chlorpromazine has been researched along with clozapine in 342 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 129 (37.72) | 18.7374 |
| 1990's | 54 (15.79) | 18.2507 |
| 2000's | 88 (25.73) | 29.6817 |
| 2010's | 63 (18.42) | 24.3611 |
| 2020's | 8 (2.34) | 2.80 |
| Authors | Studies |
|---|---|
| Kehr, JR; Kukla, MJ; Miller, A; Woo, CM | 1 |
| Ellefson, CR; Kehr, JR; Miller, A; Woo, CM | 1 |
| Day, IP; Eudy, NH; Fanshawe, WJ; Greenblatt, EN; Hofmann, CM; Press, JB; Safir, SR | 1 |
| Baldy, WJ; Barrett, DL; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Kukla, MJ; Martin, GE; Mathiasen, JR; Scott, MK | 1 |
| Andrieux, M; Besançon, R; Giros, B; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P | 1 |
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P | 1 |
| Butler, R; Christopher, WL; Cipollina, JA; New, JS; Schlemmer, RF; VanderMaelen, CP; Yevich, JP | 1 |
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Cascio, G; Fregnan, G; Manghisi, E | 1 |
| Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Abou-Gharbia, M; Moyer, JA; Muth, EA; Patel, UR | 1 |
| Hino, K; Karasawa, T; Masuda, Y; Nagai, Y; Oka, M; Uno, H | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Day, IP; Greenblatt, EN; Hardy, RA; Quinones, NQ; Wright, WB | 1 |
| Chakrabarti, JK; Horsman, L; Hotten, TM; Pullar, IA; Tupper, DE; Wright, FC | 1 |
| Chakrabarti, JK; Fairhurst, J; Gutteridge, NJ; Horsman, L; Pullar, IA; Smith, CW; Steggles, DJ; Tupper, DE; Wright, FC | 1 |
| Brougham, LR; Ellefson, CR; Miller, A; Prodan, KA | 1 |
| Chiang, GH; Unger, SH | 1 |
| Audiau, F; Carpy, A; Guérémy, C; Le Fur, G; Léger, JM; Uzan, A | 1 |
| Glennon, RA; Nelson, S; Salley, JJ; Steinsland, OS | 1 |
| Ellefson, CR; Prodan, KA | 1 |
| Bruhwyler, J; Chleide, EM; Damas, J; Delarge, JE; Inarejos, MO; Liégeois, JF; Mercier, MG; Nguyen, TP; Rogister, FA | 1 |
| Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A | 1 |
| Clemens, JA; Fairhurst, J; Pullar, IA; Risius, FC; Timms, GH; Tupper, DE; Wedley, S | 1 |
| Bruhwyler, J; Chleide, EM; Damas, J; Delarge, JE; Liégeois, JF; Mercier, MG; Nguyen, TP; Rogister, FA | 1 |
| Evans, DL; Figur, LM; Lahti, RA; Stratman, NC | 1 |
| Emms, F; Freedman, SB; Knowles, MR; Marwood, R; McAllister, G; Patel, S; Seabrook, GR | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Druck, T; Hamblin, MW; Huebner, K; Khan, N; Kohen, R; Lachowicz, JE; Meltzer, HY; Metcalf, MA; Roth, BL; Sibley, DR | 1 |
| Egan, CT; Herrick-Davis, K; Teitler, M | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Grinde, E; Herrick-Davis, K; Teitler, M | 1 |
| Faller, B; Wohnsland, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Boulton, DW; DeVane, CL; Liston, HL; Markowitz, JS | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S | 1 |
| McKinnon, RA; Miners, JO; Smith, PA; Sorich, MJ | 1 |
| Glennon, RA | 1 |
| Keserü, GM | 1 |
| Fang, X; Hu, Z; Levant, B; Min, J; Varady, J; Wang, S; Wu, X | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Andaluz, B; Buschmann, H; Codony, X; Cubí, R; Díaz, JL; Dordal, A; Guitart, X; Hernández, E; Hernández, S; Holenz, J; Mas, J; Mercè, R; Monroy, X; Pérez, R; Romero, G; Sánchez, E; Sanfeliu, O; Torrens, A | 1 |
| Herrick-Davis, K; Purohit, A; Smith, C; Teitler, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Coolen, HK; Glennon, JC; Kruse, CG; Lange, JH; Reinders, JH; Tolboom, JT | 1 |
| Farasati, NA; Huang, Y; Randhawa, P | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Kottke, T; Ligneau, X; Stark, H; von Coburg, Y; Weizel, L | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Barr, JT; Jones, JP | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Peters, JU | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bandyopadhyaya, A; Rajagopalan, DR; Rajagopalan, P; Rajagopalan, R | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bruno, C; Carrieri, A; Cavalluzzi, MM; Franchini, C; Giannuzzi, G; Illario, M; Lentini, G; Lovece, A; Polimeno, L; Pracella, R; Rusciano, MR; Viale, M | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J; Ulenberg, S | 1 |
| Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Podsadni, P; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J | 1 |
| Freeman, BB; Rankovic, Z; Yang, L | 1 |
| Bojarski, AJ; Dehaen, W; Janousek, J; Juza, R; Karasova, JZ; Kobrlova, T; Korabecny, J; Kubacka, M; Mezeiova, E; Mogilski, S; Musilek, K; Pejchal, J; Petrasek, T; Prchal, L; Randakova, A; Satala, G; Soukup, O; Stark, H; Stefkova-Mazochova, K; Svozil, D; Vlcek, P; Vojtechova, I | 1 |
| Modestin, J; Petrin, A | 1 |
| Bartholini, G | 1 |
| Bowers, MB; Rozitis, A | 2 |
| Cheney, DL; Costa, E; Mao, CC; Marco, E; Revuelta, A | 1 |
| Ahlenius, S; Engel, J | 1 |
| Apfelbach, R; Schmidt, W | 1 |
| Cheney, DL; Costa, E; Zsilla, G | 1 |
| Stanley, M; Wilk, S | 1 |
| Canon, JG; Lippa, AS | 2 |
| Setler, P; Weidley, E; Zarevics, P | 1 |
| Honma, T; Kitagawa, S | 1 |
| Munday, KA; Poat, JA; Sumners, C; Woodruff, GN | 1 |
| Hirose, A; Honma, T | 1 |
| Herman, RL; Kubena, RK; Malick, JB | 1 |
| Buus Lassen, J | 1 |
| Canon, JG | 1 |
| Sedvall, G; Wiesel, FA | 1 |
| Bartholini, G; Keller, HH; Pletscher, A | 1 |
| Costa, E; Guidotti, A; Revuelta, A; Zivkovic, B | 1 |
| Dingell, JV; Hill, H; Robinson, SE; Setler, P; Stawarz, RJ; Sulser, F | 1 |
| Leon, CA | 2 |
| Balastíková, B; Misurec, J; Náhunek, K; Výborová, L | 1 |
| Doller, JC; Gelenberg, AJ | 1 |
| Aaronsom, M; Collora, M; Klein, H; Shopsin, B | 1 |
| Coupet, J; Rauh, CE | 1 |
| Ford, KE; Fowler, SC; Nail, GL | 1 |
| Fang, VS; Goode, DJ; Meltzer, HY; Schyve, PM; Young, M | 1 |
| Wenger, GR | 1 |
| Krause, R; Lotz, W | 1 |
| Gillin, JC; Moja, EA; Stoff, DM; Wyatt, RJ | 1 |
| Hafner, RJ; Milton, F; Patwa, VK | 1 |
| Boston, JE; Goas, JA | 1 |
| Balakleevskiĭ, AI; Maslova, IV | 1 |
| Burrows, G; Chiu, E; Stevenson, J | 1 |
| Carlson, KR; Eibergen, RD | 2 |
| Bianchi, S; Consolo, S; Ghezzi, D; Ladinsky, H | 1 |
| Maître, L; Waldmeier, PC | 1 |
| Roufogalis, BD; Thornton, M; Wade, DN | 1 |
| Ito, T; Shimizu, M | 1 |
| Fukushima, H; Honma, T | 1 |
| Fielding, S; Lal, H; Marky, M | 1 |
| Baudis, P; Peterová, E; Vencovský, E | 1 |
| Dick, P; Rémy, M; Rey-Bellet, JJ | 1 |
| Kelly, PH; Miller, RJ | 1 |
| Daniels, S; Fang, VS; Meltzer, HY | 1 |
| Fog, R | 1 |
| Asper, H; Bürki, HR; Ruch, W; Sayers, AC | 1 |
| Clody, DE; Haubrich, DR; Herman, RL; Wang, PF | 1 |
| Marsden, CD; Pycock, C; Tarsy, D | 1 |
| Manian, AA; Palmer, GC; Spiker, MD | 1 |
| Awad, AG; Collins, EJ; Hogan, TP | 1 |
| Saltz, BL | 1 |
| Wang, H | 1 |
| Ashby, CR; Edwards, E; Wang, RY | 1 |
| Christensson, E; Egbe, P; Engel, J; Gustafsson, B | 1 |
| Broekkamp, CL; De Graaf, JS; van Delft, AM | 1 |
| Amato, G; Calzà, L; Giardino, L; Piazza, PV; Zanni, M | 1 |
| Bolden, C; Cusack, B; Richelson, E | 1 |
| Burrell, MF; Cashman, M; Fewster, C; Szabadi, E | 1 |
| Meltzer, HY | 2 |
| Cold, JA | 1 |
| Matsubara, S; Meltzer, HY | 1 |
| Ashby, CR; Edwards, E; Harkins, KL; Wang, RY | 1 |
| Mott, J; Sherman, AD | 2 |
| Ko, GN; Potter, WZ; Yan, WW; Zhang, LD | 1 |
| Fowler, SC; Gramling, SE | 1 |
| Johnson, KM; Snell, LD | 1 |
| Andree, TH; Koenig, JI; Meltzer, HY; Mikuni, M; Tong, CY | 1 |
| Kovacic, B; Ruffing, D; Stanley, M | 1 |
| Salama, AI; Saller, CF | 1 |
| Cohen, BM; Lipinski, JF | 1 |
| Blaha, CD; Lane, RF | 1 |
| Bartkó, G; Herczeg, I; Mayláth, E | 1 |
| Cools, AR; Ellenbroek, BA; Honig, WM; Peeters, BW | 1 |
| Hamrah, M; Mott, J; Sherman, AD | 1 |
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Fuchs, A; Krähling, H; Ruhland, M; Schön, U | 1 |
| Fuchs, A; Krähling, H; Mol, F; Ruhland, M; Schön, U; Tulp, M | 1 |
| Aghajanian, GK; Rasmussen, K | 1 |
| Arbilla, S; Baud, P; Langer, SZ | 1 |
| Honigfeld, G; Kane, J; Meltzer, H; Singer, J | 1 |
| Bao, XQ | 1 |
| Yang, WJ | 1 |
| Zhang, MD | 1 |
| Abuzzahab, FS; Claghorn, J; Honigfeld, G; Klerman, G; Steinbook, R; Tuason, V; Wang, R | 1 |
| Li, Y | 1 |
| Costa, JF; Heh, CW; Herrera, JN; Nguyen, BN; Roy, S; Sramek, JJ | 1 |
| Corsaro, CJ; Kellams, JJ; Miller, MJ; Milstein, V; Small, IF; Small, JG | 1 |
| Ban, S; Cronkite, C; Miller, RC; Pisciotta, AV | 1 |
| Dews, PB; Lehr, E; Morse, WH | 1 |
| Greenberg, D; Snyder, SH; Yamumura, HI | 1 |
| Christodoulou, GN; Koutras, DA; Rinieris, P; Souvatzoglou, A; Stefanis, C | 1 |
| Schechter, MD | 1 |
| Michael, RP; Schaefer, GJ | 1 |
| Bochkarev, VK; Paniushkina, SV | 1 |
| de Belleroche, JS; Neal, MJ | 1 |
| Buravlev, VM | 1 |
