chlorpromazine and flupenthixol

chlorpromazine has been researched along with flupenthixol in 46 studies

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199025 (54.35)18.7374
1990's9 (19.57)18.2507
2000's4 (8.70)29.6817
2010's7 (15.22)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Fang, VS; Meltzer, HY; Paul, SM1
Juorio, AV1
Munday, KA; Poat, JA; Sumners, C; Woodruff, GN1
Barnes, JL; Mee, TJ; Smith, JA1
Carney, MW; Crow, TJ; Frith, CD; Johnstone, EC; Price, JS1
Horn, AS; Kennard, O; Post, ML1
Bartlett, W; Bourne, RC; Cotes, PM; Crow, TJ; Johnstone, EC1
Miller, RJ1
Johnson, DA; Malik, NA1
Kelly, PH; Miller, RJ1
Gregory, RP; Rudge, P; Smith, PT1
Hawton, K; Reznek, L; Shepstone, B; Soper, N1
Grosman, N1
Matsubara, S; Meltzer, HY1
Kehoe, R; Young, A1
Dymock, IW; Lo, TC; Unwin, MR1
Ardern, M; Gelder, MG; Jambor, K; Kolakowska, T; Mandelbrote, BM; Reveley, MA; Williams, AO1
Crow, TJ; Johnson, AL; Johnstone, EC; MacMillan, JF1
Dinan, TG1
Barakat, S; Berkal, A; Brown, JH; McIlwraith, R1
Nielsen, IM1
Daus, FJ; Hansen, HA; Plantjé, JF; Stoof, JC1
Bourne, RC; Crow, TJ; Fadhli, AA; Johnstone, EC; Owen, F1
Matsubara, R1
Vohra, SB1
Szabo, CP1
Bindl, A; Eberlein-König, B; Przybilla, B1
Blenau, W; Marg, S; Walz, B1
Lam, D; Patten, SB; Pringsheim, T; Tano, DS1
Chen, YC; Chen, YW; Chu, CC; Leung, YM; Wang, JJ1
Dold, M; Engel, RR; Leucht, S; Tardy, M1
Osman, E; Yıldız, M1
George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH1
Andrews, PR; Craik, DJ; Martin, JL1
Chakrabarti, JK; Horsman, L; Hotten, TM; Pullar, IA; Tupper, DE; Wright, FC1
Chakrabarti, JK; Fairhurst, J; Gutteridge, NJ; Horsman, L; Pullar, IA; Smith, CW; Steggles, DJ; Tupper, DE; Wright, FC1
Bøgesø, KP1
Emms, F; Freedman, SB; Knowles, MR; Marwood, R; McAllister, G; Patel, S; Seabrook, GR1
Pajeva, I; Wiese, M1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ekins, S; Williams, AJ; Xu, JJ1
Brincat, JP; Carosati, E; Cruciani, G; Fravolini, A; Kaatz, GW; Manfroni, G; Patel, D; Raygada, JL; Sabatini, S1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Bennis, K; Ducki, S; Lesage, F; Vivier, D1

Reviews

2 review(s) available for chlorpromazine and flupenthixol

ArticleYear
Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia.
    The Cochrane database of systematic reviews, 2014, Sep-01, Issue:9

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Chlorpromazine; Flupenthixol; Humans; Randomized Controlled Trials as Topic; Schizophrenia; Xerostomia

2014
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship

2016

Trials

4 trial(s) available for chlorpromazine and flupenthixol

ArticleYear
Mechanism of the antipsychotic effect in the treatment of acute schizophrenia.
    Lancet (London, England), 1978, Apr-22, Volume: 1, Issue:8069

    Topics: Acute Disease; Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Female; Flupenthixol; Humans; Isomerism; Male; Placebos; Receptors, Dopamine; Research Design; Schizophrenia; Thioxanthenes

1978
Neuroendocrine changes in acute schizophrenia as a function of clinical state and neuroleptic medication.
    Psychological medicine, 1978, Volume: 8, Issue:4

    Topics: Acute Disease; Chlorpromazine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Flupenthixol; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing Hormone; Orphenadrine; Prolactin; Receptors, Dopamine; Schizophrenia; Testosterone; Thioxanthenes

