chlorpromazine and clonidine

chlorpromazine has been researched along with clonidine in 86 studies

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (43.02)	18.7374
1990's	7 (8.14)	18.2507
2000's	19 (22.09)	29.6817
2010's	18 (20.93)	24.3611
2020's	5 (5.81)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM	1
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM	1
Chen, J; Chen, X; Huang, L; Li, X; Sun, Y	1
Huang, L; Li, X; Meng, F; Miao, H; Sun, Y	1
Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S	1
Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL	1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T	1
Chen, Y; Feng, F; He, S; Li, Q; Liao, Q; Liu, W; Liu, Y; Lu, W; Sun, H; Xing, S; Xiong, B; Yang, H	1
Chen, L; Chen, Y; Duan, Y; Feng, F; Huang, J; Jiang, X; Liu, C; Liu, W; Qu, W; Sun, H; Wang, Y; Zhou, J	1
Chen, T; Chen, Y; Feng, F; Jiang, X; Li, Q; Liu, C; Liu, W; Lyu, W; Sun, H; Wang, S; Wang, Y; Xing, C	1
Dinnendahl, V; Gumulka, SW	1
Doherty, J; Fang, VS; Fessler, RG; Meltzer, HY; Simonovic, M	1
Paalzow, G; Paalzow, L	1
Fujiwara, M; Oishi, R; Razzak, A; Ueki, S	1
Lal, S; Tsang, D	1
Gaillard, JM; Kafi, S	1
Bernthal, PJ; Koss, MC	1
Revzin, A; Spencer, J	1
Koss, MC	1
Chen, CS; Ozawa, H; Uematsu, T; Watanabe, H	1
Ozawa, H; Uematsu, T	1
Poignant, JC; Rismondo, N	1
Crabbe, JC; Feller, DJ	1
Burnham, DB; Fondacaro, JD; Kolpak, DC; McCafferty, GP	1
Luo, ZP; Yang, XM; Zhou, JH	1
Cools, V; Cox, E; Houvenaghel, A	1
Ferguson, RK; Fruncillo, RJ; Gibbons, WJ; Vlasses, PH	1
Fujita, M; Horikomi, K	1
Hong, M; Jenner, P; Marsden, CD; Roots, EJ	1
Rice, HE; Rosen, J; Silk, KR; Smith, CB	2
Gupta, AK; Jha, BK	1
Fukuda, H; Kato, F; Kato, K; Matsumoto, K; Miyamoto, M; Mori, T; Nakamura, T; Oka, J; Ono, H	1
Kobinger, W; Walland, A	2
Chinea, G; Oronsky, AL; Perper, RJ; Sanda, M	1
Hornykiewicz, O; Kuschinsky, K	1
Dandiya, PC; Patni, SK	1
Gaillard, JM	1
Borsini, F; Nowakowska, E; Samanin, R	1
Handley, SL	1
Scuvée-Moreau, JJ; Svensson, TH	1
Gaillard, JM; Justafre, JC; Kafi, S	1
Beatty, WW; Berry, SL; Costello, KB	1
Westerink, BH	1
Atrens, DM; Gleeson, RM	1
Dwoskin, LP; Sparber, SB	1
Inoue, K; Kasai, H; Kobayashi, M; Kohno, S; Murata, T; Nagasaka, Y; Ohata, K; Sakamoto, H	1
Dearlove, OR; Whelan, R	1
Egawa, M; Inoue, S; Minami, S; Mori, T; Takamura, Y; Wakabayashi, I	1
Ikizler, Y; Koren, G; Selby, P; Theis, JG	1
Ruiz-Ortega, JA; Ugedo, L	1
Hushcha, TO; Luik, AI; Mischenko, NI; Mogilevich, SE	1
Cole, MJ; Jeffery, HE; Osborn, DA	3
Hamasaki, T; Huang, J; Ozoe, Y	1
Davey, JG; Martin, J; Osborn, DA; Zankl, A	2

Reviews

7 review(s) available for chlorpromazine and clonidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Current management of the neonatal abstinence syndrome: a critical analysis of the evidence. Biology of the neonate, 1997, Volume: 71, Issue:6 Topics: Analgesics, Opioid; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Clonidine; Diazepam; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; MEDLINE; Methadone; Morphine; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; Phenobarbital; Sympatholytics	1997
Sedatives for opiate withdrawal in newborn infants. The Cochrane database of systematic reviews, 2002, Issue:3 Topics: Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic	2002
Sedatives for opiate withdrawal in newborn infants. The Cochrane database of systematic reviews, 2005, Jul-20, Issue:3 Topics: Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic	2005
Sedatives for opiate withdrawal in newborn infants. The Cochrane database of systematic reviews, 2010, Oct-06, Issue:10 Topics: Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic	2010
Sedatives for opioid withdrawal in newborn infants. The Cochrane database of systematic reviews, 2021, 05-18, Volume: 5 Topics: Bias; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Randomized Controlled Trials as Topic; Treatment Outcome	2021