| Bazán, E; Galindo, A; Somoza, E | 1 |
| Barrett, JE | 1 |
| Bunney, BS; Chiodo, LA | 1 |
| Borison, RL; Diamond, BI | 1 |
| Alloway, KD; Bashore, TR; Gelman, J; Rebec, GV | 1 |
| Bochkarev, VK; Danilenko, IuM; Nikiforov, AI | 1 |
| Frey, P | 1 |
| Borsini, F; Nowakowska, E; Samanin, R | 1 |
| Ford, KE; Fowler, SC; Gramling, SE; Nail, GL | 1 |
| Ojeda, G; Portoles, A; Portoles, MP; Rojo, JM | 1 |
| Daus, FJ; Hansen, HA; Plantjé, JF; Stoof, JC | 1 |
| Nobrega, JN; Wiener, NI | 1 |
| Fink, H; Morgenstern, R; Oelssner, W | 1 |
| Katz, JL; Spealman, RD | 1 |
| DeWeese, J; Goldberg, DM; Goldberg, SR; Kelleher, RT; Spealman, RD | 1 |
| Angeby, T; Haglund, L; Köhler, C; Ogren, SO | 1 |
| Franco, C; Fuentes, JA; Laviña, M; Somoza, E | 1 |
| Stefanova, D | 1 |
| Gale, K | 1 |
| Aghajanian, GK; Gellman, RL | 1 |
| DeVane, CL | 1 |
| Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT | 1 |
| Matsubara, R | 1 |
| Altman, S; Honer, WG; Kopala, L; MacEwan, GW; Smith, A; Smith, GN | 1 |
| Denney, D; Stevens, JR | 1 |
| Burkhardt, C; Filley, CM; Kelly, JP; Lim, YH; Parker, WD | 1 |
| Compton, AD; Porter, JH; Wiley, JL | 1 |
| Cecyre, D; Lal, S; Nair, NP; Quirion, R | 1 |
| Hietala, J; Kuoppamäki, M; Pälvimäki, EP; Syvälahti, E | 1 |
| Obuchowicz, E | 1 |
| Guze, B; Quintana, J; Shah, B | 1 |
| Das, I; Khan, NS | 1 |
| Barbini, B; Benedetti, F; Colombo, C; Crespi, G; Scherillo, P; Smeraldi, E | 1 |
| Braghiroli, L; Cheng, CY; De Feo, G; Fiani, M; Mazzanti, G; Ponzianelli, A | 1 |
| Chen, JY; Chiu, HJ; Hong, CJ; Sim, CB | 1 |
| Meyer, JM; Simpson, GM | 1 |
| Buckland, PR; D'Souza, U; Maher, NA; McGuffin, P | 1 |
| Attar-Levy, D; Martinot, JL; Monnet, F; Paillère-Martinot, ML; Recassens, C; Trichard, C | 1 |
| Hatzimanolis, J; Lykouras, L; Markianos, M; Oulis, P | 1 |
| Obuchowicz, E; Turchan, J | 1 |
| Bakshi, V; Geyer, MA; Swerdlow, NR; Taaid, N; Waikar, M | 1 |
| Hayashi, T; Kagaya, A; Nishida, A; Shimizu, M; Su, TP; Yamawaki, S | 1 |
| Eisenstein, N; Engelhart, C; Howanitz, E; Losonczy, MF; Pardo, M; Smelson, DA; Stern, RG | 1 |
| Crocker, AD; Hemsley, KM | 1 |
| Lyon, ER | 1 |
| Dwivedi, Y; Pandey, GN | 1 |
| Bradley, RJ; Dwyer, DS; Liu, Y | 1 |
| Honigfeld, G | 1 |
| McCallum, SE; Porter, JH; Vann, RE; Varvel, SA | 1 |
| Aguilar, MA; Arenas, MC; Miñarro, J; Parra, A; Simón, VM; Vinader-Caerols, C | 1 |
| Arolt, V; Kirchner, H; Rothermundt, M; Wandinger, KP | 1 |
| Lal, S | 1 |
| Rosendaal, FR; Thomassen, R; Vandenbroucke, JP | 1 |
| Rymsha, SV; Zhuchenko, IA; Zhuchenko, LN | 1 |
| Bradshaw, CM; Chiang, TJ; Ho, MY; Mobini, S; Szabadi, E | 1 |
| Allen, SA | 1 |
| Dean, B | 1 |
| Bae, S; Choi, S; Kang, B; Kim, K; Park, T | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Copolov, DL; Dean, B; Hussain, T; Pavey, G; Scarr, E | 1 |
| Huttunen, M; Jutila, A; Kinnunen, PK; Pakkanen, AL; Söderlund, T | 1 |
| Badawoud, M; Delieu, JM; Duguid, JK; Horobin, RW; Williams, MA | 1 |
| Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Addis, A; Einarson, TR; Iskedjian, M; Lanctôt, K; Oh, PI | 1 |
| Nomikos, GG; Rodriguez, DE; Shirazi-Southall, S | 1 |
| Dean, B; Parkin, FM; Pavey, G; Scarr, E | 1 |
| Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M | 1 |
| Hägg, S; Hedenmalm, K; Mortimer, O; Spigset, O; Ståhl, M | 1 |
| Goudie, AJ; Smith, JA | 1 |
| Fatemi, SH; Patterson, PH; Shi, L; Sidwell, RW | 1 |
| Kalkman, HO; Loetscher, E | 1 |
| Gu, H; Hamer, RM; Ji, Z; Koch, G; Kong, L; Lieberman, JA; Phillips, M; Stroup, S; Zhang, P | 1 |
| Ashok, A; Atwood, WJ; Baum, S; Dimitrova, S; Gee, G; Jordan, J; Querbes, W | 1 |
| Morishita, S | 1 |
| Agam, G; Belmaker, RH; Kozlovsky, N; Nadri, C | 1 |
| Abidi, S; Bhaskara, SM | 1 |
| Bowers, L; Callaghan, P; Clark, N; Evers, C | 1 |
| Burnet, PW; Harrison, PJ; Hutchinson, LJ; Law, AJ | 1 |
| Porter, JH; Prus, AJ; Vann, RE; Varvel, SA | 1 |
| Lawrie, S; McIntosh, A; Nadeem, Z | 2 |
| Nardi, AE | 1 |
| Lawrie, S; McIntosh, A | 1 |
| Cai, Y; Chen, H; Ding, G; Huang, P; Li, X; Liang, S; Liu, L; Xiao, A; Yu, G; Zhang, J | 1 |
| Chau, DT; Green, AI; McCarley, R; Niznikiewicz, MA; Patel, JK; Sutton, J; Wojcik, J | 1 |
| Dwyer, DS; Lu, XH | 1 |
| Balit, CR; Isbister, GK; Kilham, HA | 1 |
| Morrison, PD; Murray, RM | 1 |
| Bareggi, S; Bonomi, A; Cavicchini, L; Croera, C; Guizzardi, F; Pessina, A; Turlizzi, E | 1 |
| Mahadik, SP; Parikh, V; Pillai, A; Terry, AV | 1 |
| Bastianetto, S; Danik, M; Mennicken, F; Quirion, R; Williams, S | 1 |
| Bianchi, MG; Bussolati, O; Dall'Asta, V; Gazzola, GC; Maggini, C; Marchesi, C; Rotoli, BM | 1 |
| DeVane, CL; Donovan, JL; Markowitz, JS; Wang, JS; Zhu, HJ | 1 |
| Chen, Y; Feng, G; He, L; Ji, B; La, Y; Pan, Y; Wan, C; Yang, Y; Zhu, H | 1 |
| Lieberman, JA | 1 |
| Chen, YS; Feng, GY; He, L; La, YJ; Pan, YX; Wan, CL; Yang, YF; Zhu, H | 1 |
| Bishnoi, M; Chopra, K; Kulkarni, SK; Kumar, A | 1 |
| Jin, GX; Tong, Y; Wang, XP; Wang, XY; Yao, SM; Zhang, ZJ | 1 |
| Weiden, PJ | 1 |
| Hodneland, E; Holmsen, H; Oruch, R; Pryme, IF | 1 |
| Humberstone, V; Robinson, E; Wheeler, A | 1 |
| Johnsen, E; Jørgensen, HA; Kroken, RA; Ruud, T; Wentzel-Larsen, T | 1 |
| Dejanovic, SM; Jakovljevic, V; Janjic, V; Jovic, SD; Milovanovic, DR; Pantovic, M; Pantovic, MM; Pantovic, V; Ravanic, B; Ravanic, DB | 1 |
| Feng, G; He, L; Ji, B; Li, Y; Sun, L; Wan, C; Wang, Y; Yang, J; Zhang, M; Zhang, Z; Zhou, K; Zhu, H | 1 |
| Du, J; Feng, G; Gao, R; Guo, T; He, G; He, L; Li, S; Li, X; Lin, Z; Liu, J; St Clair, D; Wang, L; Wu, S; Xing, Q; Xu, M; Xu, Y; Xuan, J; Yang, Y; Yu, L; Zhang, A; Zhao, X; Zheng, Y; Zhou, J | 1 |
| Correll, CU; Kane, JM | 1 |
| Basta-Kaim, A; Budziszewska, B; Fijał, K; Kubera, M; Lasoń, W; Leśkiewicz, M; Regulska, M; Wędzony, K | 1 |
| Duan, N; Girgis, RR; Jiang, H; Li, K; Li, X; Lieberman, JA; Niu, Y; Phillips, MR; Wu, C | 1 |
| Chen, J; Ruan, J; Su, Z; Xiong, C | 1 |
| Aw, CC; Browne, ER; Hirano, K; Nasir, S; Rutter, AR; Searle, KL | 1 |
| Chen, YS; Gong, FJ; Liang, C; Wang, R; Wang, W; Wu, ZP; Zhang, RS; Zhang, YR; Zheng, SQ | 1 |
| Lam, D; Patten, SB; Pringsheim, T; Tano, DS | 1 |
| Kendall, T | 1 |
| Davis, JM; Leucht, S | 1 |
| Grover, S; Nebhinani, N | 1 |
| Umeda, K | 1 |
| McKenna, P | 1 |
| Honer, WG; Sherwood, M; Thornton, AE | 1 |
| Bauer, K; Becker, S; Ceglarek, U; Himmerich, H; Kortz, L; Mergl, R; Sack, U; Schmidt, L; Schonherr, J; Sheldrick, AJ; Thiery, J | 1 |
| Basta-Kaim, A; Budziszewska, B; Głombik, K; Kubera, M; Lasoń, W; Leśkiewicz, M; Nowak, W; Regulska, M; Slusarczyk, J; Szczęsny, E; Wędzony, K | 1 |
| Cairns, MJ; Carroll, A; Gardiner, E; Tooney, PA | 1 |
| Cao, B; Hou, R; Jian, J; Mi, G; Qiu, H; Tang, M; Wang, M | 1 |
| Elmorsy, E; Elsheikha, HM; Elzalabany, LM; Smith, PA | 1 |
| De Luca, MA; Di Chiara, G; Perra, V; Serra, GP; Tanda, G; Valentini, V | 1 |
| Barr, AM; Honer, WG; Jones, AA; Procyshyn, RM; Thornton, AE; Vila-Rodriguez, F | 1 |
| He, L; Huang, H; Li, M; Minica, C; Qin, S; Shen, L; Shi, Y; Wang, G; Wu, X; Xing, Q; Xu, Q; Yi, Z | 1 |
| Ben Hadj Ali, B; Ben Salem, C; Bouhlel, S; Saguem, BN | 1 |
| Cassoli, JS; Guest, PC; Martins-de-Souza, D; Santana, AG | 1 |
| Flanagan, RJ; Handley, S; Patel, MX | 1 |
| Jovicic, MJ; Maric, NP; Mihaljevic, M; Miljevic, C | 1 |
| Birky, T; Che, P; Cottingham, C; Jiao, K; Percival, S; Wang, H; Wang, Q; Wang, RX; Zhang, W; Zhou, L | 1 |
| Butler, T; Cardozo, T; Felsovalyi, K; Malaspina, D; Shmelkov, E; Shmelkov, SV; Swetnam, J | 1 |
| Asghari, A; Bazregar, M; Boutorabi, L; Fahimi, E; Rajabi, M | 1 |
| Aggour, AM; Al-Ghafari, A; Amer, S; Elmorsy, E; Khan, R | 1 |
| Blessing, EM; Blessing, WW; Mohammed, M; Ootsuka, Y | 1 |
| Beloti, LGM; Miranda, LFC; Queiroz, MEC | 1 |
| Alelwani, W; Alnajeebi, A; Babteen, N; Elmorsy, E; Ghulam, J; Kattan, S; Mosad, S | 1 |
| Abe, Y; Hamamatsu, S; Hattori, Y; Ikegami, Y; Iwata, N; Matsuo, K; Matsuoka, Y; Obara, K; Shioda, N; Tanaka, Y; Yamaki, F; Yoshio, T; Yoshioka, K | 1 |
| Bampali, K; Ernst, M; Garon, A; Koniuszewski, F; Langer, T; Rehman, S; Scholze, P; Seidel, T; Silva, LL; Vogel, FD; Willeit, M; Zirpel, F | 1 |
| Chen, X; Cui, D; Cui, M; Fang, Y; Li, Z; Sheng, J; Su, Y; Xing, M; Zhang, C | 1 |
| Osman, E; Yıldız, M | 1 |
| Araujo, ARTS; Barroso, M; Gallardo, E; Gameiro, C; Gonçalves, J; Passarinha, LA; Rosado, T; Soares, S | 1 |
| Hashimoto, N; Ishikawa, S; Ito, YM; Kusumi, I; Miyakoshi, T; Okubo, R; Sato, N | 1 |
24 review(s) available for chlorpromazine and clozapine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Polypharmacology - foe or friend?
Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Practical approaches to evaluating and optimizing brain exposure in early drug discovery.
Topics: Animals; Blood-Brain Barrier; Central Nervous System; Central Nervous System Agents; Drug Delivery Systems; Drug Discovery; Humans; Molecular Structure; Structure-Activity Relationship | 2019 |
[Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Fluphenazine; Humans; Imipramine; Nortriptyline; Perazine; Phenelzine; Thioridazine | 1976 |
Brief comparison of the pharmacokinetics and pharmacodynamics of the traditional and newer antipsychotic drugs.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Haloperidol; Humans; Isoxazoles; Piperidines; Risperidone; Time Factors | 1995 |
A review of the effects of nicotine on schizophrenia and antipsychotic medications.
Topics: Antipsychotic Agents; Auditory Perception; Chlorpromazine; Chronic Disease; Clozapine; Databases as Topic; Dopamine; Dose-Response Relationship, Drug; Frontal Lobe; Humans; Nicotine; Nucleus Accumbens; Prefrontal Cortex; Schizophrenia; Severity of Illness Index; Smoking Cessation | 1999 |
Schizophrenia: an illness of distorted reality.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Delusions; Dopamine Antagonists; Female; GABA Antagonists; Hallucinations; Humans; Magnetic Resonance Angiography; Male; Neurotransmitter Agents; Receptors, Dopamine D2; Schizophrenia; Synapses; Tomography, Emission-Computed | 2000 |
Pharmacoeconomic evaluation of clozapine in treatment-resistant schizophrenia: a cost-utility analysis.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Cost-Benefit Analysis; Decision Support Techniques; Economics, Pharmaceutical; Haloperidol; Humans; Quality of Life; Schizophrenia | 2001 |
[Late schizophrenia].
Topics: Adult; Age of Onset; Aged; Antipsychotic Agents; Chlorpromazine; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Electroconvulsive Therapy; Haloperidol; Humans; Middle Aged; Reference Standards; Risk Factors; Risperidone; Schizophrenia; Schizophrenic Psychology | 2003 |
From chlorpromazine to clozapine--antipsychotic adverse effects and the clinician's dilemma.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Diabetes Mellitus; Humans; Hyperlipidemias; Long QT Syndrome; Myocarditis; Schizophrenia; Torsades de Pointes | 2003 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride | 2003 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride | 2004 |
Antipsychotic poisoning in young children: a systematic review.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Child; Child, Preschool; Chlorpromazine; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Infant; Infant, Newborn; Olanzapine; Pimozide; Piperazines; Poisoning; Quetiapine Fumarate; Quinolones; Risperidone | 2005 |
Schizophrenia.
Topics: Antipsychotic Agents; Brain; Carrier Proteins; Chlorpromazine; Clozapine; Dopamine; Dopamine Antagonists; Dysbindin; Dystrophin-Associated Proteins; Genetic Predisposition to Disease; Humans; Magnetic Resonance Imaging; Models, Neurological; Nerve Tissue Proteins; Neuregulin-1; Schizophrenia; Social Alienation; Synapses | 2005 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Family Therapy; Haloperidol; Humans; Patient Compliance; Risperidone; Schizophrenia; Secondary Prevention; Sulpiride; Thioridazine | 2005 |
Past and present progress in the pharmacologic treatment of schizophrenia.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Evidence-Based Medicine; Humans; Long-Term Care; Metabolic Clearance Rate; Parkinsonian Disorders; Precision Medicine; Psychiatric Status Rating Scales; Research; Schizophrenia; Schizophrenic Psychology; Secondary Prevention; Treatment Outcome | 2010 |
[Antipsychotics].
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Drug Discovery; Drug Interactions; Haloperidol; History, 20th Century; History, 21st Century; Humans; Olanzapine | 2011 |
A quantitative review of the profile and time course of symptom change in schizophrenia treated with clozapine.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Randomized Controlled Trials as Topic; Schizophrenia; Severity of Illness Index | 2012 |
Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Humans; Outcome Assessment, Health Care; Schizophrenia | 2015 |
Employing proteomics to unravel the molecular effects of antipsychotics and their role in schizophrenia.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Brain; Chlorpromazine; Clozapine; Disease Models, Animal; Gene Expression Regulation; Glycolysis; Humans; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Phosphorylation; Proteome; Proteomics; Schizophrenia; Treatment Outcome | 2016 |
Antipsychotic-related fatal poisoning, England and Wales, 1993-2013: impact of the withdrawal of thioridazine.
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Drug Recalls; England; Heroin; Humans; Methadone; Morphine; Olanzapine; Poisoning; Quetiapine Fumarate; Thioridazine; Wales | 2016 |
Improving Current Treatments for Schizophrenia.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Cognitive Dysfunction; Dopamine Antagonists; Drug Design; Humans; Schizophrenia | 2016 |
24 trial(s) available for chlorpromazine and clozapine
| Article | Year |
|---|---|
Efficacy of clozapine.
Topics: Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Humans; Schizophrenia | 1978 |
Clozapin in psychomotor instability. A controlled study.
Topics: Adolescent; Child; Child, Preschool; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Humans; Hyperkinesis | 1978 |
Clozapine versus chlorpromazine for the treatment of schizophrenia: preliminary results from a double-blind study.
Topics: Adult; Aged; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Drug Administration Schedule; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia | 1979 |
Clozapine, chlorpromazine, and placebo in newly hospitalized, acutely schizophrenic patients: a controlled, double-blind comparison.
Topics: Acute Disease; Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Female; Hospitals, Psychiatric; Humans; Male; Middle Aged; Placebos; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Social Adjustment; United States | 1979 |
Therapeutic effects of clozapine. A 4-year follow-up of a controlled clinical trial.
Topics: Adult; Ambulatory Care; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Drug Evaluation; Female; Follow-Up Studies; Humans; Length of Stay; Male; Patient Readmission; Psychiatric Status Rating Scales; Schizophrenia; Social Behavior Disorders | 1979 |
Double-blind comparison of clozapine with chlorpromazine in acute schizophrenic illness.
Topics: Acute Disease; Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Female; Humans; Male; Middle Aged; Schizophrenia | 1976 |
[Comparison of therapeutic effect of clozapin and chlorpromazin (author's transl)].
Topics: Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Drug Evaluation; Drug Tolerance; Humans; Psychiatric Status Rating Scales; Schizophrenia | 1975 |
[Comparison of two antipsychotic drugs: chlorpromazine and clozapine (author's transl)].
Topics: Adult; Aged; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia | 1975 |
Clozapine in China: a review and preview of US/PRC collaboration.
Topics: Adult; China; Chlorpromazine; Clozapine; Dibenzazepines; Double-Blind Method; Female; Homovanillic Acid; Humans; International Cooperation; Male; Middle Aged; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Schizophrenia; United States | 1989 |
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Topics: Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Random Allocation; Schizophrenia | 1988 |
[A double-blind study on the effect of clozapine penfluridol and chlorpromazine in the treatment of schizophrenia].
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Humans; Male; Middle Aged; Penfluridol; Piperidines; Schizophrenia | 1988 |
[Three antipsychotic drugs in the treatment of schizophrenia--a controlled and double-blind study].
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Schizophrenia; Sulpiride | 1988 |
The risks and benefits of clozapine versus chlorpromazine.
Topics: Adult; Basal Ganglia Diseases; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Random Allocation; Risk Factors; Schizophrenia | 1987 |
[Application of NOSIE in the study of neuroleptic treatment].
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Humans; Male; Penfluridol; Piperidines; Psychiatric Status Rating Scales; Schizophrenia | 1987 |
High potency neuroleptics and violence in schizophrenics.
Topics: Adult; Akathisia, Drug-Induced; Chlorpromazine; Clozapine; Haloperidol; Humans; Schizophrenia; Schizophrenic Psychology; Verbal Behavior; Violence | 1988 |
Computerized EEG profiles of haloperidol, chlorpromazine, clozapine and placebo in treatment resistant schizophrenia.
Topics: Adolescent; Adult; Alpha Rhythm; Benztropine; Beta Rhythm; Brain Mapping; Chlorpromazine; Clozapine; Delta Rhythm; Dibenzazepines; Double-Blind Method; Electroencephalography; Female; Haloperidol; Humans; Male; Schizophrenia; Signal Processing, Computer-Assisted; Theta Rhythm | 1987 |
Response to clozapine in acute mania is more rapid than that of chlorpromazine.
Topics: Acute Disease; Adult; Antipsychotic Agents; Bipolar Disorder; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Lithium; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome | 1997 |
A double-blind comparative study of clozapine versus chlorpromazine on Chinese patients with treatment-refractory schizophrenia.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Double-Blind Method; Drug Resistance; Female; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1997 |
The efficacy and safety of clozapine versus chlorpromazine in geriatric schizophrenia.
Topics: Age Factors; Aged; Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Clozapine; Double-Blind Method; Humans; Intestinal Pseudo-Obstruction; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Weight Gain | 1999 |
Atypical and conventional antipsychotic drugs in treatment-naive first-episode schizophrenia: a 52-week randomized trial of clozapine vs chlorpromazine.
Topics: Adolescent; Adult; Analysis of Variance; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Follow-Up Studies; Humans; Male; Schizophrenia | 2003 |
The therapeutic effects of ling gui zhu gan tang mixture in 50 psychotic patients with obesity induced by the psychoactive drugs.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Middle Aged; Obesity; Phytotherapy; Plant Extracts | 2005 |
Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.
Topics: Adolescent; Adult; Aged; Alkaloids; Antipsychotic Agents; Chlorpromazine; Cholinesterase Inhibitors; Clozapine; Drug Resistance; Drug Synergism; Female; Humans; Male; Middle Aged; Risperidone; Schizophrenia; Sesquiterpenes | 2007 |
Effectiveness of clozapine, haloperidol and chlorpromazine in schizophrenia during a five-year period.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Prospective Studies; Schizophrenia; Time Factors; Treatment Outcome | 2009 |
Clozapine v. chlorpromazine in treatment-naive, first-episode schizophrenia: 9-year outcomes of a randomised clinical trial.