1978
A double-blind comparison of fluphenazine decanoate and flupenthixol decanoate in the treatment of acute schizophrenia.
    Acta psychiatrica Scandinavica, 1975, Volume: 51, Issue:4

    Topics: Acute Disease; Chlorpromazine; Clinical Trials as Topic; Drug Evaluation; Flupenthixol; Fluphenazine; Humans; Placebos; Schizophrenia; Time Factors

1975
A randomised controlled trial of prophylactic neuroleptic treatment.
    The British journal of psychiatry : the journal of mental science, 1986, Volume: 148

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Female; Flupenthixol; Follow-Up Studies; Haloperidol; Humans; Male; Middle Aged; Pimozide; Random Allocation; Recurrence; Schizophrenia; Time Factors; Trifluoperazine

1986

Other Studies

40 other study(ies) available for chlorpromazine and flupenthixol

ArticleYear
Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats.
    Psychopharmacology, 1977, Jan-31, Volume: 51, Issue:2

    Topics: Animals; Antipsychotic Agents; Chlorpromazine; Dibenzocycloheptenes; Flupenthixol; Haloperidol; Male; Prolactin; Quinolizines; Rats; Receptors, Dopamine; Stereoisomerism; Thioxanthenes

1977
Effect of chlorpromazine and other anti-psychotic drugs on mouse striatal tyramines.
    Life sciences, 1977, May-15, Volume: 20, Issue:10

    Topics: Animals; Antipsychotic Agents; Chlorpromazine; Corpus Striatum; Flupenthixol; Haloperidol; Male; Mice; Motor Activity; Structure-Activity Relationship; Tyramine

1977
The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol.
    Psychopharmacology, 1979, Feb-28, Volume: 60, Issue:3

    Topics: Angiotensin II; Animals; Antipsychotic Agents; Carbachol; Chlorpromazine; Clozapine; Dopamine; Drinking Behavior; Flupenthixol; Fluphenazine; Haloperidol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pimozide; Rats; Sulpiride

1979
The effect of neuroleptic drugs on serum and cerebrospinal fluid melatonin concentrations in psychiatric subjects.
    The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Antipsychotic Agents; Chlorpromazine; Female; Flupenthixol; Fluphenazine; Humans; Male; Melatonin; Mental Disorders; Middle Aged

1979
Dopamine receptor blockade and the neuroleptics, a crystallographic study.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:8

    Topics: Chlorpromazine; Chlorprothixene; Crystallography; Dopamine Antagonists; Flupenthixol; Imipramine; Molecular Conformation; Phenothiazines; Promazine; Promethazine; Receptors, Drug; Structure-Activity Relationship; Thiethylperazine; Tranquilizing Agents; Triflupromazine

1975
Comparison of the inhibitory effects of neuroleptic drugs on adenylate cyclase in rat tissues stimulated by dopamine, noradrenaline and glucagon.
    Biochemical pharmacology, 1976, Mar-01, Volume: 25, Issue:5

    Topics: Adenylyl Cyclase Inhibitors; Adipose Tissue; Animals; Chlorpromazine; Chlorprothixene; Corpus Striatum; Dopamine; Flupenthixol; Glucagon; Haloperidol; In Vitro Techniques; Liver; Membranes; Norepinephrine; Pimozide; Promazine; Rats; Receptors, Adrenergic; Tranquilizing Agents

1976
The interaction of neuroleptic and muscarinic agents with central dopaminergic systems.
    British journal of pharmacology, 1975, Volume: 54, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clopenthixol; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Male; Methamphetamine; Models, Biological; Oxotremorine; Parasympathomimetics; Pimozide; Rats; Scopolamine; Substantia Nigra; Thioridazine; Tranquilizing Agents

1975
Tardive dyskinesia presenting as severe dysphagia.
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:12

    Topics: Bipolar Disorder; Chlorpromazine; Deglutition Disorders; Dyskinesia, Drug-Induced; Female; Flupenthixol; Humans; Middle Aged; Neurologic Examination; Substance Withdrawal Syndrome

1992
Single-photon emission computerised tomography (SPECT) in schizophrenia.
    The British journal of psychiatry : the journal of mental science, 1990, Volume: 156

    Topics: Adult; Brain; Cerebrovascular Circulation; Chlorpromazine; Female; Flupenthixol; Humans; Schizophrenia; Temporal Lobe; Tomography, Emission-Computed, Single-Photon

