chlorpromazine and diazoxide

chlorpromazine has been researched along with diazoxide in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199013 (52.00)18.7374
1990's1 (4.00)18.2507
2000's3 (12.00)29.6817
2010's8 (32.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Gozalbes, R; Pineda-Lucena, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Aynsley-Green, A; Illig, R1
Casara, D; Erle, G; Federspil, G; Scandellari, C; Sicolo, N; Zaccaria, M1
De Palo, C; Erle, G; Federspil, G; Scandellari, C; Sicolo, N; Zaccaria, M; Zago, E1
Vague, PH; Vialettes, B1
Herbsman, H; Powers, JC; Shaftan, GW1
De Weille, JR; Lazdunski, M; Müller, M1
Hellman, B; Sehlin, J; Täljedal, IB1
Casara, D; Federspil, G; Stauffacher, W1
Bianchetti, A; Jori, A1
Hilden, T; Krogsgaard, A; McNair, A; Nielsen, PE1
Halawa, B1

Reviews

2 review(s) available for chlorpromazine and diazoxide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Treatment of arterial hypertension in elderly patients].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1981, Aug-15, Volume: 34, Issue:16

    Topics: Age Factors; Aged; Antihypertensive Agents; Chlorpromazine; Diazoxide; Dihydralazine; Drug Therapy, Combination; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Methyldopa; Middle Aged; Spironolactone

1981

Trials

3 trial(s) available for chlorpromazine and diazoxide

ArticleYear
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
    Acta medica Scandinavica. Supplementum, 1983, Volume: 678

    Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; Dihydralazine; Emergencies; Furosemide; Humans; Hydralazine; Hypertension; Hypotension; Paralysis; Risk

1983
[Treatment of acute, severe hypertension assessed in a multicentre study. The effects of rest and furosemide and a randomized clinical trial of chlorpromazine, dihydralazine and diazoxide].
    Ugeskrift for laeger, 1981, Jun-01, Volume: 143, Issue:23

    Topics: Adult; Aged; Bed Rest; Chlorpromazine; Clinical Trials as Topic; Diazoxide; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Random Allocation

1981
Emergency treatment of severe hypertension evaluated in a randomized study. Effect of rest and furosemide and a randomized evaluation of chlorpromazine, dihydralazine and diazoxide. Danish Multicenter Study.
    Acta medica Scandinavica, 1980, Volume: 208, Issue:6

    Topics: Adult; Aged; Chlorpromazine; Denmark; Diazoxide; Dihydralazine; Drug Administration Schedule; Female; Furosemide; Humans; Hydralazine; Hypertension; Male; Middle Aged; Posture; Prospective Studies; Random Allocation

1980

Other Studies

20 other study(ies) available for chlorpromazine and diazoxide

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Letter: Enhancement by chlorpromazine of hyperglycaemic action of diazoxide.
    Lancet (London, England), 1975, Oct-04, Volume: 2, Issue:7936

    Topics: Blood Glucose; Chlorpromazine; Diazoxide; Drug Synergism; Humans; Infant; Male

1975
Medical treatment of endogenous organic hyperinsulinism.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1976, Volume: Suppl 6

    Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Child; Chlorpromazine; Diazoxide; Female; Humans; Hyperinsulinism; Male; Pancreatic Diseases; Phenytoin; Propranolol; Streptozocin

1976
[Medical treatment of spontaneous hypoglycemic syndromes].
    Minerva medica, 1979, Jun-16, Volume: 70, Issue:28

    Topics: Adenoma, Islet Cell; Chlorpromazine; Diazoxide; Fasting; Glucagon; Glucose; Humans; Hypoglycemia; Liver; Pancreatic Neoplasms; Streptozocin

1979
[Potentiation of the effects of diazoxide by chlorpromazine in the treatment of organic hyperinsulinism].
    La Nouvelle presse medicale, 1977, May-21, Volume: 6, Issue:21

    Topics: Chlorpromazine; Diazoxide; Drug Synergism; Female; Humans; Hyperinsulinism; Middle Aged

1977
Evaluation of various hypotensive agents in the control of experimental hemorrhage.
    The Journal of surgical research, 1975, Volume: 18, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Chlorpromazine; Diazoxide; Dogs; Drug Evaluation, Preclinical; Guanethidine; Hemorrhage; Hydralazine; Phenoxybenzamine; Protoveratrines; Tolazoline

1975
Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel.
    European journal of pharmacology, 1991, May-30, Volume: 198, Issue:1

    Topics: Adenosine Triphosphate; Antipsychotic Agents; Chlorpromazine; Diazoxide; Electrophysiology; Insulinoma; Pancreatic Neoplasms; Potassium Channels; Rubidium Radioisotopes; Tumor Cells, Cultured

1991
The pancreatic -cell recognition of insulin secretagogues. IV. Islet uptake of sulfonylureas.
    Diabetologia, 1973, Volume: 9, Issue:3

    Topics: Animals; Antimycin A; Carbon Isotopes; Chlorpromazine; Diazoxide; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Leucine; Male; Mice; Serum Albumin; Sulfur Isotopes; Tolbutamide

1973
Chlorpromazine in the treatment of endogenous organic hyperinsulinism.
    Diabetologia, 1974, Volume: 10, Issue:3

    Topics: Adult; Bendroflumethiazide; Blood Glucose; Chlorpromazine; Diazoxide; Female; Glucose Tolerance Test; Hirsutism; Humans; Hyperinsulinism; Hypoglycemia; Insulin Antagonists; Nausea; Pancreas

1974
Effect of benzyloxyguanidine (13958 RP) on the increase of blood glucose and plasma free fatty acids induced by various drugs in rats.
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1967, Volume: 17, Issue:1

    Topics: Animals; Blood Glucose; Body Temperature; Chlorpromazine; Diabetes Mellitus, Experimental; Diazoxide; Epinephrine; Fatty Acids, Nonesterified; Female; Guanidines; Norepinephrine; Rats; Reserpine

1967