Topics: Adolescent; Adult; Antipsychotic Agents; China; Chlorpromazine; Clozapine; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; Linear Models; Male; Psychiatric Status Rating Scales; Schizophrenia; Severity of Illness Index; Survival Analysis; Time Factors; Treatment Outcome; Young Adult | 2011 |
294 other study(ies) available for chlorpromazine and clozapine
| Article | Year |
|---|---|
5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanimines, potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Cattle; Dextroamphetamine; Dopamine; Dopamine Antagonists; Haloperidol; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Rats; Receptors, Dopamine; Thiophenes | 1978 |
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Rats | 1978 |
10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catalepsy; Dextroamphetamine; Exploratory Behavior; Humans; Mice; Motor Activity; Rats; Structure-Activity Relationship; Tetrabenazine | 1979 |
Pyrrole mannich bases as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Male; Mannich Bases; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship | 1992 |
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.
Topics: Animals; Chlorides; CHO Cells; Cricetinae; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanylyl Imidodiphosphate; Humans; Lithium; Lithium Chloride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sodium Chloride; Sulpiride; Transfection | 1992 |
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution | 1990 |
The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity.
Topics: Amphetamines; Animals; Avoidance Learning; Binding, Competitive; Catalepsy; Chemical Phenomena; Chemistry; Dioxanes; Female; Furans; Macaca; Male; Mice; Molecular Structure; Motor Activity; Piperazines; Psychoses, Substance-Induced; Psychotic Disorders; Pyridines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stereotyped Behavior; Structure-Activity Relationship; Thiophenes | 1989 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
5-Piperazinylalkyl-2(3H)-oxazolones with neuroleptic activity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Catalepsy; Dogs; Indicators and Reagents; Male; Mice; Molecular Structure; Motor Activity; Muscles; Oxazoles; Oxazolone; Piperazines; Rats; Stereotyped Behavior; Structure-Activity Relationship | 1989 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1986 |
Psychotropic agents: synthesis and antipsychotic activity of substituted beta-carbolines.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Carbolines; Male; Mice; Rats; Stereotyped Behavior; Structure-Activity Relationship | 1987 |
A novel class of potential central nervous system agents. 3-Phenyl-2-(1-piperazinyl)-5H-1-benzazepines.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Body Temperature Regulation; Brain; Electroshock; Exploratory Behavior; Homovanillic Acid; Hypothermia; Indicators and Reagents; Male; Mice; Mice, Inbred Strains; Piperazines; Rats; Rats, Inbred Strains; Reserpine; Seizures; Structure-Activity Relationship | 1988 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Derivatives of 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine as central nervous system agents.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Dextroamphetamine; Mice; Motor Activity; Psychotropic Drugs; Rats; Structure-Activity Relationship; Tetrabenazine | 1980 |
4-Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats; Structure-Activity Relationship | 1980 |
10-Piperazinyl-4H-theino[3,2-b][1,5]- and -[3,4-b][1,5]benzodiazepines as potential neuroleptics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats | 1980 |
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Cattle; Central Nervous System; Dopamine; Dopamine Antagonists; Haloperidol; In Vitro Techniques; Isoquinolines; Male; Mice; Rats; Receptors, Dopamine | 1980 |
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship | 1981 |
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.
Topics: Animals; Binding, Competitive; Butyrophenones; Chemical Phenomena; Chemistry; Clozapine; Corpus Striatum; Crystallography; Haloperidol; In Vitro Techniques; Molecular Conformation; Piperazines; Pyrimidines; Rats; Receptors, Dopamine; Spiperone; X-Ray Diffraction | 1982 |
Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists.
Topics: Animals; Dimethylamines; Dopamine Antagonists; Ear; In Vitro Techniques; Male; Piperazines; Rabbits; Receptors, Dopamine; Structure-Activity Relationship; Vasoconstriction | 1981 |
Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists.
Topics: Animals; Avoidance Learning; Behavior, Animal; Chemical Phenomena; Chemistry; Dopamine Antagonists; Isoquinolines; Rats; Thiophenes | 1981 |
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.
Topics: Animals; Antipsychotic Agents; Binding Sites; Dogs; Oxazepines; Pyridines; Rats; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Serotonin; Structure-Activity Relationship; Thiazepines | 1994 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin | 1994 |
Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dogs; Dopamine Antagonists; Ergolines; Female; Male; Mice; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Sulfides | 1993 |
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding Sites; Dogs; Rats; Structure-Activity Relationship | 1993 |
Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications.
Topics: Animals; Apomorphine; Butyrophenones; Cell Line; Chlorpromazine; Clozapine; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Raclopride; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Salicylamides; Trifluoperazine | 1993 |
Expression and pharmacological characterization of the human D3 dopamine receptor.
Topics: Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanine Nucleotides; Humans; Potassium Channels; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Second Messenger Systems; Sulpiride | 1994 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line, Transformed; Chlorocebus aethiops; Chromosome Mapping; Chromosomes, Human, Pair 1; Cloning, Molecular; Clozapine; DNA, Complementary; Genes; Humans; Kinetics; Molecular Sequence Data; Open Reading Frames; Protein Conformation; Rats; Receptors, Serotonin; Recombinant Proteins; Sequence Alignment; Sequence Homology, Nucleic Acid; Serotonin Agents; Signal Transduction; Species Specificity | 1996 |
Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; COS Cells; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Conformation; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.
Topics: Animals; Antipsychotic Agents; COS Cells; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Radioligand Assay; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Receptor Agonists | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
In vitro P-glycoprotein affinity for atypical and conventional antipsychotics.
Topics: Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Humans; Kinetics; Olanzapine; Pirenzepine; Quetiapine Fumarate; Recombinant Proteins; Risperidone | 2002 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain | 2003 |
Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity.
Topics: Catalysis; Glucuronides; Glucuronosyltransferase; Humans; Isoenzymes; Models, Molecular; Protein Binding; Quantitative Structure-Activity Relationship; Substrate Specificity | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Topics: Algorithms; Binding Sites; Computational Biology; Crystallography, X-Ray; Databases, Protein; Humans; Kinetics; Ligands; Lipid Bilayers; Models, Molecular; Molecular Conformation; Mutation; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Solvents; Structure-Activity Relationship; Tetrahydronaphthalenes; Water | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.
Topics: Adenylyl Cyclases; Benzoxazines; Cell Line; Humans; Indoles; Ligands; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Sulfonamides | 2005 |
Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.
Topics: Amino Acid Substitution; Antipsychotic Agents; Cell Line; Cyclic AMP; Humans; Mutagenesis, Site-Directed; Mutation; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzoxazines; Biogenic Monoamines; Humans; Hyperprolactinemia; Indoles; Metabolic Diseases; Phthalimides; Piperazines; Principal Component Analysis; Pyridines; Radioligand Assay; Receptors, Biogenic Amine; Weight Gain | 2007 |
BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.
Topics: Antiviral Agents; BK Virus; Cell Line; Chloroquine; Humans; Microbial Sensitivity Tests; Molecular Structure; Nystatin; Virus Replication | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics.
Topics: Animals; Antipsychotic Agents; Cell Line; CHO Cells; Cricetinae; Cricetulus; Histamine Antagonists; Humans; Radioligand Assay; Receptors, Histamine H3 | 2009 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase.
Topics: Aldehyde Oxidase; Aminoacridines; Chromatography, Liquid; Enzyme Inhibitors; Humans; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction | 2013 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Topics: Benzodiazepinones; Isomerism; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface | 2014 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cattle; Humans; Molecular Docking Simulation; Piperidines; Protein Conformation; Protein Kinase Inhibitors; Thiazoles | 2016 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Ligands; Mice; Pyrimidines; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tryptamines | 2019 |
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Receptor, Serotonin, 5-HT1A; RNA-Binding Proteins; Structure-Activity Relationship; Tryptamines | 2019 |
Novel D
Topics: Animals; Antipsychotic Agents; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Schizophrenia | 2022 |
Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system.
Topics: Animals; Caudate Nucleus; Chlorpromazine; Clozapine; Dopamine; Extrapyramidal Tracts; Haloperidol; Homovanillic Acid; Limbic System; Male; Olfactory Bulb; Rats; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
Brain homovanillic acid: regional changes over time with antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Caudate Nucleus; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Homovanillic Acid; Hypothalamus; Limbic System; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1976 |
The effects of antipsychotics on the turnover rate of GABA and acetylcholine in rat brain nuclei.
Topics: Acetylcholine; Aminobutyrates; Animals; Antipsychotic Agents; Brain; Caudate Nucleus; Chlorpromazine; Clozapine; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Olfactory Bulb; Rats; Substantia Nigra | 1976 |
Potentiation by alpha-methyltyrosine of the suppression of food-reinforced lever-pressing behaviour induced by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Catecholamines; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Feeding Behavior; Haloperidol; Male; Methyltyrosines; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Thioridazine | 1977 |
[Psychopharmacological influence on the prey catching behavior of ferrets (Putorius furo L.) (author's transl)].
Topics: Animals; Antipsychotic Agents; Appetitive Behavior; Carnivora; Chlorpromazine; Clozapine; Conditioning, Classical; Ferrets; Haloperidol; Male; Orientation; Predatory Behavior | 1977 |
Acetylcholine turnover rate in n. accumbens, n. caudatus, globus pallidus, and substantia nigra: action of cataleptogenic and non-cataleptogenic antipsychotics.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Catalepsy; Caudate Nucleus; Chlorpromazine; Clozapine; Globus Pallidus; Haloperidol; Humans; Male; Olfactory Bulb; Rats; Substantia Nigra | 1977 |
Brain homovanillic acid: regional changes following chronic antipsychotic drug administration.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Haloperidol; Homovanillic Acid; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1977 |
The effect of antipsychotic drugs and their clinically inactive analogs on dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Benzazepines; Butyrophenones; Chlorpromazine; Chromatography, Gas; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Olfactory Bulb; Rats; Time Factors | 1977 |
Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chlorpromazine; Clozapine; Conditioning, Operant; Dextroamphetamine; Diazepam; Drug Evaluation, Preclinical; Male; Psychotropic Drugs; Rats; Reinforcement Schedule; Tranquilizing Agents | 1977 |
Blockade of intracranial self-stimulation by antipsychotic drugs: failure to correlate with central alpha-noradrenergic blockade.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Depression, Chemical; Electric Stimulation; Male; Muscle Contraction; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Reflex; Self Stimulation; Thioridazine; Time Factors | 1977 |
[Effects of minor tranquilizers and neuroleptics on open-field behavior in rats (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Butyrophenones; Chlorpromazine; Clozapine; Defecation; Haloperidol; Male; Methamphetamine; Motor Activity; Rats; Thioridazine; Tranquilizing Agents; Trifluperidol | 1977 |
The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol.
Topics: Angiotensin II; Animals; Antipsychotic Agents; Carbachol; Chlorpromazine; Clozapine; Dopamine; Drinking Behavior; Flupenthixol; Fluphenazine; Haloperidol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pimozide; Rats; Sulpiride | 1979 |
Neuroleptics-induced changes of tyrosine hydroxylase activity in rat striatum in vitro and in vivo.
Topics: Animals; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Homovanillic Acid; Kinetics; Male; Rats; Tyrosine 3-Monooxygenase | 1979 |
A comparison between a new antipsychotic screening technique (shelf jump avoidance) and a classical discriminative avoidance paradigm.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Chlorpromazine; Clozapine; Conditioning, Classical; Discrimination Learning; Dose-Response Relationship, Drug; Haloperidol; Male; Rats; Thioridazine | 1979 |
Inhibition of 4,alpha-dimethyl-m-tyramine (H 77/77)-induced hypermotility in rats by single and repeated administration of chloropromazine, haloperidol, clozapine and thioridazine.