1990
Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells.
    Agents and actions, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Calcimycin; Calmodulin; Chlorpromazine; Flupenthixol; Glucose; Histamine Release; Imidazoles; Imipramine; In Vitro Techniques; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Trifluoperazine

1986
Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex.
    Life sciences, 1989, Volume: 45, Issue:15

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Butyrophenones; Cerebral Cortex; Chlorpromazine; Clozapine; Dibenzazepines; Dibenzothiazepines; Down-Regulation; Flupenthixol; Kinetics; Loxapine; Male; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiro Compounds; Time Factors

1989
Two cases of agranulocytosis on addition of a butyrophenone to a long-standing course of phenothiazine treatment.
    The British journal of psychiatry : the journal of mental science, 1989, Volume: 154

    Topics: Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Droperidol; Drug Therapy, Combination; Female; Flupenthixol; Fluphenazine; Humans; Long-Term Care; Male; Middle Aged; Paranoid Disorders; Psychotic Disorders

1989
Neuroleptic malignant syndrome: another medical cause of acute abdomen.
    Postgraduate medical journal, 1989, Volume: 65, Issue:767

    Topics: Abdomen, Acute; Adult; Chlorpromazine; Diagnostic Errors; Female; Flupenthixol; Humans; Intestinal Pseudo-Obstruction; Neuroleptic Malignant Syndrome; Sepsis; Tranquilizing Agents

1989
Schizophrenia with good and poor outcome. I: Early clinical features, response to neuroleptics and signs of organic dysfunction.
    The British journal of psychiatry : the journal of mental science, 1985, Volume: 146

    Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Brain; Chlorpromazine; Cognition Disorders; Female; Flupenthixol; Fluphenazine; Humans; Male; Middle Aged; Prognosis; Prolactin; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Tomography, X-Ray Computed

1985
Neuroleptic effects on platelet aggregation: a study in normal volunteers and schizophrenics.
    Psychological medicine, 1987, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Delayed-Action Preparations; Flupenthixol; Fluphenazine; Haloperidol; Humans; Male; Platelet Aggregation; Procyclidine; Schizophrenia; Sulpiride; Trifluoperazine

1987
Personality diagnosis and illness diagnosis.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1985, Volume: 30, Issue:6

    Topics: Adult; Bipolar Disorder; Borderline Personality Disorder; Chlorpromazine; Drug Therapy, Combination; Female; Flupenthixol; Hospitalization; Humans; Lithium; Lithium Carbonate; Personality Disorders; Schizotypal Personality Disorder

1985
Pharmacological vs. clinical physiognomy of neuroleptics, with special reference to their sedative and antipsychotic effects.
    Acta psychiatrica Belgica, 1974, Volume: 74, Issue:5

    Topics: Animals; Behavior, Animal; Chlorpromazine; Chlorprothixene; Clopenthixol; Dogs; Drug Evaluation, Preclinical; Drug Tolerance; Flupenthixol; Fluphenazine; Haloperidol; Mice; Motor Activity; Perphenazine; Rats; Tranquilizing Agents

1974
The effects of SCH 23390, YM 09151-2, (+)- and (-)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Antipsychotic Agents; Aporphines; Benzamides; Benzazepines; Caudate Nucleus; Chlorpromazine; Clozapine; Flupenthixol; Haloperidol; In Vitro Techniques; Male; Piperidines; Potassium; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2

1984
Platelet monoamine oxidase activity in acute schizophrenia: relationship to symptomatology and neuroleptic medication.
    The British journal of psychiatry : the journal of mental science, 1981, Volume: 139

    Topics: Acute Disease; Blood Platelets; Chlorpromazine; Female; Flupenthixol; Humans; Male; Monoamine Oxidase; Schizophrenia; Sex Factors; Thioxanthenes

1981
[A study on the pharmacological properties of atypical antipsychotic drugs: in vivo dopamine and serotonin receptor occupancy by atypical antipsychotic drugs in the rat brain].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1993, Volume: 68, Issue:4

    Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Chlorpromazine; Clozapine; Dibenzothiepins; Flupenthixol; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Piperidines; Pyrimidinones; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone

1993
Convulsions after enflurane in a schizophrenic patient receiving neuroleptics.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:5 Pt 1

    Topics: Adult; Anesthesia, Inhalation; Chlorpromazine; Drug Synergism; Enflurane; Epilepsy, Tonic-Clonic; Flupenthixol; Humans; Male; Schizophrenia; Seizures

1994
Depot flupenthixol-induced mania.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1993, Volume: 83, Issue:6

    Topics: Adult; Bipolar Disorder; Chlorpromazine; Delayed-Action Preparations; Flupenthixol; Humans; Lithium; Male

1993
Phototoxic properties of neuroleptic drugs.
    Dermatology (Basel, Switzerland), 1997, Volume: 194, Issue:2

    Topics: Antipsychotic Agents; Chlorpromazine; Chlorprothixene; Clopenthixol; Dermatitis, Phototoxic; Drug Eruptions; Erythrocytes; Flupenthixol; Fluphenazine; Hemolysis; Humans; Methotrimeprazine; Perazine; Perphenazine; Phenothiazines; Promazine; Promethazine; Radiation Dosage; Thiazines; Thioridazine; Thiothixene; Trifluoperazine; Triflupromazine; Ultraviolet Rays

1997
The effects of dopamine receptor agonists and antagonists on the secretory rate of cockroach (Periplaneta americana) salivary glands.
    Journal of insect physiology, 2004, Volume: 50, Issue:9

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Butaclamol; Chlorpromazine; Cockroaches; Dopamine Agonists; Dopamine Antagonists; Flupenthixol; Linear Models; Lisuride; Microscopy, Video; Proteins; Salivary Glands; Tetrahydronaphthalenes

2004
The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2011, Volume: 56, Issue:10

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Canada; Chlorpromazine; Clopenthixol; Clozapine; Female; Flupenthixol; Humans; Loxapine; Male; Olanzapine; Pharmacoepidemiology; Schizophrenia

2011
Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.
    European journal of pharmacology, 2012, Oct-15, Volume: 693, Issue:1-3

    Topics: Anesthesia, Spinal; Anesthetics; Animals; Antipsychotic Agents; Behavior, Animal; Chlorpromazine; Chlorprothixene; Dopamine Antagonists; Flupenthixol; Fluphenazine; Injections, Spinal; Male; Nociception; Rats; Rats, Sprague-Dawley; Sensation

2012
Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020.
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2022,Summer, Volume: 33, Issue:2

    Topics: Adenosine Monophosphate; Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Chlorpromazine; Clopenthixol; Clozapine; Flupenthixol; Fluphenazine; Haloperidol; Humans; Olanzapine; Paliperidone Palmitate; Pharmaceutical Preparations; Pimozide; Quetiapine Fumarate; Risperidone; Sulpiride; Trifluoperazine

2022
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
    Nature, 1991, Apr-18, Volume: 350, Issue:6319

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection

1991
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
4-Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:8

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats; Structure-Activity Relationship

1980
10-Piperazinyl-4H-theino[3,2-b][1,5]- and -[3,4-b][1,5]benzodiazepines as potential neuroleptics.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:8

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats

1980
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:7

    Topics: Amphetamine; Animals; Antipsychotic Agents; Biological Assay; Biological Transport; Brain; Cell Membrane; Corpus Striatum; Dopamine; Haloperidol; Indans; Indenes; Male; Mice; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Structure-Activity Relationship; Synaptosomes

1983
Expression and pharmacological characterization of the human D3 dopamine receptor.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1

    Topics: Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanine Nucleotides; Humans; Potassium Channels; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Second Messenger Systems; Sulpiride

1994
Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study.
    Journal of medicinal chemistry, 1998, May-21, Volume: 41, Issue:11

    Topics: Antineoplastic Agents; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Conformation; Phenothiazines; Thioxanthenes; Tumor Cells, Cultured

1998
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.
    Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Benzimidazoles; Ciprofloxacin; Databases, Factual; Drug Resistance, Bacterial; Drug Synergism; Ethidium; Microbial Sensitivity Tests; Models, Molecular; Multidrug Resistance-Associated Proteins; Phenyl Ethers; Propanolamines; Quantitative Structure-Activity Relationship; Staphylococcus aureus; Structure-Activity Relationship; Sulfonamides

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012