinetics; Leishmania donovani; Models, Chemical; NADH, NADPH Oxidoreductases; NADP; Phenothiazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

1998
Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study.
    Journal of medicinal chemistry, 1998, May-21, Volume: 41, Issue:11

    Topics: Antineoplastic Agents; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Conformation; Phenothiazines; Thioxanthenes; Tumor Cells, Cultured

1998
Treatment of toxic epidermal necrolysis and a review of six cases.
    Burns : journal of the International Society for Burn Injuries, 1990, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antimalarials; Chlorpromazine; Clavulanic Acids; Diagnosis, Differential; Drug Combinations; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Pyrimethamine; Retrospective Studies; Stevens-Johnson Syndrome; Sulfadoxine; Trimethoprim, Sulfamethoxazole Drug Combination; Zimeldine

1990
Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists.
    Molecular pharmacology, 1985, Volume: 27, Issue:3

    Topics: Animals; Bleomycin; Calmodulin; Cell Survival; Chlorpromazine; DNA; Drug Synergism; Intercellular Signaling Peptides and Proteins; Leukemia L1210; Melitten; Mice; Peptides; Pimozide; Sulfonamides; Trifluoperazine; Wasp Venoms

1985
In vivo photodegradation of chlorpromazine.
    Photochemistry and photobiology, 1989, Volume: 50, Issue:5

    Topics: Animals; Chlorpromazine; Free Radicals; Photochemistry; Promazine; Rats; Rats, Inbred Strains; Skin; Ultraviolet Rays

1989
Is hemoglobin a catalyst for sulfoxidation of chlorpromazine? An investigation with isolated purified hemoglobin and hemoglobin in monooxygenase and peroxidase mimicking systems.
    Biochemical pharmacology, 1989, Oct-15, Volume: 38, Issue:20

    Topics: Chlorpromazine; Hemoglobins; Humans; Hydrogen Peroxide; Oxidation-Reduction; Spectrophotometry

1989
Involvement of erythrocyte skeletal proteins in the modulation of membrane fluidity by phenothiazines.
    Biochemistry, 1987, Dec-15, Volume: 26, Issue:25

    Topics: Chlorpromazine; Colchicine; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; Kinetics; Membrane Fluidity; Membrane Proteins; Trifluoperazine; Vinblastine

1987
Effects of phenothiazines on the Na+-H+ exchanger of the brush-border membrane from the proximal small intestine of the rabbit.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3

    Topics: Amiloride; Animals; Carrier Proteins; Chlorpromazine; Glucose; In Vitro Techniques; Intestine, Small; Kinetics; Microvilli; Phenothiazines; Potassium Chloride; Proline; Rabbits; Sodium; Sodium-Hydrogen Exchangers

1988
Generation of electronically excited species during enzymatic oxidation of chlorpromazine and related compound.
    Biochemical and biophysical research communications, 1985, Aug-15, Volume: 130, Issue:3

    Topics: Chlorpromazine; Free Radicals; Horseradish Peroxidase; Hydrogen-Ion Concentration; Kinetics; Luminescent Measurements; Oxidation-Reduction; Peroxidases; Phenothiazines; Structure-Activity Relationship

1985
Chlorpromazine, but not chlorpromazine sulphoxide, stimulates transmitter release from motor nerve terminals.
    Brain research, 1987, Dec-29, Volume: 437, Issue:2

    Topics: Animals; Calcium; Calmodulin; Chlorpromazine; In Vitro Techniques; Magnesium; Membrane Potentials; Motor Endplate; Motor Neurons; Neuromuscular Junction; Neurotransmitter Agents; Rana temporaria; Structure-Activity Relationship

1987
Free radical production by chlorpromazine sulfoxide, an ESR spin-trapping and flash photolysis study.
    Photochemistry and photobiology, 1986, Volume: 44, Issue:1

    Topics: Chlorpromazine; Electron Spin Resonance Spectroscopy; Free Radicals; Oxidation-Reduction; Photolysis

1986
Photobinding of chlorpromazine and its sulfoxide in vitro and in vivo.
    Photochemistry and photobiology, 1988, Volume: 48, Issue:5

    Topics: Animals; Chlorpromazine; Rats; Tissue Distribution; Ultraviolet Rays

1988
Radioimmunoassay for the N-oxide metabolite of chlorpromazine in human plasma and its application to a pharmacokinetic study in healthy humans.
    Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:10