Opioid treatment for opioid withdrawal in newborn infants. The Cochrane database of systematic reviews, 2021, 07-07, Volume: 7 Topics: Buprenorphine; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Opium; Phenobarbital; Randomized Controlled Trials as Topic	2021

Trials

1 trial(s) available for chlorpromazine and clonidine

Article	Year
Clonidine in heroin withdrawal syndrome: a controlled study in India. British journal of addiction, 1988, Volume: 83, Issue:9 Topics: Adolescent; Adult; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; India; Male; Random Allocation; Substance Withdrawal Syndrome	1988

Other Studies

78 other study(ies) available for chlorpromazine and clonidine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Molecular pharmacology, 2003, Volume: 63, Issue:3 Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry, 2011, Volume: 46, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine	2011
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding	2012
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine	2013
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease. European journal of medicinal chemistry, 2014, Nov-24, Volume: 87 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates	2014
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European journal of medicinal chemistry, 2015, May-05, Volume: 95 Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine	2015
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured	2016
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species	2017
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques	2017
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Feb-01, Volume: 163 Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram	2019
Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor. Journal of medicinal chemistry, 2020, 09-10, Volume: 63, Issue:17 Topics: Aminoquinolines; Animals; Benzimidazoles; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Female; Humans; Male; Mice, Inbred ICR; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuroprotective Agents; Protein Binding; Small Molecule Libraries	2020
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease. European journal of medicinal chemistry, 2020, Dec-01, Volume: 207 Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Glycogen Synthase Kinase 3; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Morris Water Maze Test; Phosphorylation; Protein Conformation; tau Proteins; Thiazoles	2020
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease. Bioorganic & medicinal chemistry, 2021, 01-15, Volume: 30 Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Glycogen Synthase Kinase 3 beta; Humans; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Pyridines; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured	2021
Stress-induced alterations of cyclic nucleotide levels in brain: effects of centrally acting drugs. Psychopharmacology, 1977, May-09, Volume: 52, Issue:3 Topics: Aminooxyacetic Acid; Animals; Brain; Brain Chemistry; Chlorpromazine; Clonidine; Cyclic AMP; Cyclic GMP; Diazepam; Diphenhydramine; Haloperidol; Indomethacin; Male; Mice; Pentobarbital; Phentolamine; Propanolamines; Propranolol; Reserpine; Stress, Physiological	1977
Effect of d- and l-amphetamine on rat plasma prolactin levels. Psychopharmacology, 1979, Mar-14, Volume: 61, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Chlorpromazine; Clonidine; Dextroamphetamine; Male; Methyltyrosines; Prolactin; Rats; Reserpine	1979
Clonidine antinociceptive activity: effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 292, Issue:2 Topics: 5-Hydroxytryptophan; Analgesia; Animals; Atropine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Chlorpromazine; Clonidine; Electroshock; Fenclonine; Lysergic Acid Diethylamide; Male; Methyltyrosines; Naloxone; Parasympathetic Nervous System; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Reserpine; Sympathetic Nervous System; Vocalization, Animal; Yohimbine	1976