Topics: Adrenergic Agents; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Motor Activity; Rats; Thioridazine; Tyramine | 1975 |
A comparison of clozapine, chlorpromazine, and thioridazine upon DRL performance in the squirrel monkey.
Topics: Animals; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Female; Haplorhini; Male; Reinforcement Schedule; Saimiri; Thioridazine | 1979 |
Effect of antipsychotic drugs on homovanillic acid levels in striatum and olfactory tubercle of the rat.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Olfactory Bulb; Phenylacetates; Rats; Stimulation, Chemical; Thioridazine | 1975 |
Drug-induced changes of dopamine turnover in striatum and limbic system of the rat.
Topics: Animals; Brain Chemistry; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Limbic System; Male; Oxotremorine; Rats; Species Specificity; Stimulation, Chemical; Tranquilizing Agents; Trihexyphenidyl | 1975 |
Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Catecholamines; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzothiepins; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hypothalamus; Kinetics; Male; Norepinephrine; Pimozide; Promethazine; Rats; Thioridazine; Tyrosine 3-Monooxygenase | 1975 |
On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Phenylacetates; Pimozide; Rats; Receptors, Drug; Rotation; Stereotyped Behavior; Substantia Nigra; Thioridazine | 1975 |
3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.
Topics: Animals; Butyrophenones; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzoxazepines; Haloperidol; Hydroxylation; In Vitro Techniques; Loxapine; Membranes; Rats; Receptors, Dopamine; Spiperone | 1979 |
Effects of clozapine and chlorpromazine upon operant response measures in rats.
Topics: Animals; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Male; Rats; Reinforcement Schedule | 1979 |
Effect of clozapine on human serum prolactin levels.
Topics: Animals; Binding, Competitive; Chlorpromazine; Clozapine; Dibenzazepines; Female; Humans; Male; Prolactin; Rats; Receptors, Dopamine; Schizophrenia; Spiperone; Time Factors | 1979 |
Effects of clozapine, chlorpromazine and haloperidol on schedule-controlled behavior.
Topics: Animals; Chlorpromazine; Clozapine; Columbidae; Conditioning, Operant; Dibenzazepines; Haloperidol; Male; Mice; Mice, Inbred C57BL; Reinforcement Schedule | 1979 |
Correlation between the effects of neuroleptics on prolactin release, mammary stimulation and the vaginal cycle in rats.
Topics: Animals; Chlorpromazine; Clozapine; Estrus; Female; Luteinizing Hormone; Male; Mammary Glands, Animal; Ovulation; Pregnancy; Prolactin; Rats; Secretory Rate; Sulpiride; Tranquilizing Agents | 1978 |
Neuroleptics attentuate stereotyped behavior induced by beta-phenylethylamine in rats.
Topics: Animals; Behavior; Chlorpromazine; Clozapine; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation; Haloperidol; Humans; Male; Phenethylamines; Pimozide; Rats; Receptors, Dopamine; Stereotyped Behavior; Tranquilizing Agents | 1978 |
Confrontation vs. belief modification in persistently deluded patients.
Topics: Behavior Therapy; Chlorpromazine; Clozapine; Delusions; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales | 1978 |
Discriminative stimulus properties of clozapine and chlorpromazine.
Topics: Animals; Chlorpromazine; Clozapine; Dibenzazepines; Discrimination, Psychological; Electroshock; Haloperidol; Male; Rats | 1978 |
[Effect of neuroleptics on acetylcholine metabolism in the basal ganglia of the brain].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Ganglia; Chlorpromazine; Clozapine; Haloperidol; Male; Pimozide; Rats; Tranquilizing Agents | 1978 |
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior | 1976 |
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors | 1976 |
Effects of clozapine, chlorpromazine and diazepam upon adjunctive and schedule controlled behaviors.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dibenzazepines; Drinking Behavior; Male; Rats; Reinforcement Schedule | 1977 |
Apparent lack of a dopaminergic-cholinergic link in the rat nucleus accumbens septi-tuberculum olfactorium.
Topics: Acetylcholine; Animals; Apomorphine; Bromocriptine; Chlorpromazine; Clozapine; Dextroamphetamine; Haloperidol; Nucleus Accumbens; Olfactory Bulb; Pimozide; Piribedil; Rats; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei | 1977 |
Clozapine: reduction of the initial dopamine turnover increase by repeated treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Tolerance; Female; Homovanillic Acid; Limbic System; Rats; Thioridazine; Time Factors | 1976 |
Specificity of the dopamine sensitive adenylate cyclase for antipsychotic antagonists.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Activation; Haloperidol; Male; Metoclopramide; Rats; Sulpiride | 1976 |
Effect of psychotropic drugs on caudate spindle in cats.
Topics: Animals; Arousal; Biperiden; Cats; Caudate Nucleus; Chlorpromazine; Clozapine; Diazepam; Electric Stimulation; Electroencephalography; Female; Haloperidol; Imipramine; Male; Pentobarbital; Psychotropic Drugs; Time Factors | 1976 |
Correlation between catalepsy and dopamine decrease in the rat striatum induced by neuroleptics.
Topics: Animals; Butyrophenones; Catalepsy; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Rats; Sulpiride; Thioridazine; Time Factors; Tranquilizing Agents; Trifluperidol | 1976 |
Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine treated mice.
Topics: Amphetamine; Animals; Behavior; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Levodopa; Male; Mice; Pimozide; Promethazine; Psychotropic Drugs; Stereotyped Behavior; Thioridazine; Tranquilizing Agents | 1976 |
The interaction of neuroleptic and muscarinic agents with central dopaminergic systems.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clopenthixol; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Male; Methamphetamine; Models, Biological; Oxotremorine; Parasympathomimetics; Pimozide; Rats; Scopolamine; Substantia Nigra; Thioridazine; Tranquilizing Agents | 1975 |
Clozapine increases rat serum prolactin levels.
Topics: Animals; Brain; Chlorpromazine; Clozapine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Male; Prolactin; Rats; Receptors, Drug; Stimulation, Chemical | 1975 |
Neuroleptic action of clozapine injected into various brain areas in rats.
Topics: Amphetamine; Animals; Brain; Catalepsy; Cerebral Cortex; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Hippocampus; Humans; Injections; Male; Rats; Stereotyped Behavior; Thalamus; Tranquilizing Agents | 1975 |
Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Dibenzoxazepines; Disease Models, Animal; Dopamine; Drug Tolerance; Female; Haloperidol; Homovanillic Acid; Humans; Loxapine; Male; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior; Substance Withdrawal Syndrome | 1975 |
Acetylcholine synthesis in rat brain: dissimilar effects of clozapine and chlorpromazine.
Topics: Acetylcholine; Animals; Avoidance Learning; Behavior, Animal; Cerebral Cortex; Chlorpromazine; Choline; Choline O-Acetyltransferase; Clozapine; Corpus Striatum; Dibenzazepines; Homovanillic Acid; Male; Rats | 1975 |
Inhibition of circling behavior by neuroleptic drugs in mice with unilateral 6-hydroxydopamine lesions of the striatum.
Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior; Biogenic Amines; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Diazepam; Dopamine; Haloperidol; Humans; Hydroxydopamines; Levodopa; Male; Metoclopramide; Mice; Motor Activity; Pentobarbital; Phenoxybenzamine; Pimozide; Promethazine; Stereotyped Behavior; Tranquilizing Agents | 1975 |
Action of neuroleptic agents on histamine-sensitive adenylate cyclase in rabbit cerebral cortex.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Histamine; Promethazine; Rabbits; Thioridazine; Tranquilizing Agents | 1976 |
The pharmacoepidemiology of treatment-refractory schizophrenia.
Topics: Activities of Daily Living; Antipsychotic Agents; Chlorpromazine; Chronic Disease; Clozapine; Cross-Sectional Studies; Dose-Response Relationship, Drug; Humans; Incidence; Long-Term Care; Ontario; Psychiatric Status Rating Scales; Psychotropic Drugs; Schizophrenia; Schizophrenic Psychology | 1992 |
Tardive dyskinesia in the elderly patient.
Topics: Aged; Chlorpromazine; Chronic Disease; Clonazepam; Clozapine; Depressive Disorder; Desipramine; Diphenhydramine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Neurologic Examination | 1992 |
[An investigation on changes in blood CuZn-superoxide dismutase contents in type I, II schizophrenics].
Topics: Adult; Chlorpromazine; Clozapine; Female; Humans; Male; Schizophrenia; Superoxide Dismutase | 1992 |
The effect of typical and atypical antipsychotic drugs on the stimulation of phosphoinositide hydrolysis produced by the 5-HT3 receptor agonist 2-methyl-serotonin.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Dibenzazepines; Hydrolysis; In Vitro Techniques; Inositol; Inositol Phosphates; Male; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin | 1991 |
Amperozide and conditioned behaviour in rats: potentiation by classical neuroleptics and alpha-methylparatyrosine.
Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Butyrophenones; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Female; Food; Haloperidol; Male; Methyltyrosines; Piperazines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1990 |
Behavioural pharmacology of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro- 1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrolidine maleate, a compound interacting with dopaminergic and serotonergic receptors.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Chlorpromazine; Clozapine; Conflict, Psychological; Dibenzocycloheptenes; Dibenzoxepins; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Male; Mice; Mice, Inbred ICR; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Stereotyped Behavior | 1990 |
DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Corpus Striatum; Haloperidol; Limbic System; Male; Neurotensin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotensin; Receptors, Neurotransmitter; Thioridazine; Time Factors | 1990 |
Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells.
Topics: Animals; Atropine; Cell Line; Chlorpromazine; Clozapine; Cricetinae; Cricetulus; Female; Humans; Parasympatholytics; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thioridazine | 1991 |
Clozapine-treated NMS.
Topics: Adult; Chlorpromazine; Clopenthixol; Clozapine; Drug Therapy, Combination; Humans; Male; Neuroleptic Malignant Syndrome; Procyclidine; Recurrence; Schizophrenia; Schizophrenic Psychology | 1991 |
Defining treatment refractoriness in schizophrenia.
Topics: Chlorpromazine; Chronic Disease; Clozapine; Humans; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1990 |
Correction: Seizure activity associated with antipsychotic therapy.
Topics: Chlorpromazine; Clozapine; Humans; Medication Errors; Therapeutic Equivalency | 1990 |
Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Butyrophenones; Cerebral Cortex; Chlorpromazine; Clozapine; Dibenzazepines; Dibenzothiazepines; Down-Regulation; Flupenthixol; Kinetics; Loxapine; Male; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiro Compounds; Time Factors | 1989 |
Differential effect of typical and atypical antipsychotic drugs on the suppressant action of 2-methylserotonin on medical prefrontal cortical cells: a microiontophoretic study.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Iontophoresis; Male; Neurons; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Amphetamine stimulation of glutaminase is blocked by neuroleptics.
Topics: Amphetamine; Animals; Antipsychotic Agents; Brain; Butaclamol; Chlorpromazine; Clozapine; Enzyme Activation; Glutaminase; Haloperidol; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
Effects of neuroleptics on rate and duration of operant versus reflexive licking in rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Conditioning, Operant; Haloperidol; Male; Rats; Rats, Inbred Strains; Reflex; Time Factors | 1985 |
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex.
Topics: 5,7-Dihydroxytryptamine; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Female; Haloperidol; Imipramine; Ketanserin; Loxapine; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Sulpiride | 1986 |
Effect of neuroleptics and of potential new antipsychotic agents (MJ 13859-1 and MJ 13980-1) on a monkey model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Cebus; Chlorpromazine; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Motor Activity; Posture; Spiro Compounds; Thioridazine | 1986 |
3-Methoxytyramine accumulation: effects of typical neuroleptics and various atypical compounds.