    Topics: Adult; Chlorpromazine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Half-Life; Humans; Male; Plasma; Radioimmunoassay; Spectrophotometry, Ultraviolet

1987
Postsynaptic inhibitory effects of phenothiazines at cholinergic synapses may not involve calmodulin.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 333, Issue:4

    Topics: Animals; Calmodulin; Chlorpromazine; Evoked Potentials; In Vitro Techniques; Motor Endplate; Parasympathetic Nervous System; Phenothiazines; Rana temporaria; Synapses

1986
Therapeutic monitoring of chlorpromazine. IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites.
    Therapeutic drug monitoring, 1987, Volume: 9, Issue:3

    Topics: Chlorpromazine; Chromatography, High Pressure Liquid; Male; Monitoring, Physiologic; Radioimmunoassay; Regression Analysis

1987
Therapeutic monitoring of chlorpromazine. III: Minimal interconversion between chlorpromazine and metabolites in human blood.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:1

    Topics: Biotransformation; Chlorpromazine; Chromatography, High Pressure Liquid; Erythrocytes; Humans

1986
Therapeutic monitoring of chlorpromazine I: Pitfalls in plasma analysis.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:2

    Topics: Chlorpromazine; Chromatography, High Pressure Liquid; Humans; Monitoring, Physiologic; Time Factors

1985
Determination of chlorpromazine and its sulphoxide in pharmaceutical dosage forms by third-order derivative ultraviolet spectroscopy.
    The Analyst, 1985, Volume: 110, Issue:9

    Topics: Chlorpromazine; Solutions; Spectrophotometry, Ultraviolet; Tablets

1985
Therapeutic monitoring of chlorpromazine II: Pitfalls in whole blood analysis.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Chlorpromazine; Chromatography, High Pressure Liquid; Humans; Time Factors

1985
Lack of correlation between intercalation and plasmid curing ability of some tricyclic compounds.
    Acta microbiologica Academiae Scientiarum Hungaricae, 1980, Volume: 27, Issue:1

    Topics: Amitriptyline; Chlorpromazine; DNA, Bacterial; Escherichia coli; Imipramine; Methylene Blue; Plasmids; Promethazine; Psychotropic Drugs

1980
Chlorpromazine, methotrimeprazine, and metabolites. Structural changes accompanying the loss of neuroleptic potency by ring sulfoxidation.
    Molecular pharmacology, 1982, Volume: 21, Issue:2

    Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Methotrimeprazine; Models, Molecular; Molecular Conformation; Rats; Structure-Activity Relationship

1982
Role of calmodulin in the flagellar axoneme: effect of phenothiazines on reactivated axonemes of Chlamydomonas.
    Progress in clinical and biological research, 1982, Volume: 80

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Calcium; Calcium-Binding Proteins; Calmodulin; Chlamydomonas; Chlorpromazine; Flagella; Fluphenazine; Movement; Phenothiazines

1982
Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron.
    Brain research, 1983, Aug-29, Volume: 273, Issue:2

    Topics: Animals; Calmodulin; Chlorpromazine; Cyclic AMP; Ganglia; In Vitro Techniques; Phenothiazines; Phosphoric Diester Hydrolases; Snails; Trifluoperazine

1983
Binding of 125I-calmodulin to platelet alpha-granules.
    FEBS letters, 1982, Apr-05, Volume: 140, Issue:1

    Topics: Animals; Binding Sites; Blood Platelets; Calcium; Calcium-Binding Proteins; Calmodulin; Chlorpromazine; Cytoplasmic Granules; Egtazic Acid; Microscopy, Electron; Swine; Trifluoperazine

1982
A study of the kinetics of chlorpromazine sulfoxide by a specific radioimmunoassay after a single oral dose of chlorpromazine in healthy volunteers.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Administration, Oral; Animals; Antibody Specificity; Chlorpromazine; Humans; Immune Sera; Kinetics; Rabbits; Radioimmunoassay

1983
A hyperosmotic stimulus regulates intracellular pH, calcium, and S-100 protein levels in avian chondrocytes.
    Biochemical and biophysical research communications, 1996, Oct-14, Volume: 227, Issue:2