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice. Japanese journal of pharmacology, 1977, Volume: 27, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline	1977
Accumulation of cyclic adenosine 3',5'-monophosphate in human cerebellar cortex slices: effect of monoamine receptor agonists and antagonists. Brain research, 1978, Jan-27, Volume: 140, Issue:2 Topics: Adolescent; Cerebellar Cortex; Chlorpromazine; Clonidine; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Isoproterenol; Male; Norepinephrine; Phentolamine; Serotonin	1978
Involvement of pre- and postsynaptic receptors in catecholaminergic control of paradoxical sleep in man. European journal of clinical pharmacology, 1979, Mar-26, Volume: 15, Issue:2 Topics: Adult; Catecholamines; Chlorpromazine; Clonidine; Drug Interactions; Female; Humans; Male; Receptors, Adrenergic; Sleep, REM; Synapses	1979
Effects of clonidine and chlorpromazine on a sympathetic-cholinergic reflex. European journal of pharmacology, 1979, Nov-23, Volume: 60, Issue:1 Topics: Animals; Blood Pressure; Cats; Chlorpromazine; Clonidine; Galvanic Skin Response; Parasympathetic Nervous System; Reflex; Sympathetic Nervous System; Yohimbine	1979
Amphetamine, chlorpromazine and clonidine effects on self-stimulation in caudate or hypothalamus of the squirrel monkey. Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2 Topics: Amphetamine; Animals; Caudate Nucleus; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Haplorhini; Hypothalamus; Organ Specificity; Saimiri; Self Stimulation	1976
Effect of clonidine and chlorpromazine on centrally evoked electrodermal responses and their interaction with yohimbine. European journal of pharmacology, 1977, Jan-21, Volume: 41, Issue:2 Topics: Animals; Cats; Chlorpromazine; Clonidine; Drug Interactions; Electric Stimulation; Galvanic Skin Response; Hypothalamus; Time Factors; Yohimbine	1977
Effect of clonidine on blood pressure, heart rate and body temperature in conscious rats. Japanese journal of pharmacology, 1977, Volume: 27, Issue:1 Topics: Anesthesia; Animals; Atropine; Blood Pressure; Body Temperature; Chlorpromazine; Clonidine; Desipramine; Drug Synergism; Guanethidine; Heart Rate; Hexamethonium Compounds; Injections, Intravenous; Injections, Subcutaneous; Male; Phentolamine; Rats; Reserpine	1977
[Mode of action of clonidine, a central hypotensive agent, analyzed by the interaction with various sympathomimetic agents]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:3 Topics: Animals; Blood Pressure; Central Nervous System; Chlorpromazine; Clonidine; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Ephedrine; Guanethidine; Guinea Pigs; Haloperidol; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Male; Methamphetamine; Norepinephrine; Rats; Sympathomimetics; Tyramine; Vas Deferens	1975
[Influence of the administration of psychopharmacological compounds on the take up time of an alimentary material in the hamster and a study of the associated behaviour (author's transl)]. Psychopharmacologia, 1975, Jul-23, Volume: 43, Issue:1 Topics: Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clonidine; Cricetinae; Dextroamphetamine; Diazepam; Feeding Behavior; Fenfluramine; Humans; Imipramine; Male; Meprobamate; Mesocricetus; Morphine; Motor Activity; Phenobarbital; Piribedil; Psychotropic Drugs; Stereotyped Behavior; Sulpiride; Time Factors	1975
Effect of neurotransmitter-selective drugs in mice selected for differential sensitivity to the hypothermic actions of ethanol. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3 Topics: Animals; Body Temperature; Chlorpromazine; Clonidine; Dopamine Agents; Drug Interactions; Ethanol; Female; Hypothermia; Male; Mice; Narcotics; Neurotransmitter Agents; Receptors, Drug	1991
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. Journal of pharmacological methods, 1990, Volume: 24, Issue:1 Topics: Animals; Antidiarrheals; Carbachol; Cecum; Chlorpromazine; Cholera Toxin; Clonidine; Colon; Diarrhea; Dose-Response Relationship, Drug; Intestinal Secretions; Intestine, Small; Male; Morphine; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Time Factors	1990
Behavioral evidence for the role of noradrenaline in the putative anxiogenic actions of the inverse benzodiazepine receptor agonist methyl-4-ethyl-6,7-dimethoxy-beta-carboline-3-carboxylate. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:1 Topics: Animals; Carbolines; Chlorpromazine; Clonidine; Conditioning, Operant; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Yohimbine	1989
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets. Veterinary research communications, 1989, Volume: 13, Issue:2 Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia coli Infections; Female; Gastroenteritis, Transmissible, of Swine; Propranolol; Swine; Swine Diseases; Verapamil	1989
Severe hypotension associated with concurrent clonidine and antipsychotic medication. The American journal of psychiatry, 1985, Volume: 142, Issue:2 Topics: Acute Disease; Aged; Antipsychotic Agents; Chlorpromazine; Clonidine; Drug Interactions; Drug Therapy, Combination; Female; Haloperidol; Humans; Hypotension; Male; Middle Aged	1985
[Comparative study of the pharmacological properties of sultopride sulpiride and other antipsychotic drugs: influence of sultopride, sulpiride and other antipsychotic drugs on spontaneous locomotor activity and changes in locomotor activity induced by apo Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1986, Volume: 6, Issue:3 Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Chlorpromazine; Clonidine; Drug Interactions; Haloperidol; Imipramine; Male; Mice; Motor Activity; Pimozide; Sulpiride; Yohimbine	1986
The effect of long-term treatment with amine-depleting drugs or chlorpromazine on alpha-adrenoreceptors and 5-HT2 receptors in the brain of the rat. Neuropharmacology, 1988, Volume: 27, Issue:5 Topics: Animals; Binding, Competitive; Biogenic Amines; Brain; Chlorpromazine; Clonidine; In Vitro Techniques; Ketanserin; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reserpine; Tetrabenazine	1988
Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study. Biological psychiatry, 1985, Volume: 20, Issue:5 Topics: Blood Platelets; Chlorpromazine; Clonidine; Humans; Kinetics; Psychiatric Status Rating Scales; Receptors, Adrenergic, alpha; Schizophrenia; Schizophrenic Psychology; Yohimbine	1985
Effects of tizanidine, a centrally acting muscle relaxant, on motor systems. General pharmacology, 1986, Volume: 17, Issue:2 Topics: Animals; Cerebral Cortex; Chlorpromazine; Clonidine; Decerebrate State; Diazepam; Male; Membranes; Motor Neurons; Muscle Relaxants, Central; Neuromuscular Junction; Neurons, Afferent; Rats; Rats, Inbred Strains; Reflex; Spinal Cord	1986
Modulating effect of central adrenergic neurones on a vagally mediated cardioinhibitory reflex. European journal of pharmacology, 1973, Volume: 22, Issue:3 Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Chlorpromazine; Clonidine; Depression, Chemical; Dogs; Female; Heart; Heart Rate; Isoproterenol; Male; Methacholine Compounds; Neurons; Phentolamine; Receptors, Cholinergic; Reflex; Sympathetic Nervous System; Vagus Nerve	1973
Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation. The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:3 Topics: Animals; Bucladesine; Carrageenan; Chemotaxis; Chloroquine; Chlorpromazine; Chromium Radioisotopes; Clonidine; Colchicine; Cyclophosphamide; Female; Flufenamic Acid; Indomethacin; Inflammation; Leukocyte Transfusion; Leukocytes; Methylprednisolone; Monocytes; Neutrophils; Phenylbutazone; Rats; Transplantation, Homologous; Venoms; Vinblastine	1974
Facilitation of vagal reflex bradycardia by an action of clonidine on central -receptors. European journal of pharmacology, 1972, Volume: 19, Issue:2 Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Bradycardia; Cerebellum; Chlorpromazine; Clonidine; Dogs; Electrocardiography; Female; Guanethidine; Haloperidol; Heart Rate; Male; Phenoxybenzamine; Phentolamine; Receptors, Adrenergic; Time Factors; Vagus Nerve	1972
Effects of morphine on striatal dopamine metabolism: possible mechanism of its opposite effect on locomotor activity in rats and mice. European journal of pharmacology, 1974, Volume: 26, Issue:1 Topics: Animals; Apomorphine; Brain Chemistry; Catalepsy; Catechols; Caudate Nucleus; Chlorpromazine; Clonidine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Fluorometry; Homovanillic Acid; Humans; Male; Methyltyrosines; Mice; Morphine; Motor Activity; Rats; Serine; Species Specificity; Stereotaxic Techniques; Thiocarbamates	1974
Apomorphine induced biting and fighting behaviour in reserpinized rats and an approach to the mechanism of action. Life sciences, 1974, Feb-16, Volume: 14, Issue:4 Topics: Aggression; Amphetamine; Animals; Apomorphine; Behavior, Animal; Benserazide; Chlorpromazine; Clonidine; Dihydroxyphenylalanine; Dopamine; Humans; Methyltyrosines; Norepinephrine; Phenoxybenzamine; Pimozide; Rats; Receptors, Drug; Reserpine; Thiocarbamates; Time Factors	1974
Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment. Psychiatry research, 1984, Volume: 12, Issue:1 Topics: Adult; Blood Platelets; Chlorpromazine; Chronic Disease; Clonidine; Humans; Kinetics; Male; Norepinephrine; Receptors, Adrenergic; Schizophrenia; Yohimbine	1984
Biochemical pharmacology of paradoxical sleep. British journal of clinical pharmacology, 1983, Volume: 16 Suppl 2 Topics: alpha-Methyltyrosine; Animals; Chlorpromazine; Clonidine; Humans; Hydroxydopamines; Locus Coeruleus; Membrane Fluidity; Membrane Lipids; Membrane Proteins; Methyltyrosines; Norepinephrine; Oxidopamine; Piperoxan; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Serotonin; Sleep, REM; Synaptic Transmission; Tyrosine 3-Monooxygenase; Yohimbine	1983
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs. Life sciences, 1984, Mar-19, Volume: 34, Issue:12 Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride	1984
The pinna reflex and its inhibition by clonidine: relationship to sedation and quantitation of central alpha 2-antagonist potency. The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:7 Topics: Adrenergic alpha-Antagonists; Animals; Brain; Chlorpromazine; Clonidine; Ear, External; Hypnotics and Sedatives; Male; Mice; Phenobarbital; Reflex	1984
Sensitivity in vivo of central alpha 2- and opiate receptors after chronic treatment with various antidepressants. Journal of neural transmission, 1982, Volume: 54, Issue:1-2 Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpromazine; Clomipramine; Clonidine; Desipramine; Evoked Potentials; Imipramine; Iprindole; Locus Coeruleus; Male; Mianserin; Morphine; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Zimeldine	1982
On the role of brain alpha-adrenergic systems in the production of paradoxical sleep. L'Encephale, 1982, Volume: 8, Issue:3 Topics: Animals; Chlorpromazine; Clonidine; Desipramine; Male; Phenoxybenzamine; Piperoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Secologanin Tryptamine Alkaloids; Sleep, REM	1982
Suppression of play fighting by amphetamine: effects of catecholamine antagonists, agonists and synthesis inhibitors. Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:5 Topics: Aggression; alpha-Methyltyrosine; Animals; Catecholamines; Chlorpromazine; Clonidine; Dextroamphetamine; Haloperidol; Humans; Male; Methyltyrosines; Motor Activity; Phenoxybenzamine; Propranolol; Rats; Rats, Inbred Strains	1984
Determination of normetanephrine, 3,4-dihydroxyphenylethyleneglycol (free and total), and 3-methoxy-4-hydroxyphenylethyleneglycol (free and total) in rat brain by high-performance liquid chromatography with electrochemical detection and effects of drugs o Journal of neurochemistry, 1984, Volume: 42, Issue:4 Topics: Animals; Brain Chemistry; Chlorpromazine; Chromatography, High Pressure Liquid; Clonidine; Glycols; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes; Yohimbine	1984
Chlorpromazine hyperalgesia antagonizes clonidine analgesia, but enhances morphine analgesia in rats tested in a hot-water tail-flick paradigm. Psychopharmacology, 1982, Volume: 78, Issue:2 Topics: Analgesics; Animals; Chlorpromazine; Clonidine; Drug Interactions; Hypnotics and Sedatives; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reaction Time	1982
Comparison of yohimbine, mianserin, chlorpromazine and prazosin as antagonists of the suppressant effect of clonidine on operant behavior. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1 Topics: Animals; Behavior, Animal; Chlorpromazine; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Mianserin; Prazosin; Rats; Rats, Inbred Strains; Yohimbine	1983
[Pharmacological studies of guanabenz: effects of the central nervous system]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 80, Issue:6 Topics: Animals; Anticonvulsants; Avoidance Learning; Body Temperature; Brain; Chlorpromazine; Clonidine; Diazepam; Guanabenz; Guanidines; Male; Mice; Muscle Relaxants, Central; Psychomotor Performance; Rabbits; Rats; Rats, Inbred Strains; Sleep	1982
Management of clonidine overdose in a child with Tourette syndrome. Developmental medicine and child neurology, 1995, Volume: 37, Issue:5 Topics: Child; Chlorpromazine; Clonidine; Drug Overdose; Humans; Male; Suicide, Attempted; Tourette Syndrome	1995
Impaired growth hormone secretion in VMH lesioned rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1993, Volume: 17, Issue:6 Topics: Animals; Arginine; Chlorpromazine; Clonidine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Immunization, Passive; Kinetics; Periodicity; Rats; Rats, Sprague-Dawley; Somatostatin; Ventromedial Hypothalamic Nucleus	1993
Activation of 5-HT1A receptors potentiates the clonidine inhibitory effect in the locus coeruleus. European journal of pharmacology, 1997, Aug-27, Volume: 333, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Chlorpromazine; Clonidine; Dopamine Antagonists; Dose-Response Relationship, Drug; Injections, Intravenous; Isoquinolines; Locus Coeruleus; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists	1997
Study of human serum albumin structure by dynamic light scattering: two types of reactions under different pH and interaction with physiologically active compounds. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 1998, Volume: 54A, Issue:10 Topics: Atropine; Carbachol; Chlorpromazine; Clonidine; Diphenhydramine; Humans; Hydrogen-Ion Concentration; Isoproterenol; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Phenylephrine; Propranolol; Protein Binding; Scattering, Radiation; Serum Albumin; Yohimbine	1998
Pharmacological characterization of a Bombyx mori alpha-adrenergic-like octopamine receptor stably expressed in a mammalian cell line. Archives of insect biochemistry and physiology, 2010, Volume: 73, Issue:2 Topics: Amidines; Animals; Bombyx; Calcium; Cell Line; Chlorpromazine; Clonidine; Cyclic AMP; Imidazolidines; Insect Proteins; Insecticides; Mammals; Naphazoline; Receptors, Adrenergic, alpha; Receptors, Biogenic Amine; Tolazoline; Yohimbine	2010