Topics: 4-Butyrolactone; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Buspirone; Carbazoles; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluphenazine; Haloperidol; Male; Molindone; Pargyline; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Regression Analysis | 1986 |
In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; Clozapine; Fluphenazine; Haloperidol; Kinetics; Male; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Thioridazine | 1986 |
Effect of neuroleptics on the schizophrenic syndrome.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Chronic Disease; Clozapine; Female; Humans; Male; Schizophrenia; Sulpiride; Syndrome | 1987 |
Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Promethazine; Rats; Rats, Inbred Strains; Septal Nuclei; Thioridazine | 1987 |
Comparative study of schizophrenic patients relapsed on and off medication.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Delayed-Action Preparations; Female; Haloperidol; Humans; Life Change Events; Middle Aged; Psychiatric Status Rating Scales; Recurrence; Risk Factors; Schizophrenia; Schizophrenic Psychology | 1987 |
The paw test: a behavioural paradigm for differentiating between classical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Forelimb; Haloperidol; Hindlimb; Male; Metoclopramide; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Thioridazine | 1987 |
Effects of neuroleptics on glutaminase from rat synaptosomes.
Topics: Amygdala; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Glutaminase; Haloperidol; Hippocampus; Male; Phosphates; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
KC 9172 (free base of KC 7218)--an antipsychotic/anxiolytic compound. I. Antipsychotic and anxiolytic activity in comparison with chlorpromazine, clozapine, diazepam and buspirone.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Buspirone; Chlorpromazine; Clozapine; Diazepam; Male; Mice; Rats; Rats, Inbred Strains; Time Factors | 1988 |
KC 9172 (free base of KC 7218)--an antipsychotic/anxiolytic compound. II. Discrimination from typical neuroleptics and benzodiazepine-like minor tranquilizers.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Buspirone; Chlorpromazine; Clozapine; Conflict, Psychological; Diazepam; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1988 |
Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity.
Topics: Amphetamines; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; DOM 2,5-Dimethoxy-4-Methylamphetamine; Electric Stimulation; Evoked Potentials; Haloperidol; Locus Coeruleus; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sciatic Nerve; Spiperone; Sulpiride | 1988 |
Inhibition of the electrically evoked release of [3H]acetylcholine in rat striatal slices: an experimental model for drugs that enhance dopaminergic neurotransmission.
Topics: Acetylcholine; Amphetamine; Animals; Chlorpromazine; Clozapine; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Haloperidol; Male; Nomifensine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride; Synaptic Transmission | 1985 |
[A comparative study of evoked potentials on clinical symptoms and treatment efficiency in acute schizophrenics].
Topics: Adolescent; Adult; Chlorpromazine; Clozapine; Evoked Potentials, Auditory; Evoked Potentials, Visual; Female; Humans; Male; Middle Aged; Schizophrenia | 1988 |
Inhibition of fibroblast proliferation by myelotoxic drugs.
Topics: Animals; Cell Cycle; Cell Survival; Chlorpromazine; Clozapine; Cricetinae; Dibenzazepines; Dose-Response Relationship, Drug; Fibroblasts; HeLa Cells; Humans | 1985 |
Effects of drugs on schedule-controlled running of mice in a circular runway.
Topics: Amphetamine; Animals; Chlordiazepoxide; Chlorpromazine; Clozapine; Female; Food Deprivation; Imipramine; Mice; Morphine; Motor Activity; Pentobarbital; Reinforcement Schedule | 1985 |
Antischizophrenic drugs: affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Brain; Chlorpromazine; Clozapine; Fluphenazine; Guinea Pigs; Haloperidol; Haplorhini; Humans; In Vitro Techniques; Perphenazine; Phenothiazines; Promazine; Rats; Receptors, Cholinergic; Schizophrenia; Thioridazine; Trifluoperazine; Triflupromazine | 1974 |
Direct effect of neuroleptics on glutamate release.
Topics: Amygdala; Animals; Antipsychotic Agents; Atropine; Avoidance Learning; Butaclamol; Calcium; Chlorpromazine; Clozapine; Glutamates; Glutamic Acid; Glutamine; Haloperidol; In Vitro Techniques; Male; Rats; Synaptosomes | 1984 |
Free-thyroxine index in schizophrenic patients before and after neuroleptic treatment.
Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Middle Aged; Schizophrenia; Thyroxine; Trifluoperazine; Triiodothyronine | 1980 |
Effect of neuroleptics and tricyclic antidepressants upon d-amphetamine discrimination.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imipramine; Male; Nortriptyline; Promethazine; Rats; Sodium Chloride; Thioridazine; Trifluoperazine | 1980 |
Acute effects of neuroleptics on brain self-stimulation thresholds in rats.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Haloperidol; Loxapine; Male; Pimozide; Rats; Self Stimulation | 1980 |
[Dynamics of integral parameters of the background EEG during treatment with neuroleptics].
Topics: Antipsychotic Agents; Automatism; Brain; Chlorpromazine; Clozapine; Electroencephalography; Haloperidol; Humans; Perphenazine; Schizophrenia; Trifluoperazine | 1982 |
The contrasting effects of neuroleptics on transmitter release from the nucleus accumbens and corpus striatum.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Atropine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Female; Haloperidol; Neurotransmitter Agents; Nucleus Accumbens; Potassium; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei; Thioridazine | 1982 |
[Effect of leponex on lactate dehydrogenase activity in a tissue culture of embryonal human brain].
Topics: Anti-Anxiety Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Culture Techniques; Dibenzazepines; Embryo, Mammalian; Humans; L-Lactate Dehydrogenase; Mitochondria; Schizophrenia | 1982 |
Inhibition of leu-enkephalin binding by neuroleptics.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Leucine; Haloperidol; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Comparison of the effects of antipsychotic drugs on the schedule-controlled behavior of squirrel monkeys and pigeons.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Columbidae; Conditioning, Psychological; Haloperidol; Male; Molindone; Promazine; Saimiri; Species Specificity; Thiothixene | 1983 |
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; gamma-Aminobutyric Acid; Haloperidol; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Synaptic Transmission; Tegmentum Mesencephali | 1983 |
Regional selectivity of neuroleptic drugs: an argument for site specificity.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Fluphenazine; Haloperidol; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thioridazine | 1983 |
Cataleptogenic potency of the antipsychotic drugs is inversely correlated with neuronal activity in the amygdaloid complex of the rat.
Topics: Action Potentials; Amygdala; Animals; Antipsychotic Agents; Catalepsy; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Neurons; Pimozide; Rats; Rats, Inbred Strains; Thioridazine | 1983 |
[Use of systematic organization of the EEG in the diagnosis of psychopathologic states].
Topics: Adult; Antipsychotic Agents; Automatism; Chlorpromazine; Clozapine; Dibenzazepines; Drug Evaluation; Electroencephalography; Humans; Schizophrenia, Paranoid; Syndrome | 1983 |
Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Chlorpromazine; Cholecystokinin; Clozapine; Haloperidol; Male; Rats; Rats, Inbred Strains; Sincalide; Tetragastrin | 1983 |
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride | 1984 |
Acute and subchronic effects of neuroleptics on quantitative measures of discriminative motor control in rats.
Topics: Animals; Antipsychotic Agents; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Haloperidol; Male; Psychomotor Performance; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1984 |
Effects of several neuroleptic compounds on the blastogenic response of spleen cells from mice.
Topics: Animals; Antipsychotic Agents; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chlorpromazine; Clozapine; Dextran Sulfate; Dextrans; Dibenzothiazepines; Haloperidol; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Spleen; T-Lymphocytes | 1982 |
The effects of SCH 23390, YM 09151-2, (+)- and (-)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Antipsychotic Agents; Aporphines; Benzamides; Benzazepines; Caudate Nucleus; Chlorpromazine; Clozapine; Flupenthixol; Haloperidol; In Vitro Techniques; Male; Piperidines; Potassium; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1984 |
Effects of catecholamine agonist and antagonist drugs on acute stomach ulceration induced by medial hypothalamic lesions in rats.
Topics: Amphetamine; Animals; Catecholamines; Chlorpromazine; Clozapine; Desipramine; Haloperidol; Hypothalamus, Middle; Isoproterenol; Male; Pargyline; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
LSD-potentiated apomorphine hypermotility: a model for differentiating antipsychotic drugs.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Disease Models, Animal; Drug Antagonism; Haloperidol; Humans; Hyperkinesis; Lysergic Acid Diethylamide; Male; Motor Activity; Rats; Rats, Inbred Strains; Sulpiride | 1983 |
Some effects of clozapine on punished responding by mice and squirrel monkeys.
Topics: Animals; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Haplorhini; Male; Mice; Punishment; Reinforcement Schedule; Saimiri | 1980 |
Behavioral effects of clozapine: comparison with thioridazine, chlorpromazine, haloperidol and chlordiazepoxide in squirrel monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Electroshock; Food; Haloperidol; Male; Reinforcement Schedule; Saimiri; Thioridazine; Tranquilizing Agents | 1983 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Clozapine inhibition of metenkephalin binding to synaptosome-enriched fractions of rat whole brain and hippocampus.
Topics: Animals; Brain; Chlorpromazine; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Haloperidol; Hippocampus; Prochlorperazine; Rats; Synaptosomes | 1981 |
[Cloxazepine: neuropharmacological studies].
Topics: Animals; Behavior, Animal; Chlorpromazine; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Lethal Dose 50; Mice; Mice, Inbred Strains; Motor Activity; Nervous System; Rats | 1981 |
Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra.
Topics: Animals; Binding Sites; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; gamma-Aminobutyric Acid; Haloperidol; Male; Rats; Receptors, Dopamine; Substantia Nigra | 1980 |
Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: antagonism by atypical antipsychotic drugs.
Topics: Action Potentials; Animals; Antipsychotic Agents; Bicuculline; Cerebral Cortex; Chlorpromazine; Clozapine; Electrophysiology; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Risperidone; Serotonin Antagonists | 1994 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
[A study on the pharmacological properties of atypical antipsychotic drugs: in vivo dopamine and serotonin receptor occupancy by atypical antipsychotic drugs in the rat brain].
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Chlorpromazine; Clozapine; Dibenzothiepins; Flupenthixol; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Piperidines; Pyrimidinones; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone | 1993 |
Obstetric complications and severity of illness in schizophrenia.
Topics: Activities of Daily Living; Chlorpromazine; Clozapine; Female; Follow-Up Studies; Humans; Obstetric Labor Complications; Patient Readmission; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Psychiatric Status Rating Scales; Risk Factors; Schizophrenia; Schizophrenic Psychology | 1995 |
Clozapine and seizures.
Topics: Amygdala; Animals; Brain; Brain Mapping; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Evoked Potentials; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission | 1995 |
Neuroleptic medications inhibit complex I of the electron transport chain.
Topics: Adult; Animals; Antipsychotic Agents; Blood Platelets; Brain; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex III; Female; Haloperidol; Humans; Kinetics; Male; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Rats; Thiothixene | 1993 |
Effects of four antipsychotics on punished responding in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conflict, Psychological; Drug Evaluation, Preclinical; Haloperidol; Male; Punishment; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Thioridazine | 1993 |
Levomepromazine receptor binding profile in human brain--implications for treatment-resistant schizophrenia.
Topics: Adolescent; Aged; Binding, Competitive; Brain; Chlorpromazine; Clozapine; Corpus Striatum; Culture Techniques; Female; Frontal Lobe; Humans; Male; Methotrimeprazine; Receptors, Dopamine; Receptors, Neurotransmitter; Schizophrenia; Schizophrenic Psychology; Synaptic Membranes | 1993 |
Differential regulation of rat 5-HT2A and 5-HT2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin | 1995 |
Long-term treatment with chlorpromazine and haloperidol but not with sulpiride and clozapine markedly elevates neuropeptide Y-like immunoreactivity in the rat hypothalamus.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Benzazepines; Chlorpromazine; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Haloperidol; Hypothalamus; Male; Neuropeptide Y; Prazosin; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D1; Sulpiride | 1996 |
Clozapine-chlorpromazine allergic cross-reactivity in a psychotic patient with asymptomatic AIDS.
Topics: Acids; Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Cross Reactions; Drug Hypersensitivity; Humans; Male; Psychotic Disorders | 1996 |
Differential effects of antipsychotics on nitric oxide synthase activity.
Topics: Animals; Antipsychotic Agents; Cerebellum; Chlorpromazine; Clozapine; Nitric Oxide Synthase; omega-N-Methylarginine; Rats | 1997 |
Effect of clozapine on dopamine-induced inhibition of prolactin release from cultured rat pituitary cells.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Chlorpromazine; Clozapine; Dopamine; Fluphenazine; Humans; Pituitary Gland; Prolactin; Rats; Receptors, Dopamine | 1997 |
From chlorpromazine to olanzapine: a brief history of antipsychotics.
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; History, 20th Century; Humans; Olanzapine; Pirenzepine; Psychotic Disorders | 1997 |
The effects of antipsychotic drugs on the mRNA levels of serotonin 5HT2A and 5HT2C receptors.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Down-Regulation; Haloperidol; Male; Organ Specificity; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; RNA, Messenger; Sulpiride; Time Factors; Transcription, Genetic; Up-Regulation | 1997 |
Binding of antipsychotic drugs to cortical 5-HT2A receptors: a PET study of chlorpromazine, clozapine, and amisulpride in schizophrenic patients.
Topics: Adolescent; Adult; Amisulpride; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorine Radioisotopes; Humans; Male; Pyrimidinones; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Schizophrenia; Sulpiride; Tomography, Emission-Computed | 1998 |
Neurochemical variables in schizophrenic patients during switching from neuroleptics to clozapine.
Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Homovanillic Acid; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Prolactin; Regression Analysis; Schizophrenia | 1998 |
Influence of typical and atypical antipsychotics on neuropeptide Y-like immunoreactivity and NPY mRNA expression in rat striatum.
Topics: Adrenergic Antagonists; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; In Situ Hybridization; Injections, Intraperitoneal; Male; Neuropeptide Y; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Sulpiride | 1998 |
Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Haloperidol; Ketamine; Male; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 1998 |
Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase.
Topics: Animals; Antipsychotic Agents; Calcium; Cells, Cultured; Chlorpromazine; Clozapine; Dopamine Antagonists; Frontal Lobe; Guanidines; Haloperidol; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, sigma; Sulpiride | 1999 |
Raclopride and chlorpromazine, but not clozapine, increase muscle rigidity in the rat: relationship with D2 dopamine receptor occupancy.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain Chemistry; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Electromyography; Hindlimb; Male; Muscle Rigidity; Muscle Tonus; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Salicylamides | 1999 |
Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Hippocampus; Isoenzymes; Male; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Protein Binding; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Specific Pathogen-Free Organisms; Time Factors; Type C Phospholipases; Visual Cortex | 1999 |
Dopamine receptor antagonists modulate glucose uptake in rat pheochromocytoma (PC12) cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Biological Transport; Chlorpromazine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fluphenazine; Glucose; Haloperidol; PC12 Cells; Pimozide; Rats; Receptors, Dopamine D2; Spiperone; Sulpiride; Tritium | 1999 |
Clozapine versus chlorpromazine in geriatric patients.
Topics: Age Factors; Aged; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Clozapine; Humans; Research Design; Schizophrenia; Treatment Outcome | 2000 |
The discriminative stimulus properties of the atypical antipsychotic olanzapine in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Discrimination Learning; Generalization, Psychological; Haloperidol; Male; Olanzapine; Pirenzepine; Raclopride; Rats; Rats, Sprague-Dawley; Risperidone; Ritanserin; Scopolamine | 2000 |
Predicting how equipotent doses of chlorpromazine, haloperidol, sulpiride, raclopride and clozapine reduce locomotor activity in mice.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Haloperidol; Male; Mice; Motor Activity; Raclopride; Sulpiride | 2000 |
Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment.
Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Interferon-gamma; Interleukin-2; Male; Middle Aged; Receptors, Interleukin-2; Reference Values; Regression Analysis; Schizophrenia | 2000 |
Chlorpromazine-induced cutaneous pigmentation--effect of replacement with clozapine.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Middle Aged; Pigmentation Disorders; Schizophrenia | 2000 |
Antipsychotic drugs and venous thromboembolism.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Humans; Imipramine; Incidence; Thromboembolism; Venous Thrombosis | 2000 |
[Mental disorders in acute neuroleptic poisoning].
Topics: Acute Disease; Adult; Age Distribution; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Haloperidol; Humans; Male; Mental Disorders; Middle Aged; Suicide, Attempted | 1999 |
Comparison of the effects of clozapine, haloperidol, chlorpromazine and d-amphetamine on performance on a time-constrained progressive ratio schedule and on locomotor behaviour in the rat.
Topics: Animals; Antipsychotic Agents; Central Nervous System Stimulants; Chlorpromazine; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Haloperidol; Motor Activity; Rats; Rats, Wistar; Reinforcement Schedule | 2000 |
Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Drug Interactions; Drug Therapy, Combination; Haloperidol; Humans; Male; Schizophrenia | 2000 |
Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells.
Topics: Adrenal Glands; Alkenes; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Chlorpromazine; Chromaffin Cells; Clozapine; Dopamine Antagonists; Drug Interactions; Electrophysiology; GABA Antagonists; In Vitro Techniques; Nicotine; Nicotinic Antagonists; Norepinephrine; Potassium; Receptors, Nicotinic; Tritium | 2001 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Atypical antipsychotic drugs: how much better are they?
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Haloperidol; Humans; Olanzapine; Pirenzepine | 2001 |
Extended treatment with typical and atypical antipsychotic drugs differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum.
Topics: Animals; Antipsychotic Agents; Benzamides; Benzazepines; Benzodiazepines; Chlorpromazine; Clozapine; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Male; Muscimol; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-A | 2001 |
Comparison of the effects of clozapine, chlorpromazine, and haloperidol on membrane lateral heterogeneity.
Topics: Antipsychotic Agents; Calorimetry, Differential Scanning; Chlorpromazine; Clozapine; Haloperidol; Liposomes; Membrane Lipids; Membranes, Artificial; Microscopy, Fluorescence | 2001 |
Antipsychotic drugs result in the formation of immature neutrophil leucocytes in schizophrenic patients.
Topics: Adolescent; Adult; Antipsychotic Agents; Cell Differentiation; Cell Nucleus; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Female; Humans; Leukocyte Count; Male; Middle Aged; Neutrophils; Reference Values; Schizophrenia | 2001 |
Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Membranes; Piperazines; Piperidines; Pyridines; Pyrimidinones; Pyrrolidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Thiazoles; Thioridazine; Tritium | 2001 |
Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Dialysis Solutions; Dopamine Antagonists; Extracellular Space; Haloperidol; Hippocampus; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Microdialysis; Olanzapine; Piperazines; Pirenzepine; Rats; Rats, Wistar; Risperidone; Serotonin Antagonists; Thiazoles; Thioridazine | 2002 |
Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Haloperidol; Ion Channels; Male; Olanzapine; Phencyclidine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2002 |
Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner.
Topics: Animals; Antipsychotic Agents; Calcimycin; Calcium; Calcium Channel Blockers; Cell Line; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Chlorpromazine; Clozapine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrenes; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Haloperidol; Histamine; Histamine H1 Antagonists; Ionophores; Mammary Tumor Virus, Mouse; Mice; Nifedipine; Phorbol Esters; Phosphodiesterase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Pyrilamine; Pyrrolidinones; Raclopride; Receptors, Glucocorticoid; Remoxipride; Sulfonamides; Sulpiride; Tetradecanoylphorbol Acetate; Thionucleotides; Transcription, Genetic; Type C Phospholipases | 2002 |
Glucose intolerance with atypical antipsychotics.
Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Bayes Theorem; Benzodiazepines; Chlorpromazine; Clozapine; Diabetes Mellitus; Glucose Intolerance; Haloperidol; Humans; Hyperglycemia; Olanzapine; Pirenzepine; Risk Factors; Risperidone; World Health Organization | 2002 |
Discriminative stimulus properties in rats of the novel antipsychotic quetiapine.
Topics: Amisulpride; Analysis of Variance; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dibenzothiazepines; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Psychological; Haloperidol; Loxapine; Quetiapine Fumarate; Quinoxalines; Rats; Rats, Wistar; Risperidone; Sulpiride | 2002 |
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Antipsychotic Agents; Antiviral Agents; Anxiety; Behavior, Animal; Chlorpromazine; Clozapine; Exploratory Behavior; Female; Immunity; Ketamine; Maternal-Fetal Relations; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Orthomyxoviridae Infections; Poly I-C; Pregnancy; Social Behavior | 2003 |
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine | 2003 |
Early events in the life cycle of JC virus as potential therapeutic targets for the treatment of progressive multifocal leukoencephalopathy.
Topics: Antipsychotic Agents; Antiviral Agents; Cell Line; Chlorpromazine; Clozapine; Drug Synergism; Drug Therapy, Combination; Humans; JC Virus; Leukoencephalopathy, Progressive Multifocal; Neuroglia | 2003 |
Lack of effect of mood stabilizers or neuroleptics on GSK-3 protein levels and GSK-3 activity.
Topics: Affect; Animals; Antimanic Agents; Antipsychotic Agents; Blotting, Western; Chlorpromazine; Clozapine; Frontal Lobe; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Haloperidol; Lithium; Rats; Rats, Sprague-Dawley; Valproic Acid | 2003 |
Comparisons of psychotropic drug prescribing patterns in acute psychiatric wards across Europe.
Topics: Adult; Benzodiazepines; Biperiden; Chlorpromazine; Clozapine; Cyclohexanols; Diazepam; Drug Administration Schedule; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization Review; Europe; Female; Humans; Male; Mood Disorders; Olanzapine; Pharmacoepidemiology; Practice Patterns, Physicians'; Psychiatric Department, Hospital; Psychotropic Drugs; Schizophrenia; Time Factors; Venlafaxine Hydrochloride | 2004 |
Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Chlorpromazine; Clozapine; Gene Expression Regulation; Haloperidol; Hippocampus; In Situ Hybridization; Male; Microfilament Proteins; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurites; Olanzapine; Rats; Rats, Sprague-Dawley; Risperidone; RNA, Messenger; Tissue Distribution | 2004 |
Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2005 |
Re: From chlorpromazine to clozapine--antipsychotic adverse effects and the clinician's dilemma.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Decision Making; Hospitalization; Humans; Schizophrenia | 2004 |
Clozapine action on auditory P3 response in schizophrenia.
Topics: Adult; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Double-Blind Method; Event-Related Potentials, P300; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 2005 |
Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Chromones; Clozapine; Dibenzothiazepines; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluphenazine; Haloperidol; Humans; Morpholines; Nerve Growth Factor; Neurites; Olanzapine; PC12 Cells; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quetiapine Fumarate; Rats | 2005 |
In vitro toxicity of clozapine, olanzapine, and quetiapine on granulocyte-macrophage progenitors (GM-CFU).
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Colony-Forming Units Assay; Dibenzothiazepines; Dose-Response Relationship, Drug; Granulocytes; Hematopoietic Stem Cells; Humans; Macrophages; Olanzapine; Quetiapine Fumarate | 2006 |
Long-term antipsychotic treatments and crossover studies in rats: differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Cross-Over Studies; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Haloperidol; Lipid Peroxidation; Male; Membrane Lipids; Olanzapine; Rats; Rats, Wistar; Risperidone; Schizophrenia; Superoxide Dismutase | 2007 |
Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
Topics: Animals; Anisoles; Antipsychotic Agents; Benzazepines; Butaclamol; Caspase Inhibitors; Cell Death; Cells, Cultured; Chlorpromazine; Clozapine; Domperidone; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ginkgo biloba; Haloperidol; Hippocampus; Indans; Isoxazoles; Neurons; Neuroprotective Agents; Peptides; Piperidines; Plant Extracts; Propylamines; Raclopride; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Remoxipride; Risperidone; Sulpiride | 2006 |
Chlorpromazine, clozapine and olanzapine inhibit anionic amino acid transport in cultured human fibroblasts.
Topics: Amino Acid Transport Systems, Acidic; Amino Acids; Antipsychotic Agents; Benzodiazepines; Biological Transport; Cells, Cultured; Chlorpromazine; Clozapine; Fibroblasts; Humans; Olanzapine | 2006 |
Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein.
Topics: Animals; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Chlorpromazine; Clozapine; Cyclosporins; Dibenzothiazepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Flow Cytometry; Fluorescent Dyes; Haloperidol; Isoxazoles; Kidney; Liver; LLC-PK1 Cells; Olanzapine; Paliperidone Palmitate; Pyrimidines; Quetiapine Fumarate; Rhodamine 123; Risperidone; Swine; Transfection | 2006 |
Hippocampus protein profiling reveals aberration of malate dehydrogenase in chlorpromazine/clozapine treated rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Hippocampus; Malate Dehydrogenase; Male; Molecular Sequence Data; Protein Array Analysis; Rats; Rats, Sprague-Dawley | 2006 |
Comparative effectiveness of antipsychotic drugs. A commentary on: Cost Utility Of The Latest Antipsychotic Drugs In Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE).
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Cost-Benefit Analysis; Humans; Randomized Controlled Trials as Topic; Research Design; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; United Kingdom; United States | 2006 |
Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients.
Topics: Adult; Animals; Antipsychotic Agents; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Biomarkers; Brain; Brain Chemistry; Chlorpromazine; Clozapine; Down-Regulation; Humans; Male; Proteomics; Rats; Rats, Sprague-Dawley; Schizophrenia | 2007 |
Comparative neurochemical changes associated with chronic administration of typical and atypical neuroleptics: implications in tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Body Weight; Chlorpromazine; Clozapine; Dopamine; Dyskinesia, Drug-Induced; Haloperidol; Male; Norepinephrine; Prosencephalon; Rats; Rats, Wistar; Risperidone; Serotonin | 2007 |
Antipsychotic-induced movement disorders - forgotten but not gone.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Dopamine; Dyskinesia, Drug-Induced; Humans; Parkinson Disease, Secondary; Risk Factors; Schizophrenia | 2008 |
Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane?
Topics: Antipsychotic Agents; Blood Platelets; Cell Membrane; Chlorpromazine; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Molecular Structure; Phosphatidylinositol Phosphates; Pimozide; Prochlorperazine; Psychotropic Drugs; Quetiapine Fumarate; Signal Transduction; Thrombin; Trifluoperazine | 2008 |
Ethnic comparisons of antipsychotic use in schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Catchment Area, Health; Chlorpromazine; Clozapine; Cross-Cultural Comparison; Delayed-Action Preparations; Drug Administration Schedule; Drug Prescriptions; Drug Therapy; Ethnicity; Female; Humans; Male; Middle Aged; New Zealand; Schizophrenia; Young Adult | 2008 |
Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Chlorpromazine; Clozapine; Cross-Sectional Studies; Drug Administration Schedule; Drug Therapy, Combination; Emergency Service, Hospital; Female; Hospitalization; Humans; Male; Medication Adherence; Middle Aged; Norway; Practice Guidelines as Topic; Practice Patterns, Physicians'; Risk Factors; Schizophrenia; Treatment Outcome | 2009 |
Differential expression profiling of the synaptosome proteome in a rat model of antipsychotic resistance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Dibenzothiazepines; Electrophoresis, Gel, Two-Dimensional; Male; Mass Spectrometry; Multivariate Analysis; Peptide Mapping; Proteome; Proteomics; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Signal Transduction; Synaptosomes | 2009 |
Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Dopamine Plasma Membrane Transport Proteins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Male; Middle Aged; Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Schizophrenia; Treatment Outcome | 2010 |
Hyperactivity of the hypothalamus-pituitary-adrenal axis in lipopolysaccharide-induced neurodevelopmental model of schizophrenia in rats: effects of antipsychotic drugs.
Topics: Amphetamine; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corticosterone; Female; Frontal Lobe; Hippocampus; Hypothalamo-Hypophyseal System; Lipopolysaccharides; Male; Maternal Exposure; Maternal-Fetal Exchange; Motor Activity; Pituitary-Adrenal System; Pregnancy; Rats; Rats, Wistar; Receptors, Glucocorticoid; Reflex, Startle; Schizophrenia; Tacrolimus Binding Proteins | 2011 |
Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of clozapine and chlorpromazine in urine.
Topics: Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid; Clozapine; Humans; Liquid Phase Microextraction; Sensitivity and Specificity; Ultraviolet Rays | 2011 |
In vivo 5-HT(6) receptor occupancy by antipsychotic drugs in the rat brain.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Male; Olanzapine; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Sulfonamides | 2011 |
[Simultaneous determination of trihexyphenidyl, chlorpromazine and clozapine in blood by GC-MS].
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Solvents; Trihexyphenidyl | 2011 |
The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Canada; Chlorpromazine; Clopenthixol; Clozapine; Female; Flupenthixol; Humans; Loxapine; Male; Olanzapine; Pharmacoepidemiology; Schizophrenia | 2011 |
The rise and fall of the atypical antipsychotics.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Schizophrenia | 2011 |
Are all antipsychotic drugs the same?
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Schizophrenia | 2011 |
Clozapine v. chlorpromazine in treatment-naive first-episode schizophrenia.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Schizophrenia | 2012 |
The fall of the atypicals?
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Schizophrenia | 2012 |
Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Middle Aged; Thromboxane A2; Young Adult | 2012 |
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs.
Topics: Age Factors; Aging; Animals; Antipsychotic Agents; Behavior, Animal; Cell Proliferation; Cells, Cultured; Chlorpromazine; Clozapine; Cytokines; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Inflammation Mediators; Injections, Subcutaneous; Lipopolysaccharides; Lymphocyte Activation; Male; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Spleen; T-Lymphocytes; Time Factors | 2012 |
Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes.
Topics: Antipsychotic Agents; Cell Culture Techniques; Chlorpromazine; Clozapine; Gene Expression; Haloperidol; Humans; Jurkat Cells; Microarray Analysis; MicroRNAs; Real-Time Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes | 2014 |
Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study.
Topics: Adult; Alkaline Phosphatase; Antipsychotic Agents; Aripiprazole; Bone Density; Chlorpromazine; Clozapine; Dibenzothiazepines; Estrogens; Female; Humans; Male; Middle Aged; Osteoporosis; Perphenazine; Piperazines; Prolactin; Prospective Studies; Quetiapine Fumarate; Quinolones; Risk Factors; Schizophrenia; Sulpiride | 2014 |
Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.
Topics: Antipsychotic Agents; Apoptosis; Blood-Brain Barrier; Capillary Permeability; Caspase 3; Caspase 8; Caspase 9; Cell Survival; Cells, Cultured; Chlorpromazine; Clozapine; DNA Breaks; Endothelial Cells; Haloperidol; Humans; Microvessels; Oxidative Stress; Reactive Oxygen Species; Risperidone | 2014 |
A systematic microdialysis study of dopamine transmission in the accumbens shell/core and prefrontal cortex after acute antipsychotics.
Topics: Administration, Intravenous; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dopamine; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Raclopride; Rats; Rats, Sprague-Dawley; Risperidone; Time Factors | 2015 |
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.
Topics: Adolescent; Adult; Antipsychotic Agents; Asian People; Chi-Square Distribution; China; Chlorpromazine; Clozapine; Cross-Sectional Studies; Female; Genetic Association Studies; Haplotypes; Humans; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Quetiapine Fumarate; Reelin Protein; Risk Factors; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Young Adult | 2016 |
Eosinophilia and parotitis occurring early in clozapine treatment.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Eosinophilia; Humans; Leukocyte Count; Male; Parotitis; Schizophrenia | 2015 |
Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α
Topics: Animals; Antipsychotic Agents; beta-Arrestin 1; beta-Arrestin 2; Caveolin 1; Chlorpromazine; Clozapine; Cyclic AMP; Endocytosis; Fibroblasts; Fluphenazine; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; MAP Kinase Signaling System; Mice; Mice, Knockout; Molecular Docking Simulation; Norepinephrine; Receptors, Adrenergic, alpha-2 | 2017 |
Chemistry-based molecular signature underlying the atypia of clozapine.
Topics: Antipsychotic Agents; Brain; Caudate Nucleus; Chlorpromazine; Clozapine; Computer Simulation; Humans; Pineal Gland; Prefrontal Cortex; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D4 | 2017 |
Rapid determination of some psychotropic drugs in complex matrices by tandem dispersive liquid-liquid microextraction followed by high performance liquid chromatography.
Topics: Chlorpromazine; Chromatography, High Pressure Liquid; Clozapine; Humans; Limit of Detection; Liquid Phase Microextraction; Psychotropic Drugs; Thioridazine; Time Factors; Wastewater | 2017 |
The role of oxidative stress in antipsychotics induced ovarian toxicity.
Topics: Animals; Antipsychotic Agents; Caspases; Cell Survival; Cells, Cultured; Chlorpromazine; Clozapine; Female; Glutathione; Haloperidol; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Risperidone; Theca Cells | 2017 |
Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience.
Topics: Animals; Arousal; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Emotions; Fever; Male; Rats; Rats, Sprague-Dawley; Risperidone; Thermogenesis; Vasoconstriction | 2017 |
Butyl Methacrylate-Co-Ethylene Glycol Dimethacrylate Monolith for Online in-Tube SPME-UHPLC-MS/MS to Determine Chlopromazine, Clozapine, Quetiapine, Olanzapine, and Their Metabolites in Plasma Samples.
Topics: Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid; Clozapine; Humans; Metabolomics; Olanzapine; Quetiapine Fumarate; Schizophrenia; Solid Phase Microextraction; Tandem Mass Spectrometry | 2019 |
Antipsychotics inhibit the mitochondrial bioenergetics of pancreatic beta cells isolated from CD1 mice.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Energy Metabolism; Haloperidol; Insulin-Secreting Cells; Male; Mice; Mitochondria | 2021 |
Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles.
Topics: Acetylcholine; Aging; Animals; Antipsychotic Agents; Chlorpromazine; Cholinergic Antagonists; Clozapine; Dibenzothiepins; Male; Mental Disorders; Methotrimeprazine; Muscle Contraction; Muscle, Smooth; Olanzapine; Quetiapine Fumarate; Rats, Wistar; Urinary Bladder; Urologic Diseases | 2021 |
Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABA
Topics: Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Clozapine; gamma-Aminobutyric Acid; Humans; Ligands; Receptors, GABA-A | 2022 |
Differing Prevalence and Correlates of Metabolic Syndromes Between Chlorpromazine and Clozapine: A 10-year Retrospective Study of a Male Chinese Cohort.
Topics: Antipsychotic Agents; Chlorpromazine; Cholesterol; Cholesterol, HDL; Clozapine; Humans; Male; Metabolic Syndrome; Prevalence; Retrospective Studies; Risk Factors | 2022 |
Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020.
Topics: Adenosine Monophosphate; Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Chlorpromazine; Clopenthixol; Clozapine; Flupenthixol; Fluphenazine; Haloperidol; Humans; Olanzapine; Paliperidone Palmitate; Pharmaceutical Preparations; Pimozide; Quetiapine Fumarate; Risperidone; Sulpiride; Trifluoperazine | 2022 |
Evaluation of Antipsychotic Drugs' Stability in Oral Fluid Samples.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Gas Chromatography-Mass Spectrometry; Haloperidol; Methotrimeprazine; Quetiapine Fumarate | 2023 |
Risk factors for abnormal glucose metabolism during antipsychotic treatment: A prospective cohort study.
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Cohort Studies; Glucose; Humans; Hypertriglyceridemia; Obesity; Olanzapine; Prospective Studies; Risk Factors | 2023 |