    Topics: Amiloride; Animals; Calcium; Cartilage, Articular; Cells, Cultured; Chick Embryo; Chlorpromazine; Cytosol; Epiphyses; Fluorescent Dyes; Fura-2; Hydrogen-Ion Concentration; Hypertonic Solutions; Immunohistochemistry; Kinetics; S100 Proteins; Sucrose; Sulfonamides; Time Factors

1996
Prediction of drug responses in schizophrenia: a method using a test dose of chlorpromazine.
    Psychiatry and clinical neurosciences, 1997, Volume: 51, Issue:4

    Topics: Adult; Algorithms; Antipsychotic Agents; Chlorpromazine; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Middle Aged; Pilot Projects; Prognosis; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome

1997
The pharmacological properties of chlorpromazine sulfoxide, a major metabolite of chlorpromazine; a comparison with chlorpromazine.
    The Journal of pharmacology and experimental therapeutics, 1956, Volume: 118, Issue:3

    Topics: Chlorpromazine

1956
Action and metabolism of chlorpromazine sulfoxide in man.
    The Journal of pharmacology and experimental therapeutics, 1957, Volume: 121, Issue:1

    Topics: Chlorpromazine; Humans; Male

1957
The effects of chlorpromazine and chlorpromazine sulfoxide in normal and touriquet-shocked mice.
    The Journal of pharmacology and experimental therapeutics, 1958, Volume: 122, Issue:2

    Topics: Animals; Chlorpromazine; Mice; Shock

1958
The inhibitory effect of chlorpromazine and chlorpromazine sulfoxide on human cholinesterases.
    Archives internationales de pharmacodynamie et de therapie, 1958, Oct-01, Volume: 117, Issue:1-2

    Topics: Chlorpromazine; Cholinesterase Inhibitors; Humans

1958
A comparative study of the effect of drugs on activating and vasomotor responses evoked by midbrain stimulation: atropine, pentobarbital, chlorpromazine and chlorpromazine sulfoxide.
    Psychopharmacologia, 1960, Jun-23, Volume: 1

    Topics: Atropine; Chlorpromazine; Electroencephalography; Mesencephalon; Pentobarbital; Psychopharmacology

1960
Spectrophotometric method for the determination of chlorpromazine and chlorpromazine sulphoxide in biological fluids.
    Journal of medicinal and pharmaceutical chemistry, 1959, Volume: 1

    Topics: Body Fluids; Chlorpromazine; Feces; Spectrophotometry

1959
Chlorpromazine. III. The effects of chlorpromazine and chlorpromazine sulfoxide on vascular responses to L-epinephrine and levarterenol.
    The Journal of pharmacology and experimental therapeutics, 1960, Volume: 130

    Topics: Chlorpromazine; Epinephrine; Humans; Norepinephrine; Vasomotor System

1960
False negative result for amphetamines on the Triage Drug of Abuse panel? The cause of the unusual phenomenon with experimental analyses.
    International journal of legal medicine, 2009, Volume: 123, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Animals; Antipsychotic Agents; Autopsy; Chlorpromazine; Cross Reactions; Drug Combinations; False Negative Reactions; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Methamphetamine; Phenobarbital; Rats; Substance Abuse Detection

2009
[Simultaneous determination of chlorpromazine and promethazine and their main metabolites by capillary electrophoresis with electrochemiluminescence].
    Se pu = Chinese journal of chromatography, 2012, Volume: 30, Issue:9

    Topics: Animals; Chlorpromazine; Dogs; Electrochemical Techniques; Electrophoresis, Capillary; Luminescence; Promethazine

2012
In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:7

    Topics: Administration, Oral; Adult; Chlorpromazine; Cytochrome P-450 Enzyme System; Drug Interactions; Epoxide Hydrolases; Female; Half-Life; Hepatocytes; Humans; Male; Microsomes, Liver; Middle Aged; Oxidation-Reduction; Proteasome Inhibitors; Recombinant Proteins; Triazoles; Young Adult

2017
Establishment of LC-MS/MS method for quantifying chlorpromazine metabolites with application to its metabolism in liver and placenta microsomes.
    Journal of pharmaceutical and biomedical analysis, 2023, Sep-05, Volume: 233

    Topics: Animals; Chlorpromazine; Chromatography, Liquid; Humans; Liver; Microsomes, Liver; Rats; Tandem Mass Spectrometry

2023