chlorpromazine and dextromethorphan

chlorpromazine has been researched along with dextromethorphan in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's1 (6.25)18.2507
2000's4 (25.00)29.6817
2010's9 (56.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Dalvie, D; Loi, CM; Smith, DA1
Berger, ML; Rebernik, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bassetto, M; Brancale, A; Ferla, S; Kandil, S; McGuigan, C; Pertusati, F; Westwell, AD2
Haigler, HJ; Spring, DD1
Koyuncuoğlu, H; Saydam, B1
Lindquist, P; Rubenstein, KE; Schneider, RS; Tong-in Wong, E; Ullman, EF1
Bhoopathy, S; Karnes, HT; Unger, SE; Xin, B1
Akahoshi, T; Takemoto, T; Wada, T1
de Jong, M; De Wael, K; Florea, A; Samyn, N; Sleegers, N; Van Loon, J; van Nuijs, ALN1

Reviews

2 review(s) available for chlorpromazine and dextromethorphan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Fever induced by various drugs].
    Rinsho byori. The Japanese journal of clinical pathology, 2009, Volume: Suppl 143

    Topics: Amphetamine; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Body Temperature Regulation; Chlorpromazine; Contraindications; Dextromethorphan; Fever; Histamine Antagonists; Homeostasis; Humans; Hydralazine; Hypothalamus; Isoniazid; Lupus Erythematosus, Systemic; Sympathetic Nervous System

2009

Trials

1 trial(s) available for chlorpromazine and dextromethorphan

ArticleYear
The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine.
    International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:4

    Topics: Adult; Chlorpromazine; Dextromethorphan; Diazepam; Double-Blind Method; Female; Heroin Dependence; Humans; Levorphanol; Male; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome

1990

Other Studies

13 other study(ies) available for chlorpromazine and dextromethorphan

ArticleYear
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers.
    Bioorganic & medicinal chemistry letters, 2015, Oct-01, Volume: 25, Issue:19

    Topics: Animals; Brain; Cations; Diamines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Molecular Structure; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

2015
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
    European journal of medicinal chemistry, 2016, Aug-08, Volume: 118

    Topics: Anilides; Antineoplastic Agents; Benzamides; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Drug Resistance, Neoplasm; Humans; Male; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Permeability; Phenylthiohydantoin; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Tosyl Compounds

2016
Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety.
    Bioorganic & medicinal chemistry letters, 2016, 08-01, Volume: 26, Issue:15

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Male; Molecular Docking Simulation; Molecular Structure; Prostatic Neoplasms; Structure-Activity Relationship; Xylenes

2016
Drugs that antagonize limb flick behavior induced by D-lysergic acid diethylamide (LSD) in cats.
    Psychopharmacology, 1979, Jun-28, Volume: 64, Issue:1

    Topics: Animals; Behavior, Animal; Cats; Chlorpromazine; Dextromethorphan; Dextrorphan; Female; Forelimb; Imipramine; Lysergic Acid Diethylamide; Pentobarbital

1979
Homogeneous enzyme immunoassay for opiates in urine.
    Clinical chemistry, 1973, Volume: 19, Issue:8

    Topics: Animals; Binding Sites; Binding Sites, Antibody; Binding, Competitive; Chlorpromazine; Chromatography, Thin Layer; Dextromethorphan; Enzymes; Humans; Immunoassay; Indicators and Reagents; Methods; Morphinans; Morphine; Muramidase; Protein Binding; Rabbits; Sheep; Spectrophotometry

1973
A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.
    Journal of pharmaceutical and biomedical analysis, 2005, Apr-01, Volume: 37, Issue:4

    Topics: Algorithms; Animals; Antitussive Agents; Chlorpromazine; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Half-Life; Humans; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Microsomes, Liver; Midazolam; Pharmaceutical Preparations; Primaquine; Quinidine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2005
Unraveling the Mechanisms Behind the Complete Suppression of Cocaine Electrochemical Signals by Chlorpromazine, Promethazine, Procaine, and Dextromethorphan.
    Analytical chemistry, 2019, 12-17, Volume: 91, Issue:24

    Topics: Anesthetics, Local; Antiemetics; Antipruritics; Antitussive Agents; Chlorpromazine; Cocaine; Dextromethorphan; Electrochemical Techniques; Molecular Structure; Procaine; Promethazine; Sensitivity and Specificity

2019