chlorpromazine and diclofenac

chlorpromazine has been researched along with diclofenac in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.50)	18.7374
1990's	3 (7.50)	18.2507
2000's	9 (22.50)	29.6817
2010's	25 (62.50)	24.3611
2020's	2 (5.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Briand, X; Faller, B; Lázaro, E; Lowe, PJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Goetz, GH; Philippe, L; Shapiro, MJ	1
Bennis, K; Ducki, S; Lesage, F; Vivier, D	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Miao, GX; Wang, YD; Yan, ZW; Zhang, LY	1
Kortelainen, ML; Särkioja, T	1
Benhamou, JP; Berson, A; Douay, C; Fréneaux, E; Fromenty, B; Larrey, D; Lepage, V; Mallet, C; Pessayre, D	1
Bigal, ME; Bordini, CA; Speciali, JG	1
Abou-Shakra, F; Bailey, NJ; Duckett, CJ; Lindon, JC; Nicholson, JK; Walker, H; Wilson, ID	1
Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M	1
Antunes, SC; de Oliveira, LL; Gonçalves, F; Nunes, B; Rocha, O	1
Antunes, SC; Gonçalves, F; Nunes, B; Oliveira, LL; Rocha, O	1
Honda, H; Ito, Y; Kawamoto, T; Morita, O	1
Arakawa, H; Idota, Y; Jomura, T; Kojima, H; Koyama, S; Ogihara, T; Yano, K	1
Dai, W; Dutta, A; Han, Y; Kumar, A; Liu, J; Liu, W; Liu, Z; Shen, X	1
Alkimin, GD; Barata, C; Daniel, D; Frankenbach, S; Nunes, B; Serôdio, J; Soares, AMVM	1
Khan, SS; Mirza, T; Naeem, S; Najam, R; Sikandar, B	1
Aboshanab, KM; Aboulwafa, MM; Ahmed, MT; Anwer, BE; Mohammed, MA	1

Reviews

2 review(s) available for chlorpromazine and diclofenac

Article	Year
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11 Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship	2016
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Article

Year

Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?

Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship

2016

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

38 other study(ies) available for chlorpromazine and diclofenac

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides. ACS medicinal chemistry letters, 2014, Oct-09, Volume: 5, Issue:10 Topics:	2014
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors. Bioorganic & medicinal chemistry letters, 2020, 07-15, Volume: 30, Issue:14 Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Glycogen Phosphorylase; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Indoles; Mice; Molecular Structure; Rats; Structure-Activity Relationship	2020
Fatal complications of intramuscular and intra-articular injections. Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1990, Volume: 103, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Arthritis, Infectious; Brain Damage, Chronic; Cause of Death; Chlorpromazine; Diclofenac; Female; Glycosaminoglycans; Heart Arrest; Humans; Injections, Intra-Articular; Injections, Intramuscular; Male; Malpractice; Middle Aged; Shock, Septic; Staphylococcal Infections; Triamcinolone	1990
Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis. Journal of hepatology, 1994, Volume: 20, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diclofenac; Female; Halothane; Haplotypes; HLA Antigens; HLA-A Antigens; HLA-A11 Antigen; HLA-B8 Antigen; HLA-DR2 Antigen; HLA-DR6 Antigen; Humans; Male; Middle Aged; Nitrofurantoin; Phenotype	1994
[Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil]. Arquivos de neuro-psiquiatria, 1999, Volume: 57, Issue:3B Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Child, Preschool; Chlorpromazine; Diclofenac; Dipyrone; Emergencies; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Retrospective Studies; Sex Distribution; Tension-Type Headache	1999
Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry investigated using diclofenac and chlorpromazine. Rapid communications in mass spectrometry : RCM, 2002, Volume: 16, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Chlorobenzoates; Chlorpromazine; Chromatography, High Pressure Liquid; Diclofenac; Mass Spectrometry; Reference Standards; Reproducibility of Results	2002
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro? PloS one, 2015, Volume: 10, Issue:4 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil	2015
Acute and chronic ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna. Drug and chemical toxicology, 2016, Volume: 39, Issue:1 Topics: Acetaminophen; Animals; Chlorpromazine; Daphnia; Diclofenac; Dose-Response Relationship, Drug; Female; Propranolol; Rats, Wistar; Reproduction; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical	2016
Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers. Ecotoxicology and environmental safety, 2015, Volume: 119 Topics: Acetaminophen; Animals; Biomarkers; Catalase; Chlorpromazine; Daphnia; Diclofenac; Ecotoxicology; Environmental Exposure; Glutathione Peroxidase; Glutathione Transferase; Oxidative Stress; Prescription Drugs; Propranolol	2015
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. The Journal of toxicological sciences, 2017, Volume: 42, Issue:4 Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics	2017
Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. The Journal of toxicological sciences, 2017, Volume: 42, Issue:4 Topics: Alanine Transaminase; Albumins; Aspartate Aminotransferases; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diclofenac; Feeder Cells; Flutamide; gamma-Glutamyltransferase; Hepatocytes; Humans; Isoniazid; L-Lactate Dehydrogenase; Liver; Spheroids, Cellular; Time Factors; Toxicity Tests	2017
Selective adsorption and removal of drug contaminants by using an extremely stable Cu(II)-based 3D metal-organic framework. Chemosphere, 2019, Volume: 215 Topics: Adsorption; Amodiaquine; Chlorpromazine; Copper; Diclofenac; Hydrogen-Ion Concentration; Kinetics; Metal-Organic Frameworks; Temperature; Water Pollutants, Chemical; Water Purification	2019
Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba. The Science of the total environment, 2019, Mar-20, Volume: 657 Topics: Acetaminophen; Anthocyanins; Aquatic Organisms; Araceae; Carotenoids; Catalase; Chlorophyll A; Chlorpromazine; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Ecotoxicology; Environmental Biomarkers; Water Pollutants, Chemical	2019
Neuroprotective effect of diclofenac on chlorpromazine induced catalepsy in rats. Metabolic brain disease, 2019, Volume: 34, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Catalepsy; Chlorpromazine; Corpus Striatum; Diclofenac; Dopamine; Female; Levodopa; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar	2019
Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones. PloS one, 2020, Volume: 15, Issue:8 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Chlorpromazine; Ciprofloxacin; Cross Infection; Diclofenac; Disk Diffusion Antimicrobial Tests; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Egypt; Fluoroquinolones; Humans; Levofloxacin; Propranolol	2020