chlorpromazine and loperamide

chlorpromazine has been researched along with loperamide in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19905 (27.78)18.7374
1990's0 (0.00)18.2507
2000's4 (22.22)29.6817
2010's7 (38.89)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Gozalbes, R; Pineda-Lucena, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bruno, C; Carrieri, A; Cavalluzzi, MM; Franchini, C; Giannuzzi, G; Illario, M; Lentini, G; Lovece, A; Polimeno, L; Pracella, R; Rusciano, MR; Viale, M1
Easwaran, M; Manickam, M; Pillaiyar, T; Wendt, LL1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Burks, TF; Norman, JA; Shook, JE; Wasley, JW1
Burke, V; Gracey, M1
Abbey, DM; Knoop, FC1
Soeparto, P1
Bestebroer, TM; de Wilde, AH; Jochmans, D; Neyts, J; Posthuma, CC; Snijder, EJ; van den Hoogen, BG; van Nieuwkoop, S; Zevenhoven-Dobbe, JC1
Badaoui, M; Dickson, CJ; Hornak, V; Kells, A; Molteni, C; Rosta, E1

Reviews

2 review(s) available for chlorpromazine and loperamide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.
    Medicinal research reviews, 2021, Volume: 41, Issue:1

    Topics: Antiviral Agents; Chemistry, Pharmaceutical; COVID-19; Disease Outbreaks; Drug Repositioning; Humans; Virus Internalization

2021

Other Studies

16 other study(ies) available for chlorpromazine and loperamide

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II.
    European journal of medicinal chemistry, 2016, Jun-30, Volume: 116

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cattle; Humans; Molecular Docking Simulation; Piperidines; Protein Conformation; Protein Kinase Inhibitors; Thiazoles

2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1

    Topics: Analgesics; Animals; Antidiarrheals; Benzimidazoles; Calmodulin; Chlorpromazine; Gastrointestinal Transit; Loperamide; Male; Mice; Mice, Inbred ICR; Morphine; Rats; Rats, Inbred Strains

1989
Studies with enterotoxigenic microorganisms: effects of candidate antidiarrhoeals in experimental animals in vivo.
    Journal of pediatric gastroenterology and nutrition, 1984, Volume: 3, Issue:4

    Topics: Aluminum Hydroxide; Animals; Antidiarrheals; Aspirin; Bacterial Infections; Charcoal; Chlorpromazine; Cholestyramine Resin; Diarrhea; Drug Combinations; Enterotoxins; Indomethacin; Loperamide; Male; Niacinamide; Rats; Rats, Inbred Strains; Water-Electrolyte Balance

1984
Effect of chemical and pharmacological agents on the secretory activity induced by Escherichia coli heat-stable enterotoxin.
    Canadian journal of microbiology, 1981, Volume: 27, Issue:8

    Topics: Animals; Aspirin; Chlorpromazine; Diphenoxylate; Egtazic Acid; Enterotoxins; Escherichia coli; Hydrocortisone; Intestinal Mucosa; Loperamide; Methylprednisolone; Mice; Phentolamine; Propranolol; Trifluoperazine

1981
Anti-diarrhoeal drugs.
    The Southeast Asian journal of tropical medicine and public health, 1982, Volume: 13, Issue:3

    Topics: Anti-Bacterial Agents; Antidiarrheals; Aspirin; Chlorpromazine; Cholestyramine Resin; Diarrhea, Infantile; Humans; Infant; Kaolin; Loperamide; Pectins

1982
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Chloroquine; Chlorpromazine; Coronavirus 229E, Human; Drug Approval; Hepatocytes; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Loperamide; Lopinavir; Middle East Respiratory Syndrome Coronavirus; Severe acute respiratory syndrome-related coronavirus; Small Molecule Libraries; Vero Cells; Virus Replication

2014
Calculating Kinetic Rates and Membrane Permeability from Biased Simulations.
    The journal of physical chemistry. B, 2018, 12-13, Volume: 122, Issue:49

    Topics: Cell Membrane Permeability; Chlorpromazine; Desipramine; Domperidone; Kinetics; Labetalol; Lipid Bilayers; Loperamide; Molecular Dynamics Simulation; Molecular Structure; Propranolol; Thermodynamics; Verapamil